ATE492542T1 - Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas - Google Patents

Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas

Info

Publication number: ATE492542T1
Authority: AT; Austria
Prior art keywords: biphenyl; carbonylaminosic; obesitas; preparation; treatment
Prior art date: 2004-10-15

Application number

AT05812611T

Other languages

English (en)

Inventor

Roger Smith

Stephen O'connor

Philip Coish

Derek Lowe

Roger Clark

Jeffrey Stebbins

Ann-Marie Campbell

Christiana Akuche

Tatiana Shelekhin

Original Assignee

Bayer Healthcare Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-15

Filing date

2005-10-14

Publication date

2011-01-15

2005-10-14 Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE492542T1 publication Critical patent/ATE492542T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05812611T 2004-10-15 2005-10-14 Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas ATE492542T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61897504P	2004-10-15	2004-10-15
PCT/US2005/037215 WO2006044775A2 (en)	2004-10-15	2005-10-14	Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity

Publications (1)

Publication Number	Publication Date
ATE492542T1 true ATE492542T1 (de)	2011-01-15

Family

ID=36203612

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05812611T ATE492542T1 (de)	2004-10-15	2005-10-14	Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas

Country Status (21)

Country	Link
US (2)	US7759376B2 (de)
EP (1)	EP1805156B1 (de)
JP (1)	JP2008516978A (de)
KR (1)	KR20070063546A (de)
CN (1)	CN101087769A (de)
AT (1)	ATE492542T1 (de)
AU (1)	AU2005295453A1 (de)
BR (1)	BRPI0516483A (de)
CA (1)	CA2583784A1 (de)
CR (1)	CR9034A (de)
DE (1)	DE602005025517D1 (de)
EA (1)	EA200700851A1 (de)
EC (1)	ECSP077397A (de)
ES (1)	ES2357015T3 (de)
IL (1)	IL182218A0 (de)
MA (1)	MA28935B1 (de)
MX (1)	MX2007004217A (de)
NO (1)	NO20072461L (de)
TN (1)	TNSN07111A1 (de)
WO (1)	WO2006044775A2 (de)
ZA (1)	ZA200703002B (de)

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KR100811100B1 (ko)	2006-09-27	2008-03-06	한국생명공학연구원	벤즈아졸 유도체를 유효성분으로 함유하는 대사성 질환예방 및 치료용 약학적 조성물
KR100795462B1 (ko)	2006-09-27	2008-01-16	한국생명공학연구원	인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물
PE20080888A1 (es)	2006-10-18	2008-08-26	Novartis Ag	COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1)
MX2009006171A (es) *	2006-12-11	2009-06-19	Novartis Ag	Metodo para la prevencion o el tratamiento de isquemia de miocardio.
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AU2008258487B2 (en)	2007-06-08	2012-11-15	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
WO2008148851A1 (en) *	2007-06-08	2008-12-11	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
AR066169A1 (es)	2007-09-28	2009-07-29	Novartis Ag	Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
TW200932235A (en)	2007-12-20	2009-08-01	Astrazeneca Ab	Carbamoyl compounds as DGAT1 inhibitors
CN102083432B (zh)	2008-05-05	2016-02-17	赛诺菲-安万特	酰基氨基取代的稠合环戊烷羧酸衍生物及它们作为药物的用途
CA2725933C (en)	2008-06-05	2018-01-16	Janssen Pharmaceutica Nv	Drug combinations comprising a dgat inhibitor and a ppar-agonist
AR075319A1 (es) *	2008-12-23	2011-03-23	Novartis Ag	Compuestos de biaril- bencil-amina, procesos para su produccion, su uso como productos farmaceuticos, y composiciones farmaceuticas que los comprenden
WO2010084979A1 (en) *	2009-01-23	2010-07-29	Banyu Pharmaceutical Co.,Ltd.	Benzodiazepin-2-on derivatives
WO2010108051A2 (en)	2009-03-20	2010-09-23	Ligand Pharmaceuticals	Inhibitors of diacylglycerol o-acyltransferase 1(dgat-1) and uses thereof
US8268820B2 (en) *	2009-03-26	2012-09-18	Hoffmann-La Roche Inc.	2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
KR20110135411A (ko)	2009-03-27	2011-12-16	브리스톨-마이어스 스큅 컴퍼니	Ｄｐｐ-ｉｖ 억제제로 주요 유해 심장혈관 이벤트를 예방하는 방법
UY32716A (es)	2009-06-19	2011-01-31	Astrazeneca Ab	Compuestos de pirazina carboxamida útiles para el tratamiento de diabetes y obesidad
AR079022A1 (es)	2009-11-02	2011-12-21	Sanofi Aventis	Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
WO2011055289A2 (en)	2009-11-05	2011-05-12	Piramal Life Sciences Limited	Heteroaryl compounds as dgat-1 inhibitors
WO2011074643A1 (ja) *	2009-12-16	2011-06-23	ポーラ化成工業株式会社	色素沈着予防又は改善剤
EP2552441B1 (de)	2010-03-30	2016-05-04	Novartis AG	Verwendung von dgat1-hemmern
KR101392334B1 (ko)	2011-05-03	2014-05-12	한국생명공학연구원	신규한 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
WO2013055910A1 (en)	2011-10-12	2013-04-18	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2892896B1 (de)	2012-09-05	2016-06-29	Bristol-Myers Squibb Company	Pyrrolon- oder pyrrolidinon-antagonisten des melaninkonzentrierenden hormonrezeptor-1
WO2014039412A1 (en)	2012-09-05	2014-03-13	Bristol-Myers Squibb Company	Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
WO2014074668A1 (en)	2012-11-08	2014-05-15	Arena Pharmaceuticals, Inc.	Modulators of gpr119 and the treatment of disorders related thereto
PT3174875T (pt) *	2014-08-01	2020-11-05	Bayer Pharma AG	Processo para a produção de (4s)-4-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-di-hidro-1,6- naftiridino-3-carboxamida e a sua purificação para a utilização como princípio ativo farmacêutico
CN105646510A (zh) *	2014-12-02	2016-06-08	重庆宁牧生态农业有限公司	一种用作抗肥胖剂的化合物
BR112020018790A2 (pt)	2018-03-16	2020-10-13	Anji Pharmaceuticals Inc.	composições e métodos para tratar constipação severa
AU2020291464A1 (en) *	2019-06-12	2022-02-03	Vanderbilt University	Amino acid transport inhibitors and the uses thereof
CN112336718A (zh) *	2020-10-19	2021-02-09	济南大学	一种苯并咪唑衍生物作为α-葡萄糖苷酶抑制剂及其应用
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2005
- 2005-10-14 AT AT05812611T patent/ATE492542T1/de not_active IP Right Cessation
- 2005-10-14 KR KR1020077008522A patent/KR20070063546A/ko not_active Application Discontinuation
- 2005-10-14 WO PCT/US2005/037215 patent/WO2006044775A2/en active Application Filing
- 2005-10-14 AU AU2005295453A patent/AU2005295453A1/en not_active Abandoned
- 2005-10-14 EP EP05812611A patent/EP1805156B1/de not_active Not-in-force
- 2005-10-14 DE DE602005025517T patent/DE602005025517D1/de active Active
- 2005-10-14 MX MX2007004217A patent/MX2007004217A/es not_active Application Discontinuation
- 2005-10-14 US US11/665,317 patent/US7759376B2/en not_active Expired - Fee Related
- 2005-10-14 CN CNA2005800433280A patent/CN101087769A/zh active Pending
- 2005-10-14 BR BRPI0516483-4A patent/BRPI0516483A/pt not_active IP Right Cessation
- 2005-10-14 ES ES05812611T patent/ES2357015T3/es active Active
- 2005-10-14 JP JP2007536988A patent/JP2008516978A/ja active Pending
- 2005-10-14 CA CA002583784A patent/CA2583784A1/en not_active Abandoned
- 2005-10-14 EA EA200700851A patent/EA200700851A1/ru unknown
2007
- 2007-03-27 IL IL182218A patent/IL182218A0/en unknown
- 2007-03-28 TN TNP2007000111A patent/TNSN07111A1/en unknown
- 2007-03-30 CR CR9034A patent/CR9034A/es not_active Application Discontinuation
- 2007-04-12 ZA ZA200703002A patent/ZA200703002B/xx unknown
- 2007-04-13 EC EC2007007397A patent/ECSP077397A/es unknown
- 2007-04-17 MA MA29831A patent/MA28935B1/fr unknown
- 2007-05-14 NO NO20072461A patent/NO20072461L/no not_active Application Discontinuation
2010
- 2010-07-14 US US12/836,035 patent/US20110118302A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20110118302A1 (en)	2011-05-19
US7759376B2 (en)	2010-07-20
DE602005025517D1 (de)	2011-02-03
IL182218A0 (en)	2007-09-20
WO2006044775A2 (en)	2006-04-27
ECSP077397A (es)	2007-05-30
MX2007004217A (es)	2007-06-11
EP1805156A2 (de)	2007-07-11
WO2006044775A3 (en)	2006-06-15
NO20072461L (no)	2007-07-03
AU2005295453A1 (en)	2006-04-27
CR9034A (es)	2008-11-18
EP1805156B1 (de)	2010-12-22
TNSN07111A1 (en)	2008-06-02
BRPI0516483A (pt)	2008-09-02
EA200700851A1 (ru)	2007-12-28
KR20070063546A (ko)	2007-06-19
CN101087769A (zh)	2007-12-12
CA2583784A1 (en)	2006-04-27
EP1805156A4 (de)	2009-06-10
ZA200703002B (en)	2008-08-27
JP2008516978A (ja)	2008-05-22
ES2357015T3 (es)	2011-04-15
MA28935B1 (fr)	2007-10-01
US20070265298A1 (en)	2007-11-15

Publication	Publication Date	Title
ATE492542T1 (de)	2011-01-15	Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas
MXPA05012061A (es)	2006-02-22	Preparacion y uso de derivados alquilarilo para el tratamiento de la obesidad.
EA200900802A1 (ru)	2010-04-30	Способы и композиции для лечения амилоидных заболеваний
EA200600078A1 (ru)	2006-08-25	Способы и композиции для лечения амилоидных заболеваний
WO2007016538A3 (en)	2007-10-04	Preparation and use of biphenyl amino acid derivatives for the treatment of obesity
DE602004020072D1 (de)	2009-04-30	1,2,3,4-tetrasubstituiertes indol zur behandlung von atemwegserkrankungen
ATE519488T1 (de)	2011-08-15	Aminopyrazin-analoga zur behandlung von glaukomen und anderen durch rho-kinase verursachten krankheiten
ATE395871T1 (de)	2008-06-15	Marknagel zur behandlung von proximalen oberschenkelknochenbrüchen
TW200730515A (en)	2007-08-16	N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
DE60303238D1 (de)	2006-04-06	Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
ATE544748T1 (de)	2012-02-15	Zusammensetzungen und verfahren für die behandlung von zellproliferationserkrankungen
NO20064325L (no)	2006-11-22	Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes
ATE538651T1 (de)	2012-01-15	Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
ATE389395T1 (de)	2008-04-15	Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson
ATE447551T1 (de)	2009-11-15	Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
DE602005021970D1 (de)	2010-08-05	Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen
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