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ATE473005T1 - Histone-deacetylase-inhibitoren - Google Patents

Histone-deacetylase-inhibitoren

Info

Publication number
ATE473005T1
ATE473005T1 AT03711981T AT03711981T ATE473005T1 AT E473005 T1 ATE473005 T1 AT E473005T1 AT 03711981 T AT03711981 T AT 03711981T AT 03711981 T AT03711981 T AT 03711981T AT E473005 T1 ATE473005 T1 AT E473005T1
Authority
AT
Austria
Prior art keywords
histone deacetylase
deacetylase inhibitors
inhibitors
histone
deacetylase
Prior art date
Application number
AT03711981T
Other languages
English (en)
Inventor
Emelen Kristof Van
Marc Gustaaf Celine Verdonck
Brandt Sven Franciscus Anna Van
Patrick Rene Angibaud
Lieven Meerpoel
Alexey Borisovich Dyatkin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE473005T1 publication Critical patent/ATE473005T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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CA2476296A1 (en) 2003-09-18
DK1485353T3 (da) 2011-11-28
US9533979B2 (en) 2017-01-03
EP1485353A1 (de) 2004-12-15
CN1639125A (zh) 2005-07-13
JP2005525381A (ja) 2005-08-25
EP1485099B1 (de) 2010-07-07
AU2003218736A1 (en) 2003-09-22
AU2003218737B2 (en) 2008-04-10
US20050119250A1 (en) 2005-06-02
AU2003212335B8 (en) 2009-04-23
AU2003212337A1 (en) 2003-09-22
EP1485353B1 (de) 2011-08-24
US20050222414A1 (en) 2005-10-06
JP4725944B2 (ja) 2011-07-13
ZA200407233B (en) 2005-10-06
CA2476583A1 (en) 2003-09-18
US8343988B2 (en) 2013-01-01
ES2322252T3 (es) 2009-06-18
US7816363B2 (en) 2010-10-19
CA2475764A1 (en) 2003-09-18
US20120108603A1 (en) 2012-05-03
WO2003075929A1 (en) 2003-09-18
AU2003212335A1 (en) 2003-09-22
US8916554B2 (en) 2014-12-23
DE60333260D1 (en) 2010-08-19
JP2005523907A (ja) 2005-08-11
NO20044194L (no) 2004-10-01
DE60326549D1 (en) 2009-04-23
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OA12791A (en) 2006-07-10
OA12790A (en) 2006-07-10
US20050107384A1 (en) 2005-05-19
ES2371632T3 (es) 2012-01-05
ZA200407234B (en) 2005-10-06
US20100048588A1 (en) 2010-02-25
HK1078473A1 (en) 2006-03-17
US9150560B2 (en) 2015-10-06
CN1642551A (zh) 2005-07-20
ZA200407237B (en) 2005-09-28
US8524711B2 (en) 2013-09-03
EP1485364B1 (de) 2009-03-11
AU2003212335B2 (en) 2008-11-27
US20130303506A1 (en) 2013-11-14
US20050096468A1 (en) 2005-05-05
IL164004A0 (en) 2005-12-18
WO2003076400A1 (en) 2003-09-18
HRP20040799A2 (en) 2005-04-30
US20150065478A1 (en) 2015-03-05
US20120252790A1 (en) 2012-10-04
US20090170836A1 (en) 2009-07-02
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US20140171439A1 (en) 2014-06-19
ES2347544T3 (es) 2010-11-02

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