ATE458730T1 - Polycyclische pyrazine als kaliumionenkanal- modulatoren - Google Patents
Polycyclische pyrazine als kaliumionenkanal- modulatorenInfo
- Publication number
- ATE458730T1 ATE458730T1 AT05779464T AT05779464T ATE458730T1 AT E458730 T1 ATE458730 T1 AT E458730T1 AT 05779464 T AT05779464 T AT 05779464T AT 05779464 T AT05779464 T AT 05779464T AT E458730 T1 ATE458730 T1 AT E458730T1
- Authority
- AT
- Austria
- Prior art keywords
- polycyclic
- pyrazine
- potassium ion
- ion channel
- channel modulators
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 2
- 108020001213 potassium channel Proteins 0.000 title abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
- -1 polycyclic pyrazines Chemical class 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Amplifiers (AREA)
- Discharge Lamp (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56214904P | 2004-04-13 | 2004-04-13 | |
| PCT/US2005/012525 WO2005121126A1 (en) | 2004-04-13 | 2005-04-13 | Polycyclic pyrazines as potassium ion channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458730T1 true ATE458730T1 (de) | 2010-03-15 |
Family
ID=35079213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05779464T ATE458730T1 (de) | 2004-04-13 | 2005-04-13 | Polycyclische pyrazine als kaliumionenkanal- modulatoren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7642354B2 (de) |
| EP (1) | EP1742935B1 (de) |
| AT (1) | ATE458730T1 (de) |
| AU (1) | AU2005252160A1 (de) |
| CA (1) | CA2561831A1 (de) |
| DE (1) | DE602005019556D1 (de) |
| WO (1) | WO2005121126A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ561000A (en) * | 2005-02-28 | 2010-01-29 | Japan Tobacco Inc | Novel aminopyridine compound with Syk inhibitory activity |
| EP1940804A2 (de) * | 2005-10-14 | 2008-07-09 | NeuroSearch A/S | Neue pyrimidin-2,4-diaminderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit |
| EP1998775B1 (de) * | 2006-03-17 | 2010-05-19 | Université de Liège | Bis-1,2,3,4-tetrahydroisochinolinderivate und ihre verwendung als pharmazeutika |
| CA2655857C (en) | 2006-06-22 | 2014-12-02 | Mallinckrodt Inc. | Pyrazine derivatives with extended conjugation and uses thereof |
| US8415358B2 (en) | 2007-09-17 | 2013-04-09 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| PT2209778E (pt) | 2007-09-21 | 2012-12-06 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazole como activadores de glucoquinase para o tratamento de diabetes mellitus |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| FR2925906B1 (fr) * | 2008-01-02 | 2010-08-20 | Sanofi Aventis | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| US20090270418A1 (en) * | 2008-01-09 | 2009-10-29 | Marianne Sloss | Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith |
| MX2010007973A (es) | 2008-02-01 | 2010-11-09 | Akinion Pharmaceuticals Ab | Derivados de pirazina y su uso como inhibidores de proteina cinasa. |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2009119528A1 (ja) * | 2008-03-24 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| GB0821307D0 (en) * | 2008-11-21 | 2008-12-31 | Summit Corp Plc | Compounds for treatment of duchenne muscular dystrophy |
| EP2776417B1 (de) | 2011-11-09 | 2018-10-31 | Cancer Research Technology Limited | 5-(pyridin-2-yl-amino)-pyrazin-2-carbonitrilverbindungen und therapeutische verwendung davon |
| EP3210980B1 (de) | 2012-05-15 | 2024-04-03 | Cancer Research Technology Ltd | Verfahren zur herstellung von 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluormethyl)-2-pyridyl]amino]pyrazin-2-carbonitril |
| BR112015017331B1 (pt) | 2013-01-23 | 2022-01-11 | Astrazeneca Ab | Compostos de formula i, forma cristalina, uso dos compostos, combinação e composição |
| MX369857B (es) | 2014-02-14 | 2019-11-25 | Takeda Pharmaceuticals Co | Pirazinas moduladoras de receptor 6 acoplado a la proteina g (gpr6). |
| EP3116506B1 (de) * | 2014-03-13 | 2019-04-17 | Merck Sharp & Dohme Corp. | 2-pyrazincarboxamide als milz-tyrosinkinase-inhibitoren |
| CN108690006B (zh) * | 2017-04-12 | 2022-02-18 | 中国药科大学 | 一类化合物及其在抗aml药物中的用途 |
| TW202317106A (zh) | 2021-08-27 | 2023-05-01 | 南韓商柳韓洋行 | 作為egfr抑制劑之取代胺基吡啶化合物 |
| TW202328096A (zh) * | 2021-08-27 | 2023-07-16 | 南韓商柳韓洋行 | 作為egfr抑制劑之含五員雜芳基之胺基吡啶化合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8504631D0 (en) | 1985-02-22 | 1985-03-27 | Ici Plc | Chromogenic compounds |
| EP1363702A4 (de) | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | Verfahren zur hemmung von kinasen |
| US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| GB0108102D0 (en) | 2001-03-30 | 2001-05-23 | Pfizer Ltd | Compounds |
| WO2003094861A2 (en) | 2002-05-13 | 2003-11-20 | Icagen, Inc. | Bis-benzimidazoles and related compounds as potassium channel modulators |
| GB0215775D0 (en) | 2002-07-06 | 2002-08-14 | Astex Technology Ltd | Pharmaceutical compounds |
| WO2004084813A2 (en) | 2003-03-21 | 2004-10-07 | Smithkline Beecham Corporation | Chemical compounds |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| RU2006118325A (ru) | 2003-10-27 | 2007-12-10 | Астеллас Фарма Инк. (Jp) | Производные пиразина и их фармацевтическое применение |
| JP4808628B2 (ja) | 2003-12-03 | 2011-11-02 | ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド | アゾール系キナーゼ阻害剤 |
| US20080194574A1 (en) | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| MXPA06007640A (es) | 2004-01-12 | 2007-04-17 | Cytopia Res Pty Ltd | Inhibidores de quinasa selectivos. |
-
2005
- 2005-04-13 AT AT05779464T patent/ATE458730T1/de not_active IP Right Cessation
- 2005-04-13 AU AU2005252160A patent/AU2005252160A1/en not_active Abandoned
- 2005-04-13 WO PCT/US2005/012525 patent/WO2005121126A1/en active Application Filing
- 2005-04-13 DE DE602005019556T patent/DE602005019556D1/de active Active
- 2005-04-13 CA CA002561831A patent/CA2561831A1/en not_active Abandoned
- 2005-04-13 EP EP05779464A patent/EP1742935B1/de not_active Not-in-force
- 2005-04-13 US US11/105,668 patent/US7642354B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005121126A1 (en) | 2005-12-22 |
| US20050239800A1 (en) | 2005-10-27 |
| AU2005252160A1 (en) | 2005-12-22 |
| US7642354B2 (en) | 2010-01-05 |
| DE602005019556D1 (de) | 2010-04-08 |
| CA2561831A1 (en) | 2005-12-22 |
| EP1742935B1 (de) | 2010-02-24 |
| EP1742935A1 (de) | 2007-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |