[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE331731T1 - Verfahren zur herstellung von diphtheria toxin - Google Patents

Verfahren zur herstellung von diphtheria toxin

Info

Publication number
ATE331731T1
ATE331731T1 AT00906484T AT00906484T ATE331731T1 AT E331731 T1 ATE331731 T1 AT E331731T1 AT 00906484 T AT00906484 T AT 00906484T AT 00906484 T AT00906484 T AT 00906484T AT E331731 T1 ATE331731 T1 AT E331731T1
Authority
AT
Austria
Prior art keywords
toxin
diphtheria toxin
glucose
eluting
purifying
Prior art date
Application number
AT00906484T
Other languages
English (en)
Inventor
Henry Raphael Wolfe
Fahar Merchant
Rosamina Merchant
Christopher D V Black
Harry Storflor
Geir O Stokke
Halldis Hellebust
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Application granted granted Critical
Publication of ATE331731T1 publication Critical patent/ATE331731T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00906484T 1999-02-26 2000-02-25 Verfahren zur herstellung von diphtheria toxin ATE331731T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9904582.5A GB9904582D0 (en) 1999-02-26 1999-02-26 Process

Publications (1)

Publication Number Publication Date
ATE331731T1 true ATE331731T1 (de) 2006-07-15

Family

ID=10848658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00906484T ATE331731T1 (de) 1999-02-26 2000-02-25 Verfahren zur herstellung von diphtheria toxin

Country Status (8)

Country Link
US (4) US6689871B1 (de)
EP (1) EP1157034B1 (de)
AT (1) ATE331731T1 (de)
AU (1) AU2814600A (de)
DE (1) DE60029091T2 (de)
ES (1) ES2267499T3 (de)
GB (1) GB9904582D0 (de)
WO (1) WO2000050449A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9904582D0 (en) * 1999-02-26 1999-04-21 Nycomed Imaging As Process
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
CA2627614A1 (en) * 2005-11-02 2007-05-18 St. Louis University Enzymes immobilized in hydrophobically modified polysaccharides
US7977283B2 (en) * 2008-06-27 2011-07-12 Baker Hughes Incorporated Method of minimizing or reducing salt deposits by use of a fluid containing a fructan and derivatives thereof
IT1398927B1 (it) 2009-06-25 2013-03-28 Consorzio Interuniversitario Per Lo Sviluppo Dei Sistemi A Grande Interfase Csgi Espressione batterica di un gene artificiale per la produzione di crm197 e derivati.
CN102869778B (zh) 2010-03-30 2015-05-20 菲尼克斯公司 重组毒素蛋白的高水平表达
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
WO2013052915A2 (en) 2011-10-05 2013-04-11 Genelux Corporation Method for detecting replication or colonization of a biological therapeutic
EP2592137A1 (de) 2011-11-11 2013-05-15 Novartis AG Fermentierungsmedium ohne Bestandteile tierischen Ursprungs zur Herstellung von Diphtherie-Impfstoffen zur menschlichen Impfung
DE102011118371B4 (de) 2011-11-11 2014-02-13 Novartis Ag Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de) 2011-11-11 2014-12-24 Novartis Ag Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
GB2495341B (en) 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
WO2013138522A2 (en) 2012-03-16 2013-09-19 Genelux Corporation Methods for assessing effectiveness and monitoring oncolytic virus treatment
WO2013158265A1 (en) 2012-04-20 2013-10-24 Genelux Corporation Imaging methods for oncolytic virus therapy
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
GB201209896D0 (en) 2012-06-01 2012-07-18 Fujifilm Diosynth Biotechnologies Uk Ltd Process
US20140140959A1 (en) 2012-10-05 2014-05-22 Aladar A. Szalay Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes
WO2015103438A2 (en) 2014-01-02 2015-07-09 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
US10329323B2 (en) * 2014-07-25 2019-06-25 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Method for purifying antibodies using PBS
NZ730563A (en) 2014-10-14 2019-05-31 Halozyme Inc Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
EP3442999A2 (de) 2016-04-15 2019-02-20 Alpine Immune Sciences, Inc. Immunmodulatorische proteine der icos-ligand-variante und verwendungen davon
AU2017248830B2 (en) 2016-04-15 2023-03-09 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
CA3032120A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
US20200040059A1 (en) 2016-10-20 2020-02-06 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
JP2020507349A (ja) 2017-02-09 2020-03-12 インダプタ セラピューティクス インコーポレイテッド 操作されたナチュラルキラー（ｎｋ）細胞ならびにその組成物および方法
CN110662758A (zh) 2017-03-16 2020-01-07 高山免疫科学股份有限公司 Cd80变体免疫调节蛋白及其用途
CA3053812A1 (en) 2017-03-16 2018-09-20 Alpine Immune Sciences, Inc. Pd-l2 variant immunomodulatory proteins and uses thereof
ES2963638T3 (es) 2017-03-16 2024-04-01 Alpine Immune Sciences Inc Proteínas inmunomoduladoras de variantes de PD-L1 y usos de las mismas
WO2018193475A2 (en) 2017-04-22 2018-10-25 Biological E Limited An improved method for high level production of crm
EP3444269A1 (de) 2017-08-17 2019-02-20 National Research Council of Canada Systeme und methoden für die produktion von diphteria-giftstoff-polypeptiden
EP3697810A2 (de) 2017-10-18 2020-08-26 Alpine Immune Sciences, Inc. Immunmodulatorische proteine der icos-ligand-varianteund entsprechende zusammensetzungen und verfahren
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy
EP3801584B1 (de) 2018-06-04 2023-09-27 Calidi Biotherapeutics, Inc. Auf zellen basierende vehikel zur potenzierung einer virentherapie
WO2019241758A1 (en) 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
EP3844276A2 (de) 2018-08-28 2021-07-07 Actym Therapeutics, Inc. Manipulierte immunstimulierende bakterienstämme und verwendungen davon
CN113271955A (zh) 2018-11-06 2021-08-17 卡利迪生物治疗有限公司 用于细胞介导的溶瘤病毒疗法的增强的系统
EP3884041A2 (de) 2018-11-21 2021-09-29 Indapta Therapeutics, Inc. Verfahren zur expansion des subsets von natürlichen killer (nk)-tellen und verwandte zusammensetzungen und verfahren
JP2022510276A (ja) 2018-11-30 2022-01-26 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｄ８６バリアント免疫調節タンパク質およびその使用
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
WO2020176809A1 (en) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
EP4139439A1 (de) 2020-04-22 2023-03-01 Indapta Therapeutics, Inc. Zusammensetzungen natürlicher killerzellen (nk) und verfahren zur erzeugung davon
WO2022147480A1 (en) 2020-12-30 2022-07-07 Ansun Biopharma, Inc. Oncolytic virus encoding sialidase and multispecific immune cell engager
CN113755380A (zh) * 2021-09-23 2021-12-07 艾美卫信生物药业（浙江）有限公司 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH660375A5 (it) * 1983-02-08 1987-04-15 Sclavo Spa Procedimento per la produzione di proteine correlate alla tossina difterica.
US4711845A (en) * 1984-08-31 1987-12-08 Cetus Corporation Portable temperature-sensitive control cassette
IN165717B (de) * 1986-08-07 1989-12-23 Battelle Memorial Institute
US5728383A (en) 1987-10-05 1998-03-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Treatment of tumors of the central nervous system with immunotoxins
GB9904582D0 (en) * 1999-02-26 1999-04-21 Nycomed Imaging As Process
US20060243666A1 (en) * 2005-04-29 2006-11-02 Jenkins Lauri L Process for the preparation of protein separation solution

Also Published As

Publication number Publication date
US6962803B2 (en) 2005-11-08
DE60029091T2 (de) 2007-05-31
GB9904582D0 (en) 1999-04-21
ES2267499T3 (es) 2007-03-16
AU2814600A (en) 2000-09-14
US20080153750A1 (en) 2008-06-26
EP1157034B1 (de) 2006-06-28
US20060035340A1 (en) 2006-02-16
EP1157034A1 (de) 2001-11-28
US20040087775A1 (en) 2004-05-06
US6689871B1 (en) 2004-02-10
WO2000050449A1 (en) 2000-08-31
US7273728B2 (en) 2007-09-25
DE60029091D1 (de) 2006-08-10
US7575891B2 (en) 2009-08-18

Similar Documents

Publication Publication Date Title
ATE331731T1 (de) Verfahren zur herstellung von diphtheria toxin
GR3034722T3 (en) ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF -i(TAXUS) SPECIES.
AU5102899A (en) Process and materials for production of glucosamine
UA27034C2 (uk) Спосіб одержаhhя лізиhу
CA2264270A1 (en) Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture
BR0012712A (pt) Métodos de produção de l-aminoácidos aumentando-se o nadph celular
EP0887420A3 (de) Verfahren zur Herstellung von L-Aminosäuren durch Fermentation
EP1254957A3 (de) Verfahren zur Herstellung einer Zielsubstanz mittels Fermentation
EA199700004A1 (ru) Усиленная аккумуляция трегалозы в растениях
HU9501951D0 (en) A process for producing immunosuppressives and a novel microbial species to be employed therein
DK1212448T3 (da) Fremgangsmåde til fremstilling af exopolysaccharider
MY113838A (en) Process for production of amide compounds using microorganism
DE69228761D1 (de) Verfahren zur herstellung von neuraminidase
ES2141258T3 (es) Enzima y su uso en la preparacion de acido (s)-pipecolico.
JPS55102393A (en) Enzymatic preparation of tyramine
SU871525A1 (ru) Способ получени НАД-зависимой формиатдегидрогеназы
WO2002064811A3 (fr) Procede pour produire des proteines recombinantes, marquees par au moins un isotope
DE60332845D1 (de) Verfahren zur herstellung von glucosedehydrogenasen
JP2946055B2 (ja) 光学活性（ｓ）‐（＋）‐３‐ハロ‐１，２―プロパンジオールの製造法
DE68918776D1 (de) Verfahren zur Herstellung von Biokatalysatoren mit vorher fehlender stereoselektiver Enzymaktivität.
KR900018384A (ko) 항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도
RU95111272A (ru) Способ получения биопрепаратов
WO2001014419A3 (en) Growth-enhancing media for mycobacteria
UA13883A (uk) Біопрепарат для рослиhhицтва
JPS5668394A (en) Production of d(-)-beta-hydroxyisobutyric acid

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties