ATE397063T1 - Fibroblasten-wachstumsfaktor-19 - Google Patents
Fibroblasten-wachstumsfaktor-19Info
- Publication number
- ATE397063T1 ATE397063T1 AT98961795T AT98961795T ATE397063T1 AT E397063 T1 ATE397063 T1 AT E397063T1 AT 98961795 T AT98961795 T AT 98961795T AT 98961795 T AT98961795 T AT 98961795T AT E397063 T1 ATE397063 T1 AT E397063T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptides
- present
- methods
- treatment
- diagnosis
- Prior art date
Links
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 title 1
- 101710153349 Fibroblast growth factor 19 Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 230000004544 DNA amplification Effects 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000008267 autocrine signaling Effects 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6684097P | 1997-11-25 | 1997-11-25 | |
| US15834298A | 1998-09-21 | 1998-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397063T1 true ATE397063T1 (de) | 2008-06-15 |
Family
ID=26747212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98961795T ATE397063T1 (de) | 1997-11-25 | 1998-11-25 | Fibroblasten-wachstumsfaktor-19 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1032668B1 (de) |
| JP (1) | JP3653469B2 (de) |
| KR (2) | KR100506786B1 (de) |
| AT (1) | ATE397063T1 (de) |
| AU (1) | AU733222B2 (de) |
| CA (1) | CA2309783C (de) |
| DE (1) | DE69839571D1 (de) |
| DK (1) | DK1032668T3 (de) |
| IL (2) | IL136055A0 (de) |
| NZ (1) | NZ504425A (de) |
| WO (1) | WO1999027100A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605441B1 (en) | 1995-06-05 | 2003-08-12 | Human Genome Sciences, Inc. | Antibodies against fibroblast growth factor 11 |
| US6787640B2 (en) | 1995-06-05 | 2004-09-07 | Human Genome Sciences, Inc. | Fibroblast growth factor 14 |
| US20050043234A1 (en) | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| JP3653469B2 (ja) * | 1997-11-25 | 2005-05-25 | ジェネンテック・インコーポレーテッド | 線維芽細胞増殖因子−１９ |
| WO2000056890A1 (en) * | 1999-03-19 | 2000-09-28 | Chiron Corporation | Human fgf gene and gene expression products |
| JP2003501087A (ja) * | 1999-06-09 | 2003-01-14 | ジェネンテック・インコーポレーテッド | 腫瘍の治療のための組成物と方法 |
| US7459540B1 (en) * | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| CA2384089A1 (en) * | 1999-09-08 | 2001-03-15 | Genentech, Inc. | Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
| DK1214409T3 (da) * | 1999-09-08 | 2006-09-04 | Genentech Inc | Fibroblast vækstfaktor-19 (FGF-19) nucleinsyrer og polypeptider samt anvendelsesmetoder til behandling af fedme |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| ATE446365T1 (de) * | 1999-11-18 | 2009-11-15 | Novartis Vaccines & Diagnostic | Menschliches fgf-21 gen und genexpressionsprodukte |
| WO2001049849A1 (en) * | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
| EP1246843A1 (de) * | 2000-01-05 | 2002-10-09 | ZymoGenetics, Inc. | Neues fgf homolog zfgf12 |
| EP1257645A2 (de) * | 2000-02-15 | 2002-11-20 | Amgen Inc. | Fibroblasten wachstumfaktor-23 moleküle und ihre verwendungen |
| EP1947182A1 (de) * | 2000-02-15 | 2008-07-23 | Amgen Inc. | Fibroblastenwachstumsfaktor-23-Moleküle und ihre Verwendung |
| CN1311212A (zh) * | 2000-03-02 | 2001-09-05 | 上海博德基因开发有限公司 | 一种新的多肽——人成纤维细胞生长因子14和编码这种多肽的多核苷酸 |
| CN1292798C (zh) * | 2000-06-02 | 2007-01-03 | 德克萨斯州立大学董事会 | 乙二半胱氨酸(ec)－药物缀合物 |
| WO2002041911A2 (en) * | 2000-11-22 | 2002-05-30 | Bayer Corporation | Use of fgf-19 for inhibiting angiogenesis |
| FI20011542A (fi) * | 2001-07-13 | 2003-01-14 | Fit Biotech Oyj Plc | Urosognaasigeenin monistuman käyttö |
| EP1553912A4 (de) | 2002-06-07 | 2007-08-08 | Genentech Inc | Zusammensetzungen und verfahren f r die tumordiagnose und behandlung |
| JP4754823B2 (ja) | 2002-10-07 | 2011-08-24 | ザイモジェネティクス， インコーポレイテッド | Ｆｇｆ１８の投与方法 |
| AR059432A1 (es) | 2006-02-10 | 2008-04-09 | Genentech Inc | Anticuerpos anti-fgf19 y metodos que usan estos |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| AU2008299779B2 (en) | 2007-08-03 | 2013-05-16 | Genentech, Inc. | Humanized anti-FGF19 antagonists and methods using same |
| CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| CA2739615C (en) | 2008-10-10 | 2017-12-05 | Amgen Inc. | Fgf21 mutants comprising polyethylene glycol and uses thereof |
| US8686175B2 (en) | 2008-12-16 | 2014-04-01 | Dow Corning Corporation | Preparation of siloxanes |
| US20120052069A1 (en) | 2009-05-05 | 2012-03-01 | Amgen Inc | Fgf21 mutants and uses thereof |
| SI3248610T1 (sl) | 2009-05-05 | 2024-03-29 | Amgen Inc., | Mutanti fgf21 in njihove uporabe |
| EP2443145A1 (de) | 2009-06-17 | 2012-04-25 | Amgen, Inc | Chimäre fgf19-polypeptide und ihreverwendung |
| KR101952453B1 (ko) * | 2009-10-15 | 2019-02-26 | 제넨테크, 인크. | 수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| TWI670283B (zh) | 2013-12-23 | 2019-09-01 | 美商建南德克公司 | 抗體及使用方法 |
| EP3108893A1 (de) | 2015-06-25 | 2016-12-28 | Universite Claude Bernard - Lyon 1 | Neuartige therapeutische verwendung von fgf19 |
| KR102315601B1 (ko) | 2020-05-13 | 2021-10-21 | 전남대학교산학협력단 | 재조합 벡터 및 이를 이용한 재조합 섬유아세포 성장인자 19의 제조 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015796A2 (en) * | 1998-09-16 | 2000-03-23 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU9312198A (en) * | 1997-09-17 | 1999-04-05 | Genentech Inc. | Genes amplified in tumours, antibodies against the proteins encoded thereby, andtheir use in diagnosis and treatment of cancer |
| KR100502596B1 (ko) * | 1997-09-17 | 2005-07-22 | 제넨테크, 인크. | 분비 폴리펩티드와 막횡단 폴리펩티드 및 이들을 코딩하는핵산 |
| JP3653469B2 (ja) * | 1997-11-25 | 2005-05-25 | ジェネンテック・インコーポレーテッド | 線維芽細胞増殖因子−１９ |
| AU5816799A (en) * | 1998-09-10 | 2000-04-03 | Genentech Inc. | Compositions and methods for the treatment of tumor |
-
1998
- 1998-11-25 JP JP2000522242A patent/JP3653469B2/ja not_active Expired - Lifetime
- 1998-11-25 KR KR10-2000-7005645A patent/KR100506786B1/ko not_active IP Right Cessation
- 1998-11-25 NZ NZ504425A patent/NZ504425A/en not_active IP Right Cessation
- 1998-11-25 KR KR10-2004-7021388A patent/KR20050009764A/ko not_active Application Discontinuation
- 1998-11-25 CA CA2309783A patent/CA2309783C/en not_active Expired - Lifetime
- 1998-11-25 EP EP98961795A patent/EP1032668B1/de not_active Expired - Lifetime
- 1998-11-25 IL IL13605598A patent/IL136055A0/xx not_active IP Right Cessation
- 1998-11-25 WO PCT/US1998/025190 patent/WO1999027100A1/en active Application Filing
- 1998-11-25 AT AT98961795T patent/ATE397063T1/de not_active IP Right Cessation
- 1998-11-25 DE DE69839571T patent/DE69839571D1/de not_active Expired - Lifetime
- 1998-11-25 DK DK98961795T patent/DK1032668T3/da active
- 1998-11-25 AU AU17033/99A patent/AU733222B2/en not_active Expired
-
2008
- 2008-08-11 IL IL193366A patent/IL193366A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3653469B2 (ja) | 2005-05-25 |
| CA2309783A1 (en) | 1999-06-03 |
| IL136055A0 (en) | 2001-05-20 |
| JP2002503446A (ja) | 2002-02-05 |
| WO1999027100A9 (en) | 2000-05-11 |
| KR20010032405A (ko) | 2001-04-16 |
| WO1999027100A1 (en) | 1999-06-03 |
| KR20050009764A (ko) | 2005-01-25 |
| CA2309783C (en) | 2011-06-28 |
| IL193366A0 (en) | 2009-02-11 |
| DE69839571D1 (de) | 2008-07-10 |
| DK1032668T3 (da) | 2008-09-29 |
| EP1032668B1 (de) | 2008-05-28 |
| KR100506786B1 (ko) | 2005-08-08 |
| AU1703399A (en) | 1999-06-15 |
| AU733222B2 (en) | 2001-05-10 |
| NZ504425A (en) | 2001-10-26 |
| EP1032668A1 (de) | 2000-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE397063T1 (de) | Fibroblasten-wachstumsfaktor-19 | |
| DK1623990T3 (da) | Sammensætninger og fremgangsmåder til tumorbehandling | |
| WO2000053755A3 (en) | Compositions and methods for the treatment of tumor | |
| AU4851900A (en) | Compositions and methods for the treatment of tumor | |
| IL186153A0 (en) | Methods and compositions for inhibiting neoplastic cell growth | |
| HK1114636A1 (en) | 1l-17 homologous polypeptides and therapeutic uses thereof | |
| WO2000073348A3 (en) | Methods and compositions for inhibiting neoplastic cell growth | |
| KR100517848B1 (en) | Compositions and Methods for The Treatment of Tumor | |
| WO2000037640A3 (en) | Compositions and methods for the treatment of tumor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |