ATE386744T1 - Pyrimidoderivate mit antiproliferativer aktivität (ii) - Google Patents
Pyrimidoderivate mit antiproliferativer aktivität (ii)Info
- Publication number
- ATE386744T1 ATE386744T1 AT03758072T AT03758072T ATE386744T1 AT E386744 T1 ATE386744 T1 AT E386744T1 AT 03758072 T AT03758072 T AT 03758072T AT 03758072 T AT03758072 T AT 03758072T AT E386744 T1 ATE386744 T1 AT E386744T1
- Authority
- AT
- Austria
- Prior art keywords
- antiproliferative activity
- pyrimido
- derivatives
- pyrimido derivatives
- antiproliferative
- Prior art date
Links
- 230000001028 anti-proliverative effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42367002P | 2002-11-04 | 2002-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386744T1 true ATE386744T1 (de) | 2008-03-15 |
Family
ID=32312700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03758072T ATE386744T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimidoderivate mit antiproliferativer aktivität (ii) |
| AT03810410T ATE384725T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03810410T ATE384725T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7129351B2 (de) |
| EP (2) | EP1560829B1 (de) |
| JP (2) | JP2006513999A (de) |
| KR (4) | KR100774230B1 (de) |
| CN (2) | CN1711266A (de) |
| AR (2) | AR041738A1 (de) |
| AT (2) | ATE386744T1 (de) |
| AU (1) | AU2003276190A1 (de) |
| BR (2) | BR0315912A (de) |
| CA (2) | CA2502182A1 (de) |
| DE (2) | DE60319260T2 (de) |
| ES (2) | ES2298622T3 (de) |
| MX (2) | MXPA05004757A (de) |
| PL (2) | PL376924A1 (de) |
| RU (2) | RU2331641C2 (de) |
| WO (2) | WO2004041821A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003903501A0 (en) * | 2003-07-07 | 2003-07-24 | Commonwealth Scientific And Industrial Research Organisation | A method of forming a reflective authentication device |
| EP1651648A4 (de) * | 2003-07-29 | 2009-09-02 | Irm Llc | Verbindungen und zusammensetzungen als proteinkinaseinhibitoren |
| FR2873127B1 (fr) | 2004-07-13 | 2008-08-29 | Omya Development Ag | Procede de fabrication de particules pigmentaires autoliantes, seches ou en suspension ou dispersion aqueuses, contenant des matieres inorganiques et des liants |
| CN1984914A (zh) * | 2004-08-31 | 2007-06-20 | 霍夫曼-拉罗奇有限公司 | 7－氨基－3－苯基－二氢嘧啶并[4,5－d]嘧啶酮的酰胺衍生物、其制备和作为蛋白激酶抑制剂的应用 |
| CN1980933B (zh) * | 2004-08-31 | 2010-07-14 | 霍夫曼-拉罗奇有限公司 | 3-苯基-二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物，它们的制备和用作药剂的用途 |
| LT1951684T (lt) * | 2005-11-01 | 2016-11-10 | Targegen, Inc. | Kinazės bi-aril-meta-pirimidino slopikliai |
| JP2009525292A (ja) | 2006-01-31 | 2009-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
| WO2007126826A2 (en) * | 2006-03-29 | 2007-11-08 | North Carolina State University | Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives |
| BRPI0711628A2 (pt) * | 2006-05-15 | 2011-12-06 | Irm Llc | composto, composição farmacêutica, uso e processo para preparação do composto |
| US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| NZ590777A (en) * | 2008-07-31 | 2012-11-30 | Genentech Inc | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE FOR INHIBITING mTOR |
| KR101444988B1 (ko) | 2008-09-25 | 2014-09-26 | 에프. 호프만-라 로슈 아게 | 3-아미노-인다졸 또는 3-아미노-4,5,6,7-테트라하이드로-인다졸 유도체 |
| US8507505B2 (en) | 2008-12-12 | 2013-08-13 | Msd K.K. | Dihydropyrazolopyrimidinone derivative |
| CA2745959A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| HUP0800768A2 (en) | 2008-12-18 | 2012-08-28 | Bioblocks Magyarorszag Gyogyszerkemiai Es Fejlesztoe Kft | 1,3-heterocycles condensed with monoterpene skeleton, their use and pharmaceutical compositions comprising such compounds |
| JP2012518657A (ja) | 2009-02-25 | 2012-08-16 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 併用抗癌治療 |
| US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| US20100318651A1 (en) * | 2009-06-10 | 2010-12-16 | Everis, Inc. | Network Communication System With Monitoring |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| ES2832497T3 (es) | 2012-06-13 | 2021-06-10 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| EP3943087A1 (de) | 2013-03-15 | 2022-01-26 | Celgene CAR LLC | Heteroarylverbindungen und verwendungen davon |
| BR112015022191A8 (pt) | 2013-03-15 | 2018-01-23 | Celgene Avilomics Res Inc | compostos heteroarila e usos dos mesmos |
| SI2986610T1 (en) | 2013-04-19 | 2018-04-30 | Incyte Holdings Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2015006492A1 (en) * | 2013-07-09 | 2015-01-15 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| WO2016014551A1 (en) | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| CA2954186A1 (en) | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| CA2955082A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (sik) inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EP4047001A3 (de) | 2016-07-05 | 2022-11-30 | The Broad Institute, Inc. | Bicyclische harnstoffkinaseinhibitoren und verwendungen davon |
| WO2018053373A1 (en) | 2016-09-16 | 2018-03-22 | The General Hospital Corporation | Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis |
| BR112019017741A2 (pt) * | 2017-02-28 | 2020-04-07 | Dana Farber Cancer Inst Inc | usos de pirimidopirimidinonas como inibidores de sik |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| MA52494B1 (fr) | 2018-05-04 | 2024-10-31 | Incyte Corporation | Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| AR115296A1 (es) * | 2018-12-27 | 2020-12-16 | Agios Pharmaceuticals Inc | Heterocíclicos inhibidores de mat2a y métodos de uso para el tratamiento del cáncer |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11407750B2 (en) | 2019-12-04 | 2022-08-09 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| EP4069696A1 (de) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949466A (en) * | 1958-03-04 | 1960-08-16 | Parke Davis & Co | Pyrimidine compounds and means of producing the same |
| ES338687A1 (es) * | 1966-04-06 | 1968-04-01 | Monsanto Co | Procedimiento para obtener composiciones de fluidos funcio-nales. |
| US4425346A (en) * | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
| JPS60226882A (ja) * | 1984-04-24 | 1985-11-12 | Nippon Zoki Pharmaceut Co Ltd | 新規ピリミドピリミジン誘導体 |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| WO1998024432A2 (en) | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| KR200143829Y1 (ko) * | 1996-12-30 | 1999-06-15 | 양재신 | 연료펌프 교환시 연료의 비산 방지구 |
| YU73300A (sh) * | 1998-05-26 | 2003-08-29 | Warner-Lambert Company | Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije |
| ID28276A (id) * | 1998-10-23 | 2001-05-10 | Hoffmann La Roche | Heterolingkar nitrogen bisiklik |
| NZ518119A (en) | 1999-10-21 | 2004-02-27 | F | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase |
| DE60032623T2 (de) | 1999-10-21 | 2007-10-11 | F. Hoffmann-La Roche Ag | Alkylamino-substituierte bicyclische heterocyclen als p38 protein-kinase-inhibitoren |
| MY141144A (en) | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| CN1275964C (zh) | 2000-08-31 | 2006-09-20 | 霍夫曼-拉罗奇有限公司 | 作为细胞增殖抑制剂的7－氧代吡啶并嘧啶 |
| AU2003237009B2 (en) | 2002-01-22 | 2008-10-02 | Warner-Lambert Company Llc | 2-(pyridin-2-ylamino)-pyrido[2,3d]pyrimidin-7-ones |
| PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| US7199119B2 (en) * | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
-
2003
- 2003-10-20 US US10/689,438 patent/US7129351B2/en not_active Expired - Fee Related
- 2003-10-20 US US10/689,235 patent/US7112676B2/en not_active Expired - Fee Related
- 2003-10-27 BR BR0315912-4A patent/BR0315912A/pt not_active IP Right Cessation
- 2003-10-27 JP JP2004548792A patent/JP2006513999A/ja active Pending
- 2003-10-27 CA CA002502182A patent/CA2502182A1/en not_active Abandoned
- 2003-10-27 CA CA002502180A patent/CA2502180A1/en not_active Abandoned
- 2003-10-27 RU RU2005117340/04A patent/RU2331641C2/ru not_active IP Right Cessation
- 2003-10-27 AT AT03758072T patent/ATE386744T1/de not_active IP Right Cessation
- 2003-10-27 DE DE60319260T patent/DE60319260T2/de not_active Expired - Fee Related
- 2003-10-27 PL PL376924A patent/PL376924A1/pl not_active Application Discontinuation
- 2003-10-27 CN CNA2003801028610A patent/CN1711266A/zh active Pending
- 2003-10-27 KR KR1020077016286A patent/KR100774230B1/ko not_active Expired - Fee Related
- 2003-10-27 MX MXPA05004757A patent/MXPA05004757A/es active IP Right Grant
- 2003-10-27 EP EP03758072A patent/EP1560829B1/de not_active Expired - Lifetime
- 2003-10-27 MX MXPA05004756A patent/MXPA05004756A/es active IP Right Grant
- 2003-10-27 WO PCT/EP2003/011892 patent/WO2004041821A1/de active IP Right Grant
- 2003-10-27 KR KR1020077017255A patent/KR100774231B1/ko not_active Expired - Fee Related
- 2003-10-27 KR KR1020057007981A patent/KR100763299B1/ko not_active Expired - Fee Related
- 2003-10-27 JP JP2004548791A patent/JP2006507292A/ja active Pending
- 2003-10-27 BR BR0316001-7A patent/BR0316001A/pt not_active IP Right Cessation
- 2003-10-27 ES ES03810410T patent/ES2298622T3/es not_active Expired - Lifetime
- 2003-10-27 ES ES03758072T patent/ES2300609T3/es not_active Expired - Lifetime
- 2003-10-27 RU RU2005117341/04A patent/RU2326882C2/ru not_active IP Right Cessation
- 2003-10-27 EP EP03810410A patent/EP1560832B1/de not_active Expired - Lifetime
- 2003-10-27 AT AT03810410T patent/ATE384725T1/de not_active IP Right Cessation
- 2003-10-27 CN CNB2003801028485A patent/CN100420688C/zh not_active Expired - Fee Related
- 2003-10-27 WO PCT/EP2003/011896 patent/WO2004041822A1/en active IP Right Grant
- 2003-10-27 PL PL376916A patent/PL376916A1/pl not_active Application Discontinuation
- 2003-10-27 KR KR1020057007906A patent/KR100763300B1/ko not_active Expired - Fee Related
- 2003-10-27 DE DE60318888T patent/DE60318888T2/de not_active Expired - Fee Related
- 2003-10-27 AU AU2003276190A patent/AU2003276190A1/en not_active Abandoned
- 2003-10-31 AR ARP030103999A patent/AR041738A1/es unknown
- 2003-10-31 AR ARP030104000A patent/AR041739A1/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1560829 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |