AR088678A1 - Procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable - Google Patents
Procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptableInfo
- Publication number
- AR088678A1 AR088678A1 ARP120104179A ARP120104179A AR088678A1 AR 088678 A1 AR088678 A1 AR 088678A1 AR P120104179 A ARP120104179 A AR P120104179A AR P120104179 A ARP120104179 A AR P120104179A AR 088678 A1 AR088678 A1 AR 088678A1
- Authority
- AR
- Argentina
- Prior art keywords
- ivabradine
- pharmaceutically acceptable
- addition salts
- acceptable acid
- synthesis procedure
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title abstract 2
- 229960003825 ivabradine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J35/00—Catalysts, in general, characterised by their form or physical properties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2235/00—Indexing scheme associated with group B01J35/00, related to the analysis techniques used to determine the catalysts form or properties
- B01J2235/05—Nuclear magnetic resonance [NMR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Procedimiento de síntesis de la ivabradina de fórmula (1) caracterizado porque se somete el compuesto de fórmula (2) a una reacción de aminación reductora por la amina de fórmula (3) en presencia de un catalizador a base de hierro, en presencia o no de N-óxido de trimetilamina, bajo una presión de dihidrógeno comprendida entre 1 y 20 bares, en un disolvente orgánico o una mezcla de disolventes orgánicos, a una temperatura comprendida entre 25 y 100ºC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1103933A FR2984319B1 (fr) | 2011-12-20 | 2011-12-20 | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088678A1 true AR088678A1 (es) | 2014-06-25 |
Family
ID=47115640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104179A AR088678A1 (es) | 2011-12-20 | 2012-11-07 | Procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8513410B2 (es) |
| EP (1) | EP2607353B1 (es) |
| JP (1) | JP5670406B2 (es) |
| KR (1) | KR101470879B1 (es) |
| CN (1) | CN103172566B (es) |
| AR (1) | AR088678A1 (es) |
| AU (1) | AU2012244188B2 (es) |
| BR (1) | BR102012028614A2 (es) |
| CA (1) | CA2795741C (es) |
| CL (1) | CL2012003136A1 (es) |
| CY (1) | CY1115682T1 (es) |
| DK (1) | DK2607353T3 (es) |
| EA (1) | EA026510B1 (es) |
| ES (1) | ES2525032T3 (es) |
| FR (1) | FR2984319B1 (es) |
| GE (1) | GEP20156350B (es) |
| HK (1) | HK1186733A1 (es) |
| HR (1) | HRP20141023T1 (es) |
| JO (1) | JO3031B1 (es) |
| MA (1) | MA34276B1 (es) |
| MD (1) | MD4336C1 (es) |
| MX (1) | MX2012012938A (es) |
| MY (1) | MY170662A (es) |
| PE (1) | PE20131097A1 (es) |
| PL (1) | PL2607353T3 (es) |
| PT (1) | PT2607353E (es) |
| RS (1) | RS53541B1 (es) |
| SA (1) | SA112330994B1 (es) |
| SG (1) | SG191471A1 (es) |
| SI (1) | SI2607353T1 (es) |
| TW (1) | TWI440627B (es) |
| UA (1) | UA111329C2 (es) |
| UY (1) | UY34423A (es) |
| WO (1) | WO2013093220A1 (es) |
| ZA (1) | ZA201208160B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| CN105669554A (zh) * | 2016-02-22 | 2016-06-15 | 徐建立 | 一种盐酸伊伐布雷定杂质及其制备方法和应用 |
| FR3071833B1 (fr) * | 2017-09-29 | 2020-01-03 | Universite Paris-Sud | Nouveau procede de synthese d'amines tertiaires dissymetriques |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| US6225487B1 (en) * | 1998-04-17 | 2001-05-01 | Symyx Technologies, Inc. | Ancillary ligands and metal complexes, catalysts and compositions using same and methods of testing |
| US6521793B1 (en) * | 1998-10-08 | 2003-02-18 | Symyx Technologies, Inc. | Catalyst ligands, catalytic metal complexes and processes using same |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| EP1595888A1 (en) * | 2004-05-11 | 2005-11-16 | Degussa AG | Cycloolefin phosphine ligands and their use in catalysis |
| ATE544754T1 (de) * | 2006-11-30 | 2012-02-15 | Cadila Healthcare Ltd | Verfahren zur herstellung von ivabradinhydrochlorid |
| KR101478855B1 (ko) * | 2007-05-30 | 2015-01-02 | 인드-스위프트 래버러토리즈 리미티드 | 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법 |
| US7857994B2 (en) | 2007-05-30 | 2010-12-28 | GE Lighting Solutions, LLC | Green emitting phosphors and blends thereof |
| FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2933975B1 (fr) * | 2008-07-17 | 2011-02-18 | Servier Lab | Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
| FR2940287B1 (fr) * | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| FR2941695B1 (fr) * | 2009-02-04 | 2011-02-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2011
- 2011-12-20 FR FR1103933A patent/FR2984319B1/fr not_active Expired - Fee Related
-
2012
- 2012-10-23 SG SG2012078705A patent/SG191471A1/en unknown
- 2012-10-23 JO JOP/2012/0320A patent/JO3031B1/ar active
- 2012-10-24 CA CA2795741A patent/CA2795741C/fr not_active Expired - Fee Related
- 2012-10-24 AU AU2012244188A patent/AU2012244188B2/en not_active Ceased
- 2012-10-25 PE PE2012002077A patent/PE20131097A1/es active IP Right Grant
- 2012-10-30 MY MYPI2012700844A patent/MY170662A/en unknown
- 2012-10-30 UY UY0001034423A patent/UY34423A/es not_active Application Discontinuation
- 2012-10-30 ZA ZA2012/08160A patent/ZA201208160B/en unknown
- 2012-10-31 MD MDA20120094A patent/MD4336C1/ro not_active IP Right Cessation
- 2012-11-06 TW TW101141192A patent/TWI440627B/zh not_active IP Right Cessation
- 2012-11-07 AR ARP120104179A patent/AR088678A1/es unknown
- 2012-11-07 MA MA35353A patent/MA34276B1/fr unknown
- 2012-11-07 MX MX2012012938A patent/MX2012012938A/es active IP Right Grant
- 2012-11-08 CN CN201210443036.8A patent/CN103172566B/zh not_active Expired - Fee Related
- 2012-11-08 UA UAA201212746A patent/UA111329C2/uk unknown
- 2012-11-08 CL CL2012003136A patent/CL2012003136A1/es unknown
- 2012-11-08 GE GEAP201212889A patent/GEP20156350B/en unknown
- 2012-11-08 KR KR1020120126314A patent/KR101470879B1/ko active IP Right Grant
- 2012-11-08 BR BR102012028614-9A patent/BR102012028614A2/pt not_active IP Right Cessation
- 2012-11-09 DK DK12191902.1T patent/DK2607353T3/en active
- 2012-11-09 EP EP12191902.1A patent/EP2607353B1/fr active Active
- 2012-11-09 PL PL12191902T patent/PL2607353T3/pl unknown
- 2012-11-09 RS RSP20140509 patent/RS53541B1/en unknown
- 2012-11-09 EA EA201201385A patent/EA026510B1/ru not_active IP Right Cessation
- 2012-11-09 SI SI201230089T patent/SI2607353T1/sl unknown
- 2012-11-09 PT PT121919021T patent/PT2607353E/pt unknown
- 2012-11-09 US US13/673,145 patent/US8513410B2/en not_active Expired - Fee Related
- 2012-11-09 ES ES12191902.1T patent/ES2525032T3/es active Active
- 2012-11-09 WO PCT/FR2012/000451 patent/WO2013093220A1/fr active Application Filing
- 2012-11-09 JP JP2012247143A patent/JP5670406B2/ja active Active
- 2012-11-10 SA SA112330994A patent/SA112330994B1/ar unknown
-
2013
- 2013-12-23 HK HK13114205.7A patent/HK1186733A1/zh not_active IP Right Cessation
-
2014
- 2014-10-14 CY CY20141100832T patent/CY1115682T1/el unknown
- 2014-10-23 HR HRP20141023AT patent/HRP20141023T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |