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CL2009001414A1 - Procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-ona sin aislacion de compuestos intermediarios; util para la sintesis de ivabradina. - Google Patents

Procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-ona sin aislacion de compuestos intermediarios; util para la sintesis de ivabradina.

Info

Publication number
CL2009001414A1
CL2009001414A1 CL2009001414A CL2009001414A CL2009001414A1 CL 2009001414 A1 CL2009001414 A1 CL 2009001414A1 CL 2009001414 A CL2009001414 A CL 2009001414A CL 2009001414 A CL2009001414 A CL 2009001414A CL 2009001414 A1 CL2009001414 A1 CL 2009001414A1
Authority
CL
Chile
Prior art keywords
synthesis
ivabradine
benzazepin
dimethoxy
dihydro
Prior art date
Application number
CL2009001414A
Other languages
English (en)
Inventor
Lecouve Jean-Pierre
Lerestif Jean-Michel
Brigot Daniel
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001414(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of CL2009001414A1 publication Critical patent/CL2009001414A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE SÍNTESIS DEL COMPUESTO DE FÓRMULA (1): APLICACIÓN EN LA SÍNTESIS DE ÍVABRADINA, DE SUS SALES DE ADICIÓN A UN ÁCIDO FARMACÉUTICAMENTE ACEPTABLE Y DE SUS HIDRATOS.  
CL2009001414A 2008-06-20 2009-06-15 Procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-ona sin aislacion de compuestos intermediarios; util para la sintesis de ivabradina. CL2009001414A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803452A FR2932800B1 (fr) 2008-06-20 2008-06-20 Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
CL2009001414A1 true CL2009001414A1 (es) 2010-06-04

Family

ID=40347797

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001414A CL2009001414A1 (es) 2008-06-20 2009-06-15 Procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-ona sin aislacion de compuestos intermediarios; util para la sintesis de ivabradina.

Country Status (36)

Country Link
US (1) US7928223B2 (es)
EP (1) EP2135861B2 (es)
JP (1) JP5216697B2 (es)
KR (1) KR101119296B1 (es)
CN (1) CN101607939B (es)
AR (1) AR072175A1 (es)
AU (1) AU2009202314B2 (es)
BR (1) BRPI0902105A2 (es)
CA (1) CA2668524C (es)
CL (1) CL2009001414A1 (es)
CY (1) CY1115623T1 (es)
DK (1) DK2135861T4 (es)
EA (1) EA017333B1 (es)
ES (1) ES2522625T5 (es)
FR (1) FR2932800B1 (es)
GE (1) GEP20125407B (es)
HK (1) HK1140188A1 (es)
HR (1) HRP20140928T4 (es)
JO (1) JO3806B1 (es)
MA (1) MA31071B1 (es)
ME (1) ME00814B (es)
MX (1) MX2009006288A (es)
MY (1) MY146245A (es)
NZ (1) NZ577540A (es)
PE (1) PE20100051A1 (es)
PL (1) PL2135861T5 (es)
PT (1) PT2135861E (es)
RS (1) RS53495B2 (es)
SA (1) SA109300396B1 (es)
SG (1) SG158026A1 (es)
SI (1) SI2135861T2 (es)
TW (1) TWI374134B (es)
UA (1) UA107779C2 (es)
UY (1) UY31883A (es)
WO (1) WO2009153461A2 (es)
ZA (1) ZA200904316B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101478855B1 (ko) * 2007-05-30 2015-01-02 인드-스위프트 래버러토리즈 리미티드 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법
CN101774969B (zh) * 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
EA201290772A1 (ru) 2010-02-12 2013-02-28 КРКА, д.д., НОВО МЕСТО Новые формы ивабрадина гидрохлорида
FR2956401B1 (fr) 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108424389A (zh) * 2017-02-13 2018-08-21 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
NZ207007A (en) * 1983-02-04 1985-08-30 Lilly Co Eli Benzazepine derivatives and pharmaceutical compositions
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
JPWO2002074746A1 (ja) * 2001-03-16 2004-07-08 山之内製薬株式会社 ベンゾアゼピン誘導体
BRPI0415842A (pt) * 2003-10-23 2007-01-02 Hoffmann La Roche derivativos de benzapepina como inibidores de mao-b
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN101495184A (zh) * 2005-07-15 2009-07-29 Amr科技公司 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用

Also Published As

Publication number Publication date
EA200900707A1 (ru) 2010-04-30
PE20100051A1 (es) 2010-02-06
EP2135861B2 (fr) 2020-12-16
JP5216697B2 (ja) 2013-06-19
UA107779C2 (en) 2015-02-25
MX2009006288A (es) 2010-02-17
AR072175A1 (es) 2010-08-11
CN101607939A (zh) 2009-12-23
SA109300396B1 (ar) 2013-09-08
SI2135861T2 (sl) 2021-04-30
RS53495B1 (en) 2015-02-27
FR2932800A1 (fr) 2009-12-25
TW201002671A (en) 2010-01-16
JP2010006807A (ja) 2010-01-14
FR2932800B1 (fr) 2015-02-20
EA017333B1 (ru) 2012-11-30
UY31883A (es) 2010-01-29
EP2135861B1 (fr) 2014-07-30
HRP20140928T4 (hr) 2021-03-05
DK2135861T3 (da) 2014-10-20
WO2009153461A3 (fr) 2010-04-29
DK2135861T4 (da) 2021-03-22
ZA200904316B (en) 2010-05-26
ES2522625T5 (es) 2021-07-29
AU2009202314A1 (en) 2010-01-14
GEP20125407B (en) 2012-02-27
MA31071B1 (fr) 2010-01-04
KR20090132544A (ko) 2009-12-30
PT2135861E (pt) 2014-09-02
SG158026A1 (en) 2010-01-29
HK1140188A1 (en) 2010-10-08
WO2009153461A2 (fr) 2009-12-23
TWI374134B (en) 2012-10-11
ME00814B (me) 2012-03-20
MY146245A (en) 2012-07-31
ES2522625T3 (es) 2014-11-17
BRPI0902105A2 (pt) 2010-04-13
NZ577540A (en) 2010-10-29
SI2135861T1 (sl) 2014-10-30
RS53495B2 (sr) 2021-02-26
KR101119296B1 (ko) 2012-03-15
US20090318682A1 (en) 2009-12-24
US7928223B2 (en) 2011-04-19
CN101607939B (zh) 2012-05-02
JO3806B1 (ar) 2021-01-31
EP2135861A1 (fr) 2009-12-23
CY1115623T1 (el) 2017-01-04
PL2135861T5 (pl) 2022-07-18
HRP20140928T1 (en) 2014-11-21
AU2009202314B2 (en) 2013-01-24
CA2668524C (fr) 2012-09-11
PL2135861T3 (pl) 2014-11-28
CA2668524A1 (fr) 2009-12-20

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