AR087433A1 - Analogos de insulina n-glicosilados - Google Patents
Analogos de insulina n-glicosiladosInfo
- Publication number
- AR087433A1 AR087433A1 ARP120102824A ARP120102824A AR087433A1 AR 087433 A1 AR087433 A1 AR 087433A1 AR P120102824 A ARP120102824 A AR P120102824A AR P120102824 A ARP120102824 A AR P120102824A AR 087433 A1 AR087433 A1 AR 087433A1
- Authority
- AR
- Argentina
- Prior art keywords
- glycans
- group
- insulin analogs
- fucosylated
- glicosilated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen composiciones y formulaciones que comprenden análogos de insulina N-glicosilados. En realizaciones particulares, los análogos de insulina glicosilados se producen in vivo y comprenden uno o más de los N-glicanos N-enlazados seleccionados entre N-glicanos con alto contenido en manosa o fucosilado o no flicosilado híbrido, de paucimanosa o complejo. En otras realizaciones, el N-glicano que comprende el N-glicano con alto contenido en manosa o fucosilado o no fucosilado híbrido, de paucimanosa o complejo se une al análogo de insulina in vitro. Los ejemplos de N-glicanos incluyen pero sin limitación una molécula que tiene una estructura seleccionada entre los N-glicanos en el grupo que consiste en el Man(1-9)GlcNAc2; o seleccionada entre los N-glicanos en el grupo que consiste en GlcNAc(1-4)Man3GlcNAc2; o seleccionada entre los N-glicanos en el grupo que consiste en Gal(1-4)GlcNAc(1-4)Man3GlcNAc2; o seleccionada entre los N-glicanos en el grupo que consiste en NANA(1-4)Gal(1-4)GIcNAc(1-4)Man3GlcNAc2. Método para producir insulina. Uso para el tratamiento de diabetes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521142P | 2011-08-08 | 2011-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR087433A1 true AR087433A1 (es) | 2014-03-26 |
Family
ID=47668823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102824A AR087433A1 (es) | 2011-08-08 | 2012-08-02 | Analogos de insulina n-glicosilados |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20140235537A1 (es) |
| EP (1) | EP2744510A4 (es) |
| JP (1) | JP2014525922A (es) |
| KR (1) | KR20140057589A (es) |
| CN (1) | CN103889444A (es) |
| AR (1) | AR087433A1 (es) |
| AU (1) | AU2012294656A1 (es) |
| CA (1) | CA2843640A1 (es) |
| TW (1) | TW201311720A (es) |
| WO (1) | WO2013022721A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2771461B1 (en) * | 2011-10-28 | 2019-12-04 | Merck Sharp & Dohme Corp. | Engineered lower eukaryotic host strains for recombinant protein expression |
| WO2015001049A1 (en) | 2013-07-04 | 2015-01-08 | Novartis Ag | O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof |
| BR112016007176A2 (pt) | 2013-10-04 | 2018-01-23 | Merck Sharp & Dohme | conjugado, composição, usos de um conjugado e de uma composição, e, método para tratar um indivíduo que tem diabete |
| US10513724B2 (en) | 2014-07-21 | 2019-12-24 | Glykos Finland Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
| PT3227454T (pt) * | 2014-12-01 | 2020-04-06 | Amgen Inc | Processo para a manipulação do nível do teor de glicano de uma glicoproteína |
| WO2016105545A2 (en) * | 2014-12-24 | 2016-06-30 | Case Western Reserve University | Insulin analogues with enhanced stabilized and reduced mitogenicity |
| US10626430B2 (en) | 2015-01-20 | 2020-04-21 | Suntory Holdings Limited | Method for preparing mogroside having no β-1,6-glucoside bond |
| EP3268384B1 (en) | 2015-03-10 | 2021-11-03 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| RU2736358C2 (ru) * | 2015-12-09 | 2020-11-16 | Общество С Ограниченной Ответственностью "Синбио" | Способ очистки полисиалированного инсулина человека |
| CN110612112B (zh) * | 2016-12-09 | 2024-03-29 | 阿卡斯通生物科学公司 | 胰岛素-fc融合物及使用方法 |
| WO2018187147A1 (en) * | 2017-04-03 | 2018-10-11 | Amidebio, Llc | Glucose-responsive insulin analogs and methods of use thereof |
| MA49896A (fr) | 2017-08-17 | 2020-06-24 | Novo Nordisk As | Nouveaux analogues d'insuline acylés et leurs utilisations |
| CN111094572B (zh) * | 2018-02-09 | 2023-04-04 | 江苏恒瑞医药股份有限公司 | 一种密码子优化的人胰岛素类似物前体基因和信号肽基因 |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| WO2020006529A1 (en) | 2018-06-29 | 2020-01-02 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| KR20220115975A (ko) | 2019-12-19 | 2022-08-19 | 악스톤 바이오사이언시스 코퍼레이션 | 초-장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| AU2020408066A1 (en) | 2019-12-20 | 2022-06-30 | Codexis, Inc. | Engineered acid alpha-glucosidase variants |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| JP7528249B2 (ja) | 2020-04-10 | 2024-08-05 | アクストン バイオサイエンシズ コーポレーション | Ｃｏｖｉｄ－１９に対する抗原特異的免疫療法、融合タンパク質、およびその使用方法 |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| CN111560379B (zh) * | 2020-05-26 | 2022-09-13 | 北京惠之衡生物科技有限公司 | 密码子优化的门冬胰岛素前体基因、重组载体、基因工程菌及其应用 |
| JP2023541138A (ja) * | 2020-09-04 | 2023-09-28 | ザ フローリー インスティテュート オブ ニューロサイエンス アンド メンタル ヘルス | ペプチド及びタンパク質の誘導体化 |
| EP4373861A2 (en) | 2021-07-23 | 2024-05-29 | Akston Biosciences Corporation | Insulin-fc fusion proteins and methods of use to treat cancer |
| WO2024218743A1 (en) * | 2023-04-21 | 2024-10-24 | Glycoera Ag | Multi-functional molecules comprising glycans and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP940432B1 (en) * | 1994-08-05 | 2003-10-31 | Pliva Pharm & Chem Works | Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin |
| US6548653B1 (en) * | 1998-06-15 | 2003-04-15 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
| AU4935701A (en) * | 2000-03-24 | 2001-10-08 | Genentech Inc | Use of insulin for the treatment of cartilagenous disorders |
| DK2279753T3 (en) * | 2001-10-10 | 2015-11-23 | Novo Nordisk As | The conversion of peptides and glycokonjugering |
| MX338336B (es) * | 2007-11-20 | 2016-04-07 | Ambrx Inc | Polipeptidos de insulina modificados y sus usos. |
| SG173112A1 (en) * | 2009-01-28 | 2011-08-29 | Smartcells Inc | Conjugate based systems for controlled drug delivery |
-
2012
- 2012-08-02 AR ARP120102824A patent/AR087433A1/es not_active Application Discontinuation
- 2012-08-03 CA CA2843640A patent/CA2843640A1/en not_active Abandoned
- 2012-08-03 US US14/237,369 patent/US20140235537A1/en not_active Abandoned
- 2012-08-03 EP EP12821921.9A patent/EP2744510A4/en not_active Withdrawn
- 2012-08-03 CN CN201280049481.4A patent/CN103889444A/zh active Pending
- 2012-08-03 WO PCT/US2012/049425 patent/WO2013022721A1/en active Application Filing
- 2012-08-03 KR KR1020147006029A patent/KR20140057589A/ko not_active Application Discontinuation
- 2012-08-03 JP JP2014525071A patent/JP2014525922A/ja not_active Withdrawn
- 2012-08-03 AU AU2012294656A patent/AU2012294656A1/en not_active Abandoned
- 2012-08-06 TW TW101128314A patent/TW201311720A/zh unknown
-
2016
- 2016-01-14 US US14/995,638 patent/US20160289290A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN103889444A (zh) | 2014-06-25 |
| AU2012294656A1 (en) | 2014-02-20 |
| JP2014525922A (ja) | 2014-10-02 |
| CA2843640A1 (en) | 2013-02-14 |
| EP2744510A4 (en) | 2015-04-29 |
| EP2744510A1 (en) | 2014-06-25 |
| US20160289290A1 (en) | 2016-10-06 |
| TW201311720A (zh) | 2013-03-16 |
| US20140235537A1 (en) | 2014-08-21 |
| WO2013022721A1 (en) | 2013-02-14 |
| KR20140057589A (ko) | 2014-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |