AR061642A1 - Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas - Google Patents
Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticasInfo
- Publication number
- AR061642A1 AR061642A1 ARP070102821A ARP070102821A AR061642A1 AR 061642 A1 AR061642 A1 AR 061642A1 AR P070102821 A ARP070102821 A AR P070102821A AR P070102821 A ARP070102821 A AR P070102821A AR 061642 A1 AR061642 A1 AR 061642A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- conr6r7
- coor5
- nr6r7
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimientos de preparacion y aplicacion en terapéutica. Reivindicacion 1: Compuesto que responde a la formula (1) en la que: X representa bien un átomo de carbono, de oxígeno, de azufre o de nitrogeno, o bien el grupo -SO2; el enlace punteado es un enlace simple o un enlace doble; R1a, b, c, d y R2a, b, idénticos o diferentes, representan cada uno un átomo de hidrogeno o de halogeno; un grupo alquilo C1-5; alcoxi C1-5; halogenoalquilo C1-5, hidroxi; hidroxialquilo C1-5, alcoxi C1-5-aIquilo C1-5; ciano; un grupo -COOR5; -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5, -SO2NR6R7; -(R2a)p O (R2b)r también pueden formar junto con el átomo de carbono al que se unen un grupo C=O; R3 representa un átomo de hidrogeno, fluor o alquilo C1-5; alcoxi C1-5; alcoxialquilo C1-5; hidroxi; hidroxialquilo C1-5; halogenoalquilo C1-5; ciano; un grupo -COOR5, -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5; R4 representa: o un átomo de hidrogeno, alquilo C1-5; cicloalquilo C3-6; heterociclo; arilo mono- o bicíclico que tiene de 5 a 10 átomos de carbono; o un grupo heteroarilo mono- o bicíclico que tiene de 2 a 9 átomos de carbono; estando el grupo arilo o heteroarilo opcionalmente sustituido por 1 a 4 sustituyentes elegidos entre los átomos de halogeno, alquilo C1-5; alcoxi C1-5; halogenoalquilo C1-5; hidroxi; hidroxialquilo C1-5, alcoxi C1-5-alquilo C1-5; ciano; fenilo opcionalmente sustituido; bencilo opcionalmente sustituido; -COOR5, -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5, -SO2NR6R7, -NR6-COR5; p y r, idénticos o diferentes, son numeros enteros iguales a 1 o 2; R5 representa un átomo de hidrogeno, un grupo alquilo C1-5; cicloalquilo C3-6; R6 y R7, idénticos o diferentes, representan cada uno un átomo de hidrogeno, alquilo C1-5; cicloalquilo C3-6; alquilcarbonilo C1-5; hidroximetil-alquilo C1-5; alcoximetilo C1-5-alquilo C1-5; arilo; -SO2-R5 o pueden formar junto con el átomo de nitrogeno al que se unen un heterociclo opcionalmente sustituido; sus sales, solvatos e hidratos así como sus enantiomeros y diastereoisomeros, incluidas las mezclas racémicas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0605785A FR2902791B1 (fr) | 2006-06-27 | 2006-06-27 | Derives d'urees de tropane,leur preparation et leur application en therapeutique |
| FR0700507A FR2911874B1 (fr) | 2007-01-25 | 2007-01-25 | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061642A1 true AR061642A1 (es) | 2008-09-10 |
Family
ID=38820110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102821A AR061642A1 (es) | 2006-06-27 | 2007-06-26 | Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7897773B2 (es) |
| EP (1) | EP2046791B1 (es) |
| JP (1) | JP2009541464A (es) |
| KR (1) | KR20090021193A (es) |
| AR (1) | AR061642A1 (es) |
| AT (1) | ATE461930T1 (es) |
| AU (1) | AU2007264792A1 (es) |
| CA (1) | CA2648769A1 (es) |
| CL (1) | CL2007001885A1 (es) |
| CY (1) | CY1110132T1 (es) |
| DE (1) | DE602007005487D1 (es) |
| DK (1) | DK2046791T3 (es) |
| ES (1) | ES2342793T3 (es) |
| IL (1) | IL195510A0 (es) |
| MX (1) | MX277822B (es) |
| PE (1) | PE20080344A1 (es) |
| PL (1) | PL2046791T3 (es) |
| PT (1) | PT2046791E (es) |
| RU (1) | RU2009102535A (es) |
| SI (1) | SI2046791T1 (es) |
| TW (1) | TW200811170A (es) |
| UY (1) | UY30447A1 (es) |
| WO (1) | WO2008000951A2 (es) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2431367A3 (en) | 2006-06-27 | 2012-07-04 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds as GPR40 receptor modulators |
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| ES2395081T3 (es) | 2007-07-26 | 2013-02-08 | Vitae Pharmaceuticals, Inc. | Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| WO2009063061A2 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| FR2926817B1 (fr) * | 2008-01-28 | 2010-02-26 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
| TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
| FR2934858B1 (fr) * | 2008-08-08 | 2010-08-27 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
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| CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
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| WO2019160813A1 (en) | 2018-02-14 | 2019-08-22 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
| US11555032B2 (en) | 2019-05-13 | 2023-01-17 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE38835T1 (de) | 1983-07-05 | 1988-12-15 | Pfizer | Karbonsaeure-derivate verwendbar bei der verhuetung der zersetzung von knorpeln. |
| AU657986B2 (en) | 1991-06-14 | 1995-03-30 | Pharmacia & Upjohn Company | Imidazo(1,5-a)quinoxalines |
| AU2001256733A1 (en) | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
| ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| HUP0202001A2 (hu) * | 2002-06-14 | 2005-08-29 | Sanofi-Aventis | DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok |
| BR0315166A (pt) | 2002-10-11 | 2005-08-16 | Astrazeneca Ab | Uso de um composto ou de um sal farmaceuticamente aceitável do mesmo, composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, que necessita de tratamento |
| EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
| GB0325745D0 (en) | 2003-11-05 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
| EA019747B1 (ru) | 2004-11-10 | 2014-06-30 | Инсайт Корпорейшн | Лактамные соединения и их применение в качестве фармацевтических препаратов |
| KR20070097441A (ko) | 2004-11-18 | 2007-10-04 | 인사이트 산 디에고 인코포레이티드 | 11-β 하이드록실 스테로이드 데하이드로게나제 유형 1의억제제 및 이를 사용하는 방법 |
| EP1866298A2 (en) | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| EP1889842A4 (en) | 2005-06-08 | 2009-07-29 | Japan Tobacco Inc | HETEROCYCLIC CONNECTION |
-
2007
- 2007-06-25 TW TW096122891A patent/TW200811170A/zh unknown
- 2007-06-25 PE PE2007000811A patent/PE20080344A1/es not_active Application Discontinuation
- 2007-06-26 JP JP2009517319A patent/JP2009541464A/ja not_active Withdrawn
- 2007-06-26 AT AT07803782T patent/ATE461930T1/de active
- 2007-06-26 DE DE602007005487T patent/DE602007005487D1/de active Active
- 2007-06-26 SI SI200730258T patent/SI2046791T1/sl unknown
- 2007-06-26 ES ES07803782T patent/ES2342793T3/es active Active
- 2007-06-26 PL PL07803782T patent/PL2046791T3/pl unknown
- 2007-06-26 RU RU2009102535/04A patent/RU2009102535A/ru not_active Application Discontinuation
- 2007-06-26 EP EP07803782A patent/EP2046791B1/fr active Active
- 2007-06-26 PT PT07803782T patent/PT2046791E/pt unknown
- 2007-06-26 WO PCT/FR2007/001070 patent/WO2008000951A2/fr active Application Filing
- 2007-06-26 AU AU2007264792A patent/AU2007264792A1/en not_active Abandoned
- 2007-06-26 CA CA002648769A patent/CA2648769A1/fr not_active Abandoned
- 2007-06-26 DK DK07803782.7T patent/DK2046791T3/da active
- 2007-06-26 CL CL2007001885A patent/CL2007001885A1/es unknown
- 2007-06-26 AR ARP070102821A patent/AR061642A1/es not_active Application Discontinuation
- 2007-06-26 KR KR1020087031631A patent/KR20090021193A/ko not_active Application Discontinuation
- 2007-06-26 MX MX2008016492A patent/MX277822B/es active IP Right Grant
- 2007-06-27 UY UY30447A patent/UY30447A1/es not_active Application Discontinuation
-
2008
- 2008-11-25 IL IL195510A patent/IL195510A0/en unknown
- 2008-12-11 US US12/332,547 patent/US7897773B2/en not_active Expired - Fee Related
-
2010
- 2010-06-21 CY CY20101100571T patent/CY1110132T1/el unknown
- 2010-08-30 US US12/871,403 patent/US20100324084A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK2046791T3 (da) | 2010-07-19 |
| CL2007001885A1 (es) | 2008-01-25 |
| WO2008000951A2 (fr) | 2008-01-03 |
| TW200811170A (en) | 2008-03-01 |
| DE602007005487D1 (de) | 2010-05-06 |
| KR20090021193A (ko) | 2009-02-27 |
| MX277822B (es) | 2010-08-03 |
| PT2046791E (pt) | 2010-06-23 |
| UY30447A1 (es) | 2008-01-31 |
| PE20080344A1 (es) | 2008-06-09 |
| ES2342793T3 (es) | 2010-07-14 |
| RU2009102535A (ru) | 2010-08-10 |
| US7897773B2 (en) | 2011-03-01 |
| CY1110132T1 (el) | 2015-01-14 |
| US20090170894A1 (en) | 2009-07-02 |
| EP2046791B1 (fr) | 2010-03-24 |
| SI2046791T1 (sl) | 2010-07-30 |
| WO2008000951A3 (fr) | 2008-02-21 |
| IL195510A0 (en) | 2009-09-01 |
| US20100324084A1 (en) | 2010-12-23 |
| JP2009541464A (ja) | 2009-11-26 |
| PL2046791T3 (pl) | 2010-08-31 |
| CA2648769A1 (fr) | 2008-01-03 |
| EP2046791A2 (fr) | 2009-04-15 |
| AU2007264792A1 (en) | 2008-01-03 |
| ATE461930T1 (de) | 2010-04-15 |
| MX2008016492A (es) | 2009-01-22 |
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