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AR012102A1 - Derivados de 2-(iminometil)amino-fenilo, su preparacion, uso de los mismos para la fabricacion de medicamentos y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de 2-(iminometil)amino-fenilo, su preparacion, uso de los mismos para la fabricacion de medicamentos y composiciones farmaceuticas que los contienen.

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Publication number
AR012102A1
AR012102A1 ARP980101221A ARP980101221A AR012102A1 AR 012102 A1 AR012102 A1 AR 012102A1 AR P980101221 A ARP980101221 A AR P980101221A AR P980101221 A ARP980101221 A AR P980101221A AR 012102 A1 AR012102 A1 AR 012102A1
Authority
AR
Argentina
Prior art keywords
branched
derivatives
radical
formula
linear
Prior art date
Application number
ARP980101221A
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English (en)
Original Assignee
Ipsen Pharma Sas
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Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Publication of AR012102A1 publication Critical patent/AR012102A1/es

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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract

Derivados de 2-(iminometil)amino-fenilo, de la formula general (I) en donde AA representa un radical de formula (II), donde R1 y R2 representan,independientemente, hidrogeno, alquilo lineal o ramificado C1-C6- n -COR4, donde R4 representaalquil o lineal o ramificado C1-C6; o un radical de formula(III), donde R3 tiene el significado ya dado a un radical, formula (IV), donde R5 representa hidrogeno, HO o alquilo o alcoxi lineal o ramificado C1-C6; Brepresenta alquilo lineal oramificado C1-C 6, arilo carbocíclico o heterocíclico con 5 o 6 miembros conteniendo 1 a 4 heteroátomos elegidos de O,S, N, en particular tiofeno, furano, pirrol o tiazol, estando el radical arilo sustituido optativamente por uno o másgrupos alquilo,a lquenilo o alcoxilineales o ramificados C1-C6; X representa -Z1-, -Z1-CO-, -CH=CH-CO-, Z1-NR3-CO-,, -Z1-NR3-CS-, -1-NR3-SO2- o un enlace simple, Y representa -Z2-Q-,piperazina, homopiperazina, 2-metilpiperazina, 2,5-dimetilpiperazina, 4-aminopiperidina, -NR3-Z2-Q, -NR3-CO-Z2-Q-, -NR3-NH-CO-Z2-, -NH-NH-Z2-, NR3-O-Z2-, -NR3-SO2NR3-Z2-, -O-Z2-Q-, -O-CO-Z2-Q- o -S-Z2-Q-, en donde Q representa un enlace simple, o un radical alquileno lineal o ramificado C1-C6;preferiblemente Z1, Z 2 y Z3 representan -(CH2)m, donde m=0 aa 6; R6 representa hidrogeno u HO, o una sal de un producto de formula (I); procedimiento para supreparacion; medicamento y composicion farmacéutica que contiene al menos uno dedichos derivados y utilizacion de los referidos derivados para producir unmedicamento.
ARP980101221A 1997-03-24 1998-03-18 Derivados de 2-(iminometil)amino-fenilo, su preparacion, uso de los mismos para la fabricacion de medicamentos y composiciones farmaceuticas que los contienen. AR012102A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703528A FR2761066B1 (fr) 1997-03-24 1997-03-24 Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant

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AR012102A1 true AR012102A1 (es) 2000-09-27

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ARP980101221A AR012102A1 (es) 1997-03-24 1998-03-18 Derivados de 2-(iminometil)amino-fenilo, su preparacion, uso de los mismos para la fabricacion de medicamentos y composiciones farmaceuticas que los contienen.

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US (1) US6340700B1 (es)
EP (1) EP0973763B1 (es)
JP (1) JP4469424B2 (es)
KR (1) KR100431917B1 (es)
CN (1) CN1143854C (es)
AR (1) AR012102A1 (es)
AT (1) ATE241612T1 (es)
AU (1) AU733173B2 (es)
BR (1) BR9808427B1 (es)
CA (1) CA2285037C (es)
CZ (1) CZ297562B6 (es)
DE (1) DE69815094T2 (es)
DK (1) DK0973763T3 (es)
ES (1) ES2200318T3 (es)
FR (1) FR2761066B1 (es)
HK (1) HK1027563A1 (es)
HU (1) HU228929B1 (es)
IL (1) IL131915A (es)
MY (1) MY124146A (es)
NO (1) NO324065B1 (es)
NZ (1) NZ338016A (es)
PL (1) PL194688B1 (es)
PT (1) PT973763E (es)
RU (1) RU2183211C2 (es)
SK (1) SK282773B6 (es)
TR (1) TR199902382T2 (es)
TW (1) TW587080B (es)
UA (1) UA56219C2 (es)
WO (1) WO1998042696A1 (es)
ZA (1) ZA982203B (es)

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Publication number Priority date Publication date Assignee Title
US6335445B1 (en) * 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
US6809088B2 (en) * 1997-03-24 2004-10-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
DE69938005T2 (de) 1998-09-22 2009-01-15 Astellas Pharma Inc. Cyanophenyl-derivate
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2784678B1 (fr) 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2798127A1 (fr) * 1999-09-03 2001-03-09 Expansia Sa Nouveau procede de preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchrommane-2-carboxy- lique
RU2380362C2 (ru) * 1999-10-11 2010-01-27 Сосьете Де Консей Де Решерш З Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств
FR2801053B1 (fr) * 1999-11-16 2004-06-25 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments
SE9904676D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds
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EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
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CA2285037A1 (fr) 1998-10-01
HK1027563A1 (en) 2001-01-19
FR2761066B1 (fr) 2000-11-24
PT973763E (pt) 2003-10-31
KR100431917B1 (ko) 2004-05-20
ATE241612T1 (de) 2003-06-15
CZ297562B6 (cs) 2007-02-07
ES2200318T3 (es) 2004-03-01
NO994620L (no) 1999-11-10
PL194688B1 (pl) 2007-06-29
IL131915A (en) 2004-06-01
AU733173B2 (en) 2001-05-10
TW587080B (en) 2004-05-11
NO994620D0 (no) 1999-09-23
HUP0001438A3 (en) 2001-09-28
JP4469424B2 (ja) 2010-05-26
HUP0001438A1 (hu) 2001-05-28
TR199902382T2 (xx) 2000-06-21
EP0973763B1 (fr) 2003-05-28
CA2285037C (fr) 2007-02-13
RU2183211C2 (ru) 2002-06-10
AU6404398A (en) 1998-10-20
SK282773B6 (sk) 2002-12-03
FR2761066A1 (fr) 1998-09-25
KR20010005648A (ko) 2001-01-15
NO324065B1 (no) 2007-08-06
CZ337399A3 (cs) 2000-06-14
US6340700B1 (en) 2002-01-22
EP0973763A1 (fr) 2000-01-26
CN1143854C (zh) 2004-03-31
WO1998042696A1 (fr) 1998-10-01
IL131915A0 (en) 2001-03-19
HU228929B1 (en) 2013-06-28
MY124146A (en) 2006-06-30
ZA982203B (en) 1998-09-16
DE69815094D1 (de) 2003-07-03
DK0973763T3 (da) 2003-09-29
JP2001518114A (ja) 2001-10-09
BR9808427B1 (pt) 2010-08-24
SK129899A3 (en) 2000-05-16
NZ338016A (en) 2000-01-28
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UA56219C2 (uk) 2003-05-15
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BR9808427A (pt) 2000-05-23

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