ATE207470T1 - Benzoxazol- und benzothiazol-derivate als arzneimittel - Google Patents

Benzoxazol- und benzothiazol-derivate als arzneimittel

Info

Publication number: ATE207470T1
Authority: AT; Austria
Prior art keywords: group; substituted; compound; alkyl; aryl
Prior art date: 1992-07-03

Application number

AT93914841T

Other languages

English (en)

Inventor

David Haigh

John Thomas Sime

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-03

Filing date

1993-06-29

Publication date

2001-11-15

1992-07-03 Priority claimed from GB929214185A external-priority patent/GB9214185D0/en

1992-12-29 Priority claimed from GB929227030A external-priority patent/GB9227030D0/en

1993-05-28 Priority claimed from GB939311027A external-priority patent/GB9311027D0/en

1993-06-29 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207470T1 publication Critical patent/ATE207470T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93914841T 1992-07-03 1993-06-29 Benzoxazol- und benzothiazol-derivate als arzneimittel ATE207470T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB929214185A GB9214185D0 (en)	1992-07-03	1992-07-03	Novel compounds
GB929227030A GB9227030D0 (en)	1992-12-29	1992-12-29	Novel compounds
GB939311027A GB9311027D0 (en)	1993-05-28	1993-05-28	Novel compounds
PCT/GB1993/001363 WO1994001420A1 (en)	1992-07-03	1993-06-29	Heterocyclic compounds as pharmaceutical

Publications (1)

Publication Number	Publication Date
ATE207470T1 true ATE207470T1 (de)	2001-11-15

Family

ID=27266276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93914841T ATE207470T1 (de)	1992-07-03	1993-06-29	Benzoxazol- und benzothiazol-derivate als arzneimittel

Country Status (19)

Country	Link
US (2)	US6048883A (de)
EP (2)	EP0648212B1 (de)
JP (1)	JPH07508747A (de)
KR (1)	KR950702545A (de)
CN (2)	CN1042532C (de)
AT (1)	ATE207470T1 (de)
AU (1)	AU678974B2 (de)
CA (1)	CA2139442A1 (de)
CZ (1)	CZ1095A3 (de)
DE (1)	DE69331010D1 (de)
FI (1)	FI950016A (de)
HU (1)	HUT71247A (de)
MX (1)	MX9303981A (de)
NO (2)	NO305318B1 (de)
NZ (1)	NZ253742A (de)
PL (2)	PL176885B1 (de)
RU (1)	RU2134686C1 (de)
SK (1)	SK695A3 (de)
WO (1)	WO1994001420A1 (de)

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CA2307068C (en)	1997-10-27	2007-04-10	Dr. Reddy's Research Foundation	Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
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SE9801992D0 (sv) *	1998-06-04	1998-06-04	Astra Ab	New 3-aryl-2-hydroxypropionic acid derivative I
AR023700A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Plc	Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
SI1131070T1 (sl)	1998-11-12	2008-12-31	Smithkline Beecham Plc	Farmacevtski sestavek za modificirano sproĺ äśanje senzibilizatorja za inzulin in metformina
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US6569901B2 (en)	2000-01-28	2003-05-27	Novo Nordisk A/S	Alkynyl-substituted propionic acid derivatives, their preparation and use
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GB0014969D0 (en)	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
US6559335B2 (en)	2000-09-22	2003-05-06	Dr. Reddy's Laboratories Limited	Process for the preparation of 3-aryl-2-hydroxy propanoic acid
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JP4330883B2 (ja)	2001-05-15	2009-09-16	エフ．ホフマン−ラロシュアーゲー	糖尿病の処置においてｐｐａｒ−アルファ及び−ガンマアクチベーターとして使用するためのカルボン酸置換オキサゾール誘導体
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US6869967B2 (en)	2001-07-30	2005-03-22	Novo Nordisk A/S	Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7067530B2 (en)	2001-07-30	2006-06-27	Novo Nordisk A/S	Compounds, their preparation and use
JPWO2003016265A1 (ja)	2001-08-17	2004-12-02	エーザイ株式会社	環状化合物およびｐｐａｒアゴニスト
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BR0313946A (pt) *	2002-08-30	2005-07-12	Hoffmann La Roche	Compostos, processo para a manufatura destes compostos, composições farmacêuticas que compreendem os mesmos, métodos para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppara(alfa) e/ou ppary, utilização dos compostos e/ou do método
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US7816385B2 (en)	2002-12-20	2010-10-19	High Point Pharmaceuticals, Llc	Dimeric dicarboxylic acid derivatives, their preparation and use
US6653334B1 (en)	2002-12-27	2003-11-25	Kowa Co., Ltd.	Benzoxazole compound and pharmaceutical composition containing the same
US20050182125A1 (en) *	2003-05-16	2005-08-18	Ambit Biosciences Corporation	Pyrrole compounds and uses thereof
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DK2670486T3 (en)	2011-01-31	2016-05-17	Cadila Healthcare Ltd	TREATMENT FOR LIPODYSTROPHY
GEP201706663B (en)	2013-04-22	2017-05-10	Cadila Healthcare Ltd	Novel composition for nonalcoholic fatty liver disease (nafld
ES2889916T3 (es)	2013-05-30	2022-01-14	Cadila Healthcare Ltd	Un procedimiento para la preparación de pirroles con actividades hipolipidémicas e hipocolesterémicas
TW201636015A (zh)	2013-07-05	2016-10-16	卡地拉保健有限公司	協同性組成物
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CN103467406B (zh) *	2013-09-03	2014-12-17	浙江医药高等专科学校	卤素取代的四氮唑羧酸类化合物、其制备方法和用途
CN103467405B (zh) *	2013-09-03	2015-01-07	浙江医药高等专科学校	一类四氮唑羧酸类化合物、其制备方法和用途
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CN103467408B (zh) *	2013-09-03	2015-01-21	浙江医药高等专科学校	一类四氮唑羧酸类化合物及其用途
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US5232925A (en) *	1987-09-04	1993-08-03	Beecham Group P.L.C.	Compounds
DE10199003I1 (de) *	1987-09-04	2003-06-12	Beecham Group Plc	Substituierte Thiazolidinionderivate
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GB9017218D0 (en) *	1990-08-06	1990-09-19	Beecham Group Plc	Novel compounds

1993
- 1993-06-29 AT AT93914841T patent/ATE207470T1/de not_active IP Right Cessation
- 1993-06-29 SK SK6-95A patent/SK695A3/sk unknown
- 1993-06-29 WO PCT/GB1993/001363 patent/WO1994001420A1/en not_active Application Discontinuation
- 1993-06-29 PL PL93316129A patent/PL176885B1/pl unknown
- 1993-06-29 AU AU45068/93A patent/AU678974B2/en not_active Ceased
- 1993-06-29 KR KR1019940704886A patent/KR950702545A/ko not_active Application Discontinuation
- 1993-06-29 PL PL93307087A patent/PL174610B1/pl unknown
- 1993-06-29 EP EP93914841A patent/EP0648212B1/de not_active Expired - Lifetime
- 1993-06-29 NZ NZ253742A patent/NZ253742A/en unknown
- 1993-06-29 DE DE69331010T patent/DE69331010D1/de not_active Expired - Lifetime
- 1993-06-29 JP JP6503071A patent/JPH07508747A/ja active Pending
- 1993-06-29 CZ CZ9510A patent/CZ1095A3/cs unknown
- 1993-06-29 HU HU9500006A patent/HUT71247A/hu unknown
- 1993-06-29 RU RU94046169A patent/RU2134686C1/ru active
- 1993-06-29 CA CA002139442A patent/CA2139442A1/en not_active Abandoned
- 1993-06-29 US US08/360,755 patent/US6048883A/en not_active Expired - Fee Related
- 1993-06-29 EP EP99204395A patent/EP1000938A1/de not_active Withdrawn
- 1993-07-01 MX MX9303981A patent/MX9303981A/es not_active IP Right Cessation
- 1993-07-02 CN CN93109874A patent/CN1042532C/zh not_active Expired - Fee Related
1995
- 1995-01-02 FI FI950016A patent/FI950016A/fi unknown
- 1995-01-02 NO NO950009A patent/NO305318B1/no not_active IP Right Cessation
- 1995-06-02 US US08/458,335 patent/US5869495A/en not_active Expired - Fee Related
1998
- 1998-05-14 CN CN98108909A patent/CN1215724A/zh active Pending
1999
- 1999-01-19 NO NO990227A patent/NO990227D0/no unknown

Also Published As

Publication number	Publication date
DE69331010D1 (de)	2001-11-29
PL174610B1 (pl)	1998-08-31
FI950016A (fi)	1995-03-02
PL307087A1 (en)	1995-05-02
NZ253742A (en)	1997-06-24
HUT71247A (en)	1995-11-28
NO990227L (no)	1995-03-02
RU94046169A (ru)	1996-10-27
AU678974B2 (en)	1997-06-19
NO950009D0 (no)	1995-01-02
EP0648212A1 (de)	1995-04-19
SK695A3 (en)	1995-07-11
MX9303981A (es)	1994-04-29
EP0648212B1 (de)	2001-10-24
CN1042532C (zh)	1999-03-17
NO990227D0 (no)	1999-01-19
FI950016A0 (fi)	1995-01-02
NO305318B1 (no)	1999-05-10
CN1215724A (zh)	1999-05-05
KR950702545A (ko)	1995-07-29
CZ1095A3 (en)	1995-10-18
HU9500006D0 (en)	1995-03-28
US5869495A (en)	1999-02-09
AU4506893A (en)	1994-01-31
PL176885B1 (pl)	1999-08-31
JPH07508747A (ja)	1995-09-28
WO1994001420A1 (en)	1994-01-20
RU2134686C1 (ru)	1999-08-20
EP1000938A1 (de)	2000-05-17
CN1095716A (zh)	1994-11-30
US6048883A (en)	2000-04-11
NO950009L (no)	1995-03-02
CA2139442A1 (en)	1994-01-20

Publication	Publication Date	Title
DE69331010D1 (de)	2001-11-29	Benzoxazol- und benzothiazol-derivate als arzneimittel
DE69006984D1 (de)	1994-04-07	Thiazolidinedionederivate.
ATE118487T1 (de)	1995-03-15	Thiazolidinedionederivate.
DE3856378D1 (de)	1999-12-23	Substituierte Thiazolidindionderivate
CA2143849A1 (en)	1994-03-17	Substituted Thiazolidinedione Derivatives
EP0356214A3 (de)	1990-08-08	Thiazolidindion-Derivate
DK0695183T3 (da)	2003-11-10	Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser
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