AR010643A1 - COMPOUNDS OF 2-IMIDAZOLINILAMINOINDAZOL, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents
COMPOUNDS OF 2-IMIDAZOLINILAMINOINDAZOL, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.Info
- Publication number
- AR010643A1 AR010643A1 ARP970105524A ARP970105524A AR010643A1 AR 010643 A1 AR010643 A1 AR 010643A1 AR P970105524 A ARP970105524 A AR P970105524A AR P970105524 A ARP970105524 A AR P970105524A AR 010643 A1 AR010643 A1 AR 010643A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- compounds
- compound
- unsubstituted
- manufacture
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
Abstract
Compuestos de 2-imidazolinilaminoindazol de formula (I), donde a) R1 es hidrogeno; o alquilo; b) R2 es hidrogeno; alquilo o nulo; c) R3 se seleccionade hidrogeno; alcanilo de C1-C3 no sustituido, amino, hidroxi, mercapto, alquiltio oalcox i de C1-C3, alquilamino de C1-C3 o dialquilamino de C1-C3,ciano y halo; d) R4, R5 y R7 se seleccionan independientemente de hidrogeno, alcanilo de C1-C3 no sustituido, alquenilo, alquiltio o alcoxi de C1-C3 nosustituido, hidroxi, tio,nitro, ciano , amina, alquilamino de C1-C3 y halogeno; e) cuando R2 es nulo, el enlace (a) es un enlace doble; f) elcompuesto no es 7-bromo-6-2(imidazolinilamino)indazol; y enantiomeros, isomeros opticos, estereoisomeros,diastereomeros, tautom eros, sales deadicion, amidas y ésteres, y composiciones farmacéuticas que contienen tales compuestos para prevenir o tratar trastornos modulados por alfa-2-adrenoreceptores. Uso de un compuesto para la fabricacion de unmedicamento para usar en el tratamiento de desordenes modulados por alfa 2-adrenoreceptores.2-Imidazolinylaminoindazole compounds of formula (I), wherein a) R1 is hydrogen; or alkyl; b) R2 is hydrogen; alkyl or null; c) R3 is selected from hydrogen; unsubstituted C1-C3 alkanyl, amino, hydroxy, mercapto, C1-C3 alkylthio oalcox i, C1-C3 alkylamino or C1-C3 dialkylamino, cyano and halo; d) R4, R5 and R7 are independently selected from hydrogen, unsubstituted C1-C3 alkanyl, alkenyl, alkylthio or unsubstituted C1-C3 alkoxy, hydroxy, thio, nitro, cyano, amine, C1-C3 alkylamino and halogen; e) when R2 is null, bond (a) is a double bond; f) the compound is not 7-bromo-6-2 (imidazolinilamino) indazol; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, amides and esters, and pharmaceutical compositions containing such compounds to prevent or treat alpha-2-adrenoreceptor modulated disorders. Use of a compound for the manufacture of a medicine for use in the treatment of disorders modulated by alpha 2-adrenoreceptors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3174096P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010643A1 true AR010643A1 (en) | 2000-06-28 |
Family
ID=21861136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105524A AR010643A1 (en) | 1996-11-25 | 1997-11-25 | COMPOUNDS OF 2-IMIDAZOLINILAMINOINDAZOL, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0944620A1 (en) |
| JP (1) | JP2001506599A (en) |
| KR (1) | KR20000069104A (en) |
| CN (1) | CN1244864A (en) |
| AR (1) | AR010643A1 (en) |
| AU (1) | AU5433998A (en) |
| BR (1) | BR9713535A (en) |
| CA (1) | CA2272644A1 (en) |
| CO (1) | CO4910166A1 (en) |
| CZ (1) | CZ183999A3 (en) |
| HU (1) | HUP9904660A3 (en) |
| ID (1) | ID22676A (en) |
| IL (1) | IL130067A0 (en) |
| NO (1) | NO992502L (en) |
| NZ (1) | NZ335882A (en) |
| PE (1) | PE47099A1 (en) |
| SK (1) | SK69699A3 (en) |
| TR (1) | TR199901542T2 (en) |
| WO (1) | WO1998023609A1 (en) |
| ZA (1) | ZA9710576B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| US20100311965A1 (en) | 2007-12-28 | 2010-12-09 | Carna Biosciences Inc. | 2-aminoquinazoline derivative |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| CN112538074A (en) * | 2020-12-24 | 2021-03-23 | 艾希尔（深圳）药物研发有限公司 | Preparation method of debrominated impurities of brimonidine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH641782A5 (en) * | 1978-12-07 | 1984-03-15 | Siegfried Ag | 1H- and 2H-indazole derivatives |
| US4526898A (en) * | 1980-09-05 | 1985-07-02 | Siegfried Aktiengesselschaft | Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| SK77396A3 (en) * | 1993-12-17 | 1997-01-08 | Procter & Gamble | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 BR BR9713535A patent/BR9713535A/en unknown
- 1997-11-21 AU AU54339/98A patent/AU5433998A/en not_active Abandoned
- 1997-11-21 EP EP97948238A patent/EP0944620A1/en not_active Withdrawn
- 1997-11-21 JP JP52468698A patent/JP2001506599A/en active Pending
- 1997-11-21 HU HU9904660A patent/HUP9904660A3/en unknown
- 1997-11-21 ID IDW990412A patent/ID22676A/en unknown
- 1997-11-21 CN CN97181453A patent/CN1244864A/en active Pending
- 1997-11-21 CA CA002272644A patent/CA2272644A1/en not_active Abandoned
- 1997-11-21 KR KR1019997004569A patent/KR20000069104A/en not_active Application Discontinuation
- 1997-11-21 CZ CZ991839A patent/CZ183999A3/en unknown
- 1997-11-21 NZ NZ335882A patent/NZ335882A/en unknown
- 1997-11-21 IL IL13006797A patent/IL130067A0/en unknown
- 1997-11-21 TR TR1999/01542T patent/TR199901542T2/en unknown
- 1997-11-21 WO PCT/US1997/020551 patent/WO1998023609A1/en not_active Application Discontinuation
- 1997-11-24 CO CO97068615A patent/CO4910166A1/en unknown
- 1997-11-25 ZA ZA9710576A patent/ZA9710576B/en unknown
- 1997-11-25 AR ARP970105524A patent/AR010643A1/en unknown
- 1997-11-25 PE PE1997001067A patent/PE47099A1/en not_active Application Discontinuation
-
1999
- 1999-05-25 NO NO992502A patent/NO992502L/en not_active Application Discontinuation
- 1999-05-25 SK SK696-99A patent/SK69699A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9710576B (en) | 1998-09-16 |
| PE47099A1 (en) | 1999-06-12 |
| KR20000069104A (en) | 2000-11-25 |
| IL130067A0 (en) | 2000-02-29 |
| HUP9904660A2 (en) | 2000-06-28 |
| WO1998023609A1 (en) | 1998-06-04 |
| BR9713535A (en) | 2000-03-21 |
| EP0944620A1 (en) | 1999-09-29 |
| HUP9904660A3 (en) | 2002-02-28 |
| NO992502L (en) | 1999-07-26 |
| AU5433998A (en) | 1998-06-22 |
| NZ335882A (en) | 2000-12-22 |
| CZ183999A3 (en) | 1999-11-17 |
| NO992502D0 (en) | 1999-05-25 |
| SK69699A3 (en) | 2000-06-12 |
| JP2001506599A (en) | 2001-05-22 |
| CN1244864A (en) | 2000-02-16 |
| CO4910166A1 (en) | 2000-04-24 |
| ID22676A (en) | 1999-12-09 |
| CA2272644A1 (en) | 1998-06-04 |
| TR199901542T2 (en) | 2000-01-21 |
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