NO992502L - 2-Imidazolinylaminoindazole compounds useful as <alfa> -2 adrenergic receptor agonists - Google Patents
2-Imidazolinylaminoindazole compounds useful as <alfa> -2 adrenergic receptor agonistsInfo
- Publication number
- NO992502L NO992502L NO992502A NO992502A NO992502L NO 992502 L NO992502 L NO 992502L NO 992502 A NO992502 A NO 992502A NO 992502 A NO992502 A NO 992502A NO 992502 L NO992502 L NO 992502L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- unsubstituted
- compounds
- imidazolinylaminoindazole
- alfa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
Abstract
Denne oppfinnelse vedrører forbindelser som har struktur (I) hvor: a) RT er hydrogen; eller alkyl; b) R2 er hydrogen; alkyl eller null; c) R3 er valgt fra hydrogen; usub- stituert C^ alkanyl; amino, hydroksy, merkapto; C^-C, alkyltio eller alkoksy; Ci-C3 alkylamino eller C^-C3 dialkyl- amino; cyano; og halo; d) R,, Rs og R, er hver uavhengig valgt fra hydrogen; usubstituert C^-C^ alkanyl, alkenyl eller alkynyl; cykloalkanyl, cykloalkenyl; usubstituert C^- C3 alkyltio eller alkoksy; hydroksy; tio; nitro; cyano; amino; C^-Cj alkylamino eller C^-C., dialkylamino og halo; e) når R2 er null, er binding (a) en dobbeIbinding; f) for- bindelsen er ikke 7-brom-6-(2-imidazolinylamino)indazol; og enantiomerer, optiske isomerer, stereoisomerer, diastereo- merer, tautomerer, addisjonssalter, biohydrolyserbare amider og estere, og farmasøytiske sammensetninger inne- holdende slike nye forbindelser, og anvendelsen av slike forbindelser for å forhindre eller behandle forstyrrelser modulert av alfa-2-adrenerge reseptorer.This invention relates to compounds having structure (I) wherein: a) RT is hydrogen; or alkyl; b) R 2 is hydrogen; alkyl or zero; c) R 3 is selected from hydrogen; unsubstituted C 1-6 alkanyl; amino, hydroxy, mercapto; C ^-C, alkylthio or alkoxy; C1-C3 alkylamino or C1-C3 dialkylamino; cyano; and halo; d) R 1, R 5 and R 1 are each independently selected from hydrogen; unsubstituted C ^-C ^ alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C 1 -C 3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C ^-Cj alkylamino or C ^-C., Dialkylamino and halo; e) when R 2 is zero, bond (a) is a double bond; f) the compound is not 7-bromo-6- (2-imidazolinylamino) indazole; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters, and pharmaceutical compositions containing such novel compounds, and the use of such compounds to prevent or treat disorders modulated by alpha-2 adrenoceptors. .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3174096P | 1996-11-25 | 1996-11-25 | |
| PCT/US1997/020551 WO1998023609A1 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992502D0 NO992502D0 (en) | 1999-05-25 |
| NO992502L true NO992502L (en) | 1999-07-26 |
Family
ID=21861136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992502A NO992502L (en) | 1996-11-25 | 1999-05-25 | 2-Imidazolinylaminoindazole compounds useful as <alfa> -2 adrenergic receptor agonists |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0944620A1 (en) |
| JP (1) | JP2001506599A (en) |
| KR (1) | KR20000069104A (en) |
| CN (1) | CN1244864A (en) |
| AR (1) | AR010643A1 (en) |
| AU (1) | AU5433998A (en) |
| BR (1) | BR9713535A (en) |
| CA (1) | CA2272644A1 (en) |
| CO (1) | CO4910166A1 (en) |
| CZ (1) | CZ183999A3 (en) |
| HU (1) | HUP9904660A3 (en) |
| ID (1) | ID22676A (en) |
| IL (1) | IL130067A0 (en) |
| NO (1) | NO992502L (en) |
| NZ (1) | NZ335882A (en) |
| PE (1) | PE47099A1 (en) |
| SK (1) | SK69699A3 (en) |
| TR (1) | TR199901542T2 (en) |
| WO (1) | WO1998023609A1 (en) |
| ZA (1) | ZA9710576B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| US20100311965A1 (en) | 2007-12-28 | 2010-12-09 | Carna Biosciences Inc. | 2-aminoquinazoline derivative |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| CN112538074A (en) * | 2020-12-24 | 2021-03-23 | 艾希尔（深圳）药物研发有限公司 | Preparation method of debrominated impurities of brimonidine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH641782A5 (en) * | 1978-12-07 | 1984-03-15 | Siegfried Ag | 1H- and 2H-indazole derivatives |
| US4526898A (en) * | 1980-09-05 | 1985-07-02 | Siegfried Aktiengesselschaft | Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| SK77396A3 (en) * | 1993-12-17 | 1997-01-08 | Procter & Gamble | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 BR BR9713535A patent/BR9713535A/en unknown
- 1997-11-21 AU AU54339/98A patent/AU5433998A/en not_active Abandoned
- 1997-11-21 EP EP97948238A patent/EP0944620A1/en not_active Withdrawn
- 1997-11-21 JP JP52468698A patent/JP2001506599A/en active Pending
- 1997-11-21 HU HU9904660A patent/HUP9904660A3/en unknown
- 1997-11-21 ID IDW990412A patent/ID22676A/en unknown
- 1997-11-21 CN CN97181453A patent/CN1244864A/en active Pending
- 1997-11-21 CA CA002272644A patent/CA2272644A1/en not_active Abandoned
- 1997-11-21 KR KR1019997004569A patent/KR20000069104A/en not_active Application Discontinuation
- 1997-11-21 CZ CZ991839A patent/CZ183999A3/en unknown
- 1997-11-21 NZ NZ335882A patent/NZ335882A/en unknown
- 1997-11-21 IL IL13006797A patent/IL130067A0/en unknown
- 1997-11-21 TR TR1999/01542T patent/TR199901542T2/en unknown
- 1997-11-21 WO PCT/US1997/020551 patent/WO1998023609A1/en not_active Application Discontinuation
- 1997-11-24 CO CO97068615A patent/CO4910166A1/en unknown
- 1997-11-25 ZA ZA9710576A patent/ZA9710576B/en unknown
- 1997-11-25 AR ARP970105524A patent/AR010643A1/en unknown
- 1997-11-25 PE PE1997001067A patent/PE47099A1/en not_active Application Discontinuation
-
1999
- 1999-05-25 NO NO992502A patent/NO992502L/en not_active Application Discontinuation
- 1999-05-25 SK SK696-99A patent/SK69699A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9710576B (en) | 1998-09-16 |
| PE47099A1 (en) | 1999-06-12 |
| KR20000069104A (en) | 2000-11-25 |
| IL130067A0 (en) | 2000-02-29 |
| AR010643A1 (en) | 2000-06-28 |
| HUP9904660A2 (en) | 2000-06-28 |
| WO1998023609A1 (en) | 1998-06-04 |
| BR9713535A (en) | 2000-03-21 |
| EP0944620A1 (en) | 1999-09-29 |
| HUP9904660A3 (en) | 2002-02-28 |
| AU5433998A (en) | 1998-06-22 |
| NZ335882A (en) | 2000-12-22 |
| CZ183999A3 (en) | 1999-11-17 |
| NO992502D0 (en) | 1999-05-25 |
| SK69699A3 (en) | 2000-06-12 |
| JP2001506599A (en) | 2001-05-22 |
| CN1244864A (en) | 2000-02-16 |
| CO4910166A1 (en) | 2000-04-24 |
| ID22676A (en) | 1999-12-09 |
| CA2272644A1 (en) | 1998-06-04 |
| TR199901542T2 (en) | 2000-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |