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AR007108A1 - Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. - Google Patents

Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.

Info

Publication number
AR007108A1
AR007108A1 ARP970101989A ARP970101989A AR007108A1 AR 007108 A1 AR007108 A1 AR 007108A1 AR P970101989 A ARP970101989 A AR P970101989A AR P970101989 A ARP970101989 A AR P970101989A AR 007108 A1 AR007108 A1 AR 007108A1
Authority
AR
Argentina
Prior art keywords
agents
same
antiviral
tumor
procedure
Prior art date
Application number
ARP970101989A
Other languages
English (en)
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of AR007108A1 publication Critical patent/AR007108A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un compuesto consistente en un derivado de distmicina de fórmula (I) donde: n es 2, 3 o 4; R0 es alquilo C1-C4 o haloalquilo C1-C3; R1 y R2, que pueden seriguales o diferentes, son cada uno hidrógeno, alquilo C1-C4 opcionalmente sustituido poruno o más átomos de flúor, o alcoxi C1-C4; X es un átomo dehalógeno; B se selecciona entre los radicales (II), donde R3, R4, R5, R6, R7, R8 y R9, pueden ser iguales o diferentes, son cada uno hidrógeno o alquiloC1-C4, y m es 0, 1 o 2; o una salfar macéuticamente aceptable del mismo. Dichos compuestos son útiles como agentes antineoplásicos y antivirales.
ARP970101989A 1996-05-14 1997-05-13 Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. AR007108A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9610079.7A GB9610079D0 (en) 1996-05-14 1996-05-14 Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents

Publications (1)

Publication Number Publication Date
AR007108A1 true AR007108A1 (es) 1999-10-13

Family

ID=10793694

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101989A AR007108A1 (es) 1996-05-14 1997-05-13 Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.

Country Status (27)

Country Link
US (1) US6177408B1 (es)
EP (1) EP0912509B1 (es)
JP (1) JP2000510129A (es)
CN (1) CN1089755C (es)
AR (1) AR007108A1 (es)
AT (1) ATE203011T1 (es)
AU (1) AU721140B2 (es)
BR (1) BR9709451A (es)
CA (1) CA2253652A1 (es)
DE (1) DE69705622T2 (es)
DK (1) DK0912509T3 (es)
EA (1) EA002273B1 (es)
ES (1) ES2160951T3 (es)
GB (1) GB9610079D0 (es)
GR (1) GR3036824T3 (es)
HK (1) HK1020734A1 (es)
HU (1) HUP9901387A3 (es)
IL (1) IL126840A (es)
MY (1) MY118004A (es)
NO (1) NO311886B1 (es)
NZ (1) NZ332923A (es)
PL (1) PL329878A1 (es)
PT (1) PT912509E (es)
TW (1) TW498066B (es)
UA (1) UA45457C2 (es)
WO (1) WO1997043258A1 (es)
ZA (1) ZA973883B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9812211D0 (en) 1998-06-05 1998-08-05 Pharmacia & Upjohn Spa Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) * 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0029004D0 (en) 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6825228B2 (en) * 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
US20030236198A1 (en) * 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
KR102573190B1 (ko) 2015-10-16 2023-09-01 삼성전자주식회사 전자장치 및 전자장치 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation

Also Published As

Publication number Publication date
HK1020734A1 (en) 2000-05-19
CA2253652A1 (en) 1997-11-20
US6177408B1 (en) 2001-01-23
EP0912509B1 (en) 2001-07-11
PL329878A1 (en) 1999-04-12
WO1997043258A1 (en) 1997-11-20
GR3036824T3 (en) 2002-01-31
NO311886B1 (no) 2002-02-11
MY118004A (en) 2004-08-30
DE69705622T2 (de) 2002-05-08
NO985307D0 (no) 1998-11-13
CN1222144A (zh) 1999-07-07
NZ332923A (en) 2000-03-27
NO985307L (no) 1999-01-12
UA45457C2 (uk) 2002-04-15
EA002273B1 (ru) 2002-02-28
ZA973883B (en) 1997-12-08
DK0912509T3 (da) 2001-10-22
HUP9901387A3 (en) 2002-10-28
TW498066B (en) 2002-08-11
AU2701697A (en) 1997-12-05
EP0912509A1 (en) 1999-05-06
EA199801013A1 (ru) 1999-06-24
AU721140B2 (en) 2000-06-22
ATE203011T1 (de) 2001-07-15
IL126840A (en) 2002-03-10
GB9610079D0 (en) 1996-07-17
CN1089755C (zh) 2002-08-28
ES2160951T3 (es) 2001-11-16
IL126840A0 (en) 1999-09-22
PT912509E (pt) 2001-12-28
DE69705622D1 (de) 2001-08-16
BR9709451A (pt) 1999-08-10
JP2000510129A (ja) 2000-08-08
HUP9901387A2 (hu) 2000-04-28

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