AP2009004945A0 - New tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them - Google Patents

New tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number: AP2009004945A0
Authority: AP; ARIPO
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; tricyclic compounds; new tricyclic
Prior art date: 2007-02-02

Application number

AP2009004945A

Other languages

English (en)

Inventor

John Hickman

Patrick Casara

Olivier Geneste

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-02

Filing date

2008-02-01

Publication date

2009-08-31

2008-02-01 Application filed by Servier Lab filed Critical Servier Lab

2009-08-31 Publication of AP2009004945A0 publication Critical patent/AP2009004945A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AP2009004945A 2007-02-02 2008-02-01 New tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them AP2009004945A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0700741A FR2912145B1 (fr)	2007-02-02	2007-02-02	Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2008/000121 WO2008110691A1 (fr)	2007-02-02	2008-02-01	Nouveaux derives tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
AP2009004945A0 true AP2009004945A0 (en)	2009-08-31

Family

ID=38219469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2009004945A AP2009004945A0 (en)	2007-02-02	2008-02-01	New tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (45)

Country	Link
US (1)	US20080188460A1 (es)
EP (1)	EP1953161B1 (es)
JP (1)	JP2008266296A (es)
KR (1)	KR100997027B1 (es)
CN (1)	CN101270120A (es)
AP (1)	AP2009004945A0 (es)
AR (1)	AR065131A1 (es)
AT (1)	ATE440842T1 (es)
AU (1)	AU2008200499A1 (es)
BR (1)	BRPI0800988A2 (es)
CA (1)	CA2619897C (es)
CL (1)	CL2008000318A1 (es)
CO (1)	CO6230990A2 (es)
CR (1)	CR10953A (es)
CY (1)	CY1109637T1 (es)
DE (1)	DE602008000104D1 (es)
DK (1)	DK1953161T3 (es)
EA (1)	EA014672B1 (es)
EC (1)	ECSP099546A (es)
ES (1)	ES2332337T3 (es)
FR (1)	FR2912145B1 (es)
GE (1)	GEP20115186B (es)
GT (1)	GT200900217A (es)
HR (1)	HRP20090565T1 (es)
IL (1)	IL200128A0 (es)
JO (1)	JO2616B1 (es)
MA (1)	MA29725B1 (es)
MX (1)	MX2008001504A (es)
MY (1)	MY144633A (es)
NI (1)	NI200900147A (es)
NZ (1)	NZ565643A (es)
PA (1)	PA8768301A1 (es)
PE (1)	PE20081703A1 (es)
PL (1)	PL1953161T3 (es)
PT (1)	PT1953161E (es)
RS (1)	RS51133B (es)
SA (1)	SA08290043B1 (es)
SG (1)	SG144892A1 (es)
SI (1)	SI1953161T1 (es)
SV (1)	SV2009003348A (es)
TN (1)	TN2009000307A1 (es)
TW (1)	TW200838532A (es)
UA (1)	UA90726C2 (es)
WO (1)	WO2008110691A1 (es)
ZA (1)	ZA200801103B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2064175B1 (en)	2006-09-07	2014-08-06	F. Hoffmann-La Roche AG	A process for the manufacture of snac (salcaprozate sodium)
FR2933983B1 (fr) *	2008-07-15	2010-08-27	Servier Lab	Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2010124042A2 (en) *	2009-04-23	2010-10-28	Abbott Laboratories	Modulators of 5-ht receptors and methods of use thereof
US8546377B2 (en) *	2009-04-23	2013-10-01	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) *	2009-04-23	2013-08-27	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
ES2443845T3 (es) *	2009-09-10	2014-02-20	Novartis Ag	Sulfonamidas como inhibidores de proteínas de la familia BCL-2 para el tratamiento del cáncer
CN102584744B (zh) *	2011-01-06	2015-07-01	上海药明康德新药开发有限公司	4-(4-((2-(4-氯苯基)-5,5-二甲基环己基-1-烯)甲基)哌嗪-1-基)苯甲酸的合成方法
US8946445B2 (en)	2011-10-12	2015-02-03	Nanjing Allgen Pharma Co., Ltd.	Heterocyclic molecules as apoptosis inducers
TWI620733B (zh) *	2013-05-21	2018-04-11	拜耳作物科學股份有限公司	製備特定肟類及肟醚類之改良方法
JOP20190239A1 (ar)	2017-04-19	2019-10-09	Neurocrine Biosciences Inc	مركبات مثبطة لـ vmat2 وتركيبات منها

Family Cites Families (16)

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Publication number	Priority date	Publication date	Assignee	Title
US3899490A (en) *	1968-01-12	1975-08-12	Pfizer	Hexahydro pyrazinoquinolines
DE2362539C2 (de) *	1973-12-17	1986-05-07	Merck Patent Gmbh, 6100 Darmstadt	2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5688950A (en) *	1996-04-23	1997-11-18	Neurogen Corporation	Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands
JP2000169475A (ja) *	1998-07-24	2000-06-20	Dai Ichi Seiyaku Co Ltd	ピラゾ―ル誘導体およびその塩
US6180629B1 (en) *	1998-08-14	2001-01-30	Cell Pathways, Inc.	[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
US6190629B1 (en)	1999-04-16	2001-02-20	Cbl Technologies, Inc.	Organic acid scrubber and methods
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
BR0112918A (pt) *	2000-07-31	2003-07-01	Hoffmann La Roche	Composto, utilização do mesmo, processo de tratamento de distúrbios, processo para a preparação de composto, composição farmacêutica que compreende esse composto, processo para preparar uma composição e processo de tratamento de obesidade em um ser humano
DE60231230D1 (de) *	2001-11-03	2009-04-02	Astrazeneca Ab	Quinazolin derivate als antitumor-mittel
US7094895B2 (en) *	2001-12-21	2006-08-22	King Pharmaceuticals Research & Development, Inc.	Tyrosyl derivatives and their use as P2X7 receptor modulators
FR2841243B1 (fr) *	2002-06-19	2004-08-20	Servier Lab	Nouveaux derives de 3-(4-oxo-4h-chromen-2yl)-(1h)-quinolein- 4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004055163A2 (en) *	2002-12-12	2004-07-01	Cytovia, Inc.	Substituted 1-benzoyl-3-cyano-pyrrolo[1,2-a]quinolines
WO2005049593A2 (en) *	2003-11-13	2005-06-02	Abbott Laboratories	N-acylsulfonamide apoptosis promoters
WO2005077912A1 (ja) *	2004-02-12	2005-08-25	Mitsubishi Pharma Corporation	インダゾール化合物及びその医薬用途
US7790712B2 (en) *	2005-03-17	2010-09-07	Boehringer Ingelheim Pharmaceutical, Inc.	Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
US8119640B2 (en) *	2008-02-12	2012-02-21	The Board Of Trustees Of The Leland Stanford Junior University	Hedgehog pathway antagonists methods of use

2007
- 2007-02-02 FR FR0700741A patent/FR2912145B1/fr not_active Expired - Fee Related
2008
- 2008-01-23 PE PE2008000167A patent/PE20081703A1/es not_active Application Discontinuation
- 2008-01-24 US US12/011,225 patent/US20080188460A1/en not_active Abandoned
- 2008-01-28 MA MA30601A patent/MA29725B1/fr unknown
- 2008-01-28 GE GEAP200810489A patent/GEP20115186B/en unknown
- 2008-01-28 MY MYPI20080152A patent/MY144633A/en unknown
- 2008-01-29 UA UAA200801063A patent/UA90726C2/ru unknown
- 2008-01-30 SA SA08290043A patent/SA08290043B1/ar unknown
- 2008-01-31 SG SG200800896-3A patent/SG144892A1/en unknown
- 2008-01-31 BR BRPI0800988-0A patent/BRPI0800988A2/pt not_active IP Right Cessation
- 2008-01-31 MX MX2008001504A patent/MX2008001504A/es active IP Right Grant
- 2008-02-01 SI SI200830004T patent/SI1953161T1/sl unknown
- 2008-02-01 RS RSP-2009/0449A patent/RS51133B/sr unknown
- 2008-02-01 KR KR1020080010639A patent/KR100997027B1/ko not_active IP Right Cessation
- 2008-02-01 AR ARP080100421A patent/AR065131A1/es unknown
- 2008-02-01 PL PL08290088T patent/PL1953161T3/pl unknown
- 2008-02-01 ES ES08290088T patent/ES2332337T3/es active Active
- 2008-02-01 EA EA200800235A patent/EA014672B1/ru not_active IP Right Cessation
- 2008-02-01 EP EP08290088A patent/EP1953161B1/fr active Active
- 2008-02-01 DK DK08290088T patent/DK1953161T3/da active
- 2008-02-01 PA PA20088768301A patent/PA8768301A1/es unknown
- 2008-02-01 WO PCT/FR2008/000121 patent/WO2008110691A1/fr active Application Filing
- 2008-02-01 CL CL200800318A patent/CL2008000318A1/es unknown
- 2008-02-01 PT PT08290088T patent/PT1953161E/pt unknown
- 2008-02-01 AU AU2008200499A patent/AU2008200499A1/en not_active Abandoned
- 2008-02-01 TW TW097104070A patent/TW200838532A/zh unknown
- 2008-02-01 NZ NZ565643A patent/NZ565643A/en unknown
- 2008-02-01 CA CA2619897A patent/CA2619897C/fr not_active Expired - Fee Related
- 2008-02-01 JP JP2008022515A patent/JP2008266296A/ja active Pending
- 2008-02-01 AT AT08290088T patent/ATE440842T1/de active
- 2008-02-01 DE DE602008000104T patent/DE602008000104D1/de active Active
- 2008-02-01 AP AP2009004945A patent/AP2009004945A0/xx unknown
- 2008-02-01 ZA ZA200801103A patent/ZA200801103B/xx unknown
- 2008-02-02 CN CNA2008100963808A patent/CN101270120A/zh active Pending
- 2008-02-02 JO JOP/2008/0039A patent/JO2616B1/ar active
2009
- 2009-07-23 TN TNP2009000307A patent/TN2009000307A1/fr unknown
- 2009-07-24 CR CR10953A patent/CR10953A/es unknown
- 2009-07-28 EC EC2009009546A patent/ECSP099546A/es unknown
- 2009-07-28 IL IL200128A patent/IL200128A0/en unknown
- 2009-07-29 NI NI200900147A patent/NI200900147A/es unknown
- 2009-07-31 CO CO09080210A patent/CO6230990A2/es not_active Application Discontinuation
- 2009-07-31 SV SV2009003348A patent/SV2009003348A/es unknown
- 2009-07-31 GT GT200900217A patent/GT200900217A/es unknown
- 2009-10-22 HR HR20090565T patent/HRP20090565T1/hr unknown
- 2009-11-24 CY CY20091101213T patent/CY1109637T1/el unknown

Also Published As

Publication number	Publication date
PA8768301A1 (es)	2008-11-19
MX2008001504A (es)	2009-02-24
KR100997027B1 (ko)	2010-11-25
CY1109637T1 (el)	2014-08-13
IL200128A0 (en)	2010-04-15
NI200900147A (es)	2010-02-15
PE20081703A1 (es)	2009-01-14
AR065131A1 (es)	2009-05-20
ZA200801103B (en)	2008-12-31
NZ565643A (en)	2009-05-31
BRPI0800988A2 (pt)	2008-11-25
SI1953161T1 (sl)	2009-12-31
ATE440842T1 (de)	2009-09-15
EP1953161A1 (fr)	2008-08-06
HRP20090565T1 (hr)	2009-12-31
DK1953161T3 (da)	2009-11-30
MA29725B1 (fr)	2008-09-01
CA2619897C (fr)	2011-06-14
US20080188460A1 (en)	2008-08-07
CN101270120A (zh)	2008-09-24
JP2008266296A (ja)	2008-11-06
GT200900217A (es)	2011-09-14
RS51133B (sr)	2010-10-31
PT1953161E (pt)	2009-10-26
FR2912145B1 (fr)	2009-03-06
TN2009000307A1 (fr)	2010-12-31
CR10953A (es)	2009-09-09
EA200800235A1 (ru)	2008-08-29
KR20080072574A (ko)	2008-08-06
GEP20115186B (en)	2011-03-25
FR2912145A1 (fr)	2008-08-08
SV2009003348A (es)	2010-02-01
CL2008000318A1 (es)	2008-08-08
AU2008200499A1 (en)	2008-08-21
ECSP099546A (es)	2009-08-28
CA2619897A1 (fr)	2008-08-02
UA90726C2 (ru)	2010-05-25
JO2616B1 (ar)	2011-11-01
MY144633A (en)	2011-10-14
SG144892A1 (en)	2008-08-28
SA08290043B1 (ar)	2011-06-22
PL1953161T3 (pl)	2010-01-29
CO6230990A2 (es)	2010-12-20
EP1953161B1 (fr)	2009-08-26
WO2008110691A1 (fr)	2008-09-18
EA014672B1 (ru)	2010-12-30
TW200838532A (en)	2008-10-01
ES2332337T3 (es)	2010-02-02
DE602008000104D1 (de)	2009-10-08

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