OA11959A - Diaminothiazoles and their use for inhibiting protein kinases. - Google Patents

Diaminothiazoles and their use for inhibiting protein kinases. Download PDF

Info

Publication number: OA11959A
Authority: OA; OAPI
Prior art keywords: amino; aryl; heteroaryl; formula; substituted
Prior art date: 1999-06-04

Application number

OA1200100321A

Other languages

English (en)

Inventor

Larry Andrew Alegria

Steven Lee Bender

Suzanne Pritchett Benedict

Dillip Bhumralkar

Allen J Borchardt

Shao Song Chu

Robert Steven Kania

Mitchell David Nambu

Zhengwei Peng

Sepehr Sarshar

Anna Maria Tempczyk-Russel

Yi Michelle Yang

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-04

Filing date

2000-06-02

Publication date

2006-04-17

2000-06-02 Application filed by Agouron Pharma filed Critical Agouron Pharma

2006-04-17 Publication of OA11959A publication Critical patent/OA11959A/en

Links

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108060006633 protein kinase Proteins 0.000 title claims abstract description 30
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LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
125000000565 sulfonamide group Chemical group 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
239000011593 sulfur Chemical group 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
238000012956 testing procedure Methods 0.000 description 1
DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
125000005306 thianaphthenyl group Chemical group 0.000 description 1
125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
230000036964 tight binding Effects 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
125000001680 trimethoxyphenyl group Chemical group 0.000 description 1
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Substances C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
230000008728 vascular permeability Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000012800 visualization Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

OA1200100321A 1999-06-04 2000-06-02 Diaminothiazoles and their use for inhibiting protein kinases. OA11959A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13781099P	1999-06-04	1999-06-04

Publications (1)

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OA11959A true OA11959A (en)	2006-04-17

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ID=22479135

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Application Number	Title	Priority Date	Filing Date
OA1200100321A OA11959A (en)	1999-06-04	2000-06-02	Diaminothiazoles and their use for inhibiting protein kinases.

Country Status (34)

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US (1)	US6620828B2 (es)
EP (1)	EP1181283B1 (es)
JP (1)	JP2003501420A (es)
KR (1)	KR20020015333A (es)
CN (1)	CN1359380A (es)
AP (1)	AP2001002341A0 (es)
AT (1)	ATE288424T1 (es)
AU (1)	AU778071B2 (es)
BG (1)	BG106276A (es)
BR (1)	BR0011585A (es)
CA (1)	CA2371158A1 (es)
CZ (1)	CZ20014213A3 (es)
DE (1)	DE60017894T2 (es)
EA (1)	EA200101268A1 (es)
EE (1)	EE200100659A (es)
ES (1)	ES2234628T3 (es)
HR (1)	HRP20020008A2 (es)
HU (1)	HUP0202897A3 (es)
IL (1)	IL146094A0 (es)
IS (1)	IS6183A (es)
MA (1)	MA25530A1 (es)
MX (1)	MXPA01012483A (es)
NO (1)	NO20015045L (es)
NZ (1)	NZ514881A (es)
OA (1)	OA11959A (es)
PE (1)	PE20010211A1 (es)
PL (1)	PL352714A1 (es)
SK (1)	SK17302001A3 (es)
SV (1)	SV2002000096A (es)
UA (1)	UA71971C2 (es)
UY (1)	UY26190A1 (es)
WO (1)	WO2000075120A1 (es)
YU (1)	YU85601A (es)
ZA (1)	ZA200108291B (es)

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2000
- 2000-02-06 UA UA2001129215A patent/UA71971C2/uk unknown
- 2000-06-02 AP APAP/P/2001/002341A patent/AP2001002341A0/en unknown
- 2000-06-02 NZ NZ514881A patent/NZ514881A/en unknown
- 2000-06-02 PE PE2000000553A patent/PE20010211A1/es not_active Application Discontinuation
- 2000-06-02 WO PCT/US2000/015188 patent/WO2000075120A1/en not_active Application Discontinuation
- 2000-06-02 KR KR1020017015384A patent/KR20020015333A/ko not_active Application Discontinuation
- 2000-06-02 EA EA200101268A patent/EA200101268A1/ru unknown
- 2000-06-02 DE DE60017894T patent/DE60017894T2/de not_active Expired - Fee Related
- 2000-06-02 IL IL14609400A patent/IL146094A0/xx unknown
- 2000-06-02 AU AU57254/00A patent/AU778071B2/en not_active Ceased
- 2000-06-02 EE EEP200100659A patent/EE200100659A/xx unknown
- 2000-06-02 BR BR0011585-1A patent/BR0011585A/pt not_active IP Right Cessation
- 2000-06-02 ES ES00942660T patent/ES2234628T3/es not_active Expired - Lifetime
- 2000-06-02 MX MXPA01012483A patent/MXPA01012483A/es not_active Application Discontinuation
- 2000-06-02 HU HU0202897A patent/HUP0202897A3/hu unknown
- 2000-06-02 OA OA1200100321A patent/OA11959A/en unknown
- 2000-06-02 SV SV2000000096A patent/SV2002000096A/es unknown
- 2000-06-02 YU YU85601A patent/YU85601A/sh unknown
- 2000-06-02 CN CN00808440A patent/CN1359380A/zh active Pending
- 2000-06-02 AT AT00942660T patent/ATE288424T1/de not_active IP Right Cessation
- 2000-06-02 CZ CZ20014213A patent/CZ20014213A3/cs unknown
- 2000-06-02 JP JP2001501601A patent/JP2003501420A/ja not_active Abandoned
- 2000-06-02 PL PL00352714A patent/PL352714A1/xx not_active Application Discontinuation
- 2000-06-02 UY UY26190A patent/UY26190A1/es not_active Application Discontinuation
- 2000-06-02 EP EP00942660A patent/EP1181283B1/en not_active Expired - Lifetime
- 2000-06-02 CA CA002371158A patent/CA2371158A1/en not_active Abandoned
- 2000-06-02 SK SK1730-2001A patent/SK17302001A3/sk unknown
2001
- 2001-02-15 US US09/783,584 patent/US6620828B2/en not_active Expired - Fee Related
- 2001-10-09 ZA ZA200108291A patent/ZA200108291B/xx unknown
- 2001-10-17 NO NO20015045A patent/NO20015045L/no not_active Application Discontinuation
- 2001-11-29 IS IS6183A patent/IS6183A/is unknown
2002
- 2002-01-02 MA MA26465A patent/MA25530A1/fr unknown
- 2002-01-03 BG BG106276A patent/BG106276A/bg unknown
- 2002-01-04 HR HR20020008A patent/HRP20020008A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE60017894T2 (de)	2005-12-29
NZ514881A (en)	2003-10-31
EP1181283A1 (en)	2002-02-27
AU778071B2 (en)	2004-11-11
YU85601A (sh)	2004-09-03
AU5725400A (en)	2000-12-28
NO20015045L (no)	2002-02-04
CA2371158A1 (en)	2000-12-14
ES2234628T3 (es)	2005-07-01
PE20010211A1 (es)	2001-03-16
US20020025976A1 (en)	2002-02-28
HRP20020008A2 (en)	2004-02-29
HUP0202897A3 (en)	2004-12-28
UA71971C2 (en)	2005-01-17
HUP0202897A2 (hu)	2002-12-28
IS6183A (is)	2001-11-29
UY26190A1 (es)	2000-12-29
PL352714A1 (en)	2003-09-08
US6620828B2 (en)	2003-09-16
DE60017894D1 (de)	2005-03-10
BR0011585A (pt)	2002-03-19
WO2000075120A1 (en)	2000-12-14
EA200101268A1 (ru)	2002-06-27
CN1359380A (zh)	2002-07-17
BG106276A (bg)	2002-10-31
SV2002000096A (es)	2002-06-07
ATE288424T1 (de)	2005-02-15
SK17302001A3 (sk)	2004-01-08
EE200100659A (et)	2003-02-17
NO20015045D0 (no)	2001-10-17
MA25530A1 (fr)	2002-10-01
MXPA01012483A (es)	2002-07-30
ZA200108291B (en)	2002-12-24
CZ20014213A3 (cs)	2002-04-17
JP2003501420A (ja)	2003-01-14
KR20020015333A (ko)	2002-02-27
AP2001002341A0 (en)	2001-12-31
EP1181283B1 (en)	2005-02-02
IL146094A0 (en)	2002-07-25

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