NO992169L - H°ydensitets immobilisering av nukleinsyrer - Google Patents
H°ydensitets immobilisering av nukleinsyrerInfo
- Publication number
- NO992169L NO992169L NO992169A NO992169A NO992169L NO 992169 L NO992169 L NO 992169L NO 992169 A NO992169 A NO 992169A NO 992169 A NO992169 A NO 992169A NO 992169 L NO992169 L NO 992169L
- Authority
- NO
- Norway
- Prior art keywords
- location
- vesicle
- substrate
- nucleic acids
- high density
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000000463 material Substances 0.000 abstract 4
- 239000000758 substrate Substances 0.000 abstract 4
- 239000012530 fluid Substances 0.000 abstract 3
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00387—Applications using probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00468—Beads by manipulation of individual beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00511—Walls of reactor vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/0052—Essentially linear supports in the shape of elongated tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
- B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1037—Using surface tension, e.g. pins or wires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
- G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74605596A | 1996-11-06 | 1996-11-06 | |
US08/786,988 US7285422B1 (en) | 1997-01-23 | 1997-01-23 | Systems and methods for preparing and analyzing low volume analyte array elements |
US08/787,639 US6024925A (en) | 1997-01-23 | 1997-01-23 | Systems and methods for preparing low volume analyte array elements |
US94780197A | 1997-10-08 | 1997-10-08 | |
PCT/US1997/020195 WO1998020020A2 (fr) | 1996-11-06 | 1997-11-06 | Immobilisation haute densite d'acides nucleiques |
Publications (2)
Publication Number | Publication Date |
---|---|
NO992169D0 NO992169D0 (no) | 1999-05-04 |
NO992169L true NO992169L (no) | 1999-07-06 |
Family
ID=27505633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO992169A NO992169L (no) | 1996-11-06 | 1999-05-04 | H°ydensitets immobilisering av nukleinsyrer |
Country Status (10)
Country | Link |
---|---|
US (1) | US6818394B1 (fr) |
EP (3) | EP1457496B1 (fr) |
JP (2) | JP3516146B2 (fr) |
AT (2) | ATE259056T1 (fr) |
CA (2) | CA2702219C (fr) |
DE (3) | DE69727489T2 (fr) |
DK (1) | DK0937096T3 (fr) |
ES (1) | ES2215241T3 (fr) |
NO (1) | NO992169L (fr) |
WO (1) | WO1998020020A2 (fr) |
Families Citing this family (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0679196B1 (fr) | 1993-01-07 | 2004-05-26 | Sequenom, Inc. | Sequen age d'adn par spectrometrie de masse |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
US6146854A (en) * | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
US6828435B2 (en) | 1996-04-17 | 2004-12-07 | Hk Pharmaceuticals, Inc. | Combinatorial protecting group strategy for multifunctional molecules |
US6022688A (en) | 1996-05-13 | 2000-02-08 | Sequenom, Inc. | Method for dissociating biotin complexes |
US5777324A (en) | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
JP2001526776A (ja) * | 1997-02-04 | 2001-12-18 | シークエノム・インコーポレーテツド | 生体分子を結合するための可逆性化学量論的工程 |
US6090251A (en) | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
US6762019B2 (en) * | 1997-09-30 | 2004-07-13 | Surmodics, Inc. | Epoxide polymer surfaces |
US6465178B2 (en) * | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
AU3943799A (en) | 1998-05-15 | 1999-12-06 | Isis Innovation Limited | Reagent and method |
JP2000157272A (ja) * | 1998-12-01 | 2000-06-13 | Hitachi Software Eng Co Ltd | バイオチップ及びその製造方法 |
DE19855469C2 (de) * | 1998-12-01 | 2001-01-11 | Michael Esrich | Verfahren zur Bestimmung des Apolipoprotein-E-Genotyps in einer menschlichen Probe |
AU3489900A (en) * | 1999-02-11 | 2000-08-29 | Maxygen, Inc. | High throughput mass spectrometry |
CA2361384A1 (fr) | 1999-02-11 | 2000-08-17 | Sun Ai Raillard | Spectrometrie de masse a haut rendement |
US6225061B1 (en) | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
GB9906477D0 (en) | 1999-03-19 | 1999-05-12 | Pyrosequencing Ab | Liquid dispensing apparatus |
US20020009394A1 (en) | 1999-04-02 | 2002-01-24 | Hubert Koster | Automated process line |
US7932213B2 (en) * | 1999-05-11 | 2011-04-26 | President And Fellows Of Harvard College | Small molecule printing |
US6824987B1 (en) * | 1999-05-11 | 2004-11-30 | President And Fellows Of Harvard College | Small molecule printing |
US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
DE19946525A1 (de) * | 1999-09-28 | 2001-05-03 | Fraunhofer Ges Forschung | Vorrichtung zur Aufnahme und Abgabe kleinster Flüssigkeitsmengen |
US7917301B1 (en) | 2000-09-19 | 2011-03-29 | Sequenom, Inc. | Method and device for identifying a biological sample |
WO2001027857A2 (fr) | 1999-10-13 | 2001-04-19 | Sequenom, Inc. | Methodes de generation de bases de donnees et bases de donnees pour l'identification de marqueurs genetiques polymorphes |
DE19957827C2 (de) * | 1999-11-25 | 2003-06-12 | Epigenomics Ag | Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche |
EP1111069A1 (fr) * | 1999-12-22 | 2001-06-27 | BioChip Technologies GmbH | Des acides nucléiques modifiés et leur utilisation |
US20040048252A1 (en) * | 2000-02-03 | 2004-03-11 | Frank Breitling | Method and Device For the Synthesis and the Analysis of Suppert-Bound Arrays of Oligomers, Especially of Primer Pairs for PCR, as well as Oligomer-Carrying Supports |
US6629626B1 (en) * | 2000-03-07 | 2003-10-07 | Dyax, Corporation | Liquid transfer device |
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US20060281112A1 (en) * | 2000-03-24 | 2006-12-14 | Jose Remacle | Design of capture molecules for the detection of amplicons with high sensitivity |
DE10017105A1 (de) * | 2000-04-06 | 2001-10-11 | Basf Ag | Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern |
AU2002245009B2 (en) * | 2000-08-15 | 2007-05-17 | Bioforce Nanoscience, Inc. | Nanoscale molecular arrayer |
US20020142483A1 (en) | 2000-10-30 | 2002-10-03 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
JP4675486B2 (ja) * | 2001-02-16 | 2011-04-20 | ポリプラスチックス株式会社 | ポリアセタール樹脂組成物 |
US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
EP1373573B1 (fr) | 2001-03-09 | 2013-10-02 | TrovaGene, Inc. | Sondes a conjugue et detection optique d'analytes |
WO2002080822A2 (fr) * | 2001-04-04 | 2002-10-17 | Arradial, Inc. | Systeme et procede de distribution de liquides |
US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
US7687437B2 (en) | 2001-07-13 | 2010-03-30 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
JP3935487B2 (ja) * | 2001-07-16 | 2007-06-20 | フーベルト・ケスター | 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法 |
EP1483794A4 (fr) * | 2001-07-17 | 2006-05-03 | Ciphergen Biosystems Inc | Puce adsorbante a base de latex |
US7517496B2 (en) | 2001-07-17 | 2009-04-14 | Bio-Rad Laboratories, Inc. | Latex based adsorbent chip |
WO2003035239A2 (fr) | 2001-10-26 | 2003-05-01 | Sequenom Inc. | Distributeur de resine |
ATE503845T1 (de) | 2001-12-10 | 2011-04-15 | Novartis Pharma Gmbh | Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen |
AU2003202026A1 (en) | 2002-01-16 | 2003-09-02 | Dynal Biotech Asa | Method for isolating nucleic acids and protein from a single sample |
ATE421088T1 (de) * | 2002-03-11 | 2009-01-15 | Caprotec Bioanalytics Gmbh | Verbindungen und verfahren für die analyse des proteoms |
EP1501863A4 (fr) * | 2002-05-03 | 2007-01-24 | Sequenom Inc | Muteines de proteines d'ancrage de kinase, leurs peptides, et procedes associes |
PT1363126E (pt) * | 2002-05-14 | 2006-05-31 | Univ Salamanca | Analise multidimensional diferencial de leucocitos |
US9388459B2 (en) * | 2002-06-17 | 2016-07-12 | Affymetrix, Inc. | Methods for genotyping |
CN1668923A (zh) * | 2002-06-24 | 2005-09-14 | 佳能株式会社 | 带有标准探针的dna微阵列以及包含该阵列的试剂盒 |
JP2004037128A (ja) * | 2002-06-28 | 2004-02-05 | Canon Inc | マトリクス援助レーザー脱着/イオン化飛行時間型質量分析法による基板上の物質の解析方法 |
US7563600B2 (en) | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
WO2004050839A2 (fr) | 2002-11-27 | 2004-06-17 | Sequenom, Inc. | Procedes et systemes de detection et d'analyse de variations de sequences bases sur la fragmentation |
JP2006516193A (ja) | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
EP2259068B1 (fr) * | 2003-01-16 | 2013-08-14 | caprotec bioanalytics GmbH | Composés de capture et procédés d'analyse protéomique |
DE10312628A1 (de) * | 2003-03-21 | 2004-10-07 | Friz Biochem Gmbh | Verfahren und Vorrichtung zum Benetzen eines Substrats mit einer Flüssigkeit |
US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
JP2005017155A (ja) * | 2003-06-27 | 2005-01-20 | Toyobo Co Ltd | 金属基板上のアレイの作製方法 |
WO2005012578A1 (fr) | 2003-07-31 | 2005-02-10 | Sequenom, Inc. | Methodes d'amplifications en chaine par polymerase mutliplexees a haut niveau et de reactions d'extension de masse homogene pour le genotypage de polymorphismes |
US9394565B2 (en) | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
US20120122099A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
CA2557177A1 (fr) | 2004-02-19 | 2005-09-01 | Stephen Quake | Procedes et kits pour analyser des sequences de polynucleotides |
EP1727911B1 (fr) | 2004-03-26 | 2013-01-23 | Sequenom, Inc. | Clivage specifique de base de produits d'amplification specifique a la methylation en combinaison avec une analyse de masse |
US7335897B2 (en) * | 2004-03-30 | 2008-02-26 | Purdue Research Foundation | Method and system for desorption electrospray ionization |
EP1748846B1 (fr) | 2004-04-30 | 2015-04-01 | Bioforce Nanosciences, Inc. | Procédé et appareil pour le dépôt d'un matériau sur une surface |
CA2567839C (fr) | 2004-05-24 | 2011-06-28 | Isis Pharmaceuticals, Inc. | Spectrometrie de masse a filtration ionique selective par seuillage numerique |
US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
EP1869180B1 (fr) | 2005-03-03 | 2013-02-20 | Ibis Biosciences, Inc. | Compositions utilisées pour identifier des virus polyoma |
WO2007014045A2 (fr) | 2005-07-21 | 2007-02-01 | Isis Pharmaceuticals, Inc. | Procede pour l'identification et la quantification rapide de variants d'acide nucleique |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
US11306351B2 (en) | 2005-12-21 | 2022-04-19 | Affymetrix, Inc. | Methods for genotyping |
US20090221433A1 (en) * | 2006-01-03 | 2009-09-03 | Barnes David W | Small molecule printing |
US7544933B2 (en) * | 2006-01-17 | 2009-06-09 | Purdue Research Foundation | Method and system for desorption atmospheric pressure chemical ionization |
US7560075B2 (en) * | 2006-01-24 | 2009-07-14 | Bio-Rad Laboratories, Inc. | Planar registration of multi-well plate from well side |
EP2010679A2 (fr) | 2006-04-06 | 2009-01-07 | Ibis Biosciences, Inc. | Compositions pour l'identification de champignons |
US8084734B2 (en) | 2006-05-26 | 2011-12-27 | The George Washington University | Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays |
JP4899681B2 (ja) * | 2006-07-18 | 2012-03-21 | 富士ゼロックス株式会社 | マイクロ流路デバイス |
EP2057465A4 (fr) | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | Protéines spécifiques d'organes et procédés d'utilisation |
US20100173803A1 (en) * | 2006-08-15 | 2010-07-08 | Koninklijke Philips Electronics N.V. | Ink jet device for producing a biological assay substrate by releasing a plurality of substances onto the substrate, and method for monitoring the ink jet device |
US8053191B2 (en) | 2006-08-31 | 2011-11-08 | Westend Asset Clearinghouse Company, Llc | Iterative nucleic acid assembly using activation of vector-encoded traits |
US9149473B2 (en) | 2006-09-14 | 2015-10-06 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
US8283625B2 (en) * | 2006-09-28 | 2012-10-09 | Shimadzu Corporation | Method of preparing sample for matrix-assisted laser desorption ionization mass spectrometry and matrix-assisted laser desorption ionization mass spectrometry |
JP5049549B2 (ja) * | 2006-10-25 | 2012-10-17 | キヤノン株式会社 | 質量分析用基板、その製造方法および質量分析測定装置 |
WO2008104002A2 (fr) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Procédé d'analyse d'adn médico-légale rapide |
US7881933B2 (en) * | 2007-03-23 | 2011-02-01 | Verizon Patent And Licensing Inc. | Age determination using speech |
JP5151204B2 (ja) * | 2007-03-27 | 2013-02-27 | 富士ゼロックス株式会社 | マイクロ流路デバイス及びマイクロ流路デバイスの製造方法 |
JP5036042B2 (ja) * | 2007-05-28 | 2012-09-26 | 株式会社島津製作所 | 質量分析サンプルの調製方法、リボ核酸のイオン化方法、リボ核酸の質量分析方法、及び細胞由来の低分子リボ核酸の質量分析方法 |
WO2008151023A2 (fr) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques |
US20090180931A1 (en) | 2007-09-17 | 2009-07-16 | Sequenom, Inc. | Integrated robotic sample transfer device |
JP5119848B2 (ja) * | 2007-10-12 | 2013-01-16 | 富士ゼロックス株式会社 | マイクロリアクタ装置 |
CA2717320A1 (fr) | 2008-03-11 | 2009-09-17 | Sequenom, Inc. | Tests adn pour determiner le sexe d'un bebe avant sa naissance |
EP3269366B1 (fr) | 2008-03-18 | 2020-01-15 | Genentech, Inc. | Combinaisons d'un conjugué de médicament-anticorps anti-her2 et lapatinib et procédés d'utilisation |
WO2009117524A2 (fr) * | 2008-03-18 | 2009-09-24 | The Regents Of The University Of California | Système de matrices creuses et procédé permettant l’identification de ligands ou de cibles spécifiques |
JP2009249439A (ja) | 2008-04-02 | 2009-10-29 | Lintec Corp | 改質ポリフッ化ビニリデン膜、及びタンパク吸着用積層膜、並びにその製造方法 |
WO2010033599A2 (fr) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Cartouches de mélange, postes de mélange et kits, systèmes et procédés associés |
US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
EP2347254A2 (fr) | 2008-09-16 | 2011-07-27 | Ibis Biosciences, Inc. | Unités de traitement d'échantillons, systèmes et procédés associés |
US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
WO2010033625A1 (fr) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Systèmes de manipulation de microplaques et produits-programmes informatiques et procédés connexes |
AU2009296526B2 (en) * | 2008-09-24 | 2015-11-19 | First Light Diagnostics, Inc. | Method for detecting analytes |
JP2010115624A (ja) | 2008-11-14 | 2010-05-27 | Fuji Xerox Co Ltd | マイクロ流路デバイス、分離装置、並びに、分離方法 |
WO2010067372A1 (fr) | 2008-12-11 | 2010-06-17 | Ramot At Tel-Aviv University Ltd. | Marqueurs génétiques de la schizophrénie |
US8110796B2 (en) | 2009-01-17 | 2012-02-07 | The George Washington University | Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays |
US8268264B2 (en) * | 2009-02-09 | 2012-09-18 | Caprotec Bioanalytics Gmbh | Devices, systems and methods for separating magnetic particles |
US8158936B2 (en) | 2009-02-12 | 2012-04-17 | Ibis Biosciences, Inc. | Ionization probe assemblies |
WO2010104798A1 (fr) | 2009-03-08 | 2010-09-16 | Ibis Biosciences, Inc. | Procédés de détection d'un bioagent |
JP5003702B2 (ja) | 2009-03-16 | 2012-08-15 | 富士ゼロックス株式会社 | マイクロ流体素子及びマイクロ流体制御方法 |
CN104830812B (zh) | 2009-03-16 | 2017-09-05 | 盘古生物制药有限公司 | 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法 |
WO2010114842A1 (fr) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Systèmes, dispositifs et procédés de détection d'agent biologique |
US20100310576A1 (en) | 2009-03-31 | 2010-12-09 | Adams Ryan A | COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES |
US9490113B2 (en) | 2009-04-07 | 2016-11-08 | The George Washington University | Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry |
US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
US9194877B2 (en) | 2009-07-17 | 2015-11-24 | Ibis Biosciences, Inc. | Systems for bioagent indentification |
US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
WO2011017656A2 (fr) | 2009-08-06 | 2011-02-10 | Ibis Biosciences, Inc. | Compositions de base déterminées non massiques pour détection d'acide nucléique |
US9890408B2 (en) | 2009-10-15 | 2018-02-13 | Ibis Biosciences, Inc. | Multiple displacement amplification |
WO2011056872A2 (fr) | 2009-11-03 | 2011-05-12 | Gen9, Inc. | Procédés et dispositifs microfluidiques pour la manipulation de gouttelettes dans un ensemble polynucléotidique haute fidélité |
WO2011066185A1 (fr) | 2009-11-25 | 2011-06-03 | Gen9, Inc. | Dispositifs microfluidiques et procédés pour la synthèse génique |
ES2577017T3 (es) | 2009-12-22 | 2016-07-12 | Sequenom, Inc. | Procedimientos y kits para identificar la aneuploidia |
US9217144B2 (en) | 2010-01-07 | 2015-12-22 | Gen9, Inc. | Assembly of high fidelity polynucleotides |
WO2011115840A2 (fr) | 2010-03-14 | 2011-09-22 | Ibis Biosciences, Inc. | Recherche de parasites par le biais de la recherche d'endosymbiotes |
CA2797093C (fr) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques de la cysteinyl-arnt synthetase |
JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CA2797393C (fr) | 2010-04-29 | 2020-03-10 | Atyr Pharma, Inc. | Decouverte innovatrice de compositions therapeutiques, diagnostiques, et d'anticorps associees aux fragments proteiques des valyle arnt synthesases |
JP6008838B2 (ja) | 2010-04-29 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | アスパラギニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
AU2011248355B2 (en) | 2010-05-03 | 2017-01-19 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases |
CN105820252B (zh) | 2010-05-03 | 2020-07-21 | Atyr 医药公司 | 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CA2797978C (fr) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, diagnostiques et a base d'anticorps liees des fragments proteiques de methionyl-arnt-synthetases |
CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
CN103096913B (zh) | 2010-05-27 | 2017-07-18 | Atyr 医药公司 | 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011261486B2 (en) | 2010-06-01 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases |
CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
WO2012027611A2 (fr) | 2010-08-25 | 2012-03-01 | Atyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, diagnostiques et d'anticorps associées à des fragments protéiniques des tyrosyl-arnt synthétases |
EP2637780B1 (fr) | 2010-11-12 | 2022-02-09 | Gen9, Inc. | Puces à protéines et leurs procédés d'utilisation et de fabrication |
EP3000883B8 (fr) | 2010-11-12 | 2018-02-28 | Gen9, Inc. | Procédés et dispositifs pour la synthèse d'acides nucléiques |
WO2012149339A2 (fr) | 2011-04-29 | 2012-11-01 | Sequenom, Inc. | Quantification d'une minorité d'espèces d'acide nucléique |
US8642951B2 (en) | 2011-05-04 | 2014-02-04 | Agilent Technologies, Inc. | Device, system, and method for reflecting ions |
AU2012300401B2 (en) | 2011-08-26 | 2018-02-08 | Gen9, Inc. | Compositions and methods for high fidelity assembly of nucleic acids |
WO2013045505A1 (fr) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarqueurs pour traitement combiné par des agents sraa |
US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
EP3757210B1 (fr) | 2012-03-02 | 2022-08-24 | Sequenom, Inc. | Méthodes d'enrichissement de l'acide nucléique cancer à partir d'un échantillon biologique |
US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
CN111876409A (zh) | 2012-04-24 | 2020-11-03 | Gen9股份有限公司 | 在体外克隆中分选核酸和多重制备物的方法 |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
CN113512577A (zh) | 2012-06-25 | 2021-10-19 | Gen9股份有限公司 | 用于核酸组装和高通量测序的方法 |
JP2015521862A (ja) | 2012-07-13 | 2015-08-03 | セクエノム, インコーポレイテッド | 非侵襲性の出生前診断に有用な母体サンプル由来の胎児核酸のメチル化に基づく富化のためのプロセスおよび組成物 |
WO2014021938A1 (fr) * | 2012-08-02 | 2014-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés et appareil pour la synthèse d'acides nucléiques employant une polymérisation à matrice oligonucléotidique |
JP6321318B2 (ja) * | 2012-09-14 | 2018-05-09 | 日本碍子株式会社 | 標的核酸の検出方法 |
US10260103B2 (en) | 2012-11-27 | 2019-04-16 | Pontificia Universidad Catolica De Chile | Compositions and methods for diagnosing thyroid tumors |
WO2014134144A1 (fr) | 2013-02-28 | 2014-09-04 | The General Hospital Corporation | Compositions de profilage de miarn et procédés d'utilisation |
EP3597774A1 (fr) | 2013-03-13 | 2020-01-22 | Sequenom, Inc. | Amorces pour analyse de la méthylation de l'adn |
US9341639B2 (en) | 2013-07-26 | 2016-05-17 | Industrial Technology Research Institute | Apparatus for microfluid detection |
US20160304969A1 (en) | 2013-12-17 | 2016-10-20 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
EP3736344A1 (fr) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Méthodes et procédés d'évaluation non invasive de variations génétiques |
MX2017007535A (es) | 2014-12-09 | 2017-08-10 | Merck Sharp & Dohme | Sistema y metodos para derivar biomarcadores de firmas geneticas de la respuesta a antagonistas de muerte programada 1 (pd-1). |
EP3283882B2 (fr) | 2015-04-17 | 2024-10-16 | Merck Sharp & Dohme LLC | Biomarqueurs sanguins de la sensibilité d'une tumeur à des antagonistes de pd-1 |
CN107849041B (zh) | 2015-07-23 | 2021-07-23 | 默沙东公司 | 与对crth2受体拮抗剂的反应有关的遗传标记 |
US11473081B2 (en) | 2016-12-12 | 2022-10-18 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
US11085039B2 (en) | 2016-12-12 | 2021-08-10 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
JP2020502179A (ja) | 2016-12-14 | 2020-01-23 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | クロストリジウム・ディフィシレ毒素bを標的化する治療に対する応答に関連したヒト遺伝的マーカー |
JP7208902B2 (ja) | 2016-12-30 | 2023-01-19 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マルチステージサンプル回収システム |
DE102017105600A1 (de) * | 2017-03-16 | 2018-09-20 | Bruker Daltonik Gmbh | Trennung von Tropfenflüssigkeit und davon umschlossenem sedimentierten Material |
AR111432A1 (es) | 2017-04-28 | 2019-07-10 | Merck Sharp & Dohme | Biomarcadores para agentes terapéuticos contra el cáncer |
JP7125986B2 (ja) * | 2017-08-14 | 2022-08-25 | シグマ-アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | マルチピン固相マイクロ抽出デバイス |
US10347457B1 (en) * | 2017-12-19 | 2019-07-09 | Varian Semiconductor Equipment Associates, Inc. | Dynamic temperature control of an ion source |
JP7347849B2 (ja) | 2018-04-19 | 2023-09-20 | ファースト ライト ダイアグノスティクス, インコーポレイテッド | 標的の検出 |
CN112955155A (zh) | 2018-09-07 | 2021-06-11 | 总医院公司 | 用于免疫检查点抑制的组合物和方法 |
US11768215B2 (en) * | 2019-01-04 | 2023-09-26 | Funai Electric Co., Ltd. | Digital dispense system cartridge |
US11474007B2 (en) | 2019-01-04 | 2022-10-18 | Funai Electric Co., Ltd. | Digital dispense system |
CN113658634B (zh) * | 2021-08-13 | 2022-06-21 | 天津擎科生物技术有限公司 | 碱基耦合效率检测方法及装置 |
JP2024537737A (ja) * | 2021-10-25 | 2024-10-16 | リゾルブ バイオサイエンシズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 生体試料を表面上にマウントする方法 |
EP4460583A1 (fr) | 2022-01-03 | 2024-11-13 | Checkmate Pharmaceuticals, Inc. | Biomarqueurs transcriptionnels de réponse à des activateurs immunitaires innés |
Family Cites Families (191)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3568735A (en) | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
CH543306A (de) | 1971-10-13 | 1973-10-31 | Hoffmann La Roche | Mikropipettiergerät |
US3776700A (en) | 1971-12-08 | 1973-12-04 | Linbro Chem Co Inc | Serial dilution apparatus |
US5283342A (en) | 1992-06-09 | 1994-02-01 | Neorx Corporation | Biotinylated small molecules |
US3999689A (en) | 1976-01-07 | 1976-12-28 | Ciantro Steven V | Device for simultaneously delivering equal amounts of liquid |
DE2739829C2 (de) | 1977-09-03 | 1986-04-10 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | Anordnung zur Analyse einer Probenschicht durch Beschuß mit elektromagnetischer Strahlung |
US4139346A (en) | 1977-11-28 | 1979-02-13 | Enzo Bio Chem Incorporated | Nucleic acid and protein binding paper |
US4218539A (en) | 1978-03-24 | 1980-08-19 | Weltman Joel K | Enzyme conjugates and method of preparation and use |
US4442354A (en) | 1982-01-22 | 1984-04-10 | Atom Sciences, Inc. | Sputter initiated resonance ionization spectrometry |
US4461328A (en) | 1982-06-04 | 1984-07-24 | Drummond Scientific Company | Pipette device |
DE3221681A1 (de) | 1982-06-08 | 1983-12-08 | Bayer Ag, 5090 Leverkusen | Massenspektrometer mit externer probenhalterung |
WO1984002579A1 (fr) * | 1982-12-23 | 1984-07-05 | Cooper Lipotech Inc | Procede et reactif d'essai de surface de vesicules lipidiques |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4948882A (en) | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
US4548245A (en) | 1983-03-04 | 1985-10-22 | Dynatech Laboratories Incorporated | Disposable/reusable dispenser for dispensing contaminatable and noncontaminatable liquids |
DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
US4554839A (en) | 1983-10-14 | 1985-11-26 | Cetus Corporation | Multiple trough vessel for automated liquid handling apparatus |
US4983521A (en) | 1983-10-26 | 1991-01-08 | The Regents Of The University Of California | Transmembrane integrator sequences |
US4582789A (en) | 1984-03-21 | 1986-04-15 | Cetus Corporation | Process for labeling nucleic acids using psoralen derivatives |
US4729947A (en) | 1984-03-29 | 1988-03-08 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US4683194A (en) | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
US4849077A (en) | 1984-08-06 | 1989-07-18 | Akademie Der Wissenschaften Der Ddr | Process for solid phase-sequencing of nucleic acid fragments |
US4952518A (en) | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
US5221518A (en) | 1984-12-14 | 1993-06-22 | Mills Randell L | DNA sequencing apparatus |
US5064754A (en) | 1984-12-14 | 1991-11-12 | Mills Randell L | Genomic sequencing method |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
GB2177507B (en) | 1985-06-13 | 1989-02-15 | Mitsubishi Electric Corp | Laser mass spectroscopic analyzer |
US4797355A (en) | 1985-06-13 | 1989-01-10 | Amgen Inc. | Methods for attaching polynucleotides to supports |
US5047215A (en) | 1985-06-18 | 1991-09-10 | Polyfiltronics, Inc. | Multiwell test plate |
US4948442A (en) | 1985-06-18 | 1990-08-14 | Polyfiltronics, Inc. | Method of making a multiwell test plate |
GB8518144D0 (en) | 1985-07-18 | 1985-08-21 | Univ Belfast | Solid phase peptide synthesis |
US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
US5023187A (en) | 1985-09-13 | 1991-06-11 | Fisher Scientific Company | Method and device for accelerated treatment of thin sample on surface |
US4731335A (en) | 1985-09-13 | 1988-03-15 | Fisher Scientific Company | Method for treating thin samples on a surface employing capillary flow |
US4806546A (en) | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on derivatized nylon supports |
US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
US5108703A (en) | 1986-03-26 | 1992-04-28 | Beckman Instruments, Inc. | Automated multi-purpose analytical chemistry processing center and laboratory work station |
FR2597260B1 (fr) | 1986-04-10 | 1988-07-15 | Univ Pasteur | Procede d'introduction directe automatique d'echantillons dans un spectrometre de masse, et dispositif pour la mise en oeuvre de ce procede |
US5000921A (en) | 1986-10-24 | 1991-03-19 | Hanaway Richard W | Multiple pipette samples |
GB8626075D0 (en) | 1986-10-31 | 1986-12-03 | Vg Instr Group | Time-of-flight mass spectrometer |
US4877745A (en) | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
AU603617B2 (en) | 1986-11-17 | 1990-11-22 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
IL84939A (en) | 1987-01-06 | 1991-05-12 | Baylor College Medicine | Chemically inert wafer for synthesizing biopolymers |
US5175209A (en) | 1987-01-06 | 1992-12-29 | Baylor College Of Medicine | Porous wafer for segmented synthesis of biopolymers |
US4779467A (en) | 1987-01-28 | 1988-10-25 | Rainin Instrument Co., Inc. | Liquid-end assembly for multichannel air-displacement pipette |
US4794150A (en) | 1987-03-11 | 1988-12-27 | Samuel Steel | Synthesis of peptide analogs |
CA1285536C (fr) | 1987-03-11 | 1991-07-02 | Akihiro Ohoka | Dispositif debiteur |
US5037882A (en) | 1987-03-11 | 1991-08-06 | Steel Samuel L | Synthesis of oligonucleotide analogs |
JPS63230086A (ja) * | 1987-03-17 | 1988-09-26 | Nitto Electric Ind Co Ltd | 生理活性物質固定用担体 |
US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
JPS6433070U (fr) | 1987-08-22 | 1989-03-01 | ||
US4902481A (en) | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
US5670381A (en) | 1988-01-29 | 1997-09-23 | Abbott Laboratories | Devices for performing ion-capture binding assays |
DE3809504C1 (fr) | 1988-03-22 | 1989-09-21 | Bruker - Franzen Analytik Gmbh, 2800 Bremen, De | |
JP2708590B2 (ja) * | 1988-03-28 | 1998-02-04 | スライトル・ウーウェ・ベー | 生物学的に活性な分子が固定化された酵素膜,elisa膜,センサ膜 |
EP0339781A3 (fr) * | 1988-04-29 | 1991-09-25 | Beckman Instruments, Inc. | Injecteur capillaire automatique |
US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
JPH03505576A (ja) * | 1988-05-16 | 1991-12-05 | ネクスター・フアーマシユーテイカルズ・インコーポレイテツド | 有機化合物に関する改良 |
EP0428534B1 (fr) * | 1988-06-14 | 1995-03-29 | Cetus Oncology Corporation | Agents de couplage et conjugues lies a des disulfures a empechement sterique prepares a partir de tels agents |
US5003059A (en) | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
US4925629A (en) | 1988-07-28 | 1990-05-15 | Bioquant, Inc. | Diagnostic device |
WO1990001564A1 (fr) * | 1988-08-09 | 1990-02-22 | Microprobe Corporation | Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques |
FR2636739B1 (fr) | 1988-09-20 | 1993-02-12 | Commissariat Energie Atomique | Procede et installation d'identification des bases d'un adn |
GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
DE3930312A1 (de) | 1988-10-24 | 1990-04-26 | Max Planck Gesellschaft | Verfahren zur direkten sequenzierung von nukleinsaeureketten |
US5512439A (en) | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
US5082935A (en) | 1988-12-15 | 1992-01-21 | Amoco Corporation | Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination |
US5237016A (en) | 1989-01-05 | 1993-08-17 | Siska Diagnostics, Inc. | End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids |
US5077210A (en) * | 1989-01-13 | 1991-12-31 | Eigler Frances S | Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent |
US4920264A (en) | 1989-01-17 | 1990-04-24 | Sri International | Method for preparing samples for mass analysis by desorption from a frozen solution |
JP2727625B2 (ja) * | 1989-02-15 | 1998-03-11 | 株式会社島津製作所 | 核酸の検出法 |
JP2901004B2 (ja) | 1989-04-12 | 1999-06-02 | 株式会社日立製作所 | Dnaの塩基配列決定法 |
ES2099699T3 (es) | 1989-05-02 | 1997-06-01 | Abbott Lab | Fijacion covalente de los miembros de union especificos a las fases solidas. |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
GB2233654A (en) | 1989-07-07 | 1991-01-16 | Nat Res Dev | Immobilised polynucleotides |
FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
GB2236186B (en) | 1989-08-22 | 1994-01-05 | Finnigan Mat Gmbh | Process and device for laser desorption of analyte molecular ions, especially of biomolecules |
US5045694A (en) | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
US5410068A (en) | 1989-10-23 | 1995-04-25 | Perseptive Biosystems, Inc. | Succinimidyl trityl compounds and a process for preparing same |
US5262128A (en) | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
WO1991011533A1 (fr) | 1990-01-26 | 1991-08-08 | E.I. Du Pont De Nemours And Company | Procede d'isolement de produits d'extension a partir de reactions de polymerase d'amorces d'adn orientees a l'aide d'un brin complementaire |
US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
US5583042A (en) | 1990-04-16 | 1996-12-10 | Neose Pharmaceuticals, Inc. | Apparatus for the synthesis of saccharide compositions |
US5195657A (en) | 1990-04-30 | 1993-03-23 | Source Scientific Systems | Manifold liquid handling device with backsip function |
US5387505A (en) | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
EP0455905B1 (fr) | 1990-05-11 | 1998-06-17 | Microprobe Corporation | Bâtonnets d'immersion pour l'essai d'hybridition des acides nucléiques et procédés pour l'immobilisation covalente d'oligonucléotides |
US5135870A (en) | 1990-06-01 | 1992-08-04 | Arizona Board Of Regents | Laser ablation/ionizaton and mass spectrometric analysis of massive polymers |
DE4019005C2 (de) | 1990-06-13 | 2000-03-09 | Finnigan Mat Gmbh | Vorrichtungen zur Analyse von Ionen hoher Masse |
TW221493B (fr) | 1990-07-10 | 1994-03-01 | Cardiovascular Diagnostics Inc | |
DE4024545A1 (de) | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target |
US5648462A (en) | 1990-10-09 | 1997-07-15 | Setsuko Funakoshi | Peptide purification method using novel linker and solid-phase ligand |
US5200471A (en) * | 1990-11-05 | 1993-04-06 | Minnesota Mining And Manufacturing Company | Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same |
US5234824A (en) | 1990-11-13 | 1993-08-10 | Specialty Laboratories, Inc. | Rapid purification of DNA |
EP0513332A4 (en) | 1990-11-14 | 1993-03-17 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
EP0557456A4 (en) | 1990-11-14 | 1995-11-15 | Siska Diagnostics Inc | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
US5210412A (en) | 1991-01-31 | 1993-05-11 | Wayne State University | Method for analyzing an organic sample |
WO1992013629A1 (fr) | 1991-01-31 | 1992-08-20 | Wayne State University | Procede d'analyse d'un echantillon organique |
IT1246676B (it) | 1991-02-21 | 1994-11-24 | Seac Srl | Apparecchiatura per analisi immunologiche. |
US5198531A (en) | 1991-06-14 | 1993-03-30 | Research Diagnostic Antibodies | Polymeric resin for peptide synthesis |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
DE69233331T3 (de) | 1991-11-22 | 2007-08-30 | Affymetrix, Inc., Santa Clara | Kombinatorische Strategien zur Polymersynthese |
WO1993014108A1 (fr) | 1992-01-13 | 1993-07-22 | President And Fellows Of Harvard College | Selection de molecules de liaison |
US5171989A (en) | 1992-01-24 | 1992-12-15 | Board Of Trustees Of Leland Stanford Jr. University | Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry |
DE4202123C2 (de) | 1992-01-27 | 1995-04-06 | Bruker Franzen Analytik Gmbh | Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen |
US5312233A (en) * | 1992-02-25 | 1994-05-17 | Ivek Corporation | Linear liquid dispensing pump for dispensing liquid in nanoliter volumes |
US5382793A (en) | 1992-03-06 | 1995-01-17 | Hewlett-Packard Company | Laser desorption ionization mass monitor (LDIM) |
GB9207381D0 (en) | 1992-04-03 | 1992-05-13 | Ici Plc | Synthesis of oligonucleotides |
US5616700A (en) | 1992-04-24 | 1997-04-01 | Beckman Instruments, Inc. | Processes for synthesizing nucleotides and modified nucleotides using N.sub. |
AU4536093A (en) | 1992-07-31 | 1994-03-03 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
US5757392A (en) | 1992-09-11 | 1998-05-26 | Brother Kogyo Kabushiki Kaisha | Piezoelectric type liquid droplet ejecting device which compensates for residual pressure fluctuations |
US5795714A (en) | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
FI925064A (fi) * | 1992-11-09 | 1994-05-10 | Erkki Juhani Soini | Metod och apparatur foer bioaffinitetsbestaemningar |
EP0679196B1 (fr) | 1993-01-07 | 2004-05-26 | Sequenom, Inc. | Sequen age d'adn par spectrometrie de masse |
US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
DE614989T1 (de) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Verfahren für in vivo Selektion von Ligandenbindende Proteine. |
EP0612994A3 (fr) | 1993-02-26 | 1996-03-06 | Ciba Geigy Ag | Matrice pour la spectrométrie de masse avec désorption par laser assistée par matrice. |
DE69430909T2 (de) * | 1993-03-19 | 2003-02-27 | Sequenom, Inc. | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
US5381008A (en) | 1993-05-11 | 1995-01-10 | Mds Health Group Ltd. | Method of plasma mass analysis with reduced space charge effects |
US5376788A (en) | 1993-05-26 | 1994-12-27 | University Of Manitoba | Apparatus and method for matrix-assisted laser desorption mass spectrometry |
PT700521E (pt) | 1993-05-28 | 2003-10-31 | Baylor College Medicine | Metodo e espectrometro de massa para dessorcao e ionizacao de analitos |
DE69435011T2 (de) | 1993-06-21 | 2008-10-23 | Aventis Pharmaceuticals Inc. | Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren |
US5576419A (en) | 1993-06-30 | 1996-11-19 | Regents Of The University Of Minnesota | Mild solid-phase synthesis of aligned branched triple-helical peptides |
WO1995002190A1 (fr) | 1993-07-09 | 1995-01-19 | Baxter Diagnostics Inc. | Dispositif et procede de distribution de fluide |
US5571902A (en) | 1993-07-29 | 1996-11-05 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
DE69418334T2 (de) * | 1993-08-06 | 2000-01-27 | Opperbas Holding B.V., Amsterdam | Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
US5439649A (en) | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
WO1995009688A1 (fr) | 1993-10-04 | 1995-04-13 | Hewlett-Packard Company | Systeme et procede de preparation d'echantillons |
ES2325393T3 (es) | 1993-10-28 | 2009-09-03 | Houston Advanced Research Center | Aparato poroso de flujo a traves microfabricado para la deteccion diferenciada de reacciones de union. |
WO1995013538A1 (fr) * | 1993-11-12 | 1995-05-18 | Operon Technologies, Inc. | Procede d'obtention et de criblage de bibliotheques de composes chimiques complexes |
DE4343126A1 (de) | 1993-12-17 | 1995-06-22 | Hoechst Ag | Festphasensynthese von Oligoribonucleotiden |
US5616698A (en) | 1994-01-10 | 1997-04-01 | University Of Toronto Innovations Foundation | Polymer-supported solution synthesis of oligosaccharides |
US5457041A (en) | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
EP0758403B1 (fr) | 1994-05-05 | 1998-06-24 | Beckman Instruments, Inc. | Groupements repetes d'oligonucleotides |
US5643722A (en) | 1994-05-11 | 1997-07-01 | Trustees Of Boston University | Methods for the detection and isolation of proteins |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5679773A (en) | 1995-01-17 | 1997-10-21 | Affymax Technologies N.V | Reagants and methods for immobilized polymer synthesis and display |
US5612474A (en) | 1994-06-30 | 1997-03-18 | Eli Lilly And Company | Acid labile immunoconjugate intermediates |
US5498545A (en) * | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
JP3612092B2 (ja) | 1994-09-07 | 2005-01-19 | 株式会社日立製作所 | Dnaの分離・分取法及びその解析法 |
US5545539A (en) | 1994-10-18 | 1996-08-13 | Genzyme Corporation | Method for nucleotide sequence amplification |
US6121048A (en) | 1994-10-18 | 2000-09-19 | Zaffaroni; Alejandro C. | Method of conducting a plurality of reactions |
US5985356A (en) | 1994-10-18 | 1999-11-16 | The Regents Of The University Of California | Combinatorial synthesis of novel materials |
US5504326A (en) | 1994-10-24 | 1996-04-02 | Indiana University Foundation | Spatial-velocity correlation focusing in time-of-flight mass spectrometry |
US5512295A (en) | 1994-11-10 | 1996-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Synthetic liposomes for enhanced uptake and delivery |
US5688642A (en) * | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
US5601982A (en) | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
US5609907A (en) | 1995-02-09 | 1997-03-11 | The Penn State Research Foundation | Self-assembled metal colloid monolayers |
JP3592780B2 (ja) | 1995-02-22 | 2004-11-24 | 富士写真フイルム株式会社 | 液体噴射装置 |
JPH08233710A (ja) * | 1995-02-24 | 1996-09-13 | Hitachi Ltd | 試料調製装置 |
US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5869240A (en) | 1995-05-19 | 1999-02-09 | Perseptive Biosystems, Inc. | Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry |
US5625184A (en) | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US5869242A (en) | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
US5654545A (en) | 1995-09-19 | 1997-08-05 | Bruker-Franzen Analytik Gmbh | Mass resolution in time-of-flight mass spectrometers with reflectors |
US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
US5641959A (en) | 1995-12-21 | 1997-06-24 | Bruker-Franzen Analytik Gmbh | Method for improved mass resolution with a TOF-LD source |
US5742049A (en) | 1995-12-21 | 1998-04-21 | Bruker-Franzen Analytik Gmbh | Method of improving mass resolution in time-of-flight mass spectrometry |
US5736626A (en) | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
US5580434A (en) | 1996-02-29 | 1996-12-03 | Hewlett-Packard Company | Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer |
DE19617011C2 (de) | 1996-04-27 | 2000-11-02 | Bruker Daltonik Gmbh | Matrixkomponentengemisch für die matrixunterstützte Laserdesorption und Ionisierung sowie Verfahren zur Zubereitung eines Matrixkomponentengemisches |
DE19618032C2 (de) | 1996-05-04 | 2000-04-13 | Bruker Daltonik Gmbh | Lagerfähig vorpräparierte Maldi-Probenträger |
US5777325A (en) | 1996-05-06 | 1998-07-07 | Hewlett-Packard Company | Device for time lag focusing time-of-flight mass spectrometry |
US6083762A (en) | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
DE19628178C1 (de) | 1996-07-12 | 1997-09-18 | Bruker Franzen Analytik Gmbh | Verfahren zum Beladen von Probenträgern für Massenspektrometer |
US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
FR2751989B1 (fr) | 1996-08-01 | 1998-10-30 | Soc D Rech Et De Dev En Activa | Methode d'identification de cellules eucaryotes par fixation desdites cellules sur un support et support pour mettre en oeuvre ladite methode |
US5777324A (en) | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
US5864137A (en) | 1996-10-01 | 1999-01-26 | Genetrace Systems, Inc. | Mass spectrometer |
US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
AU5173598A (en) | 1996-11-08 | 1998-06-10 | Ikonos Corporation | Method for coating substrates |
US5812272A (en) | 1997-01-30 | 1998-09-22 | Hewlett-Packard Company | Apparatus and method with tiled light source array for integrated assay sensing |
FR2758884B1 (fr) | 1997-01-30 | 1999-04-02 | Bio Merieux | Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu |
DE19754978C2 (de) | 1997-12-11 | 2000-07-13 | Bruker Daltonik Gmbh | Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben |
US6268131B1 (en) * | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
US5969350A (en) | 1998-03-17 | 1999-10-19 | Comstock, Inc. | Maldi/LDI time-of-flight mass spectrometer |
-
1997
- 1997-11-06 EP EP04075083.8A patent/EP1457496B1/fr not_active Expired - Lifetime
- 1997-11-06 US US09/297,575 patent/US6818394B1/en not_active Expired - Fee Related
- 1997-11-06 ES ES97946893T patent/ES2215241T3/es not_active Expired - Lifetime
- 1997-11-06 CA CA2702219A patent/CA2702219C/fr not_active Expired - Fee Related
- 1997-11-06 WO PCT/US1997/020195 patent/WO1998020020A2/fr active IP Right Grant
- 1997-11-06 DE DE69727489T patent/DE69727489T2/de not_active Expired - Lifetime
- 1997-11-06 DK DK97946893T patent/DK0937096T3/da active
- 1997-11-06 DE DE69735112T patent/DE69735112T2/de not_active Expired - Lifetime
- 1997-11-06 AT AT97946893T patent/ATE259056T1/de active
- 1997-11-06 DE DE19782096T patent/DE19782096T1/de not_active Withdrawn
- 1997-11-06 CA CA2268740A patent/CA2268740C/fr not_active Expired - Fee Related
- 1997-11-06 EP EP97946893A patent/EP0937096B1/fr not_active Expired - Lifetime
- 1997-11-06 AT AT04075084T patent/ATE316095T1/de not_active IP Right Cessation
- 1997-11-06 JP JP52176598A patent/JP3516146B2/ja not_active Expired - Fee Related
- 1997-11-06 EP EP04075084A patent/EP1460083B1/fr not_active Expired - Lifetime
-
1999
- 1999-05-04 NO NO992169A patent/NO992169L/no not_active Application Discontinuation
-
2003
- 2003-10-15 JP JP2003354910A patent/JP4006381B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2268740C (fr) | 2010-07-20 |
EP1460083A1 (fr) | 2004-09-22 |
DE69727489D1 (de) | 2004-03-11 |
CA2268740A1 (fr) | 1998-05-14 |
JP2004125799A (ja) | 2004-04-22 |
EP1457496B1 (fr) | 2014-01-15 |
EP1457496A1 (fr) | 2004-09-15 |
DE69735112D1 (de) | 2006-04-06 |
DK0937096T3 (da) | 2004-06-14 |
ES2215241T3 (es) | 2004-10-01 |
CA2702219C (fr) | 2013-01-08 |
NO992169D0 (no) | 1999-05-04 |
US6818394B1 (en) | 2004-11-16 |
JP4006381B2 (ja) | 2007-11-14 |
WO1998020020A3 (fr) | 1998-10-22 |
EP1460083B1 (fr) | 2006-01-18 |
CA2702219A1 (fr) | 1998-05-14 |
EP0937096A2 (fr) | 1999-08-25 |
ATE316095T1 (de) | 2006-02-15 |
DE19782096T1 (de) | 2000-03-23 |
WO1998020020A2 (fr) | 1998-05-14 |
JP2001503760A (ja) | 2001-03-21 |
JP3516146B2 (ja) | 2004-04-05 |
DE69735112T2 (de) | 2006-09-07 |
ATE259056T1 (de) | 2004-02-15 |
DE69727489T2 (de) | 2004-11-25 |
EP0937096B1 (fr) | 2004-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO992169D0 (no) | H°ydensitets immobilisering av nukleinsyrer | |
DE69804653D1 (de) | Verfahren und vorrichtung zur herstellung von matrixen von proben | |
WO2004067162A3 (fr) | Appareil pour le traitement microfluidique et la lecture de matrices de biopuces | |
WO2004031399A3 (fr) | Chargement en parallele de reseaux | |
AU5876590A (en) | Analysis method for determining substances from biological fluids | |
ES554046A0 (es) | Un metodo para analizar el adn de un individuo. | |
EP0317239A3 (fr) | Procédé et dispositif pour la détection des polymorphismes de restriction des longueurs de fragments | |
EP1249705A3 (fr) | Dispositif d'analyse moléculaire multiplexé et procédé de sa fabrication | |
EP0735378A3 (fr) | Procédé et dispositif pour l'analyse de la réponse à une excitation optique de matériaux semi-conducteurs | |
FI965260A0 (fi) | Menetelmä tilaajien osoittamiseksi kapeasädesektorien kesken | |
BR9808646A (pt) | Sequenciador de gene e processos | |
AU1983800A (en) | Method for sequencing dna using a microfluidic device | |
EP0749010A3 (fr) | Dispositif et procédé pour l'évaluation de contamination causée par des substances organiques déposées sur la surface d'une substrate | |
AU6798198A (en) | Method for verifying the location of an array of detectors | |
DE59902937D1 (de) | Vorrichtung und verfahren zur probenaufnahme aus polymeren trägermaterialien | |
IT1308266B1 (it) | Sistema di orditura con orditoio per campioni a controllo elettronicoe dispositivo per il richiamo dei fili. | |
EP0905515A3 (fr) | Méthode pour la mésure analytique et son usage | |
AU9476298A (en) | Method for dna sequencing analysis | |
FI101327B1 (fi) | ON-line menetelmä puu-kuorisuhteen määrittämiseksi massavirrasta | |
DK0875737T3 (da) | Fremgangsmåde til ultralydsflowmåling | |
IT1292829B1 (it) | Metodo e dispositivo per il controllo di banconote. | |
DE59812632D1 (de) | Vorrichtung zum vakuumdichten Verbinden von zwei Körpern aus unterschiedlichen Materialien | |
FI955452A0 (fi) | Anolysointimenetelmä, laitteisto sitä varten ja jauhatuksen säätömenetelmä | |
AU2003200012A1 (en) | Pipetting robot with an improved temperature-control apparatus | |
AU1478200A (en) | Method for measuring target polynucleotides and novel asthma biomolecules |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |