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NO303575B1 - Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter - Google Patents

Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter

Info

Publication number
NO303575B1
NO303575B1 NO19952425A NO952425A NO303575B1 NO 303575 B1 NO303575 B1 NO 303575B1 NO 19952425 A NO19952425 A NO 19952425A NO 952425 A NO952425 A NO 952425A NO 303575 B1 NO303575 B1 NO 303575B1
Authority
NO
Norway
Prior art keywords
acid
oxazoline
florfenicol
chloride
epoxide
Prior art date
Application number
NO19952425A
Other languages
English (en)
Norwegian (no)
Other versions
NO952425D0 (no
NO952425L (no
Inventor
Guang-Zhong Wu
Wanda I Tormos
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO952425D0 publication Critical patent/NO952425D0/no
Publication of NO952425L publication Critical patent/NO952425L/no
Publication of NO303575B1 publication Critical patent/NO303575B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
NO19952425A 1992-12-18 1995-06-16 Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter NO303575B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
PCT/US1993/012071 WO1994014764A1 (en) 1992-12-18 1993-12-15 Asymmetric process for preparing florfenicol, thiamphenicol, chloramphenicol and oxazoline intermediates

Publications (3)

Publication Number Publication Date
NO952425D0 NO952425D0 (no) 1995-06-16
NO952425L NO952425L (no) 1995-06-16
NO303575B1 true NO303575B1 (no) 1998-08-03

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19952425A NO303575B1 (no) 1992-12-18 1995-06-16 Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter

Country Status (20)

Country Link
US (1) US5352832A (ja)
EP (1) EP0674618B1 (ja)
JP (1) JP3428016B2 (ja)
KR (1) KR100284216B1 (ja)
AT (1) ATE170835T1 (ja)
AU (1) AU676003B2 (ja)
CA (1) CA2152089C (ja)
CZ (1) CZ287461B6 (ja)
DE (1) DE69320986T2 (ja)
DK (1) DK0674618T3 (ja)
ES (1) ES2120605T3 (ja)
FI (1) FI109295B (ja)
HU (1) HU225110B1 (ja)
NO (1) NO303575B1 (ja)
NZ (1) NZ259239A (ja)
PL (1) PL177891B1 (ja)
RU (1) RU2126383C1 (ja)
SK (1) SK281701B6 (ja)
UA (1) UA43331C2 (ja)
WO (1) WO1994014764A1 (ja)

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US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
BRPI0418133A2 (pt) * 2003-12-23 2009-03-24 Schering Plough Ltd pró-fármaco de florfenicol tendo solubilidade em água melhorada
US7361689B2 (en) * 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
CA2576589C (en) 2004-08-13 2013-11-12 Schering-Plough Ltd. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
KR20070054691A (ko) 2004-09-23 2007-05-29 쉐링-프라우 리미티드 신규한 트리플루오로메탄설폰아미드 옥심 에테르 유도체를사용하여 동물의 기생충 방제
DE602005017419D1 (de) * 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
US8680154B2 (en) * 2004-12-21 2014-03-25 Intervet International B.V. Injectable veterinary composition
JP2008545788A (ja) * 2005-06-09 2008-12-18 シェーリング−プラウ・リミテッド Ｎ−［（フェニルオキシ）フェニル］−１，１，１−トリフルオロメタンスルホンアミドおよびｎ−［（フェニルスルファニル）フェニル）］−１，１，１−トリフルオロメタンスルホンアミド誘導体による動物中の寄生生物の制御
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
AR066265A1 (es) * 2007-04-27 2009-08-05 Schering Plough Ltd Compuestos y metodos para mejorar la solubilidad de florfenicol y antibioticos estructuralmente relacionados por medio del uso de ciclodextrinas. composicion. complejo. kit. metodo de tratamiento.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX361762B (es) 2007-06-27 2018-12-17 Du Pont Metodo de control de plagas en animales.
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
AU2008324852A1 (en) 2007-11-09 2009-05-14 Intervet International B.V. Fast release solid formulation, preparation and use thereof
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
JP2011529895A (ja) 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
WO2011017347A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
US8598087B2 (en) 2010-05-27 2013-12-03 E. I. Du Pont De Nemours And Company Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
EP2671877A4 (en) * 2011-01-31 2015-07-01 Univ Nagasaki PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
WO2015157927A1 (zh) * 2014-04-16 2015-10-22 湖北美天生物科技有限公司 氟苯尼考的合成方法
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法

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Also Published As

Publication number Publication date
KR950704244A (ko) 1995-11-17
DK0674618T3 (da) 1999-02-22
CA2152089C (en) 2006-10-24
EP0674618B1 (en) 1998-09-09
EP0674618A1 (en) 1995-10-04
RU2126383C1 (ru) 1999-02-20
HUT72669A (en) 1996-05-28
SK77795A3 (en) 1995-12-06
JPH08504819A (ja) 1996-05-28
FI109295B (fi) 2002-06-28
AU676003B2 (en) 1997-02-27
SK281701B6 (sk) 2001-07-10
DE69320986D1 (de) 1998-10-15
CA2152089A1 (en) 1994-07-07
WO1994014764A1 (en) 1994-07-07
HU225110B1 (en) 2006-06-28
NO952425D0 (no) 1995-06-16
DE69320986T2 (de) 1999-03-04
US5352832A (en) 1994-10-04
AU5748494A (en) 1994-07-19
PL309393A1 (en) 1995-10-02
FI952872A0 (fi) 1995-06-12
JP3428016B2 (ja) 2003-07-22
UA43331C2 (uk) 2001-12-17
KR100284216B1 (ko) 2001-04-02
CZ159895A3 (en) 1996-01-17
NZ259239A (en) 1996-04-26
HU9501776D0 (en) 1995-08-28
FI952872A (fi) 1995-06-12
NO952425L (no) 1995-06-16
ATE170835T1 (de) 1998-09-15
PL177891B1 (pl) 2000-01-31
CZ287461B6 (en) 2000-11-15
ES2120605T3 (es) 1998-11-01

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Owner name: MERCK SHARP AND DOHME CORP

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