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NO303384B1 - FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasykloodekan- og tetradekanderivater - Google Patents

FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasykloodekan- og tetradekanderivater

Info

Publication number
NO303384B1
NO303384B1 NO973578A NO973578A NO303384B1 NO 303384 B1 NO303384 B1 NO 303384B1 NO 973578 A NO973578 A NO 973578A NO 973578 A NO973578 A NO 973578A NO 303384 B1 NO303384 B1 NO 303384B1
Authority
NO
Norway
Prior art keywords
mono
preparation
substituted
tetraazacycloodecane
tetradecane
Prior art date
Application number
NO973578A
Other languages
English (en)
Other versions
NO973578D0 (no
NO973578L (no
Inventor
Johannes Platzek
Heinz Gries
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO973578L publication Critical patent/NO973578L/no
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO973578D0 publication Critical patent/NO973578D0/no
Publication of NO303384B1 publication Critical patent/NO303384B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO973578A 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasykloodekan- og tetradekanderivater NO303384B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4140779A DE4140779A1 (de) 1991-12-06 1991-12-06 Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen

Publications (3)

Publication Number Publication Date
NO973578L NO973578L (no) 1993-06-07
NO973578D0 NO973578D0 (no) 1997-08-04
NO303384B1 true NO303384B1 (no) 1998-07-06

Family

ID=6446767

Family Applications (5)

Application Number Title Priority Date Filing Date
NO924690A NO303496B1 (no) 1991-12-06 1992-12-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater
NO973580A NO303386B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater
NO973581A NO303385B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetrasyklododekan- og tetradekanderivater
NO973578A NO303384B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasykloodekan- og tetradekanderivater
NO973579A NO303387B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater

Family Applications Before (3)

Application Number Title Priority Date Filing Date
NO924690A NO303496B1 (no) 1991-12-06 1992-12-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater
NO973580A NO303386B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater
NO973581A NO303385B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetrasyklododekan- og tetradekanderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO973579A NO303387B1 (no) 1991-12-06 1997-08-04 FremgangsmÕte for fremstilling av mono-N-substituerte tetraazasyklododekan- og tetradekanderivater

Country Status (13)

Country Link
EP (1) EP0545511B1 (no)
JP (1) JP3471836B2 (no)
AT (1) ATE218131T1 (no)
CA (1) CA2084582C (no)
CZ (1) CZ290232B6 (no)
DE (2) DE4140779A1 (no)
DK (1) DK0545511T3 (no)
ES (1) ES2176183T3 (no)
HU (2) HU224923B1 (no)
IL (1) IL103996A (no)
NO (5) NO303496B1 (no)
PT (1) PT545511E (no)
SK (1) SK282386B6 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
DE4340809C2 (de) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
FR2725449B1 (fr) * 1994-10-05 1996-12-27 Air Liquide Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
DE10002939C1 (de) * 2000-01-13 2001-09-20 Schering Ag Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln
WO2012027727A2 (en) * 2010-08-26 2012-03-01 Kunyuan Cui Lipomacrocycles and uses thereof
CA2833659C (en) 2011-04-21 2019-12-03 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232751B1 (en) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
NZ236267A (en) * 1989-12-22 1992-12-23 Squibb & Sons Inc 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
SK357392A3 (en) 1993-08-11
NO303385B1 (no) 1998-07-06
NO973580D0 (no) 1997-08-04
HU9203860D0 (en) 1993-03-29
NO973581L (no) 1993-06-07
NO303496B1 (no) 1998-07-20
JP3471836B2 (ja) 2003-12-02
JPH05279349A (ja) 1993-10-26
EP0545511B1 (de) 2002-05-29
NO303386B1 (no) 1998-07-06
NO973579L (no) 1993-06-07
NO973581D0 (no) 1997-08-04
ATE218131T1 (de) 2002-06-15
CA2084582C (en) 2005-09-20
EP0545511A3 (en) 1993-11-03
NO973578D0 (no) 1997-08-04
NO924690D0 (no) 1992-12-04
DE4140779A1 (de) 1993-06-09
DK0545511T3 (da) 2002-08-12
CA2084582A1 (en) 1993-06-07
IL103996A0 (en) 1993-05-13
DE59209957D1 (de) 2002-07-04
NO924690L (no) 1993-06-07
EP0545511A2 (de) 1993-06-09
NO303387B1 (no) 1998-07-06
CZ290232B6 (cs) 2002-06-12
NO973579D0 (no) 1997-08-04
PT545511E (pt) 2002-10-31
HUT65526A (en) 1994-06-28
HU224923B1 (en) 2006-04-28
NO973578L (no) 1993-06-07
CZ357392A3 (en) 1993-08-11
SK282386B6 (sk) 2002-01-07
NO973580L (no) 1993-06-07
IL103996A (en) 1998-02-08
ES2176183T3 (es) 2002-12-01

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