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NO308830B1 - Stabile mikroboblesuspensjoner som forsterkningsmidler for ultralydekkografi, samt fremgangsmÕter for Õ fremstille suspensjoner - Google Patents

Stabile mikroboblesuspensjoner som forsterkningsmidler for ultralydekkografi, samt fremgangsmÕter for Õ fremstille suspensjoner

Info

Publication number
NO308830B1
NO308830B1 NO942476A NO942476A NO308830B1 NO 308830 B1 NO308830 B1 NO 308830B1 NO 942476 A NO942476 A NO 942476A NO 942476 A NO942476 A NO 942476A NO 308830 B1 NO308830 B1 NO 308830B1
Authority
NO
Norway
Prior art keywords
suspensions
decography
ultrasound
methods
well
Prior art date
Application number
NO942476A
Other languages
English (en)
Other versions
NO942476L (no
NO942476D0 (no
Inventor
Michel Schneider
Jean Brochot
Jerome Puginier
Feng Yan
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO308830(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NO942476L publication Critical patent/NO942476L/no
Publication of NO942476D0 publication Critical patent/NO942476D0/no
Publication of NO308830B1 publication Critical patent/NO308830B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Physical Water Treatments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Aeration Devices For Treatment Of Activated Polluted Sludge (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Amplifiers (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
NO942476A 1992-11-02 1994-06-30 Stabile mikroboblesuspensjoner som forsterkningsmidler for ultralydekkografi, samt fremgangsmÕter for Õ fremstille suspensjoner NO308830B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810837 1992-11-02
PCT/EP1993/002915 WO1994009829A1 (en) 1992-11-02 1993-10-21 Stable microbubble suspensions as enhancement agents for ultrasound echography

Publications (3)

Publication Number Publication Date
NO942476L NO942476L (no) 1994-06-30
NO942476D0 NO942476D0 (no) 1994-06-30
NO308830B1 true NO308830B1 (no) 2000-11-06

Family

ID=8212014

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942476A NO308830B1 (no) 1992-11-02 1994-06-30 Stabile mikroboblesuspensjoner som forsterkningsmidler for ultralydekkografi, samt fremgangsmÕter for Õ fremstille suspensjoner

Country Status (22)

Country Link
US (7) US5445813A (no)
EP (1) EP0619743B1 (no)
JP (1) JP3135919B2 (no)
KR (1) KR100216138B1 (no)
CN (1) CN1069838C (no)
AT (1) ATE146972T1 (no)
AU (3) AU666238B2 (no)
CA (1) CA2125027C (no)
DE (2) DE10199055I2 (no)
DK (1) DK0619743T3 (no)
ES (1) ES2097548T3 (no)
FI (1) FI115953B (no)
GR (1) GR3022826T3 (no)
HU (1) HU227043B1 (no)
IL (1) IL107453A (no)
IS (1) IS1625B (no)
LU (1) LU90837I2 (no)
NL (1) NL300061I2 (no)
NO (1) NO308830B1 (no)
NZ (2) NZ257115A (no)
WO (1) WO1994009829A1 (no)
ZA (1) ZA938117B (no)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (no) 1990-04-02 1993-05-01 Sint Sa
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
SG52198A1 (en) * 1993-01-25 1998-09-28 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP0711179B2 (en) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
EP0682530B1 (en) * 1993-12-15 2003-03-19 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media
DE4406474A1 (de) 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
WO2004073750A1 (en) * 1995-06-07 2004-09-02 Harald Dugstad Improvements in or relating to contrast agents
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
AP890A (en) * 1996-02-19 2000-11-13 Nycomed Imaging As "Gas-containing contrast agents of use in diagnostic imaging.
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
IL126073A (en) * 1996-03-05 2002-02-10 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
JP2001507207A (ja) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 化合物を細胞に送達する方法
US5849727A (en) 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
IL128345A (en) * 1996-08-02 2003-06-24 Amersham Health As Enhanced contrast agent for ultrasound imaging of the liver
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
JP4139440B2 (ja) 1996-09-11 2008-08-27 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 造影剤及び血管拡張薬を用いる画像診断のための改良された方法
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6726650B2 (en) * 1997-12-04 2004-04-27 Bracco Research S.A. Automatic liquid injection system and method
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
CA2319433C (en) * 1998-02-09 2008-04-22 Bracco Research S.A. Targeted delivery of biologically active media
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
US6187665B1 (en) * 1999-01-14 2001-02-13 Lucent Technologies, Inc. Process for deuterium passivation and hot carrier immunity
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
FR2791249B1 (fr) 1999-03-25 2001-06-15 Edap Technomed Milieu de couplage pour ultrasons de puissance
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US6210611B1 (en) * 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US6962071B2 (en) * 2001-04-06 2005-11-08 Bracco Research S.A. Method for improved measurement of local physical parameters in a fluid-filled cavity
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
JP2006514915A (ja) 2002-03-01 2006-05-18 ダイアックス、コープ Ｋｄｒおよびｖｅｇｆ／ｋｄｒ結合ペプチドならびに診断および治療におけるその使用
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
JP2006510579A (ja) * 2002-07-11 2006-03-30 ターゲソン・エルエルシー マイクロバブル組成物およびその製法ならびに使用法
WO2004049950A1 (en) 2002-11-29 2004-06-17 Amersham Health As Ultrasound triggering method
US9364569B2 (en) * 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
WO2004071535A1 (en) 2003-02-13 2004-08-26 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
EP1635709B1 (en) 2003-06-12 2013-10-30 Bracco Suisse SA Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
CA2547024C (en) * 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2005063306A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
EP1713400B1 (en) * 2004-01-16 2012-12-26 Boston Scientific Scimed, Inc. Apparatus for medical imaging
EP1715897B2 (en) 2004-01-20 2013-10-30 Sunnybrook and Women's College Health Sciences Centre High frequency ultrasound imaging using contrast agents
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2445322B (en) 2004-08-13 2008-08-06 Stichting Tech Wetenschapp Intravasular ultrasound techniques
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
WO2006067201A2 (en) 2004-12-23 2006-06-29 Bracco Research Sa A perfusion assessment method and system based on bolus administration
WO2006128500A1 (en) * 2004-12-23 2006-12-07 Bracco Research Sa Liquid transfer device for medical dispensing containers
US7846100B2 (en) 2005-03-03 2010-12-07 Bracco International Bv Medical imaging system based on a targeted contrast agent
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
CA2624636C (en) 2005-11-10 2016-04-05 Bracco Research Sa Instantaneous visualization of contrast agent concentration in imaging applications
CA2624608C (en) 2005-11-10 2016-06-07 Bracco Research Sa Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
WO2007067979A2 (en) 2005-12-09 2007-06-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1797919A1 (en) * 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
WO2008016992A1 (en) 2006-08-01 2008-02-07 Scimed Life Systems, Inc. Pulse inversion sequences for nonlinear imaging
ITBO20060593A1 (it) * 2006-08-04 2008-02-05 Francesca Cavalieri Microbolle realizzate in alcol polivinilico e relativo caricamento delle stesse con ossido di azoto
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
WO2008075192A2 (en) * 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
WO2008074889A1 (en) 2006-12-21 2008-06-26 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2009083557A1 (en) 2007-12-28 2009-07-09 Bracco Research S.A. Quantification analisys of immobilized contrast agent in medical imaging applications
EP2090322A1 (en) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fsh receptor ligands for diagnosis and therapy of cancer
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
EP2189112A1 (en) 2008-11-24 2010-05-26 Bracco Research S.A. Real-time perfusion imaging and quantification
KR101630190B1 (ko) 2008-12-16 2016-06-14 브라코 스위스 에스.에이. 조영제의 볼러스 투여를 위한 장치
JP5593382B2 (ja) 2009-06-08 2014-09-24 ブラッコ・シュイス・ソシエテ・アノニム パラメトリック画像の自動スケーリング
AU2010279931B2 (en) * 2009-08-06 2016-07-21 Ligaric Co., Ltd. Composition and process for production thereof
AU2010291254B2 (en) 2009-09-01 2016-08-11 Bracco Suisse Sa Parametric images based on dynamic behavior over time
EP2335675B1 (de) 2009-12-10 2015-02-18 Neubourg Skin Care GmbH & Co. KG Emulgatorfreie, Polymer-stabilisierte Schaumformulierungen
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
EP2544593B1 (en) 2010-03-09 2014-12-31 Bracco Suisse SA Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2012020001A1 (en) 2010-08-09 2012-02-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
HUE037768T2 (hu) 2010-08-09 2018-09-28 Bracco Suisse Sa Targetált gázzal töltött mikrovezikulák
US9770411B2 (en) 2010-12-24 2017-09-26 Bracco Suisse S.A. Methods of using gas-filled microvesicles covalently bound to an antigen
EP2474327A1 (en) 2011-01-07 2012-07-11 RWTH Aachen Microdosing of ultrasound contrast agents
US11052043B2 (en) 2011-03-28 2021-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable formulation
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
EP2545908A1 (en) 2011-07-11 2013-01-16 RWTH Aachen Medium for microbubbles or microparticles and preparation thereof
KR102166648B1 (ko) 2012-12-21 2020-10-19 브라코 스위스 에스.에이. 시간 경과에 따른 통계 분석에 기초한 영상 진단 애플리케이션에서의 분할
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
WO2014140197A1 (en) 2013-03-15 2014-09-18 Westfaelische Wilhelms-Universitaet Muenster Detection of acute renal allograft rejection
CA2917095C (en) 2013-07-03 2021-11-02 Bracco Suisse S.A. Devices and methods for the ultrasound treatment of ischemic stroke
CA2937467C (en) 2014-04-07 2022-05-03 Bracco Suisse Sa Estimation of acoustic level in-situ with non-fundamental analysis
CN107206110B (zh) 2014-12-18 2021-07-20 博莱科瑞士股份有限公司 靶向的充气微囊制剂
CN107206065A (zh) 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
JP6728186B2 (ja) 2014-12-31 2020-07-22 ランセウス メディカル イメージング， インコーポレイテッド 脂質カプセル化ガスマイクロスフェア組成物および関連方法
US11284910B2 (en) 2015-12-09 2022-03-29 Koninklijke Philips N.V. Interleaved beam pattern for sonothhrombolysis and other vascular acoustic resonator mediated therapies
US10433817B2 (en) 2015-12-10 2019-10-08 Bracco Suisse S.A. Detection of immobilized contrast agent with dynamic thresholding
KR20180104166A (ko) 2016-02-09 2018-09-19 브라코 스위스 에스.에이. 셀렉틴 표적화를 위한 재조합 키메라 단백질
CN107233582B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种基于叔丁醇/水混合溶剂制备超声造影剂的方法
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
US20170319718A1 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10335502B1 (en) 2019-01-29 2019-07-02 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
MX2020012604A (es) * 2018-07-06 2021-01-29 Bracco Suisse Sa Formulacion congelada para microvesiculas llenas de gas.
US10232061B1 (en) 2018-07-06 2019-03-19 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
WO2020127816A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
GB201908352D0 (en) 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
US12005130B2 (en) 2019-10-16 2024-06-11 Agitated Solutions Inc. Generating microbubbles for bubble studies
JP6760630B1 (ja) * 2019-10-29 2020-09-23 学校法人 愛知医科大学 微小気泡含有電解質液の製造方法および微小気泡含有電解質液の調製に用いる微小気泡含有溶媒の製造方法
CN115103667A (zh) 2020-02-11 2022-09-23 博莱科瑞士股份有限公司 用于治疗性用途的充气微囊泡
GB202004629D0 (en) 2020-03-30 2020-05-13 Innovation Ulster Ltd Therapy
US11191888B1 (en) 2020-05-18 2021-12-07 Agitated Solutions Inc. Syringe-based microbubble generator
CN113440627B (zh) * 2021-07-30 2022-11-25 北京诺康达医药科技股份有限公司 一种冻干粉末及其制备方法与应用
CN114177317A (zh) * 2021-11-03 2022-03-15 深圳奥祺生物医药有限公司 一种用于超声造影的微泡冻干制剂、造影剂及制备方法
WO2024133827A1 (en) 2022-12-21 2024-06-27 Bracco Suisse Sa Gas-filled microvesicles with perfluoro olefin
US11833224B1 (en) 2023-02-08 2023-12-05 Leuvian Llc Lyoprotectant compositions and uses thereof

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH624011A5 (no) * 1977-08-05 1981-07-15 Battelle Memorial Institute
CH621479A5 (no) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4256251A (en) * 1978-04-24 1981-03-17 Lawrence M. Smith Surgical staplers and staple
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4587545A (en) * 1978-12-20 1986-05-06 At&T Bell Laboratories High voltage dielectrically isolated remote gate solid-state switch
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (no) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
HU221485B (en) * 1988-02-05 2002-10-28 Schering Ag Ultrasound contrast media consisting of microparticles and process for producing the same
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (de) * 1989-10-13 1991-04-18 Schering Ag Verfahren zur herstellung von waessrigen dispersionen
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
SE465300B (sv) * 1989-12-29 1991-08-26 Sjoeberg John Anitec Ab Anordning vid stickkniv foer urtagning av blod fraan slaktdjur
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
EP0522081A4 (en) * 1990-03-30 1993-06-16 Smithkline Beecham Corporation Inhibition of disease associated with immunodeficiency virus infection
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IN172208B (no) * 1990-04-02 1993-05-01 Sint Sa
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
JPH08502979A (ja) * 1992-11-02 1996-04-02 ドレクセル ユニバーシティー 表面活性剤で安定化された微小気泡混合物、その製造方法およびその使用方法
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
WO1995001187A1 (en) * 1993-07-02 1995-01-12 Molecular Biosystems, Inc. Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
EP0711179B2 (en) * 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

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