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NO2018022I1 - Letermovir, eller dets salt, solvat eller solvat av dets salt - Google Patents

Letermovir, eller dets salt, solvat eller solvat av dets salt

Info

Publication number
NO2018022I1
NO2018022I1 NO2018022C NO2018022C NO2018022I1 NO 2018022 I1 NO2018022 I1 NO 2018022I1 NO 2018022 C NO2018022 C NO 2018022C NO 2018022 C NO2018022 C NO 2018022C NO 2018022 I1 NO2018022 I1 NO 2018022I1
Authority
NO
Norway
Prior art keywords
solvate
salt
letermovir
Prior art date
Application number
NO2018022C
Other languages
English (en)
Original Assignee
Aicuris Anti Infective Cures Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Anti Infective Cures Gmbh filed Critical Aicuris Anti Infective Cures Gmbh
Publication of NO2018022I1 publication Critical patent/NO2018022I1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO2018022C 2003-05-02 2018-07-04 Letermovir, eller dets salt, solvat eller solvat av dets salt NO2018022I1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (1)

Publication Number Publication Date
NO2018022I1 true NO2018022I1 (no) 2018-07-04

Family

ID=33305099

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20055649A NO333265B3 (no) 2003-05-02 2005-11-30 Substituerte dihydrokinazoliner, fremgangsmåte for fremstilling derav, anvendelse av en slik forbindelse samt medikament inneholdende denne.
NO2018022C NO2018022I1 (no) 2003-05-02 2018-07-04 Letermovir, eller dets salt, solvat eller solvat av dets salt

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20055649A NO333265B3 (no) 2003-05-02 2005-11-30 Substituerte dihydrokinazoliner, fremgangsmåte for fremstilling derav, anvendelse av en slik forbindelse samt medikament inneholdende denne.

Country Status (39)

Country Link
US (4) US7196086B2 (no)
EP (1) EP1622880B3 (no)
JP (1) JP4733631B2 (no)
KR (1) KR100927063B1 (no)
CN (1) CN100393706C (no)
AR (1) AR044078A1 (no)
AT (1) ATE355280T1 (no)
AU (1) AU2004233978B2 (no)
BR (1) BRPI0410029B8 (no)
CA (1) CA2524069C (no)
CL (1) CL2004000930A1 (no)
CO (1) CO5700764A2 (no)
CY (2) CY1106476T1 (no)
DE (2) DE10319612A1 (no)
DK (1) DK1622880T6 (no)
EC (1) ECSP056138A (no)
EG (1) EG25273A (no)
ES (1) ES2284007T7 (no)
FR (1) FR18C1029I2 (no)
HK (1) HK1092463A1 (no)
HN (1) HN2004000146A (no)
HU (2) HUS1800018I1 (no)
IL (1) IL171513A (no)
MA (1) MA27794A1 (no)
MX (1) MXPA05011707A (no)
MY (1) MY144616A (no)
NL (1) NL300933I2 (no)
NO (2) NO333265B3 (no)
NZ (1) NZ543317A (no)
PE (1) PE20050145A1 (no)
PL (1) PL1622880T6 (no)
PT (1) PT1622880E (no)
RU (1) RU2360912C2 (no)
SI (1) SI1622880T1 (no)
TW (1) TWI335912B (no)
UA (1) UA82519C2 (no)
UY (1) UY28294A1 (no)
WO (1) WO2004096778A1 (no)
ZA (1) ZA200508710B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
ES2882531T3 (es) * 2016-08-08 2021-12-02 Phaeno Therapeutics Co Ltd Compuesto anti-virus CMVH
ES2971079T3 (es) * 2018-02-08 2024-06-03 Phaeno Therapeutics Co Ltd Forma cristalina del compuesto 3,4-dihidrotieno[3,2-d]pirimidina y método de preparación del mismo
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
JP7273951B2 (ja) 2018-09-12 2023-05-15 ノバルティス アーゲー 抗ウイルス性ピリドピラジンジオン化合物
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121440A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
CA2321153A1 (en) 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
EP1172361A4 (en) 1999-04-19 2002-05-08 Shionogi & Co SULFONAMIDE DERIVATIVES HAVING OXADIAZOLE CORES
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
AU2001283955B2 (en) 2000-07-31 2006-05-18 F. Hoffmann-La Roche Ag Piperazine derivatives
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
JP4480941B2 (ja) 2001-04-19 2010-06-16 アイキュリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コムパニー・コマンディットゲゼルシャフト 抗ウイルス剤としての新規アリールスルホンアミド
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 T-형 칼슘 채널 차단제로서 유용한 3,4-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
BRPI0607306A2 (pt) * 2005-01-25 2009-08-25 Prolexys Pharmaceuticals Inc derivados de quinoxalina como agentes anti-tumor
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
CA2614443C (en) 2005-07-21 2011-03-22 F. Hoffmann-La Roche Ag Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra

Also Published As

Publication number Publication date
EP1622880A1 (de) 2006-02-08
IL171513A (en) 2011-11-30
NO333265B3 (no) 2019-06-03
TW200510343A (en) 2005-03-16
KR20060009883A (ko) 2006-02-01
CN100393706C (zh) 2008-06-11
AU2004233978B2 (en) 2010-02-11
US8513255B2 (en) 2013-08-20
UY28294A1 (es) 2004-11-30
EG25273A (en) 2011-12-04
CY2018019I1 (el) 2018-12-12
MXPA05011707A (es) 2006-02-13
AU2004233978A1 (en) 2004-11-11
DK1622880T6 (da) 2018-06-18
NO333265B1 (no) 2013-04-22
RU2360912C2 (ru) 2009-07-10
HUS1800028I1 (hu) 2018-07-30
FR18C1029I1 (no) 2018-08-17
EP1622880B1 (de) 2007-02-28
ES2284007T3 (es) 2007-11-01
USRE49698E1 (en) 2023-10-17
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
TWI335912B (en) 2011-01-11
CO5700764A2 (es) 2006-11-30
NO20055649D0 (no) 2005-11-30
HN2004000146A (es) 2008-06-24
DE502004003052D1 (de) 2007-04-12
HUS1800018I1 (hu) 2018-05-28
BRPI0410029A (pt) 2006-04-25
BRPI0410029B8 (pt) 2021-06-15
PL1622880T3 (pl) 2007-08-31
CY1106476T1 (el) 2012-01-25
SI1622880T1 (sl) 2007-08-31
MY144616A (en) 2011-10-14
ECSP056138A (es) 2006-04-19
AR044078A1 (es) 2005-08-24
FR18C1029I2 (fr) 2020-07-17
RU2005137276A (ru) 2006-07-27
US7196086B2 (en) 2007-03-27
NL300933I2 (nl) 2018-04-26
BRPI0410029B1 (pt) 2019-12-31
PL1622880T6 (pl) 2018-08-31
JP4733631B2 (ja) 2011-07-27
CA2524069C (en) 2011-11-08
US20050065160A1 (en) 2005-03-24
PE20050145A1 (es) 2005-05-22
MA27794A1 (fr) 2006-03-01
CL2004000930A1 (es) 2005-03-18
US20070191387A1 (en) 2007-08-16
HK1092463A1 (en) 2007-02-09
CA2524069A1 (en) 2004-11-11
DE10319612A1 (de) 2004-11-18
ES2284007T7 (es) 2018-06-20
DK1622880T3 (da) 2007-06-25
USRE46791E1 (en) 2018-04-17
UA82519C2 (uk) 2008-04-25
ZA200508710B (en) 2006-12-27
WO2004096778A1 (de) 2004-11-11
NO20055649L (no) 2006-01-31
CN1784390A (zh) 2006-06-07
EP1622880B3 (de) 2018-05-23
PT1622880E (pt) 2007-06-04
CY2018019I2 (el) 2018-12-12
KR100927063B1 (ko) 2009-11-13
NZ543317A (en) 2008-05-30

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