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MXPA05011707A - Dihidroquinazolinas sustituidas con propiedades antivirales. - Google Patents

Dihidroquinazolinas sustituidas con propiedades antivirales.

Info

Publication number
MXPA05011707A
MXPA05011707A MXPA05011707A MXPA05011707A MXPA05011707A MX PA05011707 A MXPA05011707 A MX PA05011707A MX PA05011707 A MXPA05011707 A MX PA05011707A MX PA05011707 A MXPA05011707 A MX PA05011707A MX PA05011707 A MXPA05011707 A MX PA05011707A
Authority
MX
Mexico
Prior art keywords
dihydrochinazolines
substituted
antiviral properties
antiviral
treating
Prior art date
Application number
MXPA05011707A
Other languages
English (en)
Inventor
Peter Nell
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of MXPA05011707A publication Critical patent/MXPA05011707A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a dihidroquinazolinas sustituidas de formula (I) y a procedimientos para su preparacion asi como a su uso para la preparacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente para el uso como agente antiviral, especialmente contra citomegalovirus.
MXPA05011707A 2003-05-02 2004-04-17 Dihidroquinazolinas sustituidas con propiedades antivirales. MXPA05011707A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (1)

Publication Number Publication Date
MXPA05011707A true MXPA05011707A (es) 2006-02-13

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011707A MXPA05011707A (es) 2003-05-02 2004-04-17 Dihidroquinazolinas sustituidas con propiedades antivirales.

Country Status (39)

Country Link
US (4) US7196086B2 (es)
EP (1) EP1622880B3 (es)
JP (1) JP4733631B2 (es)
KR (1) KR100927063B1 (es)
CN (1) CN100393706C (es)
AR (1) AR044078A1 (es)
AT (1) ATE355280T1 (es)
AU (1) AU2004233978B2 (es)
BR (1) BRPI0410029B8 (es)
CA (1) CA2524069C (es)
CL (1) CL2004000930A1 (es)
CO (1) CO5700764A2 (es)
CY (2) CY1106476T1 (es)
DE (2) DE10319612A1 (es)
DK (1) DK1622880T6 (es)
EC (1) ECSP056138A (es)
EG (1) EG25273A (es)
ES (1) ES2284007T7 (es)
FR (1) FR18C1029I2 (es)
HK (1) HK1092463A1 (es)
HN (1) HN2004000146A (es)
HU (2) HUS1800018I1 (es)
IL (1) IL171513A (es)
MA (1) MA27794A1 (es)
MX (1) MXPA05011707A (es)
MY (1) MY144616A (es)
NL (1) NL300933I2 (es)
NO (2) NO333265B3 (es)
NZ (1) NZ543317A (es)
PE (1) PE20050145A1 (es)
PL (1) PL1622880T6 (es)
PT (1) PT1622880E (es)
RU (1) RU2360912C2 (es)
SI (1) SI1622880T1 (es)
TW (1) TWI335912B (es)
UA (1) UA82519C2 (es)
UY (1) UY28294A1 (es)
WO (1) WO2004096778A1 (es)
ZA (1) ZA200508710B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
ES2882531T3 (es) * 2016-08-08 2021-12-02 Phaeno Therapeutics Co Ltd Compuesto anti-virus CMVH
ES2971079T3 (es) * 2018-02-08 2024-06-03 Phaeno Therapeutics Co Ltd Forma cristalina del compuesto 3,4-dihidrotieno[3,2-d]pirimidina y método de preparación del mismo
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
JP7273951B2 (ja) 2018-09-12 2023-05-15 ノバルティス アーゲー 抗ウイルス性ピリドピラジンジオン化合物
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121440A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用

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DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
CA2321153A1 (en) 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
EP1172361A4 (en) 1999-04-19 2002-05-08 Shionogi & Co SULFONAMIDE DERIVATIVES HAVING OXADIAZOLE CORES
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
AU2001283955B2 (en) 2000-07-31 2006-05-18 F. Hoffmann-La Roche Ag Piperazine derivatives
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
JP4480941B2 (ja) 2001-04-19 2010-06-16 アイキュリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コムパニー・コマンディットゲゼルシャフト 抗ウイルス剤としての新規アリールスルホンアミド
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
BRPI0607306A2 (pt) * 2005-01-25 2009-08-25 Prolexys Pharmaceuticals Inc derivados de quinoxalina como agentes anti-tumor
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
CA2614443C (en) 2005-07-21 2011-03-22 F. Hoffmann-La Roche Ag Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra

Also Published As

Publication number Publication date
EP1622880A1 (de) 2006-02-08
IL171513A (en) 2011-11-30
NO333265B3 (no) 2019-06-03
TW200510343A (en) 2005-03-16
KR20060009883A (ko) 2006-02-01
CN100393706C (zh) 2008-06-11
AU2004233978B2 (en) 2010-02-11
US8513255B2 (en) 2013-08-20
UY28294A1 (es) 2004-11-30
EG25273A (en) 2011-12-04
CY2018019I1 (el) 2018-12-12
AU2004233978A1 (en) 2004-11-11
DK1622880T6 (da) 2018-06-18
NO333265B1 (no) 2013-04-22
RU2360912C2 (ru) 2009-07-10
HUS1800028I1 (hu) 2018-07-30
FR18C1029I1 (es) 2018-08-17
EP1622880B1 (de) 2007-02-28
ES2284007T3 (es) 2007-11-01
USRE49698E1 (en) 2023-10-17
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
TWI335912B (en) 2011-01-11
CO5700764A2 (es) 2006-11-30
NO20055649D0 (no) 2005-11-30
HN2004000146A (es) 2008-06-24
DE502004003052D1 (de) 2007-04-12
HUS1800018I1 (hu) 2018-05-28
BRPI0410029A (pt) 2006-04-25
BRPI0410029B8 (pt) 2021-06-15
PL1622880T3 (pl) 2007-08-31
CY1106476T1 (el) 2012-01-25
SI1622880T1 (sl) 2007-08-31
MY144616A (en) 2011-10-14
ECSP056138A (es) 2006-04-19
AR044078A1 (es) 2005-08-24
FR18C1029I2 (fr) 2020-07-17
RU2005137276A (ru) 2006-07-27
US7196086B2 (en) 2007-03-27
NL300933I2 (nl) 2018-04-26
BRPI0410029B1 (pt) 2019-12-31
PL1622880T6 (pl) 2018-08-31
JP4733631B2 (ja) 2011-07-27
CA2524069C (en) 2011-11-08
US20050065160A1 (en) 2005-03-24
PE20050145A1 (es) 2005-05-22
MA27794A1 (fr) 2006-03-01
CL2004000930A1 (es) 2005-03-18
NO2018022I1 (no) 2018-07-04
US20070191387A1 (en) 2007-08-16
HK1092463A1 (en) 2007-02-09
CA2524069A1 (en) 2004-11-11
DE10319612A1 (de) 2004-11-18
ES2284007T7 (es) 2018-06-20
DK1622880T3 (da) 2007-06-25
USRE46791E1 (en) 2018-04-17
UA82519C2 (uk) 2008-04-25
ZA200508710B (en) 2006-12-27
WO2004096778A1 (de) 2004-11-11
NO20055649L (no) 2006-01-31
CN1784390A (zh) 2006-06-07
EP1622880B3 (de) 2018-05-23
PT1622880E (pt) 2007-06-04
CY2018019I2 (el) 2018-12-12
KR100927063B1 (ko) 2009-11-13
NZ543317A (en) 2008-05-30

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