NO20053114L - Astma og allergisk inflammasjonsmodulatorer. - Google Patents
Astma og allergisk inflammasjonsmodulatorer.Info
- Publication number
- NO20053114L NO20053114L NO20053114A NO20053114A NO20053114L NO 20053114 L NO20053114 L NO 20053114L NO 20053114 A NO20053114 A NO 20053114A NO 20053114 A NO20053114 A NO 20053114A NO 20053114 L NO20053114 L NO 20053114L
- Authority
- NO
- Norway
- Prior art keywords
- asthma
- allergic inflammatory
- inflammatory modulators
- inflammatory
- conditions
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 230000000172 allergic effect Effects 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000012657 Atopic disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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PCT/US2003/040617 WO2004058164A2 (fr) | 2002-12-20 | 2003-12-19 | Modulateurs de l'asthme et de l'inflammation allergique |
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EP (1) | EP1585511B1 (fr) |
JP (1) | JP4457017B2 (fr) |
KR (1) | KR20050111314A (fr) |
CN (1) | CN100406007C (fr) |
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CA (1) | CA2511214C (fr) |
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ES (1) | ES2401079T3 (fr) |
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NZ (1) | NZ541234A (fr) |
PL (1) | PL377314A1 (fr) |
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Families Citing this family (145)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2485681C (fr) | 2002-05-24 | 2012-10-16 | Millennium Pharmaceuticals, Inc. | Inhibiteurs de ccr9 et utilisation de ceux-ci |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
JP4457017B2 (ja) | 2002-12-20 | 2010-04-28 | アムジエン・インコーポレーテツド | 喘息及びアレルギー性炎症モジュレーター |
CN1511828A (zh) * | 2002-12-31 | 2004-07-14 | �й������ž�����ҽѧ��ѧԺ����ҽ | 磺酰苯胺类衍生物及其医药用途 |
GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
US20080254053A1 (en) * | 2003-04-09 | 2008-10-16 | Mullally John P | Protocol for treatment of diabetes |
DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
US20070082907A1 (en) * | 2003-11-25 | 2007-04-12 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
MXPA06007172A (es) * | 2003-12-23 | 2006-08-23 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri. |
NZ548396A (en) * | 2004-01-31 | 2010-06-25 | Actimis Pharmaceuticals Inc | Imidazo[1,2-C]pyrimidinylacetic acid derivatives |
WO2005095397A1 (fr) | 2004-03-11 | 2005-10-13 | Actelion Pharmaceuticals Ltd | Derives de tetrahydropyridoindole |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
PT1817282E (pt) | 2004-11-23 | 2011-09-19 | Astrazeneca Ab | Derivados do ácido fenoxiacético úteis para tratar doenças respiratórias |
EP1819673A2 (fr) | 2004-11-30 | 2007-08-22 | Plexxikon, Inc. | Derivés indole utiles comme des composés actifs sur les ppar |
US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
JP5021621B2 (ja) * | 2005-04-13 | 2012-09-12 | アスション ファーマ エー/エス | 皮膚の結合組織病を治療するためのβ−2アドレナリン受容体作動薬 |
US8796280B2 (en) * | 2005-04-21 | 2014-08-05 | Merck Serono, S.A. | 2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors |
GB0510584D0 (en) * | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
WO2007014008A2 (fr) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 |
EP1937632A1 (fr) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Nouveaux composes |
TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
US20080255150A1 (en) * | 2005-11-05 | 2008-10-16 | Astrazeneca Ab | Novel Compounds |
GB0525141D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
ES2380683T3 (es) * | 2005-12-15 | 2012-05-17 | Astrazeneca Ab | Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria |
WO2007081387A1 (fr) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Dispositifs microfluidiques, méthodes d'utilisation, et trousses permettant de faire des diagnostics |
WO2007110876A2 (fr) * | 2006-03-24 | 2007-10-04 | Panacea Biotec Ltd. | Dérives innovants du sulfonanilide, compositions pharmaceutiques qui les contiennent et procédés qui les concernent |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9074242B2 (en) | 2010-02-12 | 2015-07-07 | Raindance Technologies, Inc. | Digital analyte analysis |
EP2530167A1 (fr) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Dispositifs microfluidiques |
WO2007143745A2 (fr) * | 2006-06-09 | 2007-12-13 | Icos Corporation | Acides phénylacétiques substitués utilisés en tant qu'antagonistes de dp-2 |
JP2009539881A (ja) * | 2006-06-09 | 2009-11-19 | アイコス コーポレイション | Dp−2アンタゴニストとしての置換フェニル酢酸 |
US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
US20100234364A1 (en) * | 2006-07-14 | 2010-09-16 | Arindrajit Basak | Ccr2 inhibitors and methods of use thereof |
WO2008012511A1 (fr) | 2006-07-22 | 2008-01-31 | Oxagen Limited | Composés présentant une activité d'antagonistes crth2 |
EP3536396B1 (fr) | 2006-08-07 | 2022-03-30 | The President and Fellows of Harvard College | Tensioactifs fluorocarbonés stabilisateurs d'émulsions |
WO2008024746A1 (fr) * | 2006-08-21 | 2008-02-28 | Array Biopharma, Inc. | Dérivés de l'acide phénoxyphénylacétique 4-substitué |
CA2669915C (fr) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Composes bicyclocarboxyamides substitues |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
US20100305074A1 (en) * | 2007-04-04 | 2010-12-02 | Hight H Thomas | Niacin-based pharmaceutical compositions |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
UA100983C2 (ru) * | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
PL2175859T3 (pl) | 2007-07-12 | 2012-09-28 | Chemocentryx Inc | Skondensowane heteroarylopirydylo- i fenylo-benzenosulfonamidy jako modulatory CCR2 do leczenia zapalenia |
KR20100061747A (ko) | 2007-09-25 | 2010-06-08 | 액티미스 파마수티컬스 인코포레이티드 | Crth2 길항제로서의 알킬티오 피리미딘 |
AR068633A1 (es) | 2007-09-25 | 2009-11-25 | Actimis Pharmaceuticals Inc | Pirimidinas sustituidas con 2-s- bencilo como antagonistas de crth2 |
US20100280049A1 (en) * | 2007-11-06 | 2010-11-04 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
WO2009061681A2 (fr) * | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc | Antagonistes de récepteurs pgd2 |
PL2327693T3 (pl) | 2007-12-14 | 2012-11-30 | Pulmagen Therapeutics Asthma Ltd | Indole i ich zastosowanie terapeutyczne |
AU2008343924B2 (en) | 2007-12-19 | 2013-01-17 | Amgen Inc. | Phenyl acetic acid derivatives as inflammation modulators |
WO2009090399A1 (fr) * | 2008-01-18 | 2009-07-23 | Argenta Discovery Limited | Indoles actifs sur le récepteur crth2 |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
BRPI0906786B1 (pt) | 2008-01-18 | 2021-10-05 | Atopix Therapeutics Limited | Composto, processo para a preparação de um composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, e, produto |
US20100022613A1 (en) | 2008-01-22 | 2010-01-28 | Oxagen Limited | Compounds Having CRTH2 Antagonist Activity |
EP2240444A1 (fr) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Composés présentant une activité antagoniste de crth2 |
EP2257524B1 (fr) * | 2008-02-01 | 2016-01-06 | Brickell Biotech, Inc. | Antagonistes aminoalkylbiphényle n,n-disubstitués des récepteurs de la prostaglandine d2 |
WO2009099901A1 (fr) * | 2008-02-01 | 2009-08-13 | Amira Pharmaceuticals, Inc. | Antagonistes aminoalkylbiphényle n, n' disubstitués des récepteurs d2 de la prostaglandine |
EP2257536A4 (fr) * | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | Composés diaryliques cycliques en tant qu'antagonistes de récepteurs de prostaglandine d2 |
CN103554088B (zh) | 2008-02-22 | 2016-02-24 | 大塚制药株式会社 | 苯并二氮杂*化合物及药物组合物 |
WO2009108720A2 (fr) * | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonistes des récepteurs d2 de la prostaglandine |
US8426449B2 (en) * | 2008-04-02 | 2013-04-23 | Panmira Pharmaceuticals, Llc | Aminoalkylphenyl antagonists of prostaglandin D2 receptors |
WO2010008864A2 (fr) | 2008-06-24 | 2010-01-21 | Amira Pharmaceuticals, Inc. | Antagonistes de cycloalcane[b]indole de récepteurs de prostaglandine d2 |
PL2307397T3 (pl) | 2008-06-25 | 2015-02-27 | Array Biopharma Inc | 6-Podstawione pochodne kwasów fenoksychromanokarboksylowych |
EP2307362A4 (fr) | 2008-07-03 | 2012-05-09 | Panmira Pharmaceuticals Llc | Antagonistes des recepteurs de la prostaglandine d2 |
WO2010009365A1 (fr) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Bibliothèque de gouttelettes |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
WO2010039977A2 (fr) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Antagonistes d’hétéroaryle des récepteurs de la prostaglandine d2 |
WO2010042652A2 (fr) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Antagonistes hétéroalkyl biphényle des récepteurs de la prostaglandine d2 |
GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
CA2740863A1 (fr) | 2008-11-17 | 2010-05-20 | F. Hoffmann-La Roche Ag | Acides naphtylacetiques |
US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
EP2379535B1 (fr) * | 2008-12-22 | 2016-06-15 | Array Biopharma Inc. | Dérivés d'acide 7-phénoxychromanecarboxylique |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
WO2011002814A2 (fr) * | 2009-06-30 | 2011-01-06 | Ligand Pharmaceuticals Inc. | Composés d'acide biaryl oxyacétique |
WO2011014588A2 (fr) * | 2009-07-31 | 2011-02-03 | Amira Pharmaceuticals, Inc. | Préparations dermiques d'antagonistes du récepteur dp2 |
US8785393B2 (en) | 2009-07-31 | 2014-07-22 | Panmira Pharmaceuticals, Llc | Ophthalmic pharmaceutical compositions of DP2 receptor antagonists |
MX2012001542A (es) * | 2009-08-05 | 2012-06-19 | Panmira Pharmaceuticals Llc | Antagonista dp2 y usos del mismo. |
TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
CA2771136A1 (fr) | 2009-08-21 | 2011-02-24 | Otsuka Pharmaceutical Co., Ltd. | Procede de fabrication du compose benzo[b][1,4]diazepine-2,4-dione |
WO2011042564A1 (fr) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
TW201130810A (en) * | 2009-12-23 | 2011-09-16 | Ironwood Pharmaceuticals Inc | CRTH2 modulators |
EP2521713A4 (fr) * | 2010-01-06 | 2013-10-02 | Panmira Pharmaceuticals Llc | Antagoniste du dp2 et ses utilisations |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
CA2803292C (fr) | 2010-06-30 | 2016-06-14 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de sgc |
TW201201805A (en) | 2010-07-05 | 2012-01-16 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
WO2012009134A1 (fr) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Modulateurs de crth2 |
US20130216552A1 (en) | 2010-07-12 | 2013-08-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
EP2622103B2 (fr) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Dosages sandwich dans des gouttelettes |
US20140113898A1 (en) * | 2010-11-08 | 2014-04-24 | Zalicus Pharmaceuticals Ltd. | Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers |
JP5878546B2 (ja) | 2010-11-09 | 2016-03-08 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激剤 |
EP2457900A1 (fr) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | Nouveaux dérivés de pyrazole présentant un comportement antagoniste CRTH2 |
WO2012109600A2 (fr) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Procédés de formation de gouttelettes mélangées |
EP3736281A1 (fr) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions et méthodes de marquage moléculaire |
EP2526945A1 (fr) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
EP2714970B1 (fr) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Quantification d'enzyme |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
EP2548876A1 (fr) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
EP2548863A1 (fr) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
EP2790696A1 (fr) | 2011-12-16 | 2014-10-22 | Atopix Therapeutics Limited | Combinaison d'un antagoniste de crth2 et d'un inhibiteur de pompe à protons pour le traitement de l' sophagite à éosinophiles |
EP2794563B1 (fr) | 2011-12-21 | 2017-02-22 | Actelion Pharmaceuticals Ltd | Dérivés hétérocyclyle et leur utilisation comme modulateurs de récepteurs de la prostaglandine d2 |
CA2861804C (fr) | 2011-12-27 | 2021-10-26 | Ironwood Pharmaceuticals, Inc. | Pyrazoles 2-benzyle, 3-(pyrimidin-2-yle)-substitues utiles comme stimulateurs de scg |
WO2014006585A1 (fr) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | Dérivés hétérocyclylés 1-phényl-substitués et leur utilisation en tant que modulateurs du récepteur de la prostaglandine d2 |
WO2014047111A1 (fr) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de la sgc |
WO2014047325A1 (fr) | 2012-09-19 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de sgc |
EP3998260B1 (fr) | 2013-03-15 | 2023-11-01 | Cyclerion Therapeutics, Inc. | Stimulateurs sgc |
CN104341307B (zh) * | 2013-08-05 | 2016-12-28 | 北京京朋汇药业研究发展有限公司 | 苯乙酸衍生物及其抗肿瘤用途 |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
EA032028B1 (ru) | 2013-12-11 | 2019-03-29 | Айронвуд Фармасьютикалз, Инк. | СТИМУЛЯТОРЫ рГЦ |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
WO2015103367A1 (fr) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | Système et procédé de détection d'une espèce d'arn |
EP3094327A1 (fr) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
WO2016044445A2 (fr) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de sgc |
JP2017527604A (ja) | 2014-09-17 | 2017-09-21 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激剤 |
EP3194382B1 (fr) | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Dérivés de pyrazole utilisés comme stimulateurs de sgc |
JP6770522B2 (ja) | 2015-02-13 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 全身性エリテマトーデスを予防し、及び/又は、治療するためのptgdr−1及び/又はptgdr−2アンタゴニスト |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
WO2017151409A1 (fr) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Méthodes de chimiothérapie |
CN109476686B (zh) | 2016-07-07 | 2022-01-18 | 赛克里翁治疗有限公司 | sGC刺激剂的磷前药 |
CA3029333A1 (fr) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Formes solides d'un stimulateur de la gcs |
RU2022102328A (ru) | 2016-11-23 | 2022-04-01 | Хемоцентрикс, Инк. | Способ лечения фокально-сегментарного гломерулосклероза |
EP3694504A4 (fr) | 2017-10-11 | 2021-07-14 | ChemoCentryx, Inc. | Traitement de la glomérulosclérose segmentaire focale avec des antagonistes du ccr2 |
CN114258391A (zh) | 2019-04-03 | 2022-03-29 | 阿里戈斯治疗公司 | 吡咯化合物 |
CN112500281A (zh) * | 2020-12-07 | 2021-03-16 | 唐山师范学院 | 丁香酸的制备方法 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8704158D0 (en) | 1987-02-23 | 1987-04-01 | Wellcome Found | Substituted hydantoin compounds |
DE4041780A1 (de) * | 1990-12-24 | 1992-06-25 | Boehringer Mannheim Gmbh | Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel |
CA2166413A1 (fr) | 1993-06-30 | 1995-01-12 | Richard James Arrowsmith | Composes diaryliques anti-atherosclerose |
US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
NZ297774A (en) | 1994-12-20 | 1998-10-28 | Hoffmann La Roche | Aryl and heteroaryl sulphonamide derivatives; preparation and medicaments |
EP0929547B1 (fr) | 1996-09-12 | 2002-11-27 | Schering Aktiengesellschaft | Derives benzamidine, substitues par des derives d'acides amines cycliques ou d'hydroxyacides cycliques, et leur utilisation en tant qu'anticoagulants |
US6008234A (en) | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
JPH11202458A (ja) | 1998-01-16 | 1999-07-30 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
AU3665199A (en) | 1998-04-29 | 1999-11-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
JP2000007646A (ja) * | 1998-06-16 | 2000-01-11 | Ono Pharmaceut Co Ltd | スルフォンアミド誘導体およびそれらを有効成分と して含有する薬剤 |
AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
ATE295831T1 (de) | 1999-03-10 | 2005-06-15 | Shionogi & Co | Medizinische zubereitungen mit (2.2.1) und (3.1.1)bicycloskelett die antagonisten für sowohl pgd 2? als auch txa 2? rezeptoren sind |
AU772121B2 (en) | 1999-08-23 | 2004-04-08 | Bml, Inc. | Method of identifying properties of substance to prostaglandin D receptors |
US6531291B1 (en) * | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
JPWO2001094309A1 (ja) | 2000-06-02 | 2004-02-05 | 塩野義製薬株式会社 | Pgd2/txa2両受容体拮抗性医薬組成物 |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
AU2002229611A1 (en) | 2000-12-08 | 2002-06-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of active compounds capable of modulating the intracellular pathway triggered by the dp receptor in langerhans cells |
AU2002302248B2 (en) | 2001-05-23 | 2008-03-06 | Merck Frosst Canada Ltd. | Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists |
US7491748B2 (en) * | 2001-08-09 | 2009-02-17 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
CN100378083C (zh) | 2002-03-19 | 2008-04-02 | 小野药品工业株式会社 | 羧酸化合物和含有所述化合物作为活性成分的药物制剂 |
AU2003231513A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Pgd2 receptor antagonist |
US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
JP4457017B2 (ja) | 2002-12-20 | 2010-04-28 | アムジエン・インコーポレーテツド | 喘息及びアレルギー性炎症モジュレーター |
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2003
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- 2003-12-19 BR BR0317591-0A patent/BR0317591A/pt not_active IP Right Cessation
- 2003-12-19 EP EP03814219A patent/EP1585511B1/fr not_active Expired - Lifetime
- 2003-12-19 MX MXPA05006701A patent/MXPA05006701A/es active IP Right Grant
- 2003-12-19 CN CNB2003801097235A patent/CN100406007C/zh not_active Expired - Fee Related
- 2003-12-19 ZA ZA200505523A patent/ZA200505523B/en unknown
- 2003-12-19 ES ES03814219T patent/ES2401079T3/es not_active Expired - Lifetime
- 2003-12-19 CA CA2511214A patent/CA2511214C/fr not_active Expired - Fee Related
- 2003-12-19 AU AU2003297398A patent/AU2003297398B2/en not_active Ceased
- 2003-12-19 EA EA200501017A patent/EA011087B1/ru not_active IP Right Cessation
- 2003-12-19 WO PCT/US2003/040617 patent/WO2004058164A2/fr active Application Filing
- 2003-12-19 KR KR1020057011677A patent/KR20050111314A/ko active IP Right Grant
- 2003-12-19 US US10/742,281 patent/US7321001B2/en active Active
- 2003-12-19 PL PL377314A patent/PL377314A1/pl not_active Application Discontinuation
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2005
- 2005-06-22 IS IS7907A patent/IS7907A/is unknown
- 2005-06-24 NO NO20053114A patent/NO20053114L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
IS7907A (is) | 2005-06-22 |
EP1585511A2 (fr) | 2005-10-19 |
AU2003297398B2 (en) | 2009-09-24 |
CN100406007C (zh) | 2008-07-30 |
KR20050111314A (ko) | 2005-11-24 |
NO20053114D0 (no) | 2005-06-24 |
EA011087B1 (ru) | 2008-12-30 |
AU2003297398A1 (en) | 2004-07-22 |
US7321001B2 (en) | 2008-01-22 |
CA2511214C (fr) | 2012-12-18 |
JP4457017B2 (ja) | 2010-04-28 |
PL377314A1 (pl) | 2006-01-23 |
ES2401079T3 (es) | 2013-04-16 |
JP2006516143A (ja) | 2006-06-22 |
NZ541234A (en) | 2008-06-30 |
EP1585511A4 (fr) | 2007-08-29 |
WO2004058164A3 (fr) | 2004-08-26 |
ZA200505523B (en) | 2006-09-27 |
US20040220237A1 (en) | 2004-11-04 |
EP1585511B1 (fr) | 2013-01-23 |
WO2004058164A2 (fr) | 2004-07-15 |
US20080085891A1 (en) | 2008-04-10 |
BR0317591A (pt) | 2005-11-22 |
CN1767823A (zh) | 2006-05-03 |
US7541383B2 (en) | 2009-06-02 |
EA200501017A1 (ru) | 2006-02-24 |
CA2511214A1 (fr) | 2004-07-15 |
MXPA05006701A (es) | 2006-03-30 |
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