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EG25273A - Substituted dihydroquinazolines. - Google Patents

Substituted dihydroquinazolines.

Info

Publication number
EG25273A
EG25273A EGNA2005000688A EG25273A EG 25273 A EG25273 A EG 25273A EG NA2005000688 A EGNA2005000688 A EG NA2005000688A EG 25273 A EG25273 A EG 25273A
Authority
EG
Egypt
Prior art keywords
dihydroquinazolines
substituted
substituted dihydroquinazolines
Prior art date
Application number
Other languages
English (en)
Inventor
Tobias Wunberg
Judith Baumeister
Ulrich Betz
Mario Jeske
Thomas Lampe
Susanne Nikolic
Jurgen Reefschlager
Rudolf Schohe-Loop
Frank Sussmeier
Holger Zimmermann
Rolf Grosser
Kerstin Henninger
Guy Hewlett
Jorg Keldenich
Dieter Lang
Peter Nell
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG25273(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Application granted granted Critical
Publication of EG25273A publication Critical patent/EG25273A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EGNA2005000688 2003-05-02 2005-10-29 Substituted dihydroquinazolines. EG25273A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (1)

Publication Number Publication Date
EG25273A true EG25273A (en) 2011-12-04

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
EGNA2005000688 EG25273A (en) 2003-05-02 2005-10-29 Substituted dihydroquinazolines.

Country Status (38)

Country Link
US (4) US7196086B2 (es)
EP (1) EP1622880B3 (es)
JP (1) JP4733631B2 (es)
KR (1) KR100927063B1 (es)
CN (1) CN100393706C (es)
AR (1) AR044078A1 (es)
AT (1) ATE355280T1 (es)
AU (1) AU2004233978B2 (es)
BR (1) BRPI0410029B8 (es)
CA (1) CA2524069C (es)
CL (1) CL2004000930A1 (es)
CO (1) CO5700764A2 (es)
CY (2) CY1106476T1 (es)
DE (2) DE10319612A1 (es)
DK (1) DK1622880T6 (es)
EC (1) ECSP056138A (es)
EG (1) EG25273A (es)
ES (1) ES2284007T7 (es)
FR (1) FR18C1029I2 (es)
HN (1) HN2004000146A (es)
HU (2) HUS1800018I1 (es)
IL (1) IL171513A (es)
MA (1) MA27794A1 (es)
MX (1) MXPA05011707A (es)
MY (1) MY144616A (es)
NL (1) NL300933I2 (es)
NO (2) NO333265B3 (es)
NZ (1) NZ543317A (es)
PE (1) PE20050145A1 (es)
PL (1) PL1622880T6 (es)
PT (1) PT1622880E (es)
RU (1) RU2360912C2 (es)
SI (1) SI1622880T1 (es)
TW (1) TWI335912B (es)
UA (1) UA82519C2 (es)
UY (1) UY28294A1 (es)
WO (1) WO2004096778A1 (es)
ZA (1) ZA200508710B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
PE20160659A1 (es) * 2013-06-19 2016-07-24 Aicuris Anti-Infective Cures Gmbh Letermovir amorfo y formulaciones farmaceuticas solidas del mismo para administracion por via oral
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
EP3498715B1 (en) * 2016-08-08 2021-06-09 Medshine Discovery Inc. Anti-hcmv virus compound
KR102423393B1 (ko) * 2018-02-08 2022-07-21 파에노 테라퓨틱스 씨오., 엘티디. 3,4-디하이드로티에노[3,2-d]피리미딘 화합물의 결정형 및 이의 제조방법
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
KR20230170813A (ko) 2018-09-12 2023-12-19 노파르티스 아게 항바이러스 피리도피라진디온 화합물
TWI867053B (zh) 2019-09-26 2024-12-21 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
UY39098A (es) * 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39096A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8- fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
WO2022038457A1 (en) 2020-08-17 2022-02-24 Lupin Limited A precipitation process for amorphous letermovir
CN115403528B (zh) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
CN118974026A (zh) * 2022-04-01 2024-11-15 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用
WO2025133248A1 (en) 2023-12-21 2025-06-26 Aic246 Ag & Co. Kg Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
EA200000840A1 (ru) 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
CN1347411A (zh) 1999-04-19 2002-05-01 盐野义制药株式会社 含有噁二唑环的磺酰胺衍生物
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
ATE305933T1 (de) 2000-07-31 2005-10-15 Hoffmann La Roche Piperazin derivate
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
WO2002085869A1 (de) 2001-04-19 2002-10-31 Bayer Aktiengesellschaft Arylsulfonamide als antivirale mittel
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
JP5139083B2 (ja) * 2005-01-25 2013-02-06 プロレキシーズ ファーマシューティカルズ インコーポレイテッド 抗腫瘍剤としてのキノキサリン誘導体
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
JP4880684B2 (ja) 2005-07-21 2012-02-22 エフ．ホフマン−ラ ロシュ アーゲー Ｐｔｐ１ｂ阻害剤としてのピリド［２，３−ｄ］ピリミジン−２，４−ジアミン化合物
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
PE20160659A1 (es) * 2013-06-19 2016-07-24 Aicuris Anti-Infective Cures Gmbh Letermovir amorfo y formulaciones farmaceuticas solidas del mismo para administracion por via oral

Also Published As

Publication number Publication date
CY1106476T1 (el) 2012-01-25
NO2018022I1 (no) 2018-07-04
ECSP056138A (es) 2006-04-19
AU2004233978B2 (en) 2010-02-11
AR044078A1 (es) 2005-08-24
HK1092463A1 (zh) 2007-02-09
NO20055649L (no) 2006-01-31
NO333265B3 (no) 2019-06-03
HN2004000146A (es) 2008-06-24
KR20060009883A (ko) 2006-02-01
DK1622880T3 (da) 2007-06-25
PT1622880E (pt) 2007-06-04
HUS1800018I1 (hu) 2018-05-28
CA2524069A1 (en) 2004-11-11
DK1622880T6 (da) 2018-06-18
RU2360912C2 (ru) 2009-07-10
DE502004003052D1 (de) 2007-04-12
ATE355280T1 (de) 2006-03-15
CA2524069C (en) 2011-11-08
TWI335912B (en) 2011-01-11
NZ543317A (en) 2008-05-30
DE10319612A1 (de) 2004-11-18
CL2004000930A1 (es) 2005-03-18
PL1622880T6 (pl) 2018-08-31
EP1622880B3 (de) 2018-05-23
CY2018019I2 (el) 2018-12-12
US7196086B2 (en) 2007-03-27
NO333265B1 (no) 2013-04-22
NO20055649D0 (no) 2005-11-30
USRE49698E1 (en) 2023-10-17
WO2004096778A1 (de) 2004-11-11
ES2284007T3 (es) 2007-11-01
CY2018019I1 (el) 2018-12-12
MY144616A (en) 2011-10-14
CO5700764A2 (es) 2006-11-30
TW200510343A (en) 2005-03-16
FR18C1029I1 (es) 2018-08-17
EP1622880B1 (de) 2007-02-28
UA82519C2 (uk) 2008-04-25
USRE46791E1 (en) 2018-04-17
FR18C1029I2 (fr) 2020-07-17
BRPI0410029B8 (pt) 2021-06-15
CN100393706C (zh) 2008-06-11
IL171513A (en) 2011-11-30
US8513255B2 (en) 2013-08-20
US20050065160A1 (en) 2005-03-24
RU2005137276A (ru) 2006-07-27
BRPI0410029B1 (pt) 2019-12-31
CN1784390A (zh) 2006-06-07
US20070191387A1 (en) 2007-08-16
MA27794A1 (fr) 2006-03-01
ZA200508710B (en) 2006-12-27
ES2284007T7 (es) 2018-06-20
UY28294A1 (es) 2004-11-30
AU2004233978A1 (en) 2004-11-11
HUS1800028I1 (hu) 2018-07-30
JP4733631B2 (ja) 2011-07-27
PE20050145A1 (es) 2005-05-22
BRPI0410029A (pt) 2006-04-25
KR100927063B1 (ko) 2009-11-13
PL1622880T3 (pl) 2007-08-31
MXPA05011707A (es) 2006-02-13
SI1622880T1 (sl) 2007-08-31
NL300933I2 (nl) 2018-04-26
EP1622880A1 (de) 2006-02-08
JP2006525249A (ja) 2006-11-09

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