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MXPA03010439A - Derivados de 4-(fenil-piperidin-a-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales. - Google Patents

Derivados de 4-(fenil-piperidin-a-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales.

Info

Publication number
MXPA03010439A
MXPA03010439A MXPA03010439A MXPA03010439A MXPA03010439A MX PA03010439 A MXPA03010439 A MX PA03010439A MX PA03010439 A MXPA03010439 A MX PA03010439A MX PA03010439 A MXPA03010439 A MX PA03010439A MX PA03010439 A MXPA03010439 A MX PA03010439A
Authority
MX
Mexico
Prior art keywords
phenyl
anxiety
pain
gastrointestinal disorders
ylidene
Prior art date
Application number
MXPA03010439A
Other languages
English (en)
Inventor
Brown William
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA03010439A publication Critical patent/MXPA03010439A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invencion se refiere a compuestos de la formula general I en donde R1 se selecciona de entre cualquiera del grupo que consiste de fenilo, piridinilo, pirrolilo, tienilo, furanilo, imidazolilo, triazolilo, tiazolilo y N-oxido de piridina; en donde cada anillo fenilo R1 y cada anillo heteroaromatico R1, opcional e independientemente puede estar sustituido con 1, 2 o 3 sustituyentes que se seleccionan del grupo que consiste de radicales alquilo de 1 a 6 atomos de carbono de cadena lineal y ramificada, NO2, CF3, alcoxi de 1 a 6 atomos de carbono, cloro, fluoro, bromo y yodo. Las sustituciones en el anillo fenilo y en el anillo heteroaromatico, se pueden colocar en cualquier posicion de dichos sistemas de anillo; y se reivindican en la presente solicitud, asi como las sales y composiciones farmaceuticas que comprenden los nuevos compuestos y su uso en terapia, en particular en el manejo del dolor, ansiedad Y trastornos funcionales gastrointestinales.
MXPA03010439A 2001-05-18 2002-05-16 Derivados de 4-(fenil-piperidin-a-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales. MXPA03010439A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101765A SE0101765D0 (sv) 2001-05-18 2001-05-18 Novel compounds
PCT/SE2002/000953 WO2002094812A1 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

Publications (1)

Publication Number Publication Date
MXPA03010439A true MXPA03010439A (es) 2004-03-09

Family

ID=20284168

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010439A MXPA03010439A (es) 2001-05-18 2002-05-16 Derivados de 4-(fenil-piperidin-a-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales.

Country Status (25)

Country Link
US (1) US7074808B2 (es)
EP (1) EP1395576B1 (es)
JP (1) JP2005510457A (es)
KR (1) KR20040000467A (es)
CN (1) CN1509282A (es)
AR (1) AR035973A1 (es)
AT (1) ATE303379T1 (es)
BG (1) BG108326A (es)
BR (1) BR0209676A (es)
CA (1) CA2446332A1 (es)
CO (1) CO5611136A2 (es)
CZ (1) CZ20033085A3 (es)
DE (1) DE60205894T2 (es)
EE (1) EE200300540A (es)
HU (1) HUP0401096A2 (es)
IL (1) IL158704A0 (es)
IS (1) IS7026A (es)
MX (1) MXPA03010439A (es)
NO (1) NO20035116D0 (es)
PL (1) PL366640A1 (es)
RU (1) RU2003131970A (es)
SE (1) SE0101765D0 (es)
SK (1) SK13952003A3 (es)
WO (1) WO2002094812A1 (es)
ZA (1) ZA200308633B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1395567E (pt) 2001-05-18 2009-03-26 Astrazeneca Ab Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0300103D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
US20070099957A1 (en) * 2003-05-16 2007-05-03 Astra Zeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
BRPI0411998A (pt) * 2003-06-27 2006-09-05 Janssen Pharmaceutica Nv moduladores delta-opióides tricìclicos
KR20140015122A (ko) 2003-10-01 2014-02-06 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
SE0400026D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400025D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
MX2007001240A (es) 2004-08-02 2007-03-23 Astrazeneca Ab Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas.
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2007100282A1 (en) * 2006-02-28 2007-09-07 Astrazeneca Ab New salts of an indole derivative and their use in medicine
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
BRPI0715004A2 (pt) 2006-09-12 2013-05-28 Adolor Corp mÉtodo para melhorar a funÇço cognitiva de composiÇço

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2898339A (en) 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en) 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5140029A (en) 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US4939137A (en) 1989-06-28 1990-07-03 Ortho Pharmaceutical Corporation Ring-fused thienopyrimidinedione derivatives
US5683998A (en) 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
ATE306472T1 (de) 1997-12-24 2005-10-15 Ortho Mcneil Pharm Inc (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden
CN1426411A (zh) * 2000-03-03 2003-06-25 奥索-麦克尼尔药品公司 3－(二芳基亚甲基)－8－氮杂双环[3.2.1]辛烷衍生物
US6556387B1 (en) * 2000-03-31 2003-04-29 Seagate Technology Llc Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001207D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0001208D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds

Also Published As

Publication number Publication date
IL158704A0 (en) 2004-05-12
SE0101765D0 (sv) 2001-05-18
CZ20033085A3 (cs) 2004-05-12
US20040142967A1 (en) 2004-07-22
CA2446332A1 (en) 2002-11-28
EP1395576A1 (en) 2004-03-10
CO5611136A2 (es) 2006-02-28
PL366640A1 (en) 2005-02-07
BG108326A (bg) 2004-12-30
WO2002094812A1 (en) 2002-11-28
HUP0401096A2 (hu) 2004-09-28
DE60205894D1 (de) 2005-10-06
RU2003131970A (ru) 2005-05-10
US7074808B2 (en) 2006-07-11
SK13952003A3 (sk) 2004-04-06
AR035973A1 (es) 2004-07-28
ATE303379T1 (de) 2005-09-15
EE200300540A (et) 2004-02-16
CN1509282A (zh) 2004-06-30
EP1395576B1 (en) 2005-08-31
DE60205894T2 (de) 2006-06-08
KR20040000467A (ko) 2004-01-03
ZA200308633B (en) 2005-02-07
NO20035116D0 (no) 2003-11-17
BR0209676A (pt) 2004-07-27
JP2005510457A (ja) 2005-04-21
IS7026A (is) 2003-11-11

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