DE60205894D1 - 4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen - Google Patents

4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen

Info

Publication number: DE60205894D1
Authority: DE; Germany
Prior art keywords: ylidenethyl; piperidin; anxiety; pain; phenyl
Prior art date: 2001-05-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60205894T

Other languages

English (en)

Other versions

DE60205894T2 (de

Inventor

William Brown

Christopher Walpole

Zhongyong Wei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-16

Publication date

2005-10-06

2002-05-16 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2005-10-06 Application granted granted Critical

2005-10-06 Publication of DE60205894D1 publication Critical patent/DE60205894D1/de

2006-06-08 Publication of DE60205894T2 publication Critical patent/DE60205894T2/de

2022-05-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

DE60205894T 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen Expired - Fee Related DE60205894T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0101765A SE0101765D0 (sv)	2001-05-18	2001-05-18	Novel compounds
SE0101765		2001-05-18
PCT/SE2002/000953 WO2002094812A1 (en)	2001-05-18	2002-05-16	4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

Publications (2)

Publication Number	Publication Date
DE60205894D1 true DE60205894D1 (de)	2005-10-06
DE60205894T2 DE60205894T2 (de)	2006-06-08

Family

ID=20284168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60205894T Expired - Fee Related DE60205894T2 (de)	2001-05-18	2002-05-16	4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen

Country Status (25)

Country	Link
US (1)	US7074808B2 (de)
EP (1)	EP1395576B1 (de)
JP (1)	JP2005510457A (de)
KR (1)	KR20040000467A (de)
CN (1)	CN1509282A (de)
AR (1)	AR035973A1 (de)
AT (1)	ATE303379T1 (de)
BG (1)	BG108326A (de)
BR (1)	BR0209676A (de)
CA (1)	CA2446332A1 (de)
CO (1)	CO5611136A2 (de)
CZ (1)	CZ20033085A3 (de)
DE (1)	DE60205894T2 (de)
EE (1)	EE200300540A (de)
HU (1)	HUP0401096A2 (de)
IL (1)	IL158704A0 (de)
IS (1)	IS7026A (de)
MX (1)	MXPA03010439A (de)
NO (1)	NO20035116D0 (de)
PL (1)	PL366640A1 (de)
RU (1)	RU2003131970A (de)
SE (1)	SE0101765D0 (de)
SK (1)	SK13952003A3 (de)
WO (1)	WO2002094812A1 (de)
ZA (1)	ZA200308633B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1395567B1 (de)	2001-05-18	2009-01-14	AstraZeneca AB	4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
SE0203303D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0203300D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0300103D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
AU2004238618A1 (en) *	2003-05-16	2004-11-25	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
BRPI0411998A (pt) *	2003-06-27	2006-09-05	Janssen Pharmaceutica Nv	moduladores delta-opióides tricìclicos
EP1675847B1 (de)	2003-10-01	2012-12-05	Adolor Corporation	Spirocyclische heterocyclische derivate und verfahren zu deren anwendung
SE0400026D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400027D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0400025D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
DK1781631T3 (da)	2004-08-02	2012-05-14	Astrazeneca Ab	Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
US7598261B2 (en)	2005-03-31	2009-10-06	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
EP1991539A4 (de) *	2006-02-28	2010-08-25	Astrazeneca Ab	Neue salze eines indolderivats und ihre verwendung in der medizin
US7576207B2 (en)	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
JP2010503669A (ja)	2006-09-12	2010-02-04	アドラーコーポレーション	認知機能の強化のためのｎ含有スピロ化合物の使用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2898339A (en)	1957-07-29	1959-08-04	Wm S Merrell Co	N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en)	1983-07-27	1986-04-08	Janssen Pharmaceutica, N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en)	1987-07-29	1989-03-28	Regents Of The University Of Minnesota	Delta opioid receptor antagonists
US5140029A (en)	1989-01-09	1992-08-18	Janssen Pharmaceutica N.V.	2-aminopyrimidinone derivatives
US4939137A (en)	1989-06-28	1990-07-03	Ortho Pharmaceutical Corporation	Ring-fused thienopyrimidinedione derivatives
US5683998A (en)	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
US5574159A (en)	1992-02-03	1996-11-12	Delta Pharmaceuticals, Inc.	Opioid compounds and methods for making therefor
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
SE9504661D0 (sv)	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
WO1999033806A1 (en)	1997-12-24	1999-07-08	Ortho-Mcneil Pharmaceutical, Inc.	4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
BR0108965A (pt) *	2000-03-03	2002-11-26	Ortho Mcneil Pharm Inc	Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octano
US6556387B1 (en) *	2000-03-31	2003-04-29	Seagate Technology Llc	Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001207D0 (sv) *	2000-04-04	2000-04-04	Astrazeneca Canada Inc	Novel compounds
SE0001208D0 (sv)	2000-04-04	2000-04-04	Astrazeneca Canada Inc	Novel compounds

2001
- 2001-05-18 SE SE0101765A patent/SE0101765D0/xx unknown
2002
- 2002-05-16 JP JP2002591485A patent/JP2005510457A/ja active Pending
- 2002-05-16 MX MXPA03010439A patent/MXPA03010439A/es unknown
- 2002-05-16 US US10/477,821 patent/US7074808B2/en not_active Expired - Fee Related
- 2002-05-16 RU RU2003131970/04A patent/RU2003131970A/ru not_active Application Discontinuation
- 2002-05-16 WO PCT/SE2002/000953 patent/WO2002094812A1/en active IP Right Grant
- 2002-05-16 PL PL02366640A patent/PL366640A1/xx not_active Application Discontinuation
- 2002-05-16 EE EEP200300540A patent/EE200300540A/xx unknown
- 2002-05-16 AT AT02733710T patent/ATE303379T1/de not_active IP Right Cessation
- 2002-05-16 DE DE60205894T patent/DE60205894T2/de not_active Expired - Fee Related
- 2002-05-16 CA CA002446332A patent/CA2446332A1/en not_active Abandoned
- 2002-05-16 CN CNA028101952A patent/CN1509282A/zh active Pending
- 2002-05-16 KR KR10-2003-7014941A patent/KR20040000467A/ko not_active Application Discontinuation
- 2002-05-16 EP EP02733710A patent/EP1395576B1/de not_active Expired - Lifetime
- 2002-05-16 IL IL15870402A patent/IL158704A0/xx unknown
- 2002-05-16 BR BR0209676-5A patent/BR0209676A/pt not_active Application Discontinuation
- 2002-05-16 AR ARP020101810A patent/AR035973A1/es unknown
- 2002-05-16 HU HU0401096A patent/HUP0401096A2/hu unknown
- 2002-05-16 CZ CZ20033085A patent/CZ20033085A3/cs unknown
- 2002-05-16 SK SK1395-2003A patent/SK13952003A3/sk unknown
2003
- 2003-11-05 ZA ZA200308633A patent/ZA200308633B/en unknown
- 2003-11-07 BG BG108326A patent/BG108326A/bg unknown
- 2003-11-11 IS IS7026A patent/IS7026A/is unknown
- 2003-11-12 CO CO03100156A patent/CO5611136A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035116A patent/NO20035116D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20040000467A (ko)	2004-01-03
CZ20033085A3 (cs)	2004-05-12
SK13952003A3 (sk)	2004-04-06
BG108326A (bg)	2004-12-30
PL366640A1 (en)	2005-02-07
CA2446332A1 (en)	2002-11-28
US20040142967A1 (en)	2004-07-22
AR035973A1 (es)	2004-07-28
IS7026A (is)	2003-11-11
EP1395576A1 (de)	2004-03-10
IL158704A0 (en)	2004-05-12
NO20035116D0 (no)	2003-11-17
US7074808B2 (en)	2006-07-11
EE200300540A (et)	2004-02-16
RU2003131970A (ru)	2005-05-10
BR0209676A (pt)	2004-07-27
ATE303379T1 (de)	2005-09-15
DE60205894T2 (de)	2006-06-08
ZA200308633B (en)	2005-02-07
CN1509282A (zh)	2004-06-30
EP1395576B1 (de)	2005-08-31
CO5611136A2 (es)	2006-02-28
MXPA03010439A (es)	2004-03-09
JP2005510457A (ja)	2005-04-21
HUP0401096A2 (hu)	2004-09-28
SE0101765D0 (sv)	2001-05-18
WO2002094812A1 (en)	2002-11-28

Publication	Publication Date	Title
ATE420866T1 (de)	2009-01-15	4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
DE60204548D1 (de)	2005-07-14	Mch antagonisten und deren verwendung zur behandlung von fettleibigkeit
DE60140377D1 (de)	2009-12-17	Mch antagonisten und deren verwendung zur behandlung von fettleibigkeit
DE60319865D1 (de)	2008-04-30	Substituierte amin-derivate und deren verwendung zur behandlung von angionese-bedingten erkrankungen
DE60205894D1 (de)	2005-10-06	4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
EE200300527A (et)	2004-02-16	4-(fenüülpiperidiin-4-ülideenmetüül)bensamiidi derivaadid ja nende kasutamine valu, ärevuse või seedetrakti häirete raviks
ATE362923T1 (de)	2007-06-15	4-(phenylpiperazinylmethyl)benzamidderivate und deren verwendung zur behandlung von schmerzen oder gastrointestinalen erkrankungen
ATE333452T1 (de)	2006-08-15	4-(penylpiperidin-4-ylidenmethyl)benzamidderiva e und deren verwendung zur behandlung von schmerzen,angstzuständen oder erkrankungen des magen-darm- trakts
DE60202679D1 (de)	2005-02-24	4-(phenylpiperidin-4-ylidenmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
DE60117122D1 (de)	2006-04-20	Verwendung von mirtazapin zur behandlung von schlafstörungen
DE60208192D1 (de)	2006-01-26	4-(phenyl(piperidin-4-yl)amino) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
DE60208193D1 (de)	2006-01-26	4-(phenyl(piperidin-4-yl)amino) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
EE200300535A (et)	2004-02-16	4-(fenüül(piperidiin-4-üül)amino)bensamiidi derivaadid ja nende kasutamine valu, ärevuse või seedetrakti häirete raviks
EE200300526A (et)	2004-02-16	4-(fenüül(piperidiin-4-üül)amino)bensamiidi derivaadid ja nende kasutamine valu, ärevuse või seedetrakti häirete raviks

Legal Events

Date	Code	Title	Description
2006-09-21	8364	No opposition during term of opposition
2011-03-24	8339	Ceased/non-payment of the annual fee