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MX353720B - Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3. - Google Patents

Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3.

Info

Publication number
MX353720B
MX353720B MX2013006831A MX2013006831A MX353720B MX 353720 B MX353720 B MX 353720B MX 2013006831 A MX2013006831 A MX 2013006831A MX 2013006831 A MX2013006831 A MX 2013006831A MX 353720 B MX353720 B MX 353720B
Authority
MX
Mexico
Prior art keywords
amino acid
molecules modified
analogue molecules
cyclosporine analogue
cyclosporin
Prior art date
Application number
MX2013006831A
Other languages
English (en)
Other versions
MX2013006831A (es
Inventor
Hegmans Alexander
W Fenske Bruce
J Trepanier Dan
D Abel Mark
Sugiyama Shin
R Ure Daren
Original Assignee
Contravir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contravir Pharmaceuticals Inc filed Critical Contravir Pharmaceuticals Inc
Publication of MX2013006831A publication Critical patent/MX2013006831A/es
Publication of MX353720B publication Critical patent/MX353720B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Diabetes (AREA)
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Abstract

La presente invención se refiere a análogos de ciclosporina-A que comprenden modificaciones de los substituyentes como las posiciones de aminoácidos 1 y 3, de acuerdo con la siguiente Fórmula (I). Los compuestos descritos incluyen compuestos que tienen afinidad para ciclofilina incluyendo ciclofilina-A, e inmunosupresión reducida en comparación con ciclosporina-A y sus análogos modificados solamente en la posición 1.
MX2013006831A 2010-12-15 2011-12-14 Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3. MX353720B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

Publications (2)

Publication Number Publication Date
MX2013006831A MX2013006831A (es) 2014-10-14
MX353720B true MX353720B (es) 2018-01-25

Family

ID=46243924

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006831A MX353720B (es) 2010-12-15 2011-12-14 Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3.

Country Status (25)

Country Link
US (2) US9200038B2 (es)
EP (2) EP2651965B1 (es)
JP (3) JP6144627B2 (es)
KR (3) KR102011339B1 (es)
CN (2) CN107496902B (es)
AU (1) AU2011342284C1 (es)
BR (1) BR112013014890B1 (es)
CA (1) CA2821009C (es)
DK (1) DK2651965T3 (es)
ES (1) ES2705750T3 (es)
HK (1) HK1243633A1 (es)
HR (1) HRP20190096T1 (es)
HU (1) HUE042490T2 (es)
IL (1) IL226792A (es)
LT (1) LT2651965T (es)
MX (1) MX353720B (es)
MY (2) MY165152A (es)
NZ (1) NZ611620A (es)
PL (1) PL2651965T3 (es)
PT (1) PT2651965T (es)
RU (1) RU2630690C9 (es)
SG (2) SG10201510236XA (es)
SI (1) SI2651965T1 (es)
TR (1) TR201900128T4 (es)
WO (1) WO2012079172A1 (es)

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AR111464A1 (es) 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales
US11098073B2 (en) 2017-04-20 2021-08-24 Oxford University Innovation Limited Triphenylphosphonium-tethered tetracyclines for use in treating cancer
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CN112888452A (zh) * 2018-08-22 2021-06-01 贝凯恩生物医疗技术有限公司 环孢菌素组合物及使用方法
TW202140057A (zh) * 2020-02-25 2021-11-01 美商希皮恩製藥公司 環孢素類似物於治療癌症之用途
CA3172535A1 (en) 2020-03-26 2021-09-30 Ching-Pong Mak Cyclophilin inhibitors and uses thereof
TW202144378A (zh) * 2020-03-26 2021-12-01 大陸商睿諾醫療科技（上海）有限公司 親環蛋白抑制劑及其用途
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CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
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