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MX345095B - Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. - Google Patents

Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Info

Publication number
MX345095B
MX345095B MX2013014364A MX2013014364A MX345095B MX 345095 B MX345095 B MX 345095B MX 2013014364 A MX2013014364 A MX 2013014364A MX 2013014364 A MX2013014364 A MX 2013014364A MX 345095 B MX345095 B MX 345095B
Authority
MX
Mexico
Prior art keywords
suffering
subject
irna
methods
angptl3
Prior art date
Application number
MX2013014364A
Other languages
English (en)
Other versions
MX2013014364A (es
Inventor
Fitzgerald Kevin
Milstein Stuart
Bettencourt Brian
Querbes William
Frank-Kamenetsky Maria
Shulga-Morskaya Svetlana
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47423191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX345095(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2013014364A publication Critical patent/MX2013014364A/es
Publication of MX345095B publication Critical patent/MX345095B/es

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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un agente de ácido ribonucleico de doble hebra (ARNds) para inhibir la expresión de la Angiopoyetina tipo 3 (ANGPTL3), caracterizado porque el agente ARNds comprende una hebra sentido o directa y una hebra antisentido, la hebra antisentido comprende una región de complementariedad que comprende por lo menos 21 nucleótidos contiguos que difieren por no más de 3 nucleótidos de la secuencia de nucleótidos o nucleótida ( SEQ ID NO: 471), en donde todo de los nucleótidos de la hebra directa y todo de los nucleótidos de la hebra antisentido son nucleótidos modificados, en donde las modificaciones de nucleótidos se seleccionan del grupo que consiste de las modificaciones de nucleótidos 2´-O-metilo (2´-OMe) y 2´-fluoro, y en donde un ligando que comprende un derivado de N-acetilgalactosamina (GalNAc) es conjugado al extremo 3´de la hebra directa del agente de ARNds.
MX2013014364A 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. MX345095B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161499620P 2011-06-21 2011-06-21
US201261638288P 2012-04-25 2012-04-25
PCT/US2012/043378 WO2012177784A2 (en) 2011-06-21 2012-06-20 Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2013014364A MX2013014364A (es) 2014-07-30
MX345095B true MX345095B (es) 2017-01-17

Family

ID=47423191

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2017000476A MX360782B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2013014364A MX345095B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2023000053A MX2023000053A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2022012087A MX2022012087A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017000476A MX360782B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2023000053A MX2023000053A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2022012087A MX2022012087A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Country Status (14)

Country Link
US (16) US9322018B2 (es)
EP (4) EP4092120A1 (es)
JP (5) JP6110372B2 (es)
KR (4) KR102395085B1 (es)
CN (3) CN103890000B (es)
AU (5) AU2012272970A1 (es)
BR (2) BR112013033260B1 (es)
CA (1) CA2839573A1 (es)
ES (1) ES2923573T3 (es)
HK (1) HK1199457A1 (es)
MX (4) MX360782B (es)
RU (1) RU2711799C2 (es)
SG (2) SG10201800715PA (es)
WO (1) WO2012177784A2 (es)

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