MX2020003579A - Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. - Google Patents
Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.Info
- Publication number
- MX2020003579A MX2020003579A MX2020003579A MX2020003579A MX2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazine
- pyridine
- triazine compounds
- shp2 inhibitors
- allosteric shp2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente descripción está dirigida a los inhibidores de SHP2 y a su uso en el tratamiento de enfermedades. También se describen composiciones farmacéuticas que los comprenden.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762571760P | 2017-10-12 | 2017-10-12 | |
| US201862615353P | 2018-01-09 | 2018-01-09 | |
| US201862678889P | 2018-05-31 | 2018-05-31 | |
| PCT/US2018/055502 WO2019075265A1 (en) | 2017-10-12 | 2018-10-11 | PYRIDINE, PYRAZINE AND TRIAZINE COMPOUNDS AS ALLOSTERIC INHIBITORS OF SHP2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003579A true MX2020003579A (es) | 2020-07-22 |
Family
ID=64049755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003579A MX2020003579A (es) | 2017-10-12 | 2018-10-11 | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11702411B2 (es) |
| EP (1) | EP3694848A1 (es) |
| JP (1) | JP2020536881A (es) |
| KR (1) | KR20200070295A (es) |
| CN (1) | CN111212834B (es) |
| AU (1) | AU2018347516A1 (es) |
| BR (1) | BR112020007058A2 (es) |
| CA (1) | CA3078565A1 (es) |
| CO (1) | CO2020003714A2 (es) |
| IL (1) | IL273756A (es) |
| MX (1) | MX2020003579A (es) |
| PH (1) | PH12020550216A1 (es) |
| RU (1) | RU2020115095A (es) |
| SG (1) | SG11202002941WA (es) |
| TW (1) | TW201930292A (es) |
| WO (1) | WO2019075265A1 (es) |
Families Citing this family (66)
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| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| WO2017210134A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Heterocyclic inhibitors of ptpn11 |
| DK3464272T3 (da) | 2016-06-07 | 2022-02-21 | Jacobio Pharmaceuticals Co Ltd | Nye heterocykliske derivater som SHP2-inhibitorer |
| PL3468972T3 (pl) | 2016-06-14 | 2020-11-16 | Novartis Ag | Związki i kompozycje do hamowania aktywności shp2 |
| MX2019000548A (es) | 2016-07-12 | 2019-10-30 | Revolution Medicines Inc | 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostericos de shp2. |
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| JP2020536881A (ja) | 2020-12-17 |
| CN111212834A (zh) | 2020-05-29 |
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| KR20200070295A (ko) | 2020-06-17 |
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| BR112020007058A2 (pt) | 2020-10-06 |
| CA3078565A1 (en) | 2019-04-18 |
| CN111212834B (zh) | 2024-01-19 |
| WO2019075265A1 (en) | 2019-04-18 |
| CO2020003714A2 (es) | 2020-04-24 |
| PH12020550216A1 (en) | 2021-02-15 |
| US20200339552A1 (en) | 2020-10-29 |
| US11702411B2 (en) | 2023-07-18 |
| RU2020115095A (ru) | 2021-11-12 |
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