ATE441727T1 - Noonansyndromgen - Google Patents
NoonansyndromgenInfo
- Publication number
- ATE441727T1 ATE441727T1 AT02800416T AT02800416T ATE441727T1 AT E441727 T1 ATE441727 T1 AT E441727T1 AT 02800416 T AT02800416 T AT 02800416T AT 02800416 T AT02800416 T AT 02800416T AT E441727 T1 ATE441727 T1 AT E441727T1
- Authority
- AT
- Austria
- Prior art keywords
- ptpn11
- variants
- diagnostic
- noonanic
- therapeutic applications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32653201P | 2001-10-01 | 2001-10-01 | |
| PCT/US2002/031290 WO2003029422A2 (en) | 2001-10-01 | 2002-10-01 | Noonan syndrome gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441727T1 true ATE441727T1 (de) | 2009-09-15 |
Family
ID=23272619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02800416T ATE441727T1 (de) | 2001-10-01 | 2002-10-01 | Noonansyndromgen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7335469B2 (de) |
| EP (1) | EP1448587B1 (de) |
| AT (1) | ATE441727T1 (de) |
| AU (1) | AU2002334773A1 (de) |
| CA (1) | CA2495529C (de) |
| DE (1) | DE60233586D1 (de) |
| WO (1) | WO2003029422A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5219516B2 (ja) * | 2005-03-18 | 2013-06-26 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 染色体異数性の検出方法 |
| US7776551B2 (en) * | 2005-07-12 | 2010-08-17 | Ramot At Tel Aviv University Ltd. | Methods and kits for diagnosing and treating mental retardation |
| CA2669384C (en) * | 2006-11-16 | 2019-03-19 | The Regents Of The University Of California | Compositions and methods for detecting noonan syndrome |
| WO2010129805A1 (en) * | 2009-05-06 | 2010-11-11 | Mount Sinai School Of Medicine Of New York University | Shoc2 mutations causing noonan-like syndrome with loose anagen hair |
| CN102108365A (zh) * | 2009-12-29 | 2011-06-29 | 上海新号源生物科技有限公司 | 一组恶性肿瘤中突变PTPα基因及其应用 |
| WO2011120902A1 (en) * | 2010-03-29 | 2011-10-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and tumor initiating cells |
| KR102598895B1 (ko) | 2016-07-12 | 2023-11-07 | 레볼루션 메디슨즈, 인크. | 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 |
| KR102665763B1 (ko) | 2017-01-23 | 2024-05-10 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 이환 화합물 |
| RU2019126455A (ru) | 2017-01-23 | 2021-02-24 | Революшн Медсинз, Инк. | Пиридиновые соединения в качестве аллостерических ингибиторов shp2 |
| KR20200051684A (ko) | 2017-09-07 | 2020-05-13 | 레볼루션 메디슨즈, 인크. | 암 치료를 위한 shp2 억제제 조성물 및 방법 |
| AU2018347516A1 (en) | 2017-10-12 | 2020-05-07 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors |
| IL277783B2 (en) * | 2018-04-10 | 2024-07-01 | Revolution Medicines Inc | SHP2 inhibitory compositions, methods for treating cancer and methods for identifying a subject with SHP2 mutations |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| EP0710720A1 (de) | 1988-06-13 | 1996-05-08 | American Biogenetic Sciences, Inc. | Verfahren zur Herstellung monoklonaler Antikörper mit Hilfe einer keimfreien Tieres |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5783682A (en) | 1990-07-27 | 1998-07-21 | Isis Pharmaceuticals, Inc. | Oligonucleotide mimics having nitrogen-containing linkages |
| US5792844A (en) | 1990-07-27 | 1998-08-11 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent nitrogen atoms |
| US5536636A (en) * | 1991-06-26 | 1996-07-16 | Beth Israel Hospital | Methods for identifying a tyrosine phosphatase abnormality associated with neoplastic disease |
| MX9304769A (es) * | 1992-08-05 | 1994-05-31 | Max Planck Gesellschaft | Subfamilia ptp-d de fosfatasas de la proteina tirosina. |
| US5589375A (en) * | 1992-10-06 | 1996-12-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. | PTP 1D: a novel protein tyrosine phosphatase |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| WO1999023493A1 (en) | 1997-10-31 | 1999-05-14 | The Rockefeller University | Methods of identifying agents that modulate leptin activity |
| CA2321226C (en) * | 1998-04-15 | 2011-06-07 | Genset S.A. | Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma |
| US6156551A (en) | 1998-06-05 | 2000-12-05 | Beth Israel Deaconess Medical Center | Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof |
| US6200807B1 (en) * | 1999-07-21 | 2001-03-13 | Isis Pharmaceuticals Inc. | Antisense inhibition of SHP-2 expression |
-
2002
- 2002-10-01 AU AU2002334773A patent/AU2002334773A1/en not_active Abandoned
- 2002-10-01 DE DE60233586T patent/DE60233586D1/de not_active Expired - Lifetime
- 2002-10-01 AT AT02800416T patent/ATE441727T1/de not_active IP Right Cessation
- 2002-10-01 CA CA002495529A patent/CA2495529C/en not_active Expired - Lifetime
- 2002-10-01 EP EP02800416A patent/EP1448587B1/de not_active Expired - Lifetime
- 2002-10-01 WO PCT/US2002/031290 patent/WO2003029422A2/en not_active Application Discontinuation
- 2002-10-01 US US10/262,552 patent/US7335469B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002334773A1 (en) | 2003-04-14 |
| US7335469B2 (en) | 2008-02-26 |
| DE60233586D1 (en) | 2009-10-15 |
| WO2003029422A2 (en) | 2003-04-10 |
| CA2495529C (en) | 2009-05-19 |
| EP1448587A4 (de) | 2005-06-08 |
| EP1448587B1 (de) | 2009-09-02 |
| US20030125289A1 (en) | 2003-07-03 |
| EP1448587A2 (de) | 2004-08-25 |
| CA2495529A1 (en) | 2003-04-10 |
| WO2003029422A3 (en) | 2003-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |