[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX2018008824A - Preparacion de particulas micronizadas de un compuesto antimuscarinico por cavitacion hidrodinamica. - Google Patents

Preparacion de particulas micronizadas de un compuesto antimuscarinico por cavitacion hidrodinamica.

Info

Publication number
MX2018008824A
MX2018008824A MX2018008824A MX2018008824A MX2018008824A MX 2018008824 A MX2018008824 A MX 2018008824A MX 2018008824 A MX2018008824 A MX 2018008824A MX 2018008824 A MX2018008824 A MX 2018008824A MX 2018008824 A MX2018008824 A MX 2018008824A
Authority
MX
Mexico
Prior art keywords
preparation
hydrodynamic cavitation
micronized particles
antimuscarinic compound
antimuscarinic
Prior art date
Application number
MX2018008824A
Other languages
English (en)
Inventor
Miozzi Michele
J Rouse Timothy
E Nall Barry
P Davanzo Stephen
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MX2018008824A publication Critical patent/MX2018008824A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/008—Processes for carrying out reactions under cavitation conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/06—Solidifying liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con un procedimiento para la preparación de un material particulado micronizado cristalino de una sal de glucopirronio por cavitación hidrodinámica. Las partículas de medicamento resultantes son físicamente estables con respecto a aglomeración y/o agregación al almacenamiento.
MX2018008824A 2016-01-22 2017-01-24 Preparacion de particulas micronizadas de un compuesto antimuscarinico por cavitacion hidrodinamica. MX2018008824A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16152461 2016-01-22
PCT/EP2017/051405 WO2017125611A1 (en) 2016-01-22 2017-01-24 Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation

Publications (1)

Publication Number Publication Date
MX2018008824A true MX2018008824A (es) 2019-11-05

Family

ID=55237522

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008824A MX2018008824A (es) 2016-01-22 2017-01-24 Preparacion de particulas micronizadas de un compuesto antimuscarinico por cavitacion hidrodinamica.

Country Status (13)

Country Link
US (1) US9925168B2 (es)
EP (1) EP3405173B1 (es)
KR (1) KR102676105B1 (es)
CN (1) CN108633257B (es)
AR (1) AR107406A1 (es)
BR (1) BR112018014858B1 (es)
CA (1) CA3012062C (es)
ES (1) ES2935112T3 (es)
MA (1) MA43662A (es)
MX (1) MX2018008824A (es)
PL (1) PL3405173T3 (es)
RU (1) RU2723549C2 (es)
WO (1) WO2017125611A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US7314516B2 (en) 2004-12-29 2008-01-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
GB0504463D0 (en) * 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
GB0613161D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
CA2707594C (en) * 2007-12-13 2015-08-18 Novartis Ag Process for preparing particulates of crystalline drug substance
CN101896162B (zh) 2007-12-13 2013-06-05 诺瓦提斯公司 有机化合物
US9393202B2 (en) * 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
US9554992B2 (en) 2014-06-09 2017-01-31 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic

Also Published As

Publication number Publication date
AR107406A1 (es) 2018-04-25
RU2723549C2 (ru) 2020-06-16
KR102676105B1 (ko) 2024-06-19
MA43662A (fr) 2021-04-28
CN108633257B (zh) 2023-06-06
US20170209414A1 (en) 2017-07-27
BR112018014858A2 (pt) 2018-12-18
ES2935112T3 (es) 2023-03-01
BR112018014858B1 (pt) 2023-10-03
CN108633257A (zh) 2018-10-09
PL3405173T3 (pl) 2023-03-13
EP3405173A1 (en) 2018-11-28
KR20190102981A (ko) 2019-09-04
US9925168B2 (en) 2018-03-27
BR112018014858A8 (pt) 2019-01-08
EP3405173B1 (en) 2022-12-07
RU2018130313A (ru) 2020-02-25
RU2018130313A3 (es) 2020-03-13
CA3012062C (en) 2023-10-17
WO2017125611A1 (en) 2017-07-27
CA3012062A1 (en) 2017-07-27

Similar Documents

Publication Publication Date Title
PH12015502449A1 (en) Particle size reduction of an antimuscarinic compound
BR112018006121A2 (pt) fármacos antiestrogênicos de tetra-hidro-1h-pirido[3,4-b]indol
MX2017001619A (es) Encapsulacion de compuestos hidrofobicos biologicamente activos.
UA122781C2 (uk) Пестицидно активні гетероциклічні похідні з сірковмісними замісниками
EP4397659A3 (en) Preparation containing tetracyclic compound at high dose
PH12019500727A1 (en) Crystalline and salt forms of ppar agonist compounds
EP2670397A1 (en) Pharmaceutical formulations including an amine compound
MD4490B1 (ro) Noi compuşi de indolizină, procedeu de obţinere a lor şi compoziţii farmaceutice care îi conţin
TN2016000127A1 (en) Heteroaryl butanoic acid derivatives as lta4h inhibitors.
MX2018005520A (es) Metodos para preparacion de acido obeticolico y derivados de los mismos.
MX2016009049A (es) Composicion farmaceutica que contiene compuesto de acido piridilaminoacetico.
WO2016016766A3 (en) A process for the preparation of isavuconazonium or its salt thereof
IL260040A (en) Complexes of celecoxib and its salts and derivatives, a process for their preparation and pharmaceutical preparations containing them
CL2015002712A1 (es) Cristales de laquinimod sódico y proceso para la preparación de ellos
CA2922375C (en) Alpha-tea salt forms: compositions and uses for treating disease
MX2018012777A (es) Métodos para preparación de ácido obeticólico y derivados de los mismos.
MX2015016958A (es) Sintesis de dicarbamatos de isohexida y derivados de estos.
MX2018008824A (es) Preparacion de particulas micronizadas de un compuesto antimuscarinico por cavitacion hidrodinamica.
SG11201903463PA (en) Quinolyl-substituted carboxylic acid compound or pharmaceutically acceptable salt thereof, pharmaceutical composition of the same, and use of the same
MX2018013764A (es) Cristal de derivado de quinolina.
BR112017004166A2 (pt) sal de derivado de cefalosporina, forma sólida cristalina do mesmo e método para produzir o mesmo
MX2018001219A (es) Composicion farmaceutica con estabilidad de almacenamiento mejorada y metodo para prepararla.
TH163807B (th) การลดขนาดอนุภาคของสารประกอบต้านมัสคารีน
TH163807A (th) การลดขนาดอนุภาคของสารประกอบต้านมัสคารีน
MY192061A (en) Pharmaceutical composition for external use