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MX2015016958A - Sintesis de dicarbamatos de isohexida y derivados de estos. - Google Patents

Sintesis de dicarbamatos de isohexida y derivados de estos.

Info

Publication number
MX2015016958A
MX2015016958A MX2015016958A MX2015016958A MX2015016958A MX 2015016958 A MX2015016958 A MX 2015016958A MX 2015016958 A MX2015016958 A MX 2015016958A MX 2015016958 A MX2015016958 A MX 2015016958A MX 2015016958 A MX2015016958 A MX 2015016958A
Authority
MX
Mexico
Prior art keywords
isohexide
dicarbamates
synthesis
derivatives
isohexide dicarbamates
Prior art date
Application number
MX2015016958A
Other languages
English (en)
Inventor
Kenneth Stensrud
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Publication of MX2015016958A publication Critical patent/MX2015016958A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G12/00—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen
    • C08G12/02—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes
    • C08G12/26—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G71/00—Macromolecular compounds obtained by reactions forming a ureide or urethane link, otherwise, than from isocyanate radicals in the main chain of the macromolecule
    • C08G71/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describen compuestos que son dicarbamatos de isohexida y un método para su preparación. El método implica hacer reaccionar una mezcla de una isohexida y una sal de cianato en un disolvente no acuoso, con un ácido miscible que tiene un pKa menor o igual a aproximadamente 3.7. Los dicarbamatos de isohexida pueden servir de materiales precursores a partir de los cuales se pueden sintetizar diversos compuestos derivados.
MX2015016958A 2013-06-12 2014-05-07 Sintesis de dicarbamatos de isohexida y derivados de estos. MX2015016958A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361833951P 2013-06-12 2013-06-12
PCT/US2014/037049 WO2014200637A1 (en) 2013-06-12 2014-05-07 Synthesis of isohexide dicarbamates and derivatives thereof

Publications (1)

Publication Number Publication Date
MX2015016958A true MX2015016958A (es) 2016-04-25

Family

ID=52022651

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015016958A MX2015016958A (es) 2013-06-12 2014-05-07 Sintesis de dicarbamatos de isohexida y derivados de estos.
MX2015016957A MX2015016957A (es) 2013-06-12 2014-05-07 Sintesis de dicarbamatos a partir de productos de la reduccion de 2-hidroximetil-5-furfural (hmf) y sus derivados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015016957A MX2015016957A (es) 2013-06-12 2014-05-07 Sintesis de dicarbamatos a partir de productos de la reduccion de 2-hidroximetil-5-furfural (hmf) y sus derivados.

Country Status (10)

Country Link
US (4) US9422304B2 (es)
EP (2) EP3008072A4 (es)
JP (2) JP2016523239A (es)
KR (2) KR20160018697A (es)
CN (2) CN105228998A (es)
AU (2) AU2014278694A1 (es)
BR (2) BR112015029004A2 (es)
CA (2) CA2908859A1 (es)
MX (2) MX2015016958A (es)
WO (2) WO2014200636A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102517425B1 (ko) 2013-06-27 2023-03-31 아이사이트 모빌 테크놀로지 엘티디 디지털 디바이스와 상호작용을 위한 다이렉트 포인팅 검출 시스템 및 방법
MX2016007862A (es) * 2013-12-19 2016-09-07 Archer Daniels Midland Co Sulfonatos de furan-2, 5-dimetanol y (tetrahidrofuran-2, 5-diil)dimetanol y derivados de los mismos.
JPWO2017146186A1 (ja) * 2016-02-26 2018-12-20 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５−フェニルアザインドール誘導体
WO2018220003A1 (en) * 2017-05-31 2018-12-06 Basf Se Hydrogenation of substituted furans catalyzed by nhc-containing ligands
KR102026445B1 (ko) 2017-12-01 2019-09-27 한국화학연구원 다이아민 화합물로부터 다이카바메이트 화합물의 제조방법 및 그 촉매

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US3073848A (en) * 1958-10-14 1963-01-15 Wasson Burton Kendall Tetrahydrofurfuryl carbamates
US4169152A (en) * 1977-10-31 1979-09-25 Ici Americas Inc. Isohexide and tetrahydrofuran ethers and their carbamates in method of bringing about relaxation of skeletal musculature
DE3028289C2 (de) * 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US4632937A (en) * 1984-12-21 1986-12-30 Ici Americas Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation
US4619917A (en) * 1985-07-18 1986-10-28 Sandoz Pharm. Corp. Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts
US4820718A (en) * 1987-09-17 1989-04-11 Sandoz Pharm. Corp. N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts and use thereof in PAF inhibition
ES2010568A6 (es) * 1988-08-04 1989-11-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.
WO1995034567A1 (en) * 1994-06-14 1995-12-21 Biochimica Opos Spa Cyclohexanocephalosporins and their preparation procedure
TW291481B (en) * 1994-10-27 1996-11-21 Novartis Erfind Verwalt Gmbh Poly-unsaturated carbohydrate derivatives, polymers thereof and their use
CN1162315A (zh) * 1994-10-27 1997-10-15 诺瓦提斯公司 多-不饱和糖类衍生物，其聚合物及它们的应用
WO1996034567A1 (en) * 1995-05-02 1996-11-07 Heart Rhythm Technologies, Inc. System for controlling the energy delivered to a patient for ablation
EP2945951B1 (en) * 2013-01-16 2020-10-14 DENTSPLY SIRONA Inc. Dental compositions based on polymerizable resins containing isosorbide
CN103058962B (zh) * 2013-01-24 2015-01-21 中国科学院青岛生物能源与过程研究所 一种由糠醇制备2,5-呋喃二甲醇二烷基醚的方法

Also Published As

Publication number Publication date
US9422304B2 (en) 2016-08-23
CA2909059A1 (en) 2014-12-18
CN105263938A (zh) 2016-01-20
EP3008058A1 (en) 2016-04-20
KR20160018697A (ko) 2016-02-17
US20160031842A1 (en) 2016-02-04
US20160083396A1 (en) 2016-03-24
CA2908859A1 (en) 2014-12-18
JP2016523240A (ja) 2016-08-08
JP2016523239A (ja) 2016-08-08
EP3008072A1 (en) 2016-04-20
US20160326185A1 (en) 2016-11-10
AU2014278694A1 (en) 2015-10-29
WO2014200636A1 (en) 2014-12-18
AU2014278693A1 (en) 2015-10-29
KR20160018679A (ko) 2016-02-17
EP3008058A4 (en) 2017-02-15
CN105228998A (zh) 2016-01-06
US9487537B2 (en) 2016-11-08
WO2014200637A1 (en) 2014-12-18
BR112015029004A2 (pt) 2017-07-25
EP3008072A4 (en) 2017-02-15
BR112015028740A2 (pt) 2017-07-25
MX2015016957A (es) 2016-04-25
US20170029395A1 (en) 2017-02-02

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