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MX2018005520A - Metodos para preparacion de acido obeticolico y derivados de los mismos. - Google Patents

Metodos para preparacion de acido obeticolico y derivados de los mismos.

Info

Publication number
MX2018005520A
MX2018005520A MX2018005520A MX2018005520A MX2018005520A MX 2018005520 A MX2018005520 A MX 2018005520A MX 2018005520 A MX2018005520 A MX 2018005520A MX 2018005520 A MX2018005520 A MX 2018005520A MX 2018005520 A MX2018005520 A MX 2018005520A
Authority
MX
Mexico
Prior art keywords
derivatives
preparation
methods
obeticholic acid
klca
Prior art date
Application number
MX2018005520A
Other languages
English (en)
Inventor
M Galvin Gabrial
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of MX2018005520A publication Critical patent/MX2018005520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente solicitud se refiere a un método para preparar un derivado de ácido biliar, o una sal, solvato o conjugado de aminoácidos farmacéuticamente aceptable del mismo, que comprende la alquilación directa en la posición C-6 de KLCA.
MX2018005520A 2015-11-06 2016-10-28 Metodos para preparacion de acido obeticolico y derivados de los mismos. MX2018005520A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562252077P 2015-11-06 2015-11-06
PCT/US2016/059440 WO2017079062A1 (en) 2015-11-06 2016-10-28 Methods for the preparation of obeticholic acid and derivatives thereof

Publications (1)

Publication Number Publication Date
MX2018005520A true MX2018005520A (es) 2018-08-01

Family

ID=58662647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005520A MX2018005520A (es) 2015-11-06 2016-10-28 Metodos para preparacion de acido obeticolico y derivados de los mismos.

Country Status (14)

Country Link
US (1) US10604545B2 (es)
EP (1) EP3370728A4 (es)
JP (1) JP6749406B2 (es)
KR (1) KR20180067699A (es)
CN (1) CN108348533A (es)
AR (1) AR106587A1 (es)
AU (1) AU2016350690C1 (es)
BR (1) BR112018008936A2 (es)
CA (1) CA3004275A1 (es)
HK (1) HK1254055A1 (es)
IL (1) IL258922A (es)
MX (1) MX2018005520A (es)
TW (1) TW201720839A (es)
WO (1) WO2017079062A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7308811B2 (ja) * 2017-07-26 2023-07-14 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ステロイド系誘導体ｆｘｒアゴニストの製造方法
CN107383139A (zh) * 2017-08-09 2017-11-24 杭州和泽医药科技有限公司 一种3α‑羟基‑7‑氧代‑5β‑胆烷酸新衍生物制备奥贝胆酸的方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
WO2021029656A1 (ko) * 2019-08-14 2021-02-18 주식회사 바이오톡스텍 하이드로퀴논 유도체, 및 오베티콜릭산을 포함하는 비알콜성 지방간염의 예방 또는 치료용 약학조성물
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
BR112022023359A2 (pt) 2020-05-19 2023-04-18 Kallyope Inc Ativadores de ampk
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
US11384116B2 (en) 2020-08-21 2022-07-12 Sandhill One, Llc Methods of making cholic acid derivatives and starting materials therefor
CA3235515A1 (en) 2021-11-02 2023-05-11 Sandhill One, Llc High purity non-animal derived tudca
WO2023081166A1 (en) 2021-11-02 2023-05-11 Sandhill One, Llc Stereoselective steroidal reductions
CA3235506A1 (en) 2021-11-02 2023-05-11 Sandhill One, Llc High purity non-animal derived udca

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138390B2 (en) 2001-03-12 2006-11-21 Intercept Pharmaceuticals Steroids as agonists for FXR
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
US8338628B2 (en) * 2007-08-28 2012-12-25 City Of Hope Method of synthesizing alkylated bile acid derivatives
KR102116955B1 (ko) 2012-02-07 2020-06-01 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 탄탈룸 코팅된 나노구조를 갖는 제조산물, 이를 제조 및 사용하는 방법
NZ734451A (en) 2012-06-19 2018-12-21 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid
NZ707389A (en) * 2012-10-26 2018-08-31 Intercept Pharmaceuticals Inc Process for preparing bile acid derivatives
CN104876995B (zh) 2014-02-27 2016-09-07 人福医药集团股份公司 鹅去氧胆酸衍生物的制备方法
CN104558086B (zh) * 2014-12-25 2016-10-05 康美（北京）药物研究院有限公司 一种5β-3α,7α-二羟基-6α-乙基-胆烷酸的制备方法

Also Published As

Publication number Publication date
KR20180067699A (ko) 2018-06-20
US20190062367A1 (en) 2019-02-28
EP3370728A1 (en) 2018-09-12
AR106587A1 (es) 2018-01-31
JP2018532800A (ja) 2018-11-08
AU2016350690C1 (en) 2020-04-23
AU2016350690B2 (en) 2019-12-12
AU2016350690A1 (en) 2018-05-10
CA3004275A1 (en) 2017-05-11
WO2017079062A1 (en) 2017-05-11
TW201720839A (zh) 2017-06-16
BR112018008936A2 (pt) 2018-11-27
HK1254055A1 (zh) 2019-07-12
EP3370728A4 (en) 2019-07-10
CN108348533A (zh) 2018-07-31
US10604545B2 (en) 2020-03-31
IL258922A (en) 2018-06-28
JP6749406B2 (ja) 2020-09-02

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