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MX2017010291A - Inhibidores de kdm1a para el tratamiento de enfermedades. - Google Patents

Inhibidores de kdm1a para el tratamiento de enfermedades.

Info

Publication number
MX2017010291A
MX2017010291A MX2017010291A MX2017010291A MX2017010291A MX 2017010291 A MX2017010291 A MX 2017010291A MX 2017010291 A MX2017010291 A MX 2017010291A MX 2017010291 A MX2017010291 A MX 2017010291A MX 2017010291 A MX2017010291 A MX 2017010291A
Authority
MX
Mexico
Prior art keywords
methods
treatment
diseases
kdm1a
geologic environment
Prior art date
Application number
MX2017010291A
Other languages
English (en)
Inventor
Celatka Cassandra
M Mccall John
Clare Michael
Young Rienhoff Hugh Jr
E Tapper Amy
Original Assignee
Imago Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imago Biosciences Inc filed Critical Imago Biosciences Inc
Publication of MX2017010291A publication Critical patent/MX2017010291A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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Abstract

En el presente documento se dan a conocer nuevos compuestos y composiciones, y su aplicación como productos farmacéuticos para el tratamiento de enfermedades. También se proporcionan métodos de inhibición de KDM1A, métodos para incrementar la expresión del gen de gamma globina y métodos para inducir la diferenciación de células cancerosas en un sujeto humano o animal, para el tratamiento de enfermedades tales como la leucemia mielógena aguda.
MX2017010291A 2015-02-12 2016-02-12 Inhibidores de kdm1a para el tratamiento de enfermedades. MX2017010291A (es)

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PCT/US2016/017809 WO2016130952A1 (en) 2015-02-12 2016-02-12 Kdm1a inhibitors for the treatment of disease

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EP3256218A4 (en) 2018-08-08

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