SI3160956T1 - Inhibitorji lizin-specifične demetilaze-1 - Google Patents
Inhibitorji lizin-specifične demetilaze-1Info
- Publication number
- SI3160956T1 SI3160956T1 SI201531328T SI201531328T SI3160956T1 SI 3160956 T1 SI3160956 T1 SI 3160956T1 SI 201531328 T SI201531328 T SI 201531328T SI 201531328 T SI201531328 T SI 201531328T SI 3160956 T1 SI3160956 T1 SI 3160956T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitors
- specific demethylase
- lysine specific
- lysine
- demethylase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462018365P | 2014-06-27 | 2014-06-27 | |
| EP15811526.1A EP3160956B1 (en) | 2014-06-27 | 2015-06-26 | Inhibitors of lysine specific demethylase-1 |
| PCT/US2015/038089 WO2015200843A1 (en) | 2014-06-27 | 2015-06-26 | Inhibitors of lysine specific demethylase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3160956T1 true SI3160956T1 (sl) | 2020-11-30 |
Family
ID=54938856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531328T SI3160956T1 (sl) | 2014-06-27 | 2015-06-26 | Inhibitorji lizin-specifične demetilaze-1 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10011583B2 (sl) |
| EP (1) | EP3160956B1 (sl) |
| JP (2) | JP6587241B2 (sl) |
| KR (1) | KR102438302B1 (sl) |
| CN (1) | CN106660987B (sl) |
| AU (2) | AU2015279591A1 (sl) |
| BR (1) | BR112016030697B1 (sl) |
| CA (1) | CA2953810C (sl) |
| CL (1) | CL2016003350A1 (sl) |
| CO (1) | CO2017000362A2 (sl) |
| CY (1) | CY1123475T1 (sl) |
| DK (1) | DK3160956T3 (sl) |
| EA (1) | EA030946B1 (sl) |
| EC (1) | ECSP17005635A (sl) |
| ES (1) | ES2812626T3 (sl) |
| HR (1) | HRP20201337T1 (sl) |
| HU (1) | HUE050564T2 (sl) |
| IL (1) | IL249733B (sl) |
| LT (1) | LT3160956T (sl) |
| MX (1) | MX2017000179A (sl) |
| PL (1) | PL3160956T3 (sl) |
| PT (1) | PT3160956T (sl) |
| RS (1) | RS60658B1 (sl) |
| SG (2) | SG10201911220TA (sl) |
| SI (1) | SI3160956T1 (sl) |
| WO (1) | WO2015200843A1 (sl) |
| ZA (1) | ZA201700069B (sl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102255778B1 (ko) | 2013-08-06 | 2021-05-24 | 이마고 바이오사이언시즈 인코포레이티드 | 질환의 치료를 위한 ｋｄｍ１ａ 저해인자 |
| SI3160956T1 (sl) | 2014-06-27 | 2020-11-30 | Celgene Quanticel Research, Inc. | Inhibitorji lizin-specifične demetilaze-1 |
| WO2016003917A1 (en) * | 2014-07-03 | 2016-01-07 | Quanticel Pharmaceuticals, Inc. | Inhibitors of lysine specific demethylase-1 |
| CA2976350C (en) | 2015-02-12 | 2023-09-19 | Hugh Young Rienhoff, Jr. | Kdm1a inhibitors for the treatment of disease |
| WO2016198649A1 (en) | 2015-06-12 | 2016-12-15 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| WO2017013061A1 (en) | 2015-07-17 | 2017-01-26 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| JP7158023B2 (ja) | 2016-03-15 | 2022-10-21 | オリソン ヘノミクス エセ． アー． | 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ |
| WO2017158136A1 (en) | 2016-03-16 | 2017-09-21 | Oryzon Genomics, S.A. | Methods to determine kdm1a target engagement and chemoprobes useful therefor |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN111194306B (zh) | 2016-08-16 | 2023-05-16 | 伊美格生物科学公司 | 用于制备kdm1a抑制剂的方法和过程 |
| EP3535420A1 (en) | 2016-11-03 | 2019-09-11 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| JP7071962B2 (ja) * | 2017-04-10 | 2022-05-19 | 三井化学アグロ株式会社 | ピリドン化合物と有害生物防除剤を含有する有害生物防除組成物および有害生物の防除方法 |
| JP2020121925A (ja) * | 2017-04-10 | 2020-08-13 | 三井化学アグロ株式会社 | ピリドン化合物とキノリン系化合物を含有する有害生物防除組成物および有害生物の防除方法、ならびに新規キノリン系化合物 |
| JP7089506B2 (ja) * | 2017-04-10 | 2022-06-22 | 三井化学アグロ株式会社 | ピリドン化合物を有効成分として含有する抗真菌剤およびその使用方法 |
| AU2018309372B2 (en) | 2017-08-03 | 2024-08-15 | Oryzon Genomics, S.A. | Methods of treating behavior alterations |
| CN112368272B (zh) * | 2018-03-21 | 2023-04-21 | 苏州浦合医药科技有限公司 | Shp2抑制剂及其用途 |
| EP3790867B1 (en) | 2018-05-11 | 2024-03-27 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
| BR112021016064A2 (pt) | 2019-03-20 | 2021-10-05 | Oryzon Genomics, S.A. | Métodos de tratamento do transtorno de personalidade borderline |
| CN113631164A (zh) | 2019-03-20 | 2021-11-09 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| EP3994280A1 (en) | 2019-07-05 | 2022-05-11 | Oryzon Genomics, S.A. | Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors |
| KR20230167102A (ko) | 2021-04-08 | 2023-12-07 | 오리존 지노믹스 에스.에이. | 골수성 암 치료를 위한 lsd1 억제제의 조합물 |
| WO2023217784A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| WO2023217758A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2599925A1 (en) * | 2005-03-14 | 2006-09-21 | Merck & Co., Inc. | Cgrp receptor antagonists |
| CA2652859A1 (en) | 2006-06-21 | 2007-12-27 | E.I. Du Pont De Nemours And Company | Pyrazinones as cellular proliferation inhibitors |
| CN101842361B (zh) * | 2007-06-27 | 2013-06-05 | 阿斯利康(瑞典)有限公司 | 吡嗪酮衍生物及其在治疗肺病中的用途 |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| WO2012013727A1 (en) * | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| EP2858982A4 (en) * | 2012-06-12 | 2015-11-11 | Abbvie Inc | PYRIDINONE AND PYRIDAZINONE DERIVATIVES |
| SI3080100T1 (sl) * | 2013-12-11 | 2023-04-28 | Celgene Quanticel Research, Inc. | Inhibitorji lizin specifične demetilaze-1 |
| CN103804312B (zh) * | 2014-02-17 | 2016-04-20 | 四川百利药业有限责任公司 | 一类氮杂环化合物及其制备方法和用途 |
| SI3160956T1 (sl) | 2014-06-27 | 2020-11-30 | Celgene Quanticel Research, Inc. | Inhibitorji lizin-specifične demetilaze-1 |
-
2015
- 2015-06-26 SI SI201531328T patent/SI3160956T1/sl unknown
- 2015-06-26 PT PT158115261T patent/PT3160956T/pt unknown
- 2015-06-26 PL PL15811526T patent/PL3160956T3/pl unknown
- 2015-06-26 DK DK15811526.1T patent/DK3160956T3/da active
- 2015-06-26 SG SG10201911220TA patent/SG10201911220TA/en unknown
- 2015-06-26 JP JP2016575362A patent/JP6587241B2/ja not_active Expired - Fee Related
- 2015-06-26 RS RS20200980A patent/RS60658B1/sr unknown
- 2015-06-26 CN CN201580046216.4A patent/CN106660987B/zh not_active Expired - Fee Related
- 2015-06-26 EP EP15811526.1A patent/EP3160956B1/en active Active
- 2015-06-26 ES ES15811526T patent/ES2812626T3/es active Active
- 2015-06-26 CA CA2953810A patent/CA2953810C/en active Active
- 2015-06-26 KR KR1020177000953A patent/KR102438302B1/ko active IP Right Grant
- 2015-06-26 SG SG11201610866PA patent/SG11201610866PA/en unknown
- 2015-06-26 WO PCT/US2015/038089 patent/WO2015200843A1/en active Application Filing
- 2015-06-26 LT LTEP15811526.1T patent/LT3160956T/lt unknown
- 2015-06-26 MX MX2017000179A patent/MX2017000179A/es active IP Right Grant
- 2015-06-26 BR BR112016030697-0A patent/BR112016030697B1/pt not_active IP Right Cessation
- 2015-06-26 EA EA201692513A patent/EA030946B1/ru unknown
- 2015-06-26 AU AU2015279591A patent/AU2015279591A1/en not_active Abandoned
- 2015-06-26 HU HUE15811526A patent/HUE050564T2/hu unknown
- 2015-06-26 US US15/322,277 patent/US10011583B2/en active Active
-
2016
- 2016-12-22 IL IL249733A patent/IL249733B/en active IP Right Grant
- 2016-12-27 CL CL2016003350A patent/CL2016003350A1/es unknown
-
2017
- 2017-01-04 ZA ZA2017/00069A patent/ZA201700069B/en unknown
- 2017-01-16 CO CONC2017/0000362A patent/CO2017000362A2/es unknown
- 2017-01-26 EC ECIEPI20175635A patent/ECSP17005635A/es unknown
-
2018
- 2018-05-29 US US15/991,222 patent/US10597376B2/en not_active Expired - Fee Related
-
2019
- 2019-05-03 JP JP2019087186A patent/JP6851418B2/ja active Active
- 2019-11-07 AU AU2019261771A patent/AU2019261771B2/en not_active Ceased
-
2020
- 2020-02-03 US US16/780,704 patent/US11028066B2/en active Active
- 2020-08-14 CY CY20201100759T patent/CY1123475T1/el unknown
- 2020-08-26 HR HRP20201337TT patent/HRP20201337T1/hr unknown
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