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MX2017001432A - Peptidos mimeticos de la apoe y mayor potencia para depurar el colesterol en plasma. - Google Patents

Peptidos mimeticos de la apoe y mayor potencia para depurar el colesterol en plasma.

Info

Publication number
MX2017001432A
MX2017001432A MX2017001432A MX2017001432A MX2017001432A MX 2017001432 A MX2017001432 A MX 2017001432A MX 2017001432 A MX2017001432 A MX 2017001432A MX 2017001432 A MX2017001432 A MX 2017001432A MX 2017001432 A MX2017001432 A MX 2017001432A
Authority
MX
Mexico
Prior art keywords
peptides
plasma cholesterol
higher potency
mimetic peptides
apoe mimetic
Prior art date
Application number
MX2017001432A
Other languages
English (en)
Inventor
Goldberg Dennis
M Anantharamaiah Gattadahalli
Original Assignee
Uab Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Res Found filed Critical Uab Res Found
Publication of MX2017001432A publication Critical patent/MX2017001432A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describen péptidos sintéticos imitadores de la apolipoproteína E, derivados de estos y péptidos relacionados, que son útiles como agentes terapéuticos para reducir el colesterol en plasma; métodos sintéticos para elaborar estos péptidos; composiciones farmacéuticas que comprenden los péptidos y métodos para tratar trastornos de lípidos y metabólicos usando los péptidos sintéticos imitadores de la apolipoproteína E y las composiciones de estos. Se pretende que este resumen sea una herramienta de análisis con fines de consulta en la técnica concreta y no se pretende que limite la presente invención.
MX2017001432A 2014-07-31 2015-07-20 Peptidos mimeticos de la apoe y mayor potencia para depurar el colesterol en plasma. MX2017001432A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462031585P 2014-07-31 2014-07-31
PCT/US2015/041162 WO2016018665A1 (en) 2014-07-31 2015-07-20 Apoe mimetic peptides and higher potency to clear plasma cholesterol

Publications (1)

Publication Number Publication Date
MX2017001432A true MX2017001432A (es) 2017-05-09

Family

ID=55218188

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001432A MX2017001432A (es) 2014-07-31 2015-07-20 Peptidos mimeticos de la apoe y mayor potencia para depurar el colesterol en plasma.

Country Status (10)

Country Link
US (1) US10653747B2 (es)
EP (1) EP3189069B1 (es)
JP (2) JP7081923B2 (es)
CN (1) CN107074923B (es)
AU (1) AU2015298263B2 (es)
BR (1) BR112017001860A2 (es)
CA (1) CA2954475C (es)
IL (1) IL250302B (es)
MX (1) MX2017001432A (es)
WO (1) WO2016018665A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653747B2 (en) 2014-07-31 2020-05-19 Uab Research Foundation ApoE mimetic peptides and higher potency to clear plasma cholesterol

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2753381T3 (es) * 2013-03-14 2020-04-08 Uab Research Foundation Miméticos de apolipoproteína y usos de los mismos
FI3362063T3 (fi) 2015-10-14 2023-04-06 Massachusetts Eye & Ear Infirmary Korkea-annoksisia statiineja silmänpohjan ikärappeumaan
WO2017120568A1 (en) * 2016-01-08 2017-07-13 Lipimetix Development, Inc. Apoe mimetic peptide compositions
JP2020514407A (ja) * 2017-01-24 2020-05-21 マクリーゲン, インク.Macregen, Inc. アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療
WO2018190896A1 (en) 2017-04-13 2018-10-18 Lipimetix Development, Inc. Apoe mimetic peptide compositions
WO2019199976A1 (en) 2018-04-11 2019-10-17 Lipimetix Development, Inc. Apoe mimetic peptide compositions
CN111617232B (zh) * 2020-06-04 2023-04-18 安域生物科技(杭州)有限公司 一类ApoE受体蛋白短肽阻断剂在阿尔茨海默病的应用
CN114940711B (zh) * 2021-10-25 2023-05-12 中山大学 载脂蛋白a-i模拟肽及其应用
WO2023215838A1 (en) * 2022-05-05 2023-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Short apolipoprotein e mimetic peptides and methods of use

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