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MX2014015884A - Compuestos antivirales. - Google Patents

Compuestos antivirales.

Info

Publication number
MX2014015884A
MX2014015884A MX2014015884A MX2014015884A MX2014015884A MX 2014015884 A MX2014015884 A MX 2014015884A MX 2014015884 A MX2014015884 A MX 2014015884A MX 2014015884 A MX2014015884 A MX 2014015884A MX 2014015884 A MX2014015884 A MX 2014015884A
Authority
MX
Mexico
Prior art keywords
antivirals
triazole compounds
compounds
formula
variables
Prior art date
Application number
MX2014015884A
Other languages
English (en)
Inventor
Klaus Klumpp
Joseph Anthony Bilotta
Eric Mertz
Shawn David Erickson
Stephen Deems Gabriel
Zhi Chen
Elbert Chin
Qingjie Ding
Han Ma
Jean-Marc Plancher
Robert James Weikert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014015884A publication Critical patent/MX2014015884A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe compuestos de la Fórmula I: (ver Fórmula) en donde las variables en la Fórmula I se definen como se describen en la presente. También se describen composiciones farmacéuticas que contienen tales compuestos y métodos para utilizar los compuestos de la Fórmula I en la prevención o el tratamiento de la infección del VHC.
MX2014015884A 2012-07-06 2013-07-03 Compuestos antivirales. MX2014015884A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261668547P 2012-07-06 2012-07-06
PCT/EP2013/063980 WO2014006066A1 (en) 2012-07-06 2013-07-03 Triazole compounds as antivirals

Publications (1)

Publication Number Publication Date
MX2014015884A true MX2014015884A (es) 2015-03-19

Family

ID=48793192

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015884A MX2014015884A (es) 2012-07-06 2013-07-03 Compuestos antivirales.

Country Status (11)

Country Link
US (2) US20140010783A1 (es)
EP (1) EP2870143B1 (es)
JP (1) JP6039067B2 (es)
KR (1) KR20150029016A (es)
CN (1) CN104428289B (es)
BR (1) BR112015000011A2 (es)
CA (1) CA2873512A1 (es)
HK (1) HK1208455A1 (es)
MX (1) MX2014015884A (es)
RU (1) RU2015102610A (es)
WO (1) WO2014006066A1 (es)

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RU2015136256A (ru) * 2013-03-05 2017-04-10 Ф. Хоффманн-Ля Рош Аг Противовирусные соединения
KR20150112035A (ko) * 2013-03-05 2015-10-06 에프. 호프만-라 로슈 아게 Hcv-항바이러스제로서의 n-헤테로아릴 치환된 아닐린 유도체
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US9896433B2 (en) 2013-03-05 2018-02-20 Hoffmann-La Roche Inc. Antiviral compounds
KR20150126901A (ko) * 2013-03-06 2015-11-13 에프. 호프만-라 로슈 아게 항바이러스성 화합물
CN106432031A (zh) * 2016-09-09 2017-02-22 中国药科大学 苯甲酸三氮唑类抗流感病毒化合物及其制备方法和用途
CN109422664B (zh) * 2017-08-23 2022-02-18 中国科学院福建物质结构研究所 一类干扰素调节剂及其制备方法和用途
KR20240093844A (ko) * 2021-10-26 2024-06-24 바소카데아, 인코포레이티드 Gpr39 단백질의 길항제
WO2023128786A1 (en) * 2021-12-30 2023-07-06 Collaborations Pharmaceuticals, Inc New antiviral triazole derivatives, their synthesis and their use for treatment of mammalian viral infections

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Also Published As

Publication number Publication date
JP6039067B2 (ja) 2016-12-07
US20140010783A1 (en) 2014-01-09
US20150307461A1 (en) 2015-10-29
RU2015102610A (ru) 2016-08-27
KR20150029016A (ko) 2015-03-17
WO2014006066A1 (en) 2014-01-09
CN104428289B (zh) 2017-06-23
JP2015525743A (ja) 2015-09-07
EP2870143A1 (en) 2015-05-13
HK1208455A1 (en) 2016-03-04
BR112015000011A2 (pt) 2017-06-27
EP2870143B1 (en) 2017-05-17
CA2873512A1 (en) 2014-01-09
CN104428289A (zh) 2015-03-18

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