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MX2014013508A - Soluciones proteinicas estabilizadas. - Google Patents

Soluciones proteinicas estabilizadas.

Info

Publication number
MX2014013508A
MX2014013508A MX2014013508A MX2014013508A MX2014013508A MX 2014013508 A MX2014013508 A MX 2014013508A MX 2014013508 A MX2014013508 A MX 2014013508A MX 2014013508 A MX2014013508 A MX 2014013508A MX 2014013508 A MX2014013508 A MX 2014013508A
Authority
MX
Mexico
Prior art keywords
highly concentrated
protein solutions
stabilised protein
sucrose
addition
Prior art date
Application number
MX2014013508A
Other languages
English (en)
Inventor
Ole Elvang Jensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49583182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014013508(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2014013508A publication Critical patent/MX2014013508A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención se refiere a un método para estabilizar soluciones proteínicas sumamente concentradas durante la ultrafiltración por medio de la adición de sacarosa a la solución proteínica sumamente concentrada, en particular, pero no exclusivamente a un método para estabilizar soluciones de anticuerpos sumamente concentradas durante la ultrafiltración por medio de la adición de sacarosa a la solución de anticuerpos sumamente concentrada.
MX2014013508A 2012-05-14 2013-03-15 Soluciones proteinicas estabilizadas. MX2014013508A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12167958 2012-05-14
US201261651598P 2012-05-25 2012-05-25
PCT/EP2013/055390 WO2013170977A1 (en) 2012-05-14 2013-03-15 Stabilised protein solutions

Publications (1)

Publication Number Publication Date
MX2014013508A true MX2014013508A (es) 2015-02-10

Family

ID=49583182

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013508A MX2014013508A (es) 2012-05-14 2013-03-15 Soluciones proteinicas estabilizadas.

Country Status (10)

Country Link
US (2) US11466051B2 (es)
EP (2) EP3184542A1 (es)
JP (1) JP6681711B2 (es)
CN (1) CN104271600B (es)
AU (1) AU2013262083A1 (es)
BR (1) BR112014028129A2 (es)
CA (1) CA2873647A1 (es)
ES (1) ES2622558T3 (es)
MX (1) MX2014013508A (es)
WO (1) WO2013170977A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180072769A1 (en) 2015-03-23 2018-03-15 Alexion Pharmaceuticals, Inc. Virus filtration
CN108025072A (zh) * 2015-09-22 2018-05-11 辉瑞公司 制备治疗用蛋白质制剂的方法和由这种方法生产的抗体制剂
WO2020036903A1 (en) 2018-08-14 2020-02-20 Bristol-Myers Squibb Company Improved protein recovery
CN111018968B (zh) * 2019-12-16 2021-07-27 兴盟生物医药(苏州)有限公司 一种通过超滤浓缩制备高浓度抗体制剂的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5248767A (en) * 1986-06-11 1993-09-28 Behringwerke Aktiengesellschaft Process for the preparation of a pasteurized immunoglobulin preparation using ethanol
DE3619565A1 (de) * 1986-06-11 1987-12-17 Behringwerke Ag Verfahren zur herstellung einer pasteurisierten immunglobulinpraeparation
US5656730A (en) 1995-04-07 1997-08-12 Enzon, Inc. Stabilized monomeric protein compositions
CN1151174C (zh) * 1998-12-21 2004-05-26 蒋盘宏 抗人淋巴细胞球蛋白制备方法
JP5485489B2 (ja) 2000-08-11 2014-05-07 中外製薬株式会社 抗体含有安定化製剤
GB0113179D0 (en) * 2001-05-31 2001-07-25 Novartis Ag Organic compounds
RU2335299C2 (ru) 2002-02-14 2008-10-10 Чугаи Сейяку Кабусики Кайся Препараты в форме растворов, содержащие антитела
CA2490423A1 (en) 2002-06-21 2003-12-31 Biogen Idec Inc. Buffered formulations for concentrating antibodies and methods of use thereof
ES2609010T3 (es) 2003-04-04 2017-04-18 Genentech, Inc. Formulaciones de anticuerpos y de proteínas a concentración elevada
DE102004052729A1 (de) * 2004-10-30 2006-05-04 Roche Diagnostics Gmbh Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten
US7645860B2 (en) * 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
EP2124890A2 (en) 2007-02-16 2009-12-02 Wyeth a Corporation of the State of Delaware Use of sucrose to suppress mannitol-induced protein aggregation
MX2010007728A (es) * 2008-01-15 2010-12-21 Abbott Gmbh & Co Kg Composiciones proteinicas en polvo y metodos para elaborar las mismas.
EP2297203A1 (en) * 2008-06-30 2011-03-23 Novo Nordisk A/S Anti-human interleukin-20 antibodies
SG10201702922VA (en) 2008-10-20 2017-06-29 Abbvie Inc Isolation and purification of antibodies using protein a affinity chromatography
NZ603619A (en) * 2008-10-20 2014-05-30 Abbvie Inc Antibodies that bind to il-12 and methods of purifying the same
CN102272154A (zh) 2008-10-29 2011-12-07 惠氏有限责任公司 单域抗原结合性分子的纯化方法
IN2012DN06720A (es) 2010-01-15 2015-10-23 Kirin Amgen Inc
RU2012139181A (ru) 2010-02-26 2014-04-10 Ново Нордиск А/С Стабильная композиция, содержащая антитело

Also Published As

Publication number Publication date
JP6681711B2 (ja) 2020-04-15
ES2622558T3 (es) 2017-07-06
US11466051B2 (en) 2022-10-11
EP2850099A1 (en) 2015-03-25
CA2873647A1 (en) 2013-11-21
US20150086566A1 (en) 2015-03-26
AU2013262083A1 (en) 2014-11-06
WO2013170977A1 (en) 2013-11-21
EP2850099B1 (en) 2017-01-18
US20230002443A1 (en) 2023-01-05
CN104271600B (zh) 2018-09-14
JP2015517506A (ja) 2015-06-22
BR112014028129A2 (pt) 2017-06-27
EP3184542A1 (en) 2017-06-28
CN104271600A (zh) 2015-01-07

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