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MD3532486T2 - Compuși de tirozină-tirozină peptidică ciclică cuplaţi la anticorp ca modulatori de receptori Y ai neuropeptidei - Google Patents

Compuși de tirozină-tirozină peptidică ciclică cuplaţi la anticorp ca modulatori de receptori Y ai neuropeptidei

Info

Publication number
MD3532486T2
MD3532486T2 MDE20190989T MDE20190989T MD3532486T2 MD 3532486 T2 MD3532486 T2 MD 3532486T2 MD E20190989 T MDE20190989 T MD E20190989T MD E20190989 T MDE20190989 T MD E20190989T MD 3532486 T2 MD3532486 T2 MD 3532486T2
Authority
MD
Moldova
Prior art keywords
tyrosine
neuropeptide
modulators
receptors
antibody
Prior art date
Application number
MDE20190989T
Other languages
English (en)
Inventor
Mark Macielag
Raymond J Patch
Rui Zhang
Martin A Case
Shamina M Rangwala
James N Leonard
Raul C Camacho
Michael J Hunter
Katharine E D'aquino
Wilson Edwards
Ronald V Swanson
Wenying Jian
Yue-Mei Zhang
Mark Wall
Ellen Chi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MD3532486T2 publication Critical patent/MD3532486T2/ro

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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Abstract

Prezenta invenţie cuprinde conjugaţi care cuprind un anticorp monoclonal conjugat la o peptidă PYY ciclică. Invenţia se referă de asemenea la compoziţii farmaceutice şi metode de utilizare a acestora. Noii conjugaţi sunt utili pentru prevenirea, tratatrea sau ameliorarea bolilor şi tulburărilor divulgate aici.
MDE20190989T 2016-10-27 2017-10-26 Compuși de tirozină-tirozină peptidică ciclică cuplaţi la anticorp ca modulatori de receptori Y ai neuropeptidei MD3532486T2 (ro)

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095604A2 (en) 2013-12-18 2015-06-25 President And Fellows Of Harvard College Methods and assays relating to circulating tumor cells
JOP20190095A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
US11780900B2 (en) 2018-04-25 2023-10-10 Janssen Sciences Ireland Unlimited Company Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof
TWI847981B (zh) 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途
JPWO2020262590A1 (ro) * 2019-06-28 2020-12-30
JOP20220110A1 (ar) 2019-11-11 2023-01-30 Boehringer Ingelheim Int ناهضات مستقبل npy2
CN111494606B (zh) * 2020-04-24 2021-12-14 广州医科大学 神经肽y的新应用
CR20230074A (es) 2020-08-07 2023-04-19 Boehringer Ingelheim Int Agonistas del receptor npy2 solubles
CN115073556A (zh) * 2021-03-12 2022-09-20 上海天慈生命科学发展有限公司 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用
CA3223530A1 (en) * 2021-06-14 2022-12-22 Darbix Llc Glp-1 receptor agonists having improved pharmacological and drug delivery properties
WO2023097363A1 (en) * 2021-11-30 2023-06-08 Garvan Institute Of Medical Research Improved binding proteins and uses thereof
CN115028551B (zh) * 2022-07-15 2024-01-05 成都普康生物科技有限公司 一种叠氮-九甘醇-丙酸的制备方法
CN116098987A (zh) * 2023-02-09 2023-05-12 华东医院 甘丙肽在制备治疗非酒精性脂肪性肝病药物中的用途

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434149A1 (fr) 1978-06-22 1980-03-21 Parcor Nouveaux derives de la l-cysteine
US5393669A (en) 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US7166575B2 (en) 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
US8603969B2 (en) 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same
EP1718671A2 (en) 2004-02-23 2006-11-08 Rheoscience A/S Peptide yy analogues
BRPI0507585A (pt) 2004-03-17 2007-07-03 7Tm Pharmas As agonistas seletivos do receptor y2 para intervenções terapêuticas
CA2577082A1 (en) 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
EP1870459B1 (en) 2005-03-31 2016-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
CN101389648B (zh) 2006-02-22 2013-07-17 默沙东公司 肽胃泌酸调节素衍生物
EP2004238A2 (en) * 2006-03-21 2008-12-24 Amylin Pharmaceuticals, Inc. Peptide-peptidase inhibitor conjugates and methods of using same
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
JP2010505878A (ja) 2006-10-05 2010-02-25 セントコア・オーソ・バイオテツク・インコーポレーテツド 線維症の処置のためのccr2アンタゴニスト
JP2008169195A (ja) * 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
EP2185592B1 (en) * 2007-09-13 2013-01-23 University Of Zurich Prorektorat Forschung Monoclonal amyloid beta (abeta)-specific antibody and uses thereof
ES2564523T3 (es) 2007-12-19 2016-03-23 Janssen Biotech, Inc. Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos
CN102272151B (zh) 2008-11-04 2014-08-20 詹森药业有限公司 Crhr2肽激动剂及其用途
JP2012507487A (ja) * 2008-11-05 2012-03-29 エフ.ホフマン−ラ ロシュ アーゲー 神経ペプチド2受容体(y−2r)アゴニスト及びその使用
JP2012525149A (ja) 2009-04-27 2012-10-22 オンコメッド ファーマシューティカルズ インコーポレイテッド ヘテロ多量体分子を作製するための方法
EA022816B1 (ru) 2009-07-13 2016-03-31 Зилэнд Фарма А/С Ацилированные аналоги глюкагона
US20130040877A1 (en) 2009-09-18 2013-02-14 Novo Nordisk A/S Long-acting y2 receptor agonists
US20120276098A1 (en) 2009-09-30 2012-11-01 Bruce Hamilton Drug fusions and conjugates with extended half life
DK2560993T3 (da) 2010-04-20 2024-10-14 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
WO2012047583A2 (en) * 2010-09-27 2012-04-12 Janssen Biotech, Inc. Antibodies binding human collagen ii
US8906649B2 (en) * 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
JP6167040B2 (ja) 2010-11-05 2017-07-19 ザイムワークス,インコーポレイテッド Fcドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計
ES2674600T3 (es) * 2011-01-28 2018-07-02 Sanofi Biotechnology Anticuerpos humanos contra PCSK9 para su uso en métodos de tratamiento de grupos de sujetos particulares
SI2721062T1 (sl) 2011-06-17 2019-03-29 Hanmi Science Co., Ltd. Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega
CA2854233C (en) 2011-11-04 2020-05-12 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
SI2869848T1 (sl) * 2012-07-04 2017-01-31 F. Hoffmann-La Roche Ag Kovalentno vezani konjugati antigen-protitelo
AU2013342321B2 (en) * 2012-11-06 2017-09-28 Hanmi Pharm. Co., Ltd. Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
CA2896248A1 (en) 2012-12-27 2014-07-03 Sanofi Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res FUSION BOVINE ANTIBODIES
KR20160003848A (ko) * 2013-05-02 2016-01-11 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 치료용 펩티드
PT3129406T (pt) * 2014-04-11 2019-04-24 Medimmune Llc Compostos conjugados que compreendem anticorpos com manipulação de cisteínas
AR100978A1 (es) * 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
AU2015296640B2 (en) 2014-07-30 2020-05-21 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
PE20181310A1 (es) 2015-11-02 2018-08-10 Janssen Pharmaceutica Nv Anticuerpos anti-il1rap, moleculas de union a antigenos biespecificas que se unen a il1rap y cd3, y usos de estos
JOP20190095A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
TWI847981B (zh) * 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途

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