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EA201792451A1 - Антитела к ox40 и способы их применения - Google Patents

Антитела к ox40 и способы их применения

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Publication number
EA201792451A1
EA201792451A1 EA201792451A EA201792451A EA201792451A1 EA 201792451 A1 EA201792451 A1 EA 201792451A1 EA 201792451 A EA201792451 A EA 201792451A EA 201792451 A EA201792451 A EA 201792451A EA 201792451 A1 EA201792451 A1 EA 201792451A1
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EA
Eurasian Patent Office
Prior art keywords
activity
antibodies
human
methods
modulates
Prior art date
Application number
EA201792451A
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English (en)
Inventor
Марк Ван Дийк
Екатерина Бреоус-Нистром
Фолькер Зайберт
Герд РИТТЕР
Дэвид Шаер
Дэниэл Хирчхорн-Цимерман
Таха Мергхоуб
Хао Тан
Дэвид А. Савитский
Джереми Вейт
Николас С. Уилсон
Original Assignee
Агенус Инк.
Людвиг Инститъют Фор Кансер Ресёрч Лтд.
Мемориал Слоан-Кеттеринг Кансер Сентер
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Агенус Инк., Людвиг Инститъют Фор Кансер Ресёрч Лтд., Мемориал Слоан-Кеттеринг Кансер Сентер filed Critical Агенус Инк.
Publication of EA201792451A1 publication Critical patent/EA201792451A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Abstract

В настоящем раскрытии предусмотрены антитела, которые специфически связываются с рецептором OX40 человека (OX40), и композиции, содержащие такие антитела. В конкретном аспекте антитела специфически связываются с OX40 человека и модулируют активность OX40, например, усиливают, запускают или индуцируют активность OX40, или снижают, прекращают или ингибируют активность OX40. В настоящем раскрытии также предусмотрены способы лечения нарушений, таких как рак, с помощью введения антитела, которое специфически связывается с OX40 человека и модулирует активность OX40, например, усиливает, запускает или индуцирует активность OX40. Также предусмотрены способы лечения аутоиммунных или воспалительных заболеваний или нарушений с помощью введения антитела, которое специфически связывается с OX40 человека и модулирует активность OX40, например, снижает, прекращает или ингибирует активность OX40.
EA201792451A 2015-05-07 2016-05-06 Антитела к ox40 и способы их применения EA201792451A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562158515P 2015-05-07 2015-05-07
US201562161198P 2015-05-13 2015-05-13
US201562262373P 2015-12-02 2015-12-02
US201662323458P 2016-04-15 2016-04-15
PCT/US2016/031257 WO2016179517A1 (en) 2015-05-07 2016-05-06 Anti-ox40 antibodies and methods of use thereof

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US (8) US10259882B2 (ru)
EP (1) EP3292152A1 (ru)
JP (3) JP6867955B2 (ru)
KR (1) KR20180015650A (ru)
CN (2) CN108137686B (ru)
AU (2) AU2016256911B2 (ru)
BR (1) BR112017023849A2 (ru)
CA (1) CA2984794A1 (ru)
EA (1) EA201792451A1 (ru)
HK (1) HK1250513A1 (ru)
IL (1) IL255278A0 (ru)
MA (1) MA42043A (ru)
MX (1) MX2017014188A (ru)
MY (1) MY189692A (ru)
PH (1) PH12017502013A1 (ru)
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AU2016364891A1 (en) * 2015-12-03 2018-06-07 Agenus Inc. Anti-OX40 antibodies and methods of use thereof
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MX2017014188A (es) 2018-04-10
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EP3292152A1 (en) 2018-03-14
US11472883B2 (en) 2022-10-18
CN108137686A (zh) 2018-06-08
CA2984794A1 (en) 2016-11-10
BR112017023849A2 (pt) 2018-07-17
US10259882B2 (en) 2019-04-16
US20200317796A1 (en) 2020-10-08
HK1250513A1 (zh) 2018-12-21
AU2016256911B2 (en) 2022-03-31
US11332536B2 (en) 2022-05-17
JP6867955B2 (ja) 2021-05-12
WO2016179517A1 (en) 2016-11-10
PH12017502013A1 (en) 2018-04-02
US20200270356A1 (en) 2020-08-27

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