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MD20150036A2 - Analogi de 2'-cloro nucleozide pentru tratarea hepatitei virale C - Google Patents

Analogi de 2'-cloro nucleozide pentru tratarea hepatitei virale C Download PDF

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Publication number
MD20150036A2
MD20150036A2 MDA20150036A MD20150036A MD20150036A2 MD 20150036 A2 MD20150036 A2 MD 20150036A2 MD A20150036 A MDA20150036 A MD A20150036A MD 20150036 A MD20150036 A MD 20150036A MD 20150036 A2 MD20150036 A2 MD 20150036A2
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MD
Moldova
Prior art keywords
compounds
hcv infection
nucleoside analogs
compositions
certain embodiments
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MDA20150036A
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English (en)
Russian (ru)
Inventor
Джиллс ГОССЕЛИН
Кристоф Клод ПАРСИ
Франсуа-Рене Александр
Юсин РАХАЛИ
Жан-Франсуа ГРИФФОН
Доминик СЮРЛЕРО
Сирил Б. ДУССОН
Клер ПЬЕРРА
Адел М. Мусса
Алистер Джеймс СТЮАРТ
Дэвид ДУХАН
Original Assignee
Idenix Pharmaceuticals, Inc.
Centre National De La Recherche Scientifique
Universite De Montpellier
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Application filed by Idenix Pharmaceuticals, Inc., Centre National De La Recherche Scientifique, Universite De Montpellier filed Critical Idenix Pharmaceuticals, Inc.
Publication of MD20150036A2 publication Critical patent/MD20150036A2/ro

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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Invenţia se referă la compuşi, compoziţii şi metode pentru tratarea infecţiilor Flaviviridae, inclusiv a infecţiilor VHC.În anumite exemple de realizare, compuşii sunt 2'-cloro nucleozide cu Formula (2001):sau o sare acceptabilă farmaceutic, un solvat, o formă stereoizomeră, tautomeră sau polimorfă a compusului (2001), în care PD, B şi Z sunt descrişi în prezentul document.În anumite exemple de realizare sunt dezvăluiţi compuşi şi compoziţii cu derivaţi nucleozidici, care pot fi administraţi fie separat, fie în combinaţie cu alţi agenţi antivirali.
MDA20150036A 2012-10-08 2013-10-07 Analogi de 2'-cloro nucleozide pentru tratarea hepatitei virale C MD20150036A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261711131P 2012-10-08 2012-10-08
US201361807249P 2013-04-01 2013-04-01
PCT/US2013/063731 WO2014058801A1 (en) 2012-10-08 2013-10-07 2'-chloro nucleoside analogs for hcv infection

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MD20150036A2 true MD20150036A2 (ro) 2015-08-31

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KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
WO2012154321A1 (en) 2011-03-31 2012-11-15 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
TW201329096A (zh) 2011-09-12 2013-07-16 Idenix Pharmaceuticals Inc 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
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EA030189B8 (ru) 2018-10-31
GEP201706723B (en) 2017-08-25
CL2015000870A1 (es) 2015-11-13
NI201500049A (es) 2016-02-16
CR20150199A (es) 2015-09-01
KR102001280B1 (ko) 2019-07-17
EA030189B1 (ru) 2018-07-31
CN104936970A (zh) 2015-09-23
HK1207647A1 (en) 2016-02-05
EP2906579A1 (en) 2015-08-19
US20160083413A1 (en) 2016-03-24
EA201500304A1 (ru) 2016-01-29
JP6495822B2 (ja) 2019-04-03
AU2013329521A1 (en) 2015-05-28
TR201809048T4 (tr) 2018-07-23
MX2015004348A (es) 2015-10-29
JP2015535853A (ja) 2015-12-17
ECSP15015737A (es) 2015-12-31
AU2013329521B2 (en) 2018-04-19
PH12015500749A1 (en) 2015-05-25
US10513534B2 (en) 2019-12-24
ZA201502545B (en) 2017-08-30
EP2906579B1 (en) 2018-04-18
CA2887578A1 (en) 2014-04-17
CN111848711A (zh) 2020-10-30
AP2015008384A0 (en) 2015-04-30
BR112015007698A2 (pt) 2017-08-22
US20140099283A1 (en) 2014-04-10
DOP2015000079A (es) 2015-11-30
GT201500086A (es) 2018-12-19
TN2015000117A1 (en) 2016-06-29
NZ706985A (en) 2018-08-31

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