[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MA53172A - Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1 - Google Patents

Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1

Info

Publication number
MA53172A
MA53172A MA053172A MA53172A MA53172A MA 53172 A MA53172 A MA 53172A MA 053172 A MA053172 A MA 053172A MA 53172 A MA53172 A MA 53172A MA 53172 A MA53172 A MA 53172A
Authority
MA
Morocco
Prior art keywords
interleukin
activity inhibitors
sulfonimidamide
compounds
sulfonimidamide compounds
Prior art date
Application number
MA053172A
Other languages
English (en)
Inventor
Amogh Boloor
Sarah M Bronner
Christopher Mcbride
Richard M Pastor
Nadezda Sokolova
Steven Thomas Staben
Craig Stivala
Lynnie Lin Trzoss
Matthew Volgraf
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA53172A publication Critical patent/MA53172A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA053172A 2018-07-20 2019-07-19 Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1 MA53172A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862701313P 2018-07-20 2018-07-20

Publications (1)

Publication Number Publication Date
MA53172A true MA53172A (fr) 2021-05-26

Family

ID=67659954

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053172A MA53172A (fr) 2018-07-20 2019-07-19 Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1

Country Status (21)

Country Link
US (1) US20210253596A1 (fr)
EP (1) EP3823974A1 (fr)
JP (1) JP7320595B2 (fr)
KR (1) KR20210034596A (fr)
CN (1) CN112513048A (fr)
AR (1) AR115822A1 (fr)
AU (1) AU2019306658A1 (fr)
BR (1) BR112021001044A2 (fr)
CA (1) CA3105521A1 (fr)
CL (1) CL2021000153A1 (fr)
CO (1) CO2021001530A2 (fr)
CR (1) CR20210022A (fr)
IL (1) IL279256A (fr)
MA (1) MA53172A (fr)
MX (1) MX2021000780A (fr)
PE (1) PE20211811A1 (fr)
PH (1) PH12021500005A1 (fr)
SG (1) SG11202013062VA (fr)
TW (1) TWI825134B (fr)
UA (1) UA128558C2 (fr)
WO (1) WO2020018975A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20191615A1 (es) 2017-01-23 2019-11-05 Genentech Inc Compuestos quimicos como inhibidores de la actividad de la interleuquina-1
SG11201912166XA (en) 2017-07-24 2020-02-27 Novartis Inflammasome Research Inc Compounds and compositions for treating conditions associated with nlrp activity
WO2019068772A1 (fr) 2017-10-03 2019-04-11 Inflazome Limited Nouveaux composés
JP7411631B2 (ja) 2018-07-20 2024-01-11 エフ． ホフマン－ラ ロシュ アーゲー インターロイキン－１活性の阻害剤としてのスルホニル尿素化合物
ES2957692T3 (es) 2018-11-13 2024-01-24 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP
US20230051589A1 (en) * 2018-11-16 2023-02-16 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
EP3914585A1 (fr) * 2019-01-23 2021-12-01 Novartis AG Composés sulfonimidamide et compositions pour le traitement d'états associés à une activité de nlrp
EP3986879B1 (fr) 2019-06-21 2024-10-02 AC Immune SA 1,2-thiazoles et 1,2-thiazines fusionnés qui agissent en tant que modulateurs de nlrp3
WO2021002887A1 (fr) * 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Antagonistes de nlrp3 ciblant l'intestin et leur utilisation en thérapie
US11976054B2 (en) 2019-11-12 2024-05-07 Chengdu Baiyu Pharmaceutical Co., Ltd. Amide derivative and preparation method therefore and use thereof in medicine
CA3167023A1 (fr) * 2020-01-22 2021-07-29 F. Hoffmann-La Roche Ag Composes de sulfonimidamide en tant que modulateurs de nlrp3
WO2021188450A1 (fr) 2020-03-16 2021-09-23 Zomagen Biosciences Ltd Modulateurs de nlrp3
EP4135842B1 (fr) 2020-04-15 2024-10-23 JANSSEN Pharmaceutica NV Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides en tant qu'inhibiteurs de la voie inflammasome nlrp3
US20230203044A1 (en) 2020-04-15 2023-06-29 Janssen Pharmaceutica Nv Pyrazolo[1,5-d][1,2,4]triazine-5(4h)-acetamides as inhibitors of the nlrp3 inflammasome
US20230203064A1 (en) 2020-04-23 2023-06-29 Janssen Pharmaceutica Nv Tricyclic compounds as inhibitors of nlrp3
BR112022021881A2 (pt) 2020-04-30 2022-12-20 Janssen Pharmaceutica Nv Novos compostos de triazinoindol
AU2021279305A1 (en) 2020-05-28 2023-02-09 Janssen Pharmaceutica Nv Compounds
IL299084A (en) 2020-06-19 2023-02-01 Ac Immune Sa History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway
EP3974415A1 (fr) 2020-09-24 2022-03-30 Janssen Pharmaceutica NV Nouveaux composés
EP4217347A1 (fr) 2020-09-24 2023-08-02 JANSSEN Pharmaceutica NV Nouveaux composés
CN114539256B (zh) * 2020-11-20 2024-02-02 上海拓界生物医药科技有限公司 三环化合物及其医药用途
WO2022184843A1 (fr) 2021-03-04 2022-09-09 Janssen Pharmaceutica Nv Dérivés de 4-amino-6-oxo-pyridazine modulant nlrp3
KR20230152016A (ko) 2021-03-04 2023-11-02 얀센 파마슈티카 엔브이 Nlrp3을 조절하는 4-알콕시-6-옥소-피리다진 유도체
AU2022263621A1 (en) 2021-04-29 2023-12-14 Janssen Pharmaceutica Nv Phthalazinone derivatives as nlrp3 inflammasome inhibitors
WO2022237782A1 (fr) * 2021-05-10 2022-11-17 成都百裕制药股份有限公司 Dérivé d'amide et son application
CN116917282A (zh) * 2021-05-10 2023-10-20 成都百裕制药股份有限公司 酰胺衍生物及其应用
US20240279223A1 (en) 2021-07-01 2024-08-22 Janssen Pharmaceutica Nv 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides
US20240336625A1 (en) * 2021-07-19 2024-10-10 Genentech, Inc. Sulfonimidamde compounds and uses thereof
CN115894478A (zh) * 2021-09-30 2023-04-04 杭州民生药物研究院有限公司 一种新型吡啶并吡唑类杂环化合物及其应用
WO2023118521A1 (fr) 2021-12-22 2023-06-29 Ac Immune Sa Composés dérivés de dihydro-oxazol
WO2024010772A1 (fr) * 2022-07-06 2024-01-11 Kodiak Sciences Inc. Inhibiteurs de nlrp3
WO2024013395A1 (fr) 2022-07-14 2024-01-18 Ac Immune Sa Dérivés de pyrrolotriazine et d'imidazotriazine utilisés en tant que modulateurs de la voie de l'inflammasome nlrp3
WO2024023266A1 (fr) 2022-07-28 2024-02-01 Ac Immune Sa Nouveaux composés
WO2024064245A1 (fr) 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Derives de phtalazine utiles en tant qu'inhibiteurs de la proteine receptrice de type nod 3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6929792B2 (ja) 2015-02-16 2021-09-01 ザ ユニバーシティ オブ クィーンズランド スルホニル尿素及び関連化合物並びにその使用
PE20191615A1 (es) 2017-01-23 2019-11-05 Genentech Inc Compuestos quimicos como inhibidores de la actividad de la interleuquina-1
SG11201912166XA (en) * 2017-07-24 2020-02-27 Novartis Inflammasome Research Inc Compounds and compositions for treating conditions associated with nlrp activity
WO2019068772A1 (fr) * 2017-10-03 2019-04-11 Inflazome Limited Nouveaux composés

Also Published As

Publication number Publication date
JP7320595B2 (ja) 2023-08-03
KR20210034596A (ko) 2021-03-30
PE20211811A1 (es) 2021-09-14
CN112513048A (zh) 2021-03-16
CR20210022A (es) 2021-02-18
IL279256A (en) 2021-01-31
CO2021001530A2 (es) 2021-03-08
AR115822A1 (es) 2021-03-03
BR112021001044A2 (pt) 2021-04-13
AU2019306658A1 (en) 2021-01-07
TW202016078A (zh) 2020-05-01
TWI825134B (zh) 2023-12-11
CA3105521A1 (fr) 2020-01-23
UA128558C2 (uk) 2024-08-14
SG11202013062VA (en) 2021-02-25
PH12021500005A1 (en) 2021-09-13
US20210253596A1 (en) 2021-08-19
MX2021000780A (es) 2021-03-31
EP3823974A1 (fr) 2021-05-26
WO2020018975A1 (fr) 2020-01-23
CL2021000153A1 (es) 2021-07-09
JP2021532101A (ja) 2021-11-25

Similar Documents

Publication Publication Date Title
MA53172A (fr) Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1
MA53170A (fr) Composés de sulfonylurée en tant qu'inhibiteurs de l'activité de l'interleukine 1
MA53395A (fr) Composés hétérobicycliques pour inhiber l'activité de shp2
MA47308A (fr) Composés chimiques comme inhibiteurs de l'activité interleukine-1
MA52486A (fr) Pyridazinones utilisés en tant qu'inhibiteurs de parp7
MA51878A (fr) Composés d'aminothiazole en tant qu'inhibiteurs de c-kit
MA49566A (fr) Carboxamides utilisés en tant qu'inhibiteurs des canaux sodiques
MA52421A (fr) Composés pharmaceutiques
MA52948A (fr) Composés
MA52942A (fr) Composés inhibiteurs d'oga
MA48765A (fr) Cyanopyrrolidines substituées par sulfonamide ayant une activité en tant qu'inhibiteurs de dub
MA44734A (fr) Composés et compositions destinés au traitement d'états associés à une activité de nlrp
MA53150A (fr) Composés de benzimidazole en tant qu'inhibiteurs de c-kit
MA52939A (fr) Composés inhibiteurs d'oga
MA51438A (fr) Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1
MA43169A (fr) Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma
MA45377A (fr) Composés hétérocycliques en tant qu'agents antibacteriens
MA53377A (fr) Composés de pyridin-2-one utiles en tant qu'antagonistes de smarca2
MA51669A (fr) Composés
MA47013A (fr) Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase
MA40587A (fr) Composés d'aminopyrimidinyle en tant qu'inhibiteurs de jak
MA53003A (fr) Composés
MA45375A (fr) Composés hétérocycliques utilisés en tant qu'agents antibacteriens
MA47420A (fr) Composés inhibiteurs d'oga
MA42488A (fr) Composés, compositions et procédés pour augmenter l'activité du cftr