KIF6

KIF6
Identifiers
Aliases	KIF6, C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1, kinesin family member 6
External IDs	OMIM: 613919; MGI: 1098238; HomoloGene: 35308; GeneCards: KIF6; OMA:KIF6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	39,725,408 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	50,216,875 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; corpus callosum; ; sperm; ; bronchial epithelial cell; ; C1 segment; ; oocyte; ; olfactory zone of nasal mucosa; ; testicle; ; substantia nigra; ; internal globus pallidus;
	Top expressed in
	otolith organ; ; utricle; ; lumbar subsegment of spinal cord; ; spermatocyte; ; Rostral migratory stream; ; tail of embryo; ; embryo; ; embryo; ; lateral ventricle; ; choroid plexus of lateral ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; protein binding; ATP binding;
Cellular component	cytoplasm; male germ cell nucleus; microtubule; cytoskeleton; kinesin complex;
Biological process	microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	221458
	319991
	ENSG00000164627
	ENSMUSG00000023999
	Q6ZMV9
	n/a
NM_001289020; NM_001289021; NM_001289024; NM_145027; NM_001351503;
	NM_001351566
	NM_177052
NP_001275949; NP_001275950; NP_001275953; NP_659464; NP_001338432;
	NP_001338495
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene.^[5] This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164627 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023999 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Kinesin family member 6".

Koroleva OS, Pushkov AA, Blagodatskikh KA, Baranova OA, Azizova OA, Nosikov VV, Reznichenko NE, Zateĭshchikov DA (2011). "[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease]". Kardiologiia. 51 (9): 4–12. PMID 21943003.
Bare LA, Ruiz-Narvaéz EA, Tong CH, Arellano AR, Rowland CM, Catanese JJ, Sacks FM, Devlin JJ, Campos H (September 2010). "Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population". PLOS ONE. 5 (9): e13081. Bibcode:2010PLoSO...513081B. doi:10.1371/journal.pone.0013081. PMC 2947524. PMID 20927332.
Peng P, Lian J, Huang RS, Xu L, Huang Y, Ba Y, Yang X, Huang X, Dong C, Zhang L, Ye M, Zhou J, Duan S (2012). "Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect". PLOS ONE. 7 (12): e50126. Bibcode:2012PLoSO...750126P. doi:10.1371/journal.pone.0050126. PMC 3517591. PMID 23236363.
Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ (February 2012). "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly". Atherosclerosis. 220 (2): 456–62. doi:10.1016/j.atherosclerosis.2011.11.037. PMID 22192511.
Liu X, Gomez-Pinillos A, Loder C, Carrillo-de Santa Pau E, Qiao R, Unger PD, Kurek R, Oddoux C, Melamed J, Gallagher RE, Mandeli J, Ferrari AC (September 2012). "KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation". The American Journal of Pathology. 181 (3): 1007–16. doi:10.1016/j.ajpath.2012.06.008. PMC 3432435. PMID 22819534.
Davani S, Gozalo C, Gambert S, Chalmers D, Gambert P, Schiele F, Kantelip JP, Meneveau N (May 2010). "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction". Atherosclerosis. 210 (1): 48–50. doi:10.1016/j.atherosclerosis.2009.11.041. PMID 20044086.
Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B (October 2010). "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients". Pharmacogenetics and Genomics. 20 (10): 634–7. doi:10.1097/FPC.0b013e32833de489. PMID 20679960. S2CID 3475599.
Koroleva OS, Zateĭshchikov DA (2010). "[Motor protein Kinesin-6 and ischemic heart disease]". Kardiologiia. 50 (6): 54–62. PMID 20659029.
Bhanushali AA, Contractor A, Shah VT, Das BR (December 2011). "Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians". Genetic Testing and Molecular Biomarkers. 15 (12): 883–6. doi:10.1089/gtmb.2011.0079. PMID 21810021.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164627 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Kinesin family member 6".

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References

Further reading