TUBGCP6

TUBGCP6
Identifiers
Aliases	TUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDs	OMIM: 610053; MGI: 2146071; HomoloGene: 32477; GeneCards: TUBGCP6; OMA:TUBGCP6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,245,023 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,007,315 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; granulocyte; ; sural nerve; ; right frontal lobe; ; right ovary; ; apex of heart;
	Top expressed in
	tail of embryo; ; genital tubercle; ; otic vesicle; ; granulocyte; ; ventricular zone; ; cerebellar cortex; ; superior frontal gyrus; ; yolk sac; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; structural constituent of cytoskeleton; microtubule minus-end binding; gamma-tubulin binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; equatorial microtubule organizing center; membrane; microtubule organizing center; spindle pole body; microtubule; extracellular exosome; cytoskeleton; gamma-tubulin complex; gamma-tubulin small complex;
Biological process	centrosome duplication; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly; cytoplasmic microtubule organization; microtubule cytoskeleton organization; microtubule nucleation; meiosis; mitotic cell cycle; spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	85378
	328580
	ENSG00000128159
	ENSMUSG00000051786
	Q96RT7
	G5E8P0
	NM_001008658; NM_020461
	NM_001163319
	NP_065194
	NP_001156791
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.^[5]^[6]^[7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128159 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051786 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
^ Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
^ "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128159 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051786 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11694571-5] Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.

[pmid11258795-6] Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.

[entrez-7] "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

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TUBGCP6

See also

References

Further reading