Periplakin

PPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q28
Identifiers
Aliases	PPL, periplakin
External IDs	OMIM: 602871; MGI: 1194898; HomoloGene: 2026; GeneCards: PPL; OMA:PPL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,960,741 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,950,285 bp
RNA expression pattern
	Top expressed in
	oral cavity; ; amniotic fluid; ; mucosa of pharynx; ; gums; ; buccal mucosa cell; ; gingival epithelium; ; cervix epithelium; ; skin of arm; ; vulva; ; human penis;
	Top expressed in
	superior surface of tongue; ; corneal stroma; ; esophagus; ; skin of external ear; ; skin of back; ; lip; ; skin of abdomen; ; epidermis; ; umbilical cord; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; cadherin binding; structural molecule activity;
Cellular component	cytoplasm; cell junction; plasma membrane; desmosome; extracellular exosome; cytoskeleton; membrane; mitochondrion; nucleus; cornified envelope; cytosol; intermediate filament;
Biological process	keratinization; cytoskeleton organization; cornification; response to mechanical stimulus; wound healing; intermediate filament cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	5493
	19041
	ENSG00000118898
	ENSMUSG00000039457
	O60437
	Q9R269
	NM_002705
	NM_008909
	NP_002696
	NP_032935
	Wikidata
View/Edit Human	View/Edit Mouse

Periplakin is a protein that in humans is encoded by the PPL gene.^[5]^[6]^[7]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.^[7]

Interactions

PPL (gene) has been shown to interact with Keratin 8^[8] and Envoplakin.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118898 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. doi:10.1006/geno.1997.5206. PMID 9570964.
^ Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. doi:10.1006/geno.1997.5188. PMID 9521878.
^ ^a ^b "Entrez Gene: PPL periplakin".
^ Kazerounian S, Uitto Jouni, Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5). Denmark: 428–38. doi:10.1034/j.1600-0625.2002.110506.x. ISSN 0906-6705. PMID 12366696. S2CID 25735126.
^ Karashima T, Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24). England: 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088. S2CID 22383123.
^ Ruhrberg C, Hajibagheri M A, Parry D A, Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7). UNITED STATES: 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC 2132639. PMID 9412476.

External links

Overview of all the structural information available in the PDB for UniProt: O60437 (Periplakin) at the PDBe-KB.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118898 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570964-5] Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. doi:10.1006/geno.1997.5206. PMID 9570964.

[pmid9521878-6] Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. doi:10.1006/geno.1997.5188. PMID 9521878.

[entrez-7] "Entrez Gene: PPL periplakin".

[pmid12366696-8] Kazerounian S, Uitto Jouni, Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5). Denmark: 428–38. doi:10.1034/j.1600-0625.2002.110506.x. ISSN 0906-6705. PMID 12366696. S2CID 25735126.

[pmid12432088-9] Karashima T, Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24). England: 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088. S2CID 22383123.

[pmid9412476-10] Ruhrberg C, Hajibagheri M A, Parry D A, Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7). UNITED STATES: 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC 2132639. PMID 9412476.

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Periplakin

Interactions

See also

References

Further reading

External links