KEGG ORTHOLOGY: K05855

ORTHOLOGY: K05855

Entry

K05855                      KO

Symbol

SYK

Name

spleen tyrosine kinase [EC:2.7.10.2]

Pathway

map04064

NF-kappa B signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04380

Osteoclast differentiation

map04611

Platelet activation

map04613

Neutrophil extracellular trap formation

map04625

C-type lectin receptor signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04662

B cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04666

Fc gamma R-mediated phagocytosis

map05152

Tuberculosis

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

map05203

Viral carcinogenesis

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04072 Phospholipase D signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04151 PI3K-Akt signaling pathway
    K05855  SYK; spleen tyrosine kinase
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05855  SYK; spleen tyrosine kinase
   04613 Neutrophil extracellular trap formation
    K05855  SYK; spleen tyrosine kinase
   04625 C-type lectin receptor signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04650 Natural killer cell mediated cytotoxicity
    K05855  SYK; spleen tyrosine kinase
   04662 B cell receptor signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04664 Fc epsilon RI signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04666 Fc gamma R-mediated phagocytosis
    K05855  SYK; spleen tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05855  SYK; spleen tyrosine kinase
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05855  SYK; spleen tyrosine kinase
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05855  SYK; spleen tyrosine kinase
   05168 Herpes simplex virus 1 infection
    K05855  SYK; spleen tyrosine kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05855  SYK; spleen tyrosine kinase
   05169 Epstein-Barr virus infection
    K05855  SYK; spleen tyrosine kinase
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05855  SYK; spleen tyrosine kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05855  SYK; spleen tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05855  SYK; spleen tyrosine kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SYK family
   K05855  SYK; spleen tyrosine kinase

Other DBs

GO:	0004715 0004716

Genes

HSA:

6850(SYK)

PTR:	464586(SYK)

PPS:	100978194(SYK)

GGO:	101138129(SYK)

PON:	100438875(SYK)

PPYG:

129043982(SYK)

NLE:	100590261(SYK)

HMH:	116475231(SYK)

SSYN:

129479224(SYK)

MCC:	704102(SYK)

MCF:	102145713(SYK)

MTHB:

126937655

MNI:	105498823(SYK)

CSAB:

103219736(SYK)

CATY:

105579756(SYK)

PANU:

101024880(SYK)

TGE:	112608327(SYK)

MLEU:

105547549(SYK)

RRO:	104662008(SYK)

RBB:	108516810 108538610(SYK)

TFN:	117098357(SYK)

PTEH:

111528531(SYK)

CANG:

105516007(SYK)

CJC:	100394657(SYK)

SBQ:	101031617(SYK)

CIMI:

108304303(SYK)

ANAN:

105730788(SYK)

CSYR:

103261598(SYK)

MMUR:

105876181(SYK)

LCAT:

123646461(SYK)

PCOQ:

105817784(SYK)

OGA:	100949905(SYK)

MMU:	20963(Syk)

MCAL:

110308005(Syk)

MPAH:

110333852(Syk)

RNO:	25155(Syk)

MCOC:

116081405(Syk)

ANU:	117714378(Syk)

ASYL:

127664684(Syk)

MUN:	110552352(Syk)

CGE:	100758656(Syk)

MAUA:

101830753(Syk)

PROB:

127229235(Syk)

PLEU:

114689480(Syk)

MORG:

121444492 121453505

MFOT:

126502853

AAMP:

119817382(Syk)

NGI:	103745419(Syk)

HGL:	101719494(Syk)

CPOC:

100716985(Syk)

CCAN:

109688078(Syk)

DORD:

105993222(Syk)

DSP:	122113605(Syk)

PLOP:

125346974(Syk)

NCAR:

124965691

MMMA:

107157604(Syk)

OCU:

100345556

OPI:	101521299(SYK)

TUP:	102472653(SYK)

GVR:	103585244(SYK)

CFA:	484196(SYK)

CLUD:

112644845(SYK)

VVP:	112908642(SYK)

VLG:	121485752(SYK)

NPO:	129499651(SYK)

AML:	100474543(SYK)

UMR:	103663192(SYK)

UAH:	113270132(SYK)

UAR:	123776440(SYK)

ELK:

111153538

LLV:

125083174

MPUF:

101670738

MNP:	132024902(SYK)

MLK:	131813239(SYK)

NVS:	122917804(SYK)

ORO:	101373095(SYK)

EJU:	114219726(SYK)

ZCA:	113934433(SYK)

MLX:	118026369(SYK)

NSU:	110584304(SYK)

LWW:	102734956(SYK)

FCA:	101087013(SYK)

PYU:	121013735(SYK)

PCOO:

112868539(SYK)

PBG:	122475247(SYK)

PVIV:

125149842(SYK)

LRUF:

124527767

PTG:	102964642(SYK)

PPAD:

109275517(SYK)

PUC:

125924291

AJU:

106976132

HHV:	120237950(SYK)

BTA:	515515(SYK)

BOM:	102271008(SYK)

BIU:	109563281(SYK)

BBUB:

102412306(SYK)

BBIS:

104985678(SYK)

CHX:	102174120(SYK)

OAS:	101105303(SYK)

BTAX:

128052376(SYK)

CSUM:

138080997(SYK)

ODA:	120867678(SYK)

CCAD:

122431765(SYK)

MREE:

136176765(SYK)

MBEZ:

129557183(SYK)

SSC:	100125540(SYK)

CFR:	102504839(SYK) 102521769

CBAI:

105080508

CDK:	105105766 105106413 116149854

VPC:	102539951(SYK)

BACU:

103013608(SYK)

BMUS:

118897548(SYK)

LVE:	103079796(SYK)

OOR:	101281971(SYK)

DLE:	111167662(SYK)

PCAD:

102993186(SYK)

PSIU:

116755719(SYK)

NASI:

112390842(SYK)

ECB:	100063383(SYK)

EPZ:	103565660(SYK)

EAI:	106839739(SYK)

MYB:	102243247(SYK)

MYD:	102772593(SYK)

MMYO:

118652511(SYK)

MLF:	102428843(SYK)

MDT:	132211786(SYK)

PKL:	118708680(SYK)

EFUS:

103300004(SYK)

MNA:	107529171(SYK)

DRO:	112307282(SYK)

SHON:

118983557(SYK)

AJM:	119035131(SYK)

PDIC:

114512580(SYK)

PHAS:

123815559(SYK)

MMF:	118641349(SYK)

PPAM:

129082351(SYK)

HAI:	109375897(SYK)

RFQ:	117031968(SYK)

PALE:

102888426(SYK)

PGIG:

120594126(SYK)

PVP:	105300248(SYK)

RAY:	107518638(SYK)

MJV:	108384766(SYK)

TOD:	119232025(SYK)

SARA:

101551795(SYK)

SFUM:

130035664(SYK)

SETR:

126003376(SYK)

LAV:	100663651(SYK)

TMU:

101351806

ETF:	101654763(SYK)

DNM:	101438211(SYK)

MDO:

100028356

GAS:	123251014(SYK)

SHR:	100932859(SYK)

AFZ:

127538436

PCW:	110203252(SYK)

TVP:	118831727(SYK)

PBRV:

138160624(SYK)

OAA:	103167269 114808729(SYK)

GGA:	427272(SYK)

PCOC:

116240167(SYK)

MGP:

104909903

CJO:	107306310(SYK)

TPAI:

128089461(SYK)

LMUT:

125687000(SYK)

NMEL:

110389570(SYK)

APLA:

101795007 119714503

ACYG:

106045101(SYK)

CATA:

118259664(SYK)

AFUL:

116500755(SYK)

TGU:	100229485(SYK)

LSR:	110470628(SYK)

SCAN:

103821247(SYK)

PMOA:

120509441(SYK)

OTC:	121333359(SYK)

PRUF:

121363951(SYK)

GFR:	102040272(SYK)

FAB:	101821765(SYK)

OMA:	130265347(SYK)

PHI:	102109009(SYK)

PMAJ:

107216019(SYK)

CCAE:

111941719(SYK)

CCW:	104689725(SYK)

CBRC:

103621369(SYK)

ACOE:

138103723(SYK)

ETL:	114067715(SYK)

ZAB:	102070293(SYK)

ZLE:	135459528(SYK)

ACHL:

103799831(SYK)

SVG:	106848924(SYK)

MMEA:

130584794(SYK)

HRT:	120765794(SYK)

SATI:

136373513(SYK)

FPG:	101913951(SYK)

FCH:	102056879(SYK)

CCRI:

104162108(SYK)

NNT:	104413459(SYK)

SHAB:

115600828(SYK)

ACUN:

113490089(SYK)

TALA:

104362681(SYK)

ACHC:

115337276(SYK)

HALD:

104317466

HLE:	104832487(SYK)

HHAR:

128137249(SYK)

GCL:

127027410

CSTI:

104557989(SYK)

LDI:

104347718

MNB:	103778801(SYK)

DPUB:

104301140(SYK)

PPUS:

135193273(SYK)

AVIT:

104269593

BRHI:

104495389(SYK)

EGZ:	104126918(SYK)

NNI:	104013397(SYK)

PCRI:

104029297(SYK)

PCAO:

104053412

PADL:

103922194(SYK)

AFOR:

103905520(SYK)

FGA:	104074645 104080002

GSTE:

104255974(SYK)

CLV:	102092767(SYK)

PGUU:

104459849(SYK)

PLET:

104625852(SYK)

EHS:	104506158(SYK)

CMAC:

104478444(SYK)

CUCA:

104064066(SYK)

TEO:	104377102(SYK)

BREG:

104641320(SYK)

OHA:	104331387(SYK)

ACAR:

104519362

CPEA:

104393075(SYK)

CVF:	104292952(SYK)

RTD:	128902722(SYK)

AAM:	106495447(SYK)

AROW:

112974204(SYK)

NPD:	112953500(SYK)

TGT:	104580463(SYK)

DNE:	112978814(SYK)

SCAM:

104150281(SYK)

ASN:	102369846(SYK)

AMJ:	102568856(SYK)

CPOO:

109323593(SYK)

GGN:	109297513(SYK)

PSS:	102447364(SYK)

CMY:	102938012(SYK)

CCAY:

125637036(SYK)

DCC:	119855929(SYK)

CPIC:

101948627(SYK)

TST:	117879018(SYK)

CABI:

116828365(SYK)

MRV:	120408165(SYK)

ACS:	100554859(syk)

ASAO:

132767274(SYK)

PVT:	110081110(SYK)

SUND:

121923091(SYK)

PBI:	103067015(SYK)

PMUR:

107291984(SYK)

CTIG:

120303048(SYK)

TSR:	106547757(SYK)

PGUT:

117661342(SYK)

APRI:

131191178(SYK)

PTEX:

113438520(SYK)

NSS:	113416281(SYK)

VKO:	123031540(SYK)

PMUA:

114606544(SYK)

PRAF:

128423721(SYK)

ZVI:	118076822(SYK)

HCG:	128345141(SYK) 128347871

GJA:	107108630(SYK)

STOW:

125436604(SYK)

EMC:	129334283(SYK)

XLA:	399022(syk.S) 446500(syk.L)

XTR:	100486846(syk)

NPR:	108787186(SYK)

RTEM:

120941491(SYK)

BBUF:

120989075(SYK)

BGAR:

122922643(SYK)

MUO:	115463256(SYK)

GSH:	117352405(SYK)

DRE:	405769(syk)

SRX:	107715877 107736968

SANH:

107670033

SGH:	107558251 107560409(syk)

CCAR:

109064668 109098034

CAUA:

113053997 113109547

CGIB:

127966374 128021436

PTET:

122352739(syk)

LROH:

127171799(syk)

OMC:	131548363(syk)

PPRM:

120482053(syk)

MAMB:

125255759(syk)

CIDE:

127520524

MASI:

127432345 127433277

TROS:

130546558(syk)

TDW:	130411398(syk)

MANU:

129447418(syk)

IPU:

108277200

IFU:	128620401(syk)

PHYP:

113543957(syk)

SMEO:

124393198(syk)

TFD:	113639315(syk)

TVC:	132862998(syk)

TRN:	134332450(syk)

AMEX:

103026241(syk)

CMAO:

118824916(syk)

EEE:	113576751(syk)

CHAR:

105908489(syk)

TRU:	101063503(syk)

TFS:	130516844(syk)

TNG:	GSTEN00013649G001

LCO:	104935660(syk)

TBEN:

117478858(syk)

CGOB:

115016612(syk)

PGEO:

117456005(syk)

GACU:

117562106(syk)

EMAC:

134868602(syk)

ELY:	117269678(syk)

EFO:	125905810(syk)

PLEP:

121959842(syk)

SLUC:

116037999(syk)

ECRA:

117959692(syk)

ESP:	116704603(syk)

PFLV:

114570704 114571091

GAT:	120831924(syk)

PPUG:

119226633(syk)

AFB:	129102340(syk)

CLUM:

117740800(syk)

PSWI:

130205755(syk)

CANA:

137784098(syk)

CVE:	137868960(syk)

MSAM:

119914720(syk)

SCHU:

122865229(syk)

CUD:	121525150(syk)

SPUL:

138605091(syk)

ALAT:

119030317(syk)

ASTR:

137608295(syk)

MZE:	101475188(syk)

ONL:	100693670(syk)

OAU:	116315842(syk)

OLA:	101155127(syk)

OML:	112139199(syk) 112140450

CSAI:

133455472(syk)

XCO:	114150136(syk)

XHE:	116724721(syk)

PRET:

103473520(syk)

PLAI:

106940698

PMEI:

106906888(syk)

GAF:	122846865(syk)

PPRL:

129355346(syk)

CVG:	107105134(syk)

CTUL:

119777164(syk)

GMU:	124872449(syk)

NFU:	107395023(syk)

KMR:	108246454(syk)

ALIM:

106522182(syk)

NWH:	119424396(syk)

AOCE:

111579152(syk)

EJA:	138210008(syk)

BFRE:

138635586(syk)

MCEP:

124997048(syk)

CSEM:

103389853(syk)

POV:	109625997(syk)

SSEN:

122758669(syk)

HHIP:

117771899(syk)

HSP:	118098030(syk)

PPLT:

128424517(syk)

SMAU:

118300666(syk)

LCF:

108900733

SDU:	111221242(syk)

SLAL:

111648083(syk)

XGL:	120806173(syk)

HCQ:	109530546(syk)

SSCV:

125979809(syk)

SBIA:

133515250(syk)

PEE:	133413765(syk)

PTAO:

133465077(syk)

BPEC:

110161579(syk)

MALB:

109970889(syk)

BSPL:

114866932(syk)

SJO:	128380489(syk)

SASA:

100380388(syk)

STRU:

115160112(syk)

OTW:	112219981(syk)

OMY:	110523154(syk)

OGO:	123989520 124028274 124047732

ONE:	115117893(syk)

OKI:	109868119(syk)

OKE:	118387253(syk)

SALP:

111960920(syk)

SNH:	120026007(syk)

CCLU:

121581944(syk)

ELS:	105020452(syk)

SFM:	108929949(syk)

PKI:	111841163(syk)

AANG:

118212817(syk)

CCOG:

133142014(syk)

LOC:	102693870(syk)

PSPA:

121302164 121315724

ARUT:

117409334 117971937

PSEX:

120532950(syk)

LCM:	102351878(SYK)

CMK:	103182860(syk)

CPLA:

122561831(syk)

HOC:	132824342(syk)

LERI:

129695688(syk)

LRJ:

BFO:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DSV:

RSAN:

RMP:

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:

SMM:	Smp_149460 Smp_149470

LLON:

135487075

NVE:

5502196

EPA:	110235179 110241804

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HMG:

HSY:

RES:

AQU:

Reference

PMID:9535867

Authors

Deckert M, Elly C, Altman A, Liu YC

Title

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

Journal

J Biol Chem 273:8867-74 (1998)
DOI:10.1074/jbc.273.15.8867

Sequence

[hsa:6850]

Reference

PMID:7513161

Authors

Yagi S, Suzuki K, Hasegawa A, Okumura K, Ra C

Title

Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812).

Journal

Biochem Biophys Res Commun 200:28-34 (1994)
DOI:10.1006/bbrc.1994.1409

Sequence

[hsa:6850]

DBGET integrated database retrieval system