KEGG ORTHOLOGY: K04433

ORTHOLOGY: K04433

Entry

K04433                      KO

Symbol

MAP2K6, MKK6

Name

mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04015

Rap1 signaling pathway

map04212

Longevity regulating pathway - worm

map04218

Cellular senescence

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

map05135

Yersinia infection

map05145

Toxoplasmosis

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04935 Growth hormone synthesis, secretion and action
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05161 Hepatitis B
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05163 Human cytomegalovirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05135 Yersinia infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05022 Pathways of neurodegeneration - multiple diseases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6

Other DBs

GO:

0004708

Genes

HSA:	5608(MAP2K6)

PTR:	468310(MAP2K6)

PPS:	100972424(MAP2K6)

GGO:	101142374(MAP2K6)

PON:	100448382(MAP2K6)

PPYG:

129016958(MAP2K6)

NLE:	100591256(MAP2K6)

HMH:	116483711(MAP2K6)

SSYN:

129461683(MAP2K6)

MCC:	693914(MAP2K6)

MCF:	101925060(MAP2K6)

MTHB:

126939854

MNI:	105469063(MAP2K6)

CSAB:

103243132(MAP2K6)

CATY:

105577799(MAP2K6)

PANU:

101001515(MAP2K6)

TGE:	112609390(MAP2K6)

MLEU:

105544191(MAP2K6)

RRO:	104654038(MAP2K6)

RBB:	108523215(MAP2K6)

TFN:	117066601(MAP2K6)

PTEH:

111542478(MAP2K6)

CANG:

105505905(MAP2K6)

CJC:	100397389(MAP2K6)

SBQ:	101030219(MAP2K6)

CIMI:

108281677(MAP2K6)

ANAN:

105718182(MAP2K6)

CSYR:

103254297

MMUR:

105861678(MAP2K6)

LCAT:

123650624(MAP2K6)

PCOQ:

105824710(MAP2K6)

OGA:	100962457(MAP2K6)

MMU:	26399(Map2k6)

MCAL:

110304684(Map2k6)

MPAH:

110331335(Map2k6)

RNO:	114495(Map2k6)

MCOC:

116079135(Map2k6)

ANU:	117710811(Map2k6)

ASYL:

127694765(Map2k6)

MUN:	110563015(Map2k6)

CGE:

100771767

MAUA:

101833237(Map2k6)

PROB:

127218712(Map2k6)

PLEU:

114690458(Map2k6)

MORG:

121436314(Map2k6)

MFOT:

126500469

AAMP:

119812035(Map2k6)

NGI:	103742218(Map2k6)

HGL:	101703028(Map2k6)

CPOC:

100731419(Map2k6)

CCAN:

109698990(Map2k6)

DORD:

106002705(Map2k6)

DSP:	122128383(Map2k6)

PLOP:

125365364(Map2k6)

NCAR:

124981341

MMMA:

107157181(Map2k6)

OCU:

100355230

OPI:	101519949(MAP2K6)

TUP:	102482054(MAP2K6)

GVR:	103583282(MAP2K6)

CFA:	480454(MAP2K6)

CLUD:

112652877(MAP2K6)

VVP:	112920749(MAP2K6)

VLG:	121473314(MAP2K6)

NPO:	129508745(MAP2K6)

AML:	100469111(MAP2K6)

UMR:	103665687(MAP2K6)

UAH:	113265227(MAP2K6)

UAR:	123803240(MAP2K6)

ELK:

111158041

LLV:

125087142

MPUF:

101670597(MAP2K6)

MNP:	132004478(MAP2K6)

MLK:	131816040(MAP2K6)

NVS:	122906041(MAP2K6)

ORO:	101382167(MAP2K6)

EJU:	114216197(MAP2K6)

ZCA:	113908216(MAP2K6)

MLX:	118024329(MAP2K6)

NSU:	110570428(MAP2K6)

LWW:	102743800(MAP2K6)

FCA:	101089813(MAP2K6)

PYU:	121015350(MAP2K6)

PCOO:

112864599(MAP2K6)

PBG:	122485830(MAP2K6)

PVIV:

125151813(MAP2K6)

LRUF:

124513476

PTG:	102966485(MAP2K6)

PPAD:

109277026(MAP2K6)

PUC:

125926707

AJU:

106988444

HHV:	120230246(MAP2K6)

BTA:	286883(MAP2K6)

BIU:	109573853(MAP2K6)

BBUB:

102403288(MAP2K6)

BBIS:

105000295(MAP2K6)

CHX:	102169516(MAP2K6)

OAS:	101115047(MAP2K6)

BTAX:

128065178(MAP2K6)

CSUM:

138083118(MAP2K6)

ODA:	120866612(MAP2K6)

CCAD:

122429019(MAP2K6)

MREE:

136150052(MAP2K6)

MBEZ:

129544772(MAP2K6)

SSC:	100625946(MAP2K6)

CFR:	102519784(MAP2K6)

CBAI:

105063918(MAP2K6)

CDK:	105085694(MAP2K6)

VPC:	102545165(MAP2K6)

BACU:

103012537(MAP2K6)

BMUS:

118886696(MAP2K6)

LVE:

103081641

OOR:	101280413(MAP2K6)

DLE:	111182897(MAP2K6)

PCAD:

102982175(MAP2K6)

PSIU:

116746300(MAP2K6)

NASI:

112410464(MAP2K6)

ECB:	100053056(MAP2K6)

EPZ:	103564566(MAP2K6)

EAI:	106830236(MAP2K6)

MYB:	102246913(MAP2K6)

MYD:	102759247(MAP2K6)

MMYO:

118672023(MAP2K6)

MLF:	102426303(MAP2K6)

MDT:	132219031(MAP2K6)

PKL:	118702109(MAP2K6)

EFUS:

103299424(MAP2K6)

MNA:	107528394(MAP2K6)

DRO:	112316519(MAP2K6)

SHON:

119003578(MAP2K6)

AJM:	119036284(MAP2K6)

PDIC:

114503069(MAP2K6)

PHAS:

123817154(MAP2K6)

MMF:	118634140(MAP2K6)

PPAM:

129070245(MAP2K6)

HAI:	109371344(MAP2K6)

RFQ:	117013904(MAP2K6)

PALE:

102888822(MAP2K6)

PGIG:

120600014(MAP2K6)

PVP:	105298936(MAP2K6)

RAY:	107510279(MAP2K6)

MJV:	108405137(MAP2K6)

TOD:	119231622(MAP2K6)

SARA:

101542881(MAP2K6)

SFUM:

130035909(MAP2K6)

SETR:

126008206(MAP2K6)

LAV:	100662511(MAP2K6)

TMU:

101344286

ETF:	101643832(MAP2K6)

DNM:	101431376(MAP2K6)

MDO:	100029049(MAP2K6)

GAS:	123246222(MAP2K6)

AFZ:

127560548

PCW:	110219359(MAP2K6)

TVP:	118847672(MAP2K6)

PBRV:

138152587(MAP2K6)

OAA:	100078394(MAP2K6)

GGA:	417445(MAP2K6)

PCOC:

116232481(MAP2K6)

MGP:	100545287(MAP2K6)

CJO:	107322198(MAP2K6)

TPAI:

128083050(MAP2K6)

LMUT:

125702133(MAP2K6)

NMEL:

110407251(MAP2K6)

APLA:

119713161(MAP2K6)

ACYG:

106034753(MAP2K6)

CATA:

118253982(MAP2K6)

AFUL:

116496466(MAP2K6)

TGU:	100226231(MAP2K6)

LSR:	110473926(MAP2K6)

SCAN:

103819965(MAP2K6)

PMOA:

120505376(MAP2K6)

OTC:	121338227(MAP2K6)

PRUF:

121363365(MAP2K6)

GFR:	102039445(MAP2K6)

FAB:	101819388(MAP2K6)

OMA:	130260495(MAP2K6)

PHI:	102105268(MAP2K6)

PMAJ:

107212284(MAP2K6)

CCAE:

111937452(MAP2K6)

CCW:	104696025(MAP2K6)

CBRC:

103613897(MAP2K6)

ACOE:

138120325(MAP2K6)

ETL:	114060693(MAP2K6)

ZAB:	102067681(MAP2K6)

ZLE:	135455480(MAP2K6)

ACHL:

103799486

SVG:	106856971(MAP2K6)

MMEA:

130584174(MAP2K6)

HRT:	120761127(MAP2K6)

SATI:

136369469(MAP2K6)

FPG:	101913671(MAP2K6)

FCH:	102053088(MAP2K6)

CCRI:

104169320

NNT:	104405440(MAP2K6)

SHAB:

115616735(MAP2K6)

ACUN:

113486793(MAP2K6)

TALA:

104367888(MAP2K6)

ACHC:

115341693(MAP2K6)

HALD:

104324566

HLE:	104838787(MAP2K6)

AGEN:

126044026

HHAR:

128150986(MAP2K6)

GCL:

127023976

CSTI:

104561297(MAP2K6)

LDI:	104346570(MAP2K6)

MNB:

103774940

DPUB:

104297856(MAP2K6)

PPUS:

135179688(MAP2K6)

AVIT:

104279348(MAP2K6)

BRHI:

104499360(MAP2K6)

EGZ:	104132828(MAP2K6)

NNI:	104014353(MAP2K6)

PCRI:

104033039

PCAO:

104046303

PADL:

103916640(MAP2K6)

AFOR:

103902435(MAP2K6)

FGA:	104078859(MAP2K6)

GSTE:

104261135(MAP2K6)

CLV:	102086996(MAP2K6)

MUI:	104537914(MAP2K6)

PGUU:

104464818

PLET:

104623176

EHS:

104510601

CMAC:

104476633(MAP2K6)

CUCA:

104056925(MAP2K6)

TEO:	104383544(MAP2K6)

BREG:

104640593(MAP2K6)

OHA:	104335932(MAP2K6)

ACAR:

104532186

CPEA:

104393228(MAP2K6)

CVF:	104295089(MAP2K6)

RTD:	128917839(MAP2K6)

AAM:	106490233(MAP2K6)

AROW:

112966967(MAP2K6)

NPD:	112953655(MAP2K6)

TGT:	104564900(MAP2K6)

DNE:	112982537(MAP2K6)

SCAM:

104146835(MAP2K6)

ASN:	102373782(MAP2K6)

AMJ:	106736984(MAP2K6)

CPOO:

109314938(MAP2K6)

GGN:	109296704(MAP2K6)

PSS:	102461243(MAP2K6)

CMY:	102942953(MAP2K6)

CCAY:

125621197(MAP2K6)

DCC:	119842822(MAP2K6)

CPIC:

101935028(MAP2K6)

TST:	117887377(MAP2K6)

CABI:

116834835(MAP2K6)

MRV:	120383171(MAP2K6)

ACS:	100567963(map2k6)

ASAO:

132768395(MAP2K6)

PVT:	110077815(MAP2K6)

SUND:

121921526(MAP2K6)

PBI:

103058491

PMUR:

107282569(MAP2K6)

CTIG:

120299971(MAP2K6)

TSR:

106543486

PGUT:

117662946(MAP2K6)

APRI:

131193154(MAP2K6)

PTEX:

113436987(MAP2K6)

NSS:	113417417(MAP2K6)

VKO:	123020202 123030154

PMUA:

114588447(MAP2K6)

PRAF:

128407266(MAP2K6)

ZVI:	118079658(MAP2K6)

HCG:	128345438(MAP2K6)

GJA:	107122462(MAP2K6)

STOW:

125428190(MAP2K6)

EMC:	129328147(MAP2K6)

XLA:	379638(map2k6.L) 399150(map2k3)

XTR:	448132(map2k6)

RTEM:

120919063(MAP2K6)

BBUF:

121004730(MAP2K6)

BGAR:

122940256(MAP2K6)

MUO:	115472304(MAP2K6)

GSH:	117367392(MAP2K6)

DRE:	65239(map2k6)

SRX:	107753245 107755396

SANH:

107684112

SGH:	107561815 107597823

CCAR:

109046626 109046639 109103603

CAUA:

113055995 113075496 113111626 113111658

CGIB:

127969198

PTET:

122355522(map2k6)

LROH:

127174013(map2k6)

OMC:	131551136(map2k6)

PPRM:

120474717(map2k6)

RKG:	130080158(map2k6)

MAMB:

125255310(map2k6)

CIDE:

127524204

CERY:

137007492(map2k6)

MASI:

127423123 127426946

TROS:

130569286(map2k6)

TDW:	130438964(map2k6)

MANU:

129420284(map2k6)

IPU:	108274084(map2k6)

IFU:	128616705(map2k6)

PHYP:

113527237

SMEO:

124388598(map2k6)

TFD:	113651614(map2k6)

TVC:	132862615(map2k6)

TRN:	134321172(map2k6)

AMEX:

111191499(map2k6)

CMAO:

118809070(map2k6)

EEE:

113585643

CHAR:

105893604(map2k6) 105894965

TRU:	101064673 101073869

TFS:	130515448 130523603(map2k6)

TNG:	GSTEN00018597G001

LCO:	104925053 104928151

NCC:	104944235(map2k6) 104948325

TBEN:

117473856(map2k6) 117492626

CGOB:

115012637 115024590

PGEO:

117451034 117464865(map2k6)

GACU:

117548594 117553527(map2k6)

EMAC:

134871028(map2k6) 134878240

ELY:	117247143(map2k6) 117268766

EFO:	125879506 125880680(map2k6)

PLEP:

121957025 121958775(map2k6)

SLUC:

116059565 116061169(map2k6)

ECRA:

117936952(map2k6) 117958358

ESP:	116671244 116702724

PFLV:

114548455 114569386

GAT:	120819366(map2k6) 120828362

PPUG:

119213268(map2k6) 119220864

AFB:	129091200(map2k6) 129097967

CLUM:

117735377 117748744(map2k6)

PSWI:

130188772 130203445

CANA:

137786866 137801880(map2k6)

CVE:	137878311(map2k6)

MSAM:

119890456 119915650(map2k6)

SCHU:

122867604(map2k6) 122868911

CUD:	121503317 121528906(map2k6)

SPUL:

138593211(map2k6) 138602652

ALAT:

119010027(map2k6) 119014532

ASTR:

137588098(map2k6) 137609550

MZE:	101473145 101479195

ONL:	100697168 100697345

OAU:	116325201 116328614(map2k6)

OLA:	101163933 101170843

OML:	112146636 112154201(map2k6)

CSAI:

133418847 133421715

XMA:	102219049 102221885

XCO:	114152162 114160221

XHE:	116727357 116735977

PRET:

103468828 103481589

PFOR:

103140939 103150707 103150725

PLAI:

106949098 106951757

PMEI:

106920063 106922419 106931279

GAF:	122821663 122823765(map2k6)

PPRL:

129363777 129368241(map2k6)

CVG:	107083188 107090247

CTUL:

119775958(map2k6) 119778260

GMU:	124862863 124864761 124875121(map2k6)

NFU:	107378273 107387425

KMR:	108241241 108245617

ALIM:

106528548 106529047

NWH:	119421012 119424210(map2k6)

AOCE:

111564651 111585477

EJA:	138197955 138204622(map2k6)

BFRE:

138623388 138635726(map2k6)

MCEP:

124998191 125022674(map2k6)

CSEM:

103382222 103392800

POV:	109634317 109647356

SSEN:

122759414(map2k6) 122765439 122784954

HHIP:

117752994(map2k6) 117766311

HSP:	118100279(map2k6) 118123527

PPLT:

128426937(map2k6) 128459295

SMAU:

118287208(map2k6) 118288528

LCF:	108876848(map2k6) 108902699

SDU:	111219741 111227238

SLAL:

111657787 111664323

XGL:	120794111(map2k6) 120805077

HCQ:	109518564 109532551

SSCV:

125983484(map2k6)

SBIA:

133514631(map2k6)

PEE:	133414425(map2k6)

PTAO:

133465694 133468948(map2k6)

BPEC:

110166072 110166701

MALB:

109962725 109972262

BSPL:

114846339(map2k6) 114860381

SJO:	128378855 128381286(map2k6)

SASA:

100136944(mkk6a) 100192337(mkk6b) 100192338(mkk6c) 106601934 106606355 106606359

STRU:

115153520 115171844 115201695 115207531

OTW:	112224035 112257868(map2k6) 121843802

OMY:	110487439 110499544 110502795(map2k6) 110518132

OGO:	124020632 124025444 124025716 124026110 124038478 124040414(map2k6)

ONE:	115112972 115118936

OKI:	109870395 109876913 109899929

OKE:	118375502 118397477

SALP:

111968176 111978520 112077035

SNH:	120029867 120043801 120045697(map2k6)

CCLU:

121547737 121551598 121575920 123482637 123483342

ELS:	105027407 105031287

SFM:	108922496 108924851(map2k6)

PKI:	111848425(map2k6) 111859759

AANG:

118217112(map2k6)

CCOG:

133114560(map2k6)

LOC:	102692628(map2k6)

PSPA:

121295305 121296108

ARUT:

117422947 117424624

LCM:	102362389(MAP2K6)

CMK:

103175734

RTP:

109935499

CPLA:

122562211

HOC:	132827776(map2k6)

LERI:

129708248

PMRN:

116951466 116954104

LRJ:	133340621 133347708

BFO:

118428978

BBEL:

109485302

CIN:	778902(mapkk3/6)

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

PPOI:

DSV:

RSAN:

RMP:

VDE:

TUT:

LPOL:

PMEO:

CEL:	CELE_R03G5.2(sek-1)

CBR:	CBG_16802(Cbr-sek-1)

CRQ:	GCK72_024854

NAI:	NECAME_00159

LOA:	LOAG_02233

HRO:	HELRODRAFT_74733

GAE:

121378396

HRJ:	124284413 124292347

CRG:

CANU:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

SMM:	Smp_073510

SHX:	MS3_00003218(MAP2K6_3)

LLON:

135487318

NVE:	5499944 5509635

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

XEN:

HMG:

HSY:

RES:

AQU:

Reference

PMID:8622669

Authors

Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ

Title

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

Journal

Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247

Sequence

[hsa:5608]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (50)   
   KEGG PATHWAY (50)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (903)   
   KEGG GENES (587)   
   KEGG MGENES (76)   
   RefGene (234)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (959)   

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