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KEGG   PATHWAY: hsa00071
Entry
hsa00071                    Pathway                                
Name
Fatty acid degradation - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
Pathway map
hsa00071  Fatty acid degradation
hsa00071

Module
hsa_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:hsa00071]
hsa_M00087  beta-Oxidation [PATH:hsa00071]
Network
  Element
N00765  beta-Oxidation, acyl-CoA synthesis
N00804  beta-Oxidation
Drug
D00123  Cyanamide (JP18)
D00131  Disulfiram (JP18/USP/INN)
D05292  Oxfenicine (USAN/INN)
Other DBs
GO: 0009062
Organism
Homo sapiens (human) [GN:hsa]
Gene
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
30  ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
10449  ACAA2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]
3032  HADHB; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [KO:K07509] [EC:2.3.1.16]
3033  HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
3030  HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
1962  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
1892  ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
8310  ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
51  ACOX1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]
35  ACADS; acyl-CoA dehydrogenase short chain [KO:K00248] [EC:1.3.8.1]
34  ACADM; acyl-CoA dehydrogenase medium chain [KO:K00249] [EC:1.3.8.7]
33  ACADL; acyl-CoA dehydrogenase long chain [KO:K00255] [EC:1.3.8.8]
36  ACADSB; acyl-CoA dehydrogenase short/branched chain [KO:K09478] [EC:1.3.8.5]
37  ACADVL; acyl-CoA dehydrogenase very long chain [KO:K09479] [EC:1.3.8.9]
2639  GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
23305  ACSL6; acyl-CoA synthetase long chain family member 6 [KO:K01897] [EC:6.2.1.3]
2182  ACSL4; acyl-CoA synthetase long chain family member 4 [KO:K01897] [EC:6.2.1.3]
2180  ACSL1; acyl-CoA synthetase long chain family member 1 [KO:K01897] [EC:6.2.1.3]
51703  ACSL5; acyl-CoA synthetase long chain family member 5 [KO:K01897] [EC:6.2.1.3]
2181  ACSL3; acyl-CoA synthetase long chain family member 3 [KO:K01897] [EC:6.2.1.3]
23205  ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
81616  ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
1374  CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
1375  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
126129  CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
1376  CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
1632  ECI1; enoyl-CoA delta isomerase 1 [KO:K13238] [EC:5.3.3.8]
10455  ECI2; enoyl-CoA delta isomerase 2 [KO:K13239] [EC:5.3.3.8]
113612  CYP2U1; cytochrome P450 family 2 subfamily U member 1 [KO:K07422] [EC:1.14.14.80]
124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00071  Aldehyde
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00226  Primary alcohol
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00332  Acetoacetyl-CoA
C00340  Reduced rubredoxin
C00435  Oxidized rubredoxin
C00489  Glutarate
C00517  Hexadecanal
C00527  Glutaryl-CoA
C00638  Long-chain fatty acid
C00823  1-Hexadecanol
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01371  Alkane
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02990  L-Palmitoylcarnitine
C03221  2-trans-Dodecenoyl-CoA
C03547  omega-Hydroxy fatty acid
C03561  (R)-3-Hydroxybutanoyl-CoA
C05102  alpha-Hydroxy fatty acid
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C05279  trans,cis-Lauro-2,6-dienoyl-CoA
C05280  cis,cis-3,6-Dodecadienoyl-CoA
C20683  Long-chain acyl-[acyl-carrier protein]
Reference
PMID:869535
  Authors
Parekh VR, Traxler RW, Sobek JM
  Title
N-Alkane oxidation enzymes of a pseudomonad.
  Journal
Appl Environ Microbiol 33:881-4 (1977)
DOI:10.1128/AEM.33.4.881-884.1977
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00061  Fatty acid biosynthesis
hsa00062  Fatty acid elongation
hsa00561  Glycerolipid metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00650  Butanoate metabolism
KO pathway
ko00071   

  All links  
Network (2)   
   KEGG NETWORK (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (43)   
   KEGG GENES (43)   
All databases (46)   

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