Entry |
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Symbol |
HADHA
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Name |
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC: 4.2.1.17 1.1.1.211]
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Pathway |
map00280 | Valine, leucine and isoleucine degradation |
map01110 | Biosynthesis of secondary metabolites |
map01120 | Microbial metabolism in diverse environments |
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Module |
M00032 | Lysine degradation, lysine => saccharopine => acetoacetyl-CoA |
M00085 | Fatty acid elongation in mitochondria |
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Reaction |
R01778 | (3S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase |
R02685 | (3S)-3-hydroxyacyl-CoA hydro-lyase |
R03026 | (S)-3-hydroxybutanoyl-CoA hydro-lyase |
R03045 | 3-hydroxypropionyl-CoA hydro-lyase |
R04137 | 3-hydroxyisovaleryl-CoA hydro-lyase |
R04170 | (S)-3-hydroxydodecanoyl-CoA hydro-lyase |
R04204 | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase |
R04224 | (S)-3-hydroxyisobutyryl-CoA hydro-lyase |
R04737 | (S)-3-hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase |
R04738 | (S)-3-hydroxyhexadecanoyl-CoA hydro-lyase |
R04739 | (S)-3-hydroxytetradecanoyl-CoA:NAD+ oxidoreductase |
R04740 | (S)-3-hydroxytetradecanoyl-CoA hydro-lyase |
R04741 | (S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase |
R04743 | (S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase |
R04744 | (S)-hydroxydecanoyl-CoA hydro-lyase |
R04745 | (S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase |
R04746 | (S)-hydroxyoctanoyl-CoA hydro-lyase |
R04748 | (S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase |
R04749 | (S)-hydroxyhexanoyl-CoA hydro-lyase |
R06942 | (3S)-3-hydroxyacyl-CoA hydro-lyase |
|
Disease |
H00525 | Disorders of mitochondrial fatty-acid oxidation |
H01352 | Mitochondrial trifunctional protein deficiency |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
00650 Butanoate metabolism
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
09103 Lipid metabolism
00062 Fatty acid elongation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
00071 Fatty acid degradation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
00310 Lysine degradation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
00380 Tryptophan metabolism
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
09106 Metabolism of other amino acids
00410 beta-Alanine metabolism
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
09111 Xenobiotics biodegradation and metabolism
00627 Aminobenzoate degradation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
00930 Caprolactam degradation
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.17 enoyl-CoA hydratase
K07515 HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Kamijo T, Aoyama T, Komiyama A, Hashimoto T |
Title |
Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein. |
Journal |
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Sequence |
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